data_7ZH0
# 
_entry.id   7ZH0 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7ZH0         pdb_00007zh0 10.2210/pdb7zh0/pdb 
WWPDB D_1292122245 ?            ?                   
EMDB  EMD-14716    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1  'Structure model' 1 0 2022-11-09 ? 
2  'EM metadata'     1 0 2022-11-09 ? 
3  FSC               1 0 2022-11-09 ? 
4  'Half map'        1 0 2022-11-09 1 
5  'Half map'        1 0 2022-11-09 2 
6  Image             1 0 2022-11-09 ? 
7  'Primary map'     1 0 2022-11-09 ? 
8  'Structure model' 1 1 2022-12-07 ? 
9  FSC               1 0 2022-11-09 ? 
10 'Half map'        1 0 2022-11-09 1 
11 'Half map'        1 0 2022-11-09 2 
12 Image             1 0 2022-11-09 ? 
13 'Primary map'     1 0 2022-11-09 ? 
14 'Structure model' 1 2 2023-04-19 ? 
15 FSC               1 0 2022-11-09 ? 
16 'Half map'        1 0 2022-11-09 1 
17 'Half map'        1 0 2022-11-09 2 
18 Image             1 0 2022-11-09 ? 
19 'Primary map'     1 0 2022-11-09 ? 
20 'Structure model' 1 3 2024-11-20 ? 
21 FSC               1 0 2022-11-09 ? 
22 'Half map'        1 0 2022-11-09 1 
23 'Half map'        1 0 2022-11-09 2 
24 Image             1 0 2022-11-09 ? 
25 'Primary map'     1 0 2022-11-09 ? 
26 'Structure model' 1 4 2025-07-02 ? 
27 'EM metadata'     1 1 2025-07-02 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1  1  'Structure model' repository 'Initial release' ? ? 
2  2  'EM metadata'     repository 'Initial release' ? ? 
3  3  FSC               repository 'Initial release' ? ? 
4  4  'Half map'        repository 'Initial release' ? ? 
5  5  'Half map'        repository 'Initial release' ? ? 
6  6  Image             repository 'Initial release' ? ? 
7  7  'Primary map'     repository 'Initial release' ? ? 
8  9  FSC               repository 'Initial release' ? ? 
9  10 'Half map'        repository 'Initial release' ? ? 
10 11 'Half map'        repository 'Initial release' ? ? 
11 12 Image             repository 'Initial release' ? ? 
12 13 'Primary map'     repository 'Initial release' ? ? 
13 15 FSC               repository 'Initial release' ? ? 
14 16 'Half map'        repository 'Initial release' ? ? 
15 17 'Half map'        repository 'Initial release' ? ? 
16 18 Image             repository 'Initial release' ? ? 
17 19 'Primary map'     repository 'Initial release' ? ? 
18 21 FSC               repository 'Initial release' ? ? 
19 22 'Half map'        repository 'Initial release' ? ? 
20 23 'Half map'        repository 'Initial release' ? ? 
21 24 Image             repository 'Initial release' ? ? 
22 25 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 8  'Structure model' 'Database references'  
2 14 'Structure model' 'Database references'  
3 20 'Structure model' 'Data collection'      
4 20 'Structure model' 'Structure summary'    
5 26 'Structure model' 'Data collection'      
6 27 'EM metadata'     'Data processing'      
7 27 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1  8  'Structure model' citation                  
2  14 'Structure model' citation                  
3  14 'Structure model' citation_author           
4  20 'Structure model' chem_comp_atom            
5  20 'Structure model' chem_comp_bond            
6  20 'Structure model' em_admin                  
7  20 'Structure model' pdbx_entry_details        
8  20 'Structure model' pdbx_modification_feature 
9  26 'Structure model' em_admin                  
10 26 'Structure model' em_software               
11 27 'EM metadata'     em_admin                  
12 27 'EM metadata'     em_software               
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  8  'Structure model' '_citation.title'                   
2  14 'Structure model' '_citation.country'                 
3  14 'Structure model' '_citation.journal_abbrev'          
4  14 'Structure model' '_citation.journal_id_CSD'          
5  14 'Structure model' '_citation.journal_id_ISSN'         
6  14 'Structure model' '_citation.journal_volume'          
7  14 'Structure model' '_citation.page_first'              
8  14 'Structure model' '_citation.page_last'               
9  14 'Structure model' '_citation.pdbx_database_id_DOI'    
10 14 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 14 'Structure model' '_citation.title'                   
12 14 'Structure model' '_citation.year'                    
13 20 'Structure model' '_em_admin.last_update'             
14 26 'Structure model' '_em_admin.last_update'             
15 26 'Structure model' '_em_software.name'                 
16 27 'EM metadata'     '_em_admin.last_update'             
17 27 'EM metadata'     '_em_software.name'                 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        7ZH0 
_pdbx_database_status.recvd_initial_deposition_date   2022-04-05 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Structure of human OCT1 in lipid nanodisc' 
_pdbx_database_related.db_id          EMD-14716 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              volodymyr.korkhov@psi.ch 
_pdbx_contact_author.name_first         Volodymyr 
_pdbx_contact_author.name_last          Korkhov 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0962-9433 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Khanppnavar, B.' 1 ? 
'Korkhov, V.'     2 ? 
'Qi, C.'          3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            13 
_citation.language                  ? 
_citation.page_first                6714 
_citation.page_last                 6714 
_citation.title                     'Structural basis of organic cation transporter-3 inhibition.' 
_citation.year                      2022 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-022-34284-8 
_citation.pdbx_database_id_PubMed   36344565 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Khanppnavar, B.' 1  ?                   
primary 'Maier, J.'       2  0000-0001-6016-1947 
primary 'Herborg, F.'     3  0000-0002-0159-4598 
primary 'Gradisch, R.'    4  0000-0002-3312-2472 
primary 'Lazzarin, E.'    5  ?                   
primary 'Luethi, D.'      6  0000-0003-0874-4875 
primary 'Yang, J.W.'      7  0000-0001-8928-0130 
primary 'Qi, C.'          8  0000-0003-1277-0363 
primary 'Holy, M.'        9  ?                   
primary 'Jantsch, K.'     10 ?                   
primary 'Kudlacek, O.'    11 ?                   
primary 'Schicker, K.'    12 ?                   
primary 'Werge, T.'       13 0000-0003-1829-0766 
primary 'Gether, U.'      14 0000-0002-0020-3807 
primary 'Stockner, T.'    15 0000-0002-7071-8283 
primary 'Korkhov, V.M.'   16 0000-0002-0962-9433 
primary 'Sitte, H.H.'     17 0000-0002-1339-7444 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Solute carrier family 22 member 3' 
_entity.formula_weight             61332.836 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Extraneuronal monoamine transporter,EMT,Organic cation transporter 3' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRG
PEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAI
LNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR
IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLS
SNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLT
IERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG
GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRG
PEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAI
LNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR
IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLS
SNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLT
IERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG
GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   PRO n 
1 3   SER n 
1 4   PHE n 
1 5   ASP n 
1 6   GLU n 
1 7   ALA n 
1 8   LEU n 
1 9   GLN n 
1 10  ARG n 
1 11  VAL n 
1 12  GLY n 
1 13  GLU n 
1 14  PHE n 
1 15  GLY n 
1 16  ARG n 
1 17  PHE n 
1 18  GLN n 
1 19  ARG n 
1 20  ARG n 
1 21  VAL n 
1 22  PHE n 
1 23  LEU n 
1 24  LEU n 
1 25  LEU n 
1 26  CYS n 
1 27  LEU n 
1 28  THR n 
1 29  GLY n 
1 30  VAL n 
1 31  THR n 
1 32  PHE n 
1 33  ALA n 
1 34  PHE n 
1 35  LEU n 
1 36  PHE n 
1 37  VAL n 
1 38  GLY n 
1 39  VAL n 
1 40  VAL n 
1 41  PHE n 
1 42  LEU n 
1 43  GLY n 
1 44  THR n 
1 45  GLN n 
1 46  PRO n 
1 47  ASP n 
1 48  HIS n 
1 49  TYR n 
1 50  TRP n 
1 51  CYS n 
1 52  ARG n 
1 53  GLY n 
1 54  PRO n 
1 55  SER n 
1 56  ALA n 
1 57  ALA n 
1 58  ALA n 
1 59  LEU n 
1 60  ALA n 
1 61  GLU n 
1 62  ARG n 
1 63  CYS n 
1 64  GLY n 
1 65  TRP n 
1 66  SER n 
1 67  PRO n 
1 68  GLU n 
1 69  GLU n 
1 70  GLU n 
1 71  TRP n 
1 72  ASN n 
1 73  ARG n 
1 74  THR n 
1 75  ALA n 
1 76  PRO n 
1 77  ALA n 
1 78  SER n 
1 79  ARG n 
1 80  GLY n 
1 81  PRO n 
1 82  GLU n 
1 83  PRO n 
1 84  PRO n 
1 85  GLU n 
1 86  ARG n 
1 87  ARG n 
1 88  GLY n 
1 89  ARG n 
1 90  CYS n 
1 91  GLN n 
1 92  ARG n 
1 93  TYR n 
1 94  LEU n 
1 95  LEU n 
1 96  GLU n 
1 97  ALA n 
1 98  ALA n 
1 99  ASN n 
1 100 ASP n 
1 101 SER n 
1 102 ALA n 
1 103 SER n 
1 104 ALA n 
1 105 THR n 
1 106 SER n 
1 107 ALA n 
1 108 LEU n 
1 109 SER n 
1 110 CYS n 
1 111 ALA n 
1 112 ASP n 
1 113 PRO n 
1 114 LEU n 
1 115 ALA n 
1 116 ALA n 
1 117 PHE n 
1 118 PRO n 
1 119 ASN n 
1 120 ARG n 
1 121 SER n 
1 122 ALA n 
1 123 PRO n 
1 124 LEU n 
1 125 VAL n 
1 126 PRO n 
1 127 CYS n 
1 128 ARG n 
1 129 GLY n 
1 130 GLY n 
1 131 TRP n 
1 132 ARG n 
1 133 TYR n 
1 134 ALA n 
1 135 GLN n 
1 136 ALA n 
1 137 HIS n 
1 138 SER n 
1 139 THR n 
1 140 ILE n 
1 141 VAL n 
1 142 SER n 
1 143 GLU n 
1 144 PHE n 
1 145 ASP n 
1 146 LEU n 
1 147 VAL n 
1 148 CYS n 
1 149 VAL n 
1 150 ASN n 
1 151 ALA n 
1 152 TRP n 
1 153 MET n 
1 154 LEU n 
1 155 ASP n 
1 156 LEU n 
1 157 THR n 
1 158 GLN n 
1 159 ALA n 
1 160 ILE n 
1 161 LEU n 
1 162 ASN n 
1 163 LEU n 
1 164 GLY n 
1 165 PHE n 
1 166 LEU n 
1 167 THR n 
1 168 GLY n 
1 169 ALA n 
1 170 PHE n 
1 171 THR n 
1 172 LEU n 
1 173 GLY n 
1 174 TYR n 
1 175 ALA n 
1 176 ALA n 
1 177 ASP n 
1 178 ARG n 
1 179 TYR n 
1 180 GLY n 
1 181 ARG n 
1 182 ILE n 
1 183 VAL n 
1 184 ILE n 
1 185 TYR n 
1 186 LEU n 
1 187 LEU n 
1 188 SER n 
1 189 CYS n 
1 190 LEU n 
1 191 GLY n 
1 192 VAL n 
1 193 GLY n 
1 194 VAL n 
1 195 THR n 
1 196 GLY n 
1 197 VAL n 
1 198 VAL n 
1 199 VAL n 
1 200 ALA n 
1 201 PHE n 
1 202 ALA n 
1 203 PRO n 
1 204 ASN n 
1 205 PHE n 
1 206 PRO n 
1 207 VAL n 
1 208 PHE n 
1 209 VAL n 
1 210 ILE n 
1 211 PHE n 
1 212 ARG n 
1 213 PHE n 
1 214 LEU n 
1 215 GLN n 
1 216 GLY n 
1 217 VAL n 
1 218 PHE n 
1 219 GLY n 
1 220 LYS n 
1 221 GLY n 
1 222 THR n 
1 223 TRP n 
1 224 MET n 
1 225 THR n 
1 226 CYS n 
1 227 TYR n 
1 228 VAL n 
1 229 ILE n 
1 230 VAL n 
1 231 THR n 
1 232 GLU n 
1 233 ILE n 
1 234 VAL n 
1 235 GLY n 
1 236 SER n 
1 237 LYS n 
1 238 GLN n 
1 239 ARG n 
1 240 ARG n 
1 241 ILE n 
1 242 VAL n 
1 243 GLY n 
1 244 ILE n 
1 245 VAL n 
1 246 ILE n 
1 247 GLN n 
1 248 MET n 
1 249 PHE n 
1 250 PHE n 
1 251 THR n 
1 252 LEU n 
1 253 GLY n 
1 254 ILE n 
1 255 ILE n 
1 256 ILE n 
1 257 LEU n 
1 258 PRO n 
1 259 GLY n 
1 260 ILE n 
1 261 ALA n 
1 262 TYR n 
1 263 PHE n 
1 264 ILE n 
1 265 PRO n 
1 266 ASN n 
1 267 TRP n 
1 268 GLN n 
1 269 GLY n 
1 270 ILE n 
1 271 GLN n 
1 272 LEU n 
1 273 ALA n 
1 274 ILE n 
1 275 THR n 
1 276 LEU n 
1 277 PRO n 
1 278 SER n 
1 279 PHE n 
1 280 LEU n 
1 281 PHE n 
1 282 LEU n 
1 283 LEU n 
1 284 TYR n 
1 285 TYR n 
1 286 TRP n 
1 287 VAL n 
1 288 VAL n 
1 289 PRO n 
1 290 GLU n 
1 291 SER n 
1 292 PRO n 
1 293 ARG n 
1 294 TRP n 
1 295 LEU n 
1 296 ILE n 
1 297 THR n 
1 298 ARG n 
1 299 LYS n 
1 300 LYS n 
1 301 GLY n 
1 302 ASP n 
1 303 LYS n 
1 304 ALA n 
1 305 LEU n 
1 306 GLN n 
1 307 ILE n 
1 308 LEU n 
1 309 ARG n 
1 310 ARG n 
1 311 ILE n 
1 312 ALA n 
1 313 LYS n 
1 314 CYS n 
1 315 ASN n 
1 316 GLY n 
1 317 LYS n 
1 318 TYR n 
1 319 LEU n 
1 320 SER n 
1 321 SER n 
1 322 ASN n 
1 323 TYR n 
1 324 SER n 
1 325 GLU n 
1 326 ILE n 
1 327 THR n 
1 328 VAL n 
1 329 THR n 
1 330 ASP n 
1 331 GLU n 
1 332 GLU n 
1 333 VAL n 
1 334 SER n 
1 335 ASN n 
1 336 PRO n 
1 337 SER n 
1 338 PHE n 
1 339 LEU n 
1 340 ASP n 
1 341 LEU n 
1 342 VAL n 
1 343 ARG n 
1 344 THR n 
1 345 PRO n 
1 346 GLN n 
1 347 MET n 
1 348 ARG n 
1 349 LYS n 
1 350 CYS n 
1 351 THR n 
1 352 LEU n 
1 353 ILE n 
1 354 LEU n 
1 355 MET n 
1 356 PHE n 
1 357 ALA n 
1 358 TRP n 
1 359 PHE n 
1 360 THR n 
1 361 SER n 
1 362 ALA n 
1 363 VAL n 
1 364 VAL n 
1 365 TYR n 
1 366 GLN n 
1 367 GLY n 
1 368 LEU n 
1 369 VAL n 
1 370 MET n 
1 371 ARG n 
1 372 LEU n 
1 373 GLY n 
1 374 ILE n 
1 375 ILE n 
1 376 GLY n 
1 377 GLY n 
1 378 ASN n 
1 379 LEU n 
1 380 TYR n 
1 381 ILE n 
1 382 ASP n 
1 383 PHE n 
1 384 PHE n 
1 385 ILE n 
1 386 SER n 
1 387 GLY n 
1 388 VAL n 
1 389 VAL n 
1 390 GLU n 
1 391 LEU n 
1 392 PRO n 
1 393 GLY n 
1 394 ALA n 
1 395 LEU n 
1 396 LEU n 
1 397 ILE n 
1 398 LEU n 
1 399 LEU n 
1 400 THR n 
1 401 ILE n 
1 402 GLU n 
1 403 ARG n 
1 404 LEU n 
1 405 GLY n 
1 406 ARG n 
1 407 ARG n 
1 408 LEU n 
1 409 PRO n 
1 410 PHE n 
1 411 ALA n 
1 412 ALA n 
1 413 SER n 
1 414 ASN n 
1 415 ILE n 
1 416 VAL n 
1 417 ALA n 
1 418 GLY n 
1 419 VAL n 
1 420 ALA n 
1 421 CYS n 
1 422 LEU n 
1 423 VAL n 
1 424 THR n 
1 425 ALA n 
1 426 PHE n 
1 427 LEU n 
1 428 PRO n 
1 429 GLU n 
1 430 GLY n 
1 431 ILE n 
1 432 ALA n 
1 433 TRP n 
1 434 LEU n 
1 435 ARG n 
1 436 THR n 
1 437 THR n 
1 438 VAL n 
1 439 ALA n 
1 440 THR n 
1 441 LEU n 
1 442 GLY n 
1 443 ARG n 
1 444 LEU n 
1 445 GLY n 
1 446 ILE n 
1 447 THR n 
1 448 MET n 
1 449 ALA n 
1 450 PHE n 
1 451 GLU n 
1 452 ILE n 
1 453 VAL n 
1 454 TYR n 
1 455 LEU n 
1 456 VAL n 
1 457 ASN n 
1 458 SER n 
1 459 GLU n 
1 460 LEU n 
1 461 TYR n 
1 462 PRO n 
1 463 THR n 
1 464 THR n 
1 465 LEU n 
1 466 ARG n 
1 467 ASN n 
1 468 PHE n 
1 469 GLY n 
1 470 VAL n 
1 471 SER n 
1 472 LEU n 
1 473 CYS n 
1 474 SER n 
1 475 GLY n 
1 476 LEU n 
1 477 CYS n 
1 478 ASP n 
1 479 PHE n 
1 480 GLY n 
1 481 GLY n 
1 482 ILE n 
1 483 ILE n 
1 484 ALA n 
1 485 PRO n 
1 486 PHE n 
1 487 LEU n 
1 488 LEU n 
1 489 PHE n 
1 490 ARG n 
1 491 LEU n 
1 492 ALA n 
1 493 ALA n 
1 494 VAL n 
1 495 TRP n 
1 496 LEU n 
1 497 GLU n 
1 498 LEU n 
1 499 PRO n 
1 500 LEU n 
1 501 ILE n 
1 502 ILE n 
1 503 PHE n 
1 504 GLY n 
1 505 ILE n 
1 506 LEU n 
1 507 ALA n 
1 508 SER n 
1 509 ILE n 
1 510 CYS n 
1 511 GLY n 
1 512 GLY n 
1 513 LEU n 
1 514 VAL n 
1 515 MET n 
1 516 LEU n 
1 517 LEU n 
1 518 PRO n 
1 519 GLU n 
1 520 THR n 
1 521 LYS n 
1 522 GLY n 
1 523 ILE n 
1 524 ALA n 
1 525 LEU n 
1 526 PRO n 
1 527 GLU n 
1 528 THR n 
1 529 VAL n 
1 530 ASP n 
1 531 ASP n 
1 532 VAL n 
1 533 GLU n 
1 534 LYS n 
1 535 LEU n 
1 536 GLY n 
1 537 SER n 
1 538 PRO n 
1 539 HIS n 
1 540 SER n 
1 541 CYS n 
1 542 LYS n 
1 543 CYS n 
1 544 GLY n 
1 545 ARG n 
1 546 ASN n 
1 547 LYS n 
1 548 LYS n 
1 549 THR n 
1 550 PRO n 
1 551 VAL n 
1 552 SER n 
1 553 ARG n 
1 554 SER n 
1 555 HIS n 
1 556 LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   556 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC22A3, EMTH, OCT3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   PRO 2   2   2   PRO PRO A . n 
A 1 3   SER 3   3   3   SER SER A . n 
A 1 4   PHE 4   4   4   PHE PHE A . n 
A 1 5   ASP 5   5   5   ASP ASP A . n 
A 1 6   GLU 6   6   6   GLU GLU A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   LEU 8   8   8   LEU LEU A . n 
A 1 9   GLN 9   9   9   GLN GLN A . n 
A 1 10  ARG 10  10  10  ARG ARG A . n 
A 1 11  VAL 11  11  11  VAL VAL A . n 
A 1 12  GLY 12  12  12  GLY GLY A . n 
A 1 13  GLU 13  13  13  GLU GLU A . n 
A 1 14  PHE 14  14  14  PHE PHE A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  ARG 16  16  16  ARG ARG A . n 
A 1 17  PHE 17  17  17  PHE PHE A . n 
A 1 18  GLN 18  18  18  GLN GLN A . n 
A 1 19  ARG 19  19  19  ARG ARG A . n 
A 1 20  ARG 20  20  20  ARG ARG A . n 
A 1 21  VAL 21  21  21  VAL VAL A . n 
A 1 22  PHE 22  22  22  PHE PHE A . n 
A 1 23  LEU 23  23  23  LEU LEU A . n 
A 1 24  LEU 24  24  24  LEU LEU A . n 
A 1 25  LEU 25  25  25  LEU LEU A . n 
A 1 26  CYS 26  26  26  CYS CYS A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  THR 28  28  28  THR THR A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  VAL 30  30  30  VAL VAL A . n 
A 1 31  THR 31  31  31  THR THR A . n 
A 1 32  PHE 32  32  32  PHE PHE A . n 
A 1 33  ALA 33  33  33  ALA ALA A . n 
A 1 34  PHE 34  34  34  PHE PHE A . n 
A 1 35  LEU 35  35  35  LEU LEU A . n 
A 1 36  PHE 36  36  36  PHE PHE A . n 
A 1 37  VAL 37  37  37  VAL VAL A . n 
A 1 38  GLY 38  38  38  GLY GLY A . n 
A 1 39  VAL 39  39  39  VAL VAL A . n 
A 1 40  VAL 40  40  40  VAL VAL A . n 
A 1 41  PHE 41  41  41  PHE PHE A . n 
A 1 42  LEU 42  42  42  LEU LEU A . n 
A 1 43  GLY 43  43  43  GLY GLY A . n 
A 1 44  THR 44  44  44  THR THR A . n 
A 1 45  GLN 45  45  45  GLN GLN A . n 
A 1 46  PRO 46  46  46  PRO PRO A . n 
A 1 47  ASP 47  47  47  ASP ASP A . n 
A 1 48  HIS 48  48  48  HIS HIS A . n 
A 1 49  TYR 49  49  49  TYR TYR A . n 
A 1 50  TRP 50  50  50  TRP TRP A . n 
A 1 51  CYS 51  51  51  CYS CYS A . n 
A 1 52  ARG 52  52  52  ARG ARG A . n 
A 1 53  GLY 53  53  53  GLY GLY A . n 
A 1 54  PRO 54  54  54  PRO PRO A . n 
A 1 55  SER 55  55  55  SER SER A . n 
A 1 56  ALA 56  56  56  ALA ALA A . n 
A 1 57  ALA 57  57  57  ALA ALA A . n 
A 1 58  ALA 58  58  58  ALA ALA A . n 
A 1 59  LEU 59  59  59  LEU LEU A . n 
A 1 60  ALA 60  60  60  ALA ALA A . n 
A 1 61  GLU 61  61  61  GLU GLU A . n 
A 1 62  ARG 62  62  62  ARG ARG A . n 
A 1 63  CYS 63  63  63  CYS CYS A . n 
A 1 64  GLY 64  64  64  GLY GLY A . n 
A 1 65  TRP 65  65  65  TRP TRP A . n 
A 1 66  SER 66  66  66  SER SER A . n 
A 1 67  PRO 67  67  67  PRO PRO A . n 
A 1 68  GLU 68  68  68  GLU GLU A . n 
A 1 69  GLU 69  69  69  GLU GLU A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  TRP 71  71  71  TRP TRP A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  ARG 73  73  73  ARG ARG A . n 
A 1 74  THR 74  74  74  THR THR A . n 
A 1 75  ALA 75  75  ?   ?   ?   A . n 
A 1 76  PRO 76  76  ?   ?   ?   A . n 
A 1 77  ALA 77  77  ?   ?   ?   A . n 
A 1 78  SER 78  78  ?   ?   ?   A . n 
A 1 79  ARG 79  79  ?   ?   ?   A . n 
A 1 80  GLY 80  80  ?   ?   ?   A . n 
A 1 81  PRO 81  81  ?   ?   ?   A . n 
A 1 82  GLU 82  82  ?   ?   ?   A . n 
A 1 83  PRO 83  83  ?   ?   ?   A . n 
A 1 84  PRO 84  84  ?   ?   ?   A . n 
A 1 85  GLU 85  85  ?   ?   ?   A . n 
A 1 86  ARG 86  86  ?   ?   ?   A . n 
A 1 87  ARG 87  87  ?   ?   ?   A . n 
A 1 88  GLY 88  88  88  GLY GLY A . n 
A 1 89  ARG 89  89  89  ARG ARG A . n 
A 1 90  CYS 90  90  90  CYS CYS A . n 
A 1 91  GLN 91  91  91  GLN GLN A . n 
A 1 92  ARG 92  92  92  ARG ARG A . n 
A 1 93  TYR 93  93  93  TYR TYR A . n 
A 1 94  LEU 94  94  94  LEU LEU A . n 
A 1 95  LEU 95  95  95  LEU LEU A . n 
A 1 96  GLU 96  96  96  GLU GLU A . n 
A 1 97  ALA 97  97  97  ALA ALA A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  ASN 99  99  99  ASN ASN A . n 
A 1 100 ASP 100 100 ?   ?   ?   A . n 
A 1 101 SER 101 101 ?   ?   ?   A . n 
A 1 102 ALA 102 102 ?   ?   ?   A . n 
A 1 103 SER 103 103 ?   ?   ?   A . n 
A 1 104 ALA 104 104 ?   ?   ?   A . n 
A 1 105 THR 105 105 ?   ?   ?   A . n 
A 1 106 SER 106 106 ?   ?   ?   A . n 
A 1 107 ALA 107 107 ?   ?   ?   A . n 
A 1 108 LEU 108 108 ?   ?   ?   A . n 
A 1 109 SER 109 109 ?   ?   ?   A . n 
A 1 110 CYS 110 110 ?   ?   ?   A . n 
A 1 111 ALA 111 111 ?   ?   ?   A . n 
A 1 112 ASP 112 112 ?   ?   ?   A . n 
A 1 113 PRO 113 113 ?   ?   ?   A . n 
A 1 114 LEU 114 114 114 LEU LEU A . n 
A 1 115 ALA 115 115 115 ALA ALA A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 PHE 117 117 117 PHE PHE A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 ARG 120 120 120 ARG ARG A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 ALA 122 122 122 ALA ALA A . n 
A 1 123 PRO 123 123 123 PRO PRO A . n 
A 1 124 LEU 124 124 124 LEU LEU A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 PRO 126 126 126 PRO PRO A . n 
A 1 127 CYS 127 127 127 CYS CYS A . n 
A 1 128 ARG 128 128 128 ARG ARG A . n 
A 1 129 GLY 129 129 129 GLY GLY A . n 
A 1 130 GLY 130 130 130 GLY GLY A . n 
A 1 131 TRP 131 131 131 TRP TRP A . n 
A 1 132 ARG 132 132 132 ARG ARG A . n 
A 1 133 TYR 133 133 133 TYR TYR A . n 
A 1 134 ALA 134 134 134 ALA ALA A . n 
A 1 135 GLN 135 135 135 GLN GLN A . n 
A 1 136 ALA 136 136 136 ALA ALA A . n 
A 1 137 HIS 137 137 137 HIS HIS A . n 
A 1 138 SER 138 138 138 SER SER A . n 
A 1 139 THR 139 139 139 THR THR A . n 
A 1 140 ILE 140 140 140 ILE ILE A . n 
A 1 141 VAL 141 141 141 VAL VAL A . n 
A 1 142 SER 142 142 142 SER SER A . n 
A 1 143 GLU 143 143 143 GLU GLU A . n 
A 1 144 PHE 144 144 144 PHE PHE A . n 
A 1 145 ASP 145 145 145 ASP ASP A . n 
A 1 146 LEU 146 146 146 LEU LEU A . n 
A 1 147 VAL 147 147 147 VAL VAL A . n 
A 1 148 CYS 148 148 148 CYS CYS A . n 
A 1 149 VAL 149 149 149 VAL VAL A . n 
A 1 150 ASN 150 150 150 ASN ASN A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 TRP 152 152 152 TRP TRP A . n 
A 1 153 MET 153 153 153 MET MET A . n 
A 1 154 LEU 154 154 154 LEU LEU A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 LEU 156 156 156 LEU LEU A . n 
A 1 157 THR 157 157 157 THR THR A . n 
A 1 158 GLN 158 158 158 GLN GLN A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 ILE 160 160 160 ILE ILE A . n 
A 1 161 LEU 161 161 161 LEU LEU A . n 
A 1 162 ASN 162 162 162 ASN ASN A . n 
A 1 163 LEU 163 163 163 LEU LEU A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 PHE 165 165 165 PHE PHE A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 THR 167 167 167 THR THR A . n 
A 1 168 GLY 168 168 168 GLY GLY A . n 
A 1 169 ALA 169 169 169 ALA ALA A . n 
A 1 170 PHE 170 170 170 PHE PHE A . n 
A 1 171 THR 171 171 171 THR THR A . n 
A 1 172 LEU 172 172 172 LEU LEU A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 TYR 174 174 174 TYR TYR A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 ASP 177 177 177 ASP ASP A . n 
A 1 178 ARG 178 178 178 ARG ARG A . n 
A 1 179 TYR 179 179 179 TYR TYR A . n 
A 1 180 GLY 180 180 180 GLY GLY A . n 
A 1 181 ARG 181 181 181 ARG ARG A . n 
A 1 182 ILE 182 182 182 ILE ILE A . n 
A 1 183 VAL 183 183 183 VAL VAL A . n 
A 1 184 ILE 184 184 184 ILE ILE A . n 
A 1 185 TYR 185 185 185 TYR TYR A . n 
A 1 186 LEU 186 186 186 LEU LEU A . n 
A 1 187 LEU 187 187 187 LEU LEU A . n 
A 1 188 SER 188 188 188 SER SER A . n 
A 1 189 CYS 189 189 189 CYS CYS A . n 
A 1 190 LEU 190 190 190 LEU LEU A . n 
A 1 191 GLY 191 191 191 GLY GLY A . n 
A 1 192 VAL 192 192 192 VAL VAL A . n 
A 1 193 GLY 193 193 193 GLY GLY A . n 
A 1 194 VAL 194 194 194 VAL VAL A . n 
A 1 195 THR 195 195 195 THR THR A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 VAL 197 197 197 VAL VAL A . n 
A 1 198 VAL 198 198 198 VAL VAL A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 ALA 200 200 200 ALA ALA A . n 
A 1 201 PHE 201 201 201 PHE PHE A . n 
A 1 202 ALA 202 202 202 ALA ALA A . n 
A 1 203 PRO 203 203 203 PRO PRO A . n 
A 1 204 ASN 204 204 204 ASN ASN A . n 
A 1 205 PHE 205 205 205 PHE PHE A . n 
A 1 206 PRO 206 206 206 PRO PRO A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 VAL 209 209 209 VAL VAL A . n 
A 1 210 ILE 210 210 210 ILE ILE A . n 
A 1 211 PHE 211 211 211 PHE PHE A . n 
A 1 212 ARG 212 212 212 ARG ARG A . n 
A 1 213 PHE 213 213 213 PHE PHE A . n 
A 1 214 LEU 214 214 214 LEU LEU A . n 
A 1 215 GLN 215 215 215 GLN GLN A . n 
A 1 216 GLY 216 216 216 GLY GLY A . n 
A 1 217 VAL 217 217 217 VAL VAL A . n 
A 1 218 PHE 218 218 218 PHE PHE A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 LYS 220 220 220 LYS LYS A . n 
A 1 221 GLY 221 221 221 GLY GLY A . n 
A 1 222 THR 222 222 222 THR THR A . n 
A 1 223 TRP 223 223 223 TRP TRP A . n 
A 1 224 MET 224 224 224 MET MET A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 CYS 226 226 226 CYS CYS A . n 
A 1 227 TYR 227 227 227 TYR TYR A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 ILE 229 229 229 ILE ILE A . n 
A 1 230 VAL 230 230 230 VAL VAL A . n 
A 1 231 THR 231 231 231 THR THR A . n 
A 1 232 GLU 232 232 232 GLU GLU A . n 
A 1 233 ILE 233 233 233 ILE ILE A . n 
A 1 234 VAL 234 234 234 VAL VAL A . n 
A 1 235 GLY 235 235 235 GLY GLY A . n 
A 1 236 SER 236 236 236 SER SER A . n 
A 1 237 LYS 237 237 237 LYS LYS A . n 
A 1 238 GLN 238 238 238 GLN GLN A . n 
A 1 239 ARG 239 239 239 ARG ARG A . n 
A 1 240 ARG 240 240 240 ARG ARG A . n 
A 1 241 ILE 241 241 241 ILE ILE A . n 
A 1 242 VAL 242 242 242 VAL VAL A . n 
A 1 243 GLY 243 243 243 GLY GLY A . n 
A 1 244 ILE 244 244 244 ILE ILE A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 ILE 246 246 246 ILE ILE A . n 
A 1 247 GLN 247 247 247 GLN GLN A . n 
A 1 248 MET 248 248 248 MET MET A . n 
A 1 249 PHE 249 249 249 PHE PHE A . n 
A 1 250 PHE 250 250 250 PHE PHE A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 GLY 253 253 253 GLY GLY A . n 
A 1 254 ILE 254 254 254 ILE ILE A . n 
A 1 255 ILE 255 255 255 ILE ILE A . n 
A 1 256 ILE 256 256 256 ILE ILE A . n 
A 1 257 LEU 257 257 257 LEU LEU A . n 
A 1 258 PRO 258 258 258 PRO PRO A . n 
A 1 259 GLY 259 259 259 GLY GLY A . n 
A 1 260 ILE 260 260 260 ILE ILE A . n 
A 1 261 ALA 261 261 261 ALA ALA A . n 
A 1 262 TYR 262 262 262 TYR TYR A . n 
A 1 263 PHE 263 263 263 PHE PHE A . n 
A 1 264 ILE 264 264 264 ILE ILE A . n 
A 1 265 PRO 265 265 265 PRO PRO A . n 
A 1 266 ASN 266 266 266 ASN ASN A . n 
A 1 267 TRP 267 267 267 TRP TRP A . n 
A 1 268 GLN 268 268 268 GLN GLN A . n 
A 1 269 GLY 269 269 269 GLY GLY A . n 
A 1 270 ILE 270 270 270 ILE ILE A . n 
A 1 271 GLN 271 271 271 GLN GLN A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 ALA 273 273 273 ALA ALA A . n 
A 1 274 ILE 274 274 274 ILE ILE A . n 
A 1 275 THR 275 275 275 THR THR A . n 
A 1 276 LEU 276 276 276 LEU LEU A . n 
A 1 277 PRO 277 277 277 PRO PRO A . n 
A 1 278 SER 278 278 278 SER SER A . n 
A 1 279 PHE 279 279 279 PHE PHE A . n 
A 1 280 LEU 280 280 280 LEU LEU A . n 
A 1 281 PHE 281 281 281 PHE PHE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 LEU 283 283 283 LEU LEU A . n 
A 1 284 TYR 284 284 284 TYR TYR A . n 
A 1 285 TYR 285 285 285 TYR TYR A . n 
A 1 286 TRP 286 286 286 TRP TRP A . n 
A 1 287 VAL 287 287 287 VAL VAL A . n 
A 1 288 VAL 288 288 288 VAL VAL A . n 
A 1 289 PRO 289 289 289 PRO PRO A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 SER 291 291 291 SER SER A . n 
A 1 292 PRO 292 292 292 PRO PRO A . n 
A 1 293 ARG 293 293 293 ARG ARG A . n 
A 1 294 TRP 294 294 294 TRP TRP A . n 
A 1 295 LEU 295 295 295 LEU LEU A . n 
A 1 296 ILE 296 296 296 ILE ILE A . n 
A 1 297 THR 297 297 297 THR THR A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 LYS 299 299 299 LYS LYS A . n 
A 1 300 LYS 300 300 300 LYS LYS A . n 
A 1 301 GLY 301 301 301 GLY GLY A . n 
A 1 302 ASP 302 302 302 ASP ASP A . n 
A 1 303 LYS 303 303 303 LYS LYS A . n 
A 1 304 ALA 304 304 304 ALA ALA A . n 
A 1 305 LEU 305 305 305 LEU LEU A . n 
A 1 306 GLN 306 306 306 GLN GLN A . n 
A 1 307 ILE 307 307 307 ILE ILE A . n 
A 1 308 LEU 308 308 308 LEU LEU A . n 
A 1 309 ARG 309 309 309 ARG ARG A . n 
A 1 310 ARG 310 310 310 ARG ARG A . n 
A 1 311 ILE 311 311 311 ILE ILE A . n 
A 1 312 ALA 312 312 312 ALA ALA A . n 
A 1 313 LYS 313 313 313 LYS LYS A . n 
A 1 314 CYS 314 314 314 CYS CYS A . n 
A 1 315 ASN 315 315 315 ASN ASN A . n 
A 1 316 GLY 316 316 316 GLY GLY A . n 
A 1 317 LYS 317 317 ?   ?   ?   A . n 
A 1 318 TYR 318 318 ?   ?   ?   A . n 
A 1 319 LEU 319 319 ?   ?   ?   A . n 
A 1 320 SER 320 320 ?   ?   ?   A . n 
A 1 321 SER 321 321 ?   ?   ?   A . n 
A 1 322 ASN 322 322 ?   ?   ?   A . n 
A 1 323 TYR 323 323 ?   ?   ?   A . n 
A 1 324 SER 324 324 ?   ?   ?   A . n 
A 1 325 GLU 325 325 ?   ?   ?   A . n 
A 1 326 ILE 326 326 ?   ?   ?   A . n 
A 1 327 THR 327 327 ?   ?   ?   A . n 
A 1 328 VAL 328 328 328 VAL VAL A . n 
A 1 329 THR 329 329 329 THR THR A . n 
A 1 330 ASP 330 330 330 ASP ASP A . n 
A 1 331 GLU 331 331 331 GLU GLU A . n 
A 1 332 GLU 332 332 332 GLU GLU A . n 
A 1 333 VAL 333 333 333 VAL VAL A . n 
A 1 334 SER 334 334 334 SER SER A . n 
A 1 335 ASN 335 335 335 ASN ASN A . n 
A 1 336 PRO 336 336 336 PRO PRO A . n 
A 1 337 SER 337 337 337 SER SER A . n 
A 1 338 PHE 338 338 338 PHE PHE A . n 
A 1 339 LEU 339 339 339 LEU LEU A . n 
A 1 340 ASP 340 340 340 ASP ASP A . n 
A 1 341 LEU 341 341 341 LEU LEU A . n 
A 1 342 VAL 342 342 342 VAL VAL A . n 
A 1 343 ARG 343 343 343 ARG ARG A . n 
A 1 344 THR 344 344 344 THR THR A . n 
A 1 345 PRO 345 345 345 PRO PRO A . n 
A 1 346 GLN 346 346 346 GLN GLN A . n 
A 1 347 MET 347 347 347 MET MET A . n 
A 1 348 ARG 348 348 348 ARG ARG A . n 
A 1 349 LYS 349 349 349 LYS LYS A . n 
A 1 350 CYS 350 350 350 CYS CYS A . n 
A 1 351 THR 351 351 351 THR THR A . n 
A 1 352 LEU 352 352 352 LEU LEU A . n 
A 1 353 ILE 353 353 353 ILE ILE A . n 
A 1 354 LEU 354 354 354 LEU LEU A . n 
A 1 355 MET 355 355 355 MET MET A . n 
A 1 356 PHE 356 356 356 PHE PHE A . n 
A 1 357 ALA 357 357 357 ALA ALA A . n 
A 1 358 TRP 358 358 358 TRP TRP A . n 
A 1 359 PHE 359 359 359 PHE PHE A . n 
A 1 360 THR 360 360 360 THR THR A . n 
A 1 361 SER 361 361 361 SER SER A . n 
A 1 362 ALA 362 362 362 ALA ALA A . n 
A 1 363 VAL 363 363 363 VAL VAL A . n 
A 1 364 VAL 364 364 364 VAL VAL A . n 
A 1 365 TYR 365 365 365 TYR TYR A . n 
A 1 366 GLN 366 366 366 GLN GLN A . n 
A 1 367 GLY 367 367 367 GLY GLY A . n 
A 1 368 LEU 368 368 368 LEU LEU A . n 
A 1 369 VAL 369 369 369 VAL VAL A . n 
A 1 370 MET 370 370 370 MET MET A . n 
A 1 371 ARG 371 371 371 ARG ARG A . n 
A 1 372 LEU 372 372 372 LEU LEU A . n 
A 1 373 GLY 373 373 373 GLY GLY A . n 
A 1 374 ILE 374 374 374 ILE ILE A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 GLY 376 376 376 GLY GLY A . n 
A 1 377 GLY 377 377 377 GLY GLY A . n 
A 1 378 ASN 378 378 378 ASN ASN A . n 
A 1 379 LEU 379 379 379 LEU LEU A . n 
A 1 380 TYR 380 380 380 TYR TYR A . n 
A 1 381 ILE 381 381 381 ILE ILE A . n 
A 1 382 ASP 382 382 382 ASP ASP A . n 
A 1 383 PHE 383 383 383 PHE PHE A . n 
A 1 384 PHE 384 384 384 PHE PHE A . n 
A 1 385 ILE 385 385 385 ILE ILE A . n 
A 1 386 SER 386 386 386 SER SER A . n 
A 1 387 GLY 387 387 387 GLY GLY A . n 
A 1 388 VAL 388 388 388 VAL VAL A . n 
A 1 389 VAL 389 389 389 VAL VAL A . n 
A 1 390 GLU 390 390 390 GLU GLU A . n 
A 1 391 LEU 391 391 391 LEU LEU A . n 
A 1 392 PRO 392 392 392 PRO PRO A . n 
A 1 393 GLY 393 393 393 GLY GLY A . n 
A 1 394 ALA 394 394 394 ALA ALA A . n 
A 1 395 LEU 395 395 395 LEU LEU A . n 
A 1 396 LEU 396 396 396 LEU LEU A . n 
A 1 397 ILE 397 397 397 ILE ILE A . n 
A 1 398 LEU 398 398 398 LEU LEU A . n 
A 1 399 LEU 399 399 399 LEU LEU A . n 
A 1 400 THR 400 400 400 THR THR A . n 
A 1 401 ILE 401 401 401 ILE ILE A . n 
A 1 402 GLU 402 402 402 GLU GLU A . n 
A 1 403 ARG 403 403 403 ARG ARG A . n 
A 1 404 LEU 404 404 404 LEU LEU A . n 
A 1 405 GLY 405 405 405 GLY GLY A . n 
A 1 406 ARG 406 406 406 ARG ARG A . n 
A 1 407 ARG 407 407 407 ARG ARG A . n 
A 1 408 LEU 408 408 408 LEU LEU A . n 
A 1 409 PRO 409 409 409 PRO PRO A . n 
A 1 410 PHE 410 410 410 PHE PHE A . n 
A 1 411 ALA 411 411 411 ALA ALA A . n 
A 1 412 ALA 412 412 412 ALA ALA A . n 
A 1 413 SER 413 413 413 SER SER A . n 
A 1 414 ASN 414 414 414 ASN ASN A . n 
A 1 415 ILE 415 415 415 ILE ILE A . n 
A 1 416 VAL 416 416 416 VAL VAL A . n 
A 1 417 ALA 417 417 417 ALA ALA A . n 
A 1 418 GLY 418 418 418 GLY GLY A . n 
A 1 419 VAL 419 419 419 VAL VAL A . n 
A 1 420 ALA 420 420 420 ALA ALA A . n 
A 1 421 CYS 421 421 421 CYS CYS A . n 
A 1 422 LEU 422 422 422 LEU LEU A . n 
A 1 423 VAL 423 423 423 VAL VAL A . n 
A 1 424 THR 424 424 424 THR THR A . n 
A 1 425 ALA 425 425 425 ALA ALA A . n 
A 1 426 PHE 426 426 426 PHE PHE A . n 
A 1 427 LEU 427 427 427 LEU LEU A . n 
A 1 428 PRO 428 428 428 PRO PRO A . n 
A 1 429 GLU 429 429 429 GLU GLU A . n 
A 1 430 GLY 430 430 430 GLY GLY A . n 
A 1 431 ILE 431 431 431 ILE ILE A . n 
A 1 432 ALA 432 432 432 ALA ALA A . n 
A 1 433 TRP 433 433 433 TRP TRP A . n 
A 1 434 LEU 434 434 434 LEU LEU A . n 
A 1 435 ARG 435 435 435 ARG ARG A . n 
A 1 436 THR 436 436 436 THR THR A . n 
A 1 437 THR 437 437 437 THR THR A . n 
A 1 438 VAL 438 438 438 VAL VAL A . n 
A 1 439 ALA 439 439 439 ALA ALA A . n 
A 1 440 THR 440 440 440 THR THR A . n 
A 1 441 LEU 441 441 441 LEU LEU A . n 
A 1 442 GLY 442 442 442 GLY GLY A . n 
A 1 443 ARG 443 443 443 ARG ARG A . n 
A 1 444 LEU 444 444 444 LEU LEU A . n 
A 1 445 GLY 445 445 445 GLY GLY A . n 
A 1 446 ILE 446 446 446 ILE ILE A . n 
A 1 447 THR 447 447 447 THR THR A . n 
A 1 448 MET 448 448 448 MET MET A . n 
A 1 449 ALA 449 449 449 ALA ALA A . n 
A 1 450 PHE 450 450 450 PHE PHE A . n 
A 1 451 GLU 451 451 451 GLU GLU A . n 
A 1 452 ILE 452 452 452 ILE ILE A . n 
A 1 453 VAL 453 453 453 VAL VAL A . n 
A 1 454 TYR 454 454 454 TYR TYR A . n 
A 1 455 LEU 455 455 455 LEU LEU A . n 
A 1 456 VAL 456 456 456 VAL VAL A . n 
A 1 457 ASN 457 457 457 ASN ASN A . n 
A 1 458 SER 458 458 458 SER SER A . n 
A 1 459 GLU 459 459 459 GLU GLU A . n 
A 1 460 LEU 460 460 460 LEU LEU A . n 
A 1 461 TYR 461 461 461 TYR TYR A . n 
A 1 462 PRO 462 462 462 PRO PRO A . n 
A 1 463 THR 463 463 463 THR THR A . n 
A 1 464 THR 464 464 464 THR THR A . n 
A 1 465 LEU 465 465 465 LEU LEU A . n 
A 1 466 ARG 466 466 466 ARG ARG A . n 
A 1 467 ASN 467 467 467 ASN ASN A . n 
A 1 468 PHE 468 468 468 PHE PHE A . n 
A 1 469 GLY 469 469 469 GLY GLY A . n 
A 1 470 VAL 470 470 470 VAL VAL A . n 
A 1 471 SER 471 471 471 SER SER A . n 
A 1 472 LEU 472 472 472 LEU LEU A . n 
A 1 473 CYS 473 473 473 CYS CYS A . n 
A 1 474 SER 474 474 474 SER SER A . n 
A 1 475 GLY 475 475 475 GLY GLY A . n 
A 1 476 LEU 476 476 476 LEU LEU A . n 
A 1 477 CYS 477 477 477 CYS CYS A . n 
A 1 478 ASP 478 478 478 ASP ASP A . n 
A 1 479 PHE 479 479 479 PHE PHE A . n 
A 1 480 GLY 480 480 480 GLY GLY A . n 
A 1 481 GLY 481 481 481 GLY GLY A . n 
A 1 482 ILE 482 482 482 ILE ILE A . n 
A 1 483 ILE 483 483 483 ILE ILE A . n 
A 1 484 ALA 484 484 484 ALA ALA A . n 
A 1 485 PRO 485 485 485 PRO PRO A . n 
A 1 486 PHE 486 486 486 PHE PHE A . n 
A 1 487 LEU 487 487 487 LEU LEU A . n 
A 1 488 LEU 488 488 488 LEU LEU A . n 
A 1 489 PHE 489 489 489 PHE PHE A . n 
A 1 490 ARG 490 490 490 ARG ARG A . n 
A 1 491 LEU 491 491 491 LEU LEU A . n 
A 1 492 ALA 492 492 492 ALA ALA A . n 
A 1 493 ALA 493 493 493 ALA ALA A . n 
A 1 494 VAL 494 494 494 VAL VAL A . n 
A 1 495 TRP 495 495 495 TRP TRP A . n 
A 1 496 LEU 496 496 496 LEU LEU A . n 
A 1 497 GLU 497 497 497 GLU GLU A . n 
A 1 498 LEU 498 498 498 LEU LEU A . n 
A 1 499 PRO 499 499 499 PRO PRO A . n 
A 1 500 LEU 500 500 500 LEU LEU A . n 
A 1 501 ILE 501 501 501 ILE ILE A . n 
A 1 502 ILE 502 502 502 ILE ILE A . n 
A 1 503 PHE 503 503 503 PHE PHE A . n 
A 1 504 GLY 504 504 504 GLY GLY A . n 
A 1 505 ILE 505 505 505 ILE ILE A . n 
A 1 506 LEU 506 506 506 LEU LEU A . n 
A 1 507 ALA 507 507 507 ALA ALA A . n 
A 1 508 SER 508 508 508 SER SER A . n 
A 1 509 ILE 509 509 509 ILE ILE A . n 
A 1 510 CYS 510 510 510 CYS CYS A . n 
A 1 511 GLY 511 511 511 GLY GLY A . n 
A 1 512 GLY 512 512 512 GLY GLY A . n 
A 1 513 LEU 513 513 513 LEU LEU A . n 
A 1 514 VAL 514 514 514 VAL VAL A . n 
A 1 515 MET 515 515 515 MET MET A . n 
A 1 516 LEU 516 516 516 LEU LEU A . n 
A 1 517 LEU 517 517 517 LEU LEU A . n 
A 1 518 PRO 518 518 518 PRO PRO A . n 
A 1 519 GLU 519 519 519 GLU GLU A . n 
A 1 520 THR 520 520 520 THR THR A . n 
A 1 521 LYS 521 521 521 LYS LYS A . n 
A 1 522 GLY 522 522 522 GLY GLY A . n 
A 1 523 ILE 523 523 523 ILE ILE A . n 
A 1 524 ALA 524 524 524 ALA ALA A . n 
A 1 525 LEU 525 525 525 LEU LEU A . n 
A 1 526 PRO 526 526 526 PRO PRO A . n 
A 1 527 GLU 527 527 527 GLU GLU A . n 
A 1 528 THR 528 528 528 THR THR A . n 
A 1 529 VAL 529 529 529 VAL VAL A . n 
A 1 530 ASP 530 530 530 ASP ASP A . n 
A 1 531 ASP 531 531 531 ASP ASP A . n 
A 1 532 VAL 532 532 532 VAL VAL A . n 
A 1 533 GLU 533 533 533 GLU GLU A . n 
A 1 534 LYS 534 534 534 LYS LYS A . n 
A 1 535 LEU 535 535 ?   ?   ?   A . n 
A 1 536 GLY 536 536 ?   ?   ?   A . n 
A 1 537 SER 537 537 ?   ?   ?   A . n 
A 1 538 PRO 538 538 ?   ?   ?   A . n 
A 1 539 HIS 539 539 ?   ?   ?   A . n 
A 1 540 SER 540 540 ?   ?   ?   A . n 
A 1 541 CYS 541 541 ?   ?   ?   A . n 
A 1 542 LYS 542 542 ?   ?   ?   A . n 
A 1 543 CYS 543 543 ?   ?   ?   A . n 
A 1 544 GLY 544 544 ?   ?   ?   A . n 
A 1 545 ARG 545 545 ?   ?   ?   A . n 
A 1 546 ASN 546 546 ?   ?   ?   A . n 
A 1 547 LYS 547 547 ?   ?   ?   A . n 
A 1 548 LYS 548 548 ?   ?   ?   A . n 
A 1 549 THR 549 549 ?   ?   ?   A . n 
A 1 550 PRO 550 550 ?   ?   ?   A . n 
A 1 551 VAL 551 551 ?   ?   ?   A . n 
A 1 552 SER 552 552 ?   ?   ?   A . n 
A 1 553 ARG 553 553 ?   ?   ?   A . n 
A 1 554 SER 554 554 ?   ?   ?   A . n 
A 1 555 HIS 555 555 ?   ?   ?   A . n 
A 1 556 LEU 556 556 ?   ?   ?   A . n 
# 
_software.citation_id            ? 
_software.classification         refinement 
_software.compiler_name          ? 
_software.compiler_version       ? 
_software.contact_author         ? 
_software.contact_author_email   ? 
_software.date                   ? 
_software.description            ? 
_software.dependencies           ? 
_software.hardware               ? 
_software.language               ? 
_software.location               ? 
_software.mods                   ? 
_software.name                   PHENIX 
_software.os                     ? 
_software.os_version             ? 
_software.type                   ? 
_software.version                1.19.2_4158: 
_software.pdbx_ordinal           1 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     7ZH0 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
# 
_symmetry.entry_id                         7ZH0 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   7ZH0 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 7ZH0 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004 ? 3973 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.646 ? 5408 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 4.516 ? 537  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.042 ? 630  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 671  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     7ZH0 
_struct.title                        'Structure of human OCT3 in lipid nanodisc' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        7ZH0 
_struct_keywords.text            
;Organic cation transporter, major-facilitator superfamily, SLC22 family, Corticosterone sensitive protein, membrane transport, MEMBRANE PROTEIN
;
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    S22A3_HUMAN 
_struct_ref.pdbx_db_accession          O75751 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRG
PEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAI
LNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRR
IVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLS
SNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLT
IERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG
GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7ZH0 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 556 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O75751 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  556 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       556 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 0     ? 
1 MORE         0     ? 
1 'SSA (A^2)'  22850 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 2   ? VAL A 11  ? PRO A 2   VAL A 11  1 ? 10 
HELX_P HELX_P2  AA2 GLY A 15  ? GLY A 38  ? GLY A 15  GLY A 38  1 ? 24 
HELX_P HELX_P3  AA3 VAL A 39  ? LEU A 42  ? VAL A 39  LEU A 42  5 ? 4  
HELX_P HELX_P4  AA4 GLY A 53  ? GLY A 64  ? GLY A 53  GLY A 64  1 ? 12 
HELX_P HELX_P5  AA5 SER A 66  ? THR A 74  ? SER A 66  THR A 74  1 ? 9  
HELX_P HELX_P6  AA6 LEU A 94  ? ASN A 99  ? LEU A 94  ASN A 99  1 ? 6  
HELX_P HELX_P7  AA7 THR A 139 ? ASP A 145 ? THR A 139 ASP A 145 1 ? 7  
HELX_P HELX_P8  AA8 VAL A 147 ? TRP A 152 ? VAL A 147 TRP A 152 5 ? 6  
HELX_P HELX_P9  AA9 MET A 153 ? TYR A 179 ? MET A 153 TYR A 179 1 ? 27 
HELX_P HELX_P10 AB1 GLY A 180 ? PHE A 201 ? GLY A 180 PHE A 201 1 ? 22 
HELX_P HELX_P11 AB2 ASN A 204 ? VAL A 234 ? ASN A 204 VAL A 234 1 ? 31 
HELX_P HELX_P12 AB3 GLN A 238 ? ILE A 264 ? GLN A 238 ILE A 264 1 ? 27 
HELX_P HELX_P13 AB4 ASN A 266 ? LEU A 276 ? ASN A 266 LEU A 276 1 ? 11 
HELX_P HELX_P14 AB5 LEU A 276 ? LEU A 283 ? LEU A 276 LEU A 283 1 ? 8  
HELX_P HELX_P15 AB6 TYR A 284 ? VAL A 288 ? TYR A 284 VAL A 288 5 ? 5  
HELX_P HELX_P16 AB7 SER A 291 ? ILE A 296 ? SER A 291 ILE A 296 1 ? 6  
HELX_P HELX_P17 AB8 GLY A 301 ? ALA A 312 ? GLY A 301 ALA A 312 1 ? 12 
HELX_P HELX_P18 AB9 SER A 337 ? VAL A 342 ? SER A 337 VAL A 342 1 ? 6  
HELX_P HELX_P19 AC1 THR A 344 ? GLY A 373 ? THR A 344 GLY A 373 1 ? 30 
HELX_P HELX_P20 AC2 ASN A 378 ? VAL A 389 ? ASN A 378 VAL A 389 1 ? 12 
HELX_P HELX_P21 AC3 VAL A 389 ? GLY A 405 ? VAL A 389 GLY A 405 1 ? 17 
HELX_P HELX_P22 AC4 ARG A 406 ? PHE A 426 ? ARG A 406 PHE A 426 1 ? 21 
HELX_P HELX_P23 AC5 TRP A 433 ? TYR A 461 ? TRP A 433 TYR A 461 1 ? 29 
HELX_P HELX_P24 AC6 LEU A 465 ? VAL A 470 ? LEU A 465 VAL A 470 1 ? 6  
HELX_P HELX_P25 AC7 SER A 471 ? TRP A 495 ? SER A 471 TRP A 495 1 ? 25 
HELX_P HELX_P26 AC8 GLU A 497 ? ILE A 509 ? GLU A 497 ILE A 509 1 ? 13 
HELX_P HELX_P27 AC9 ILE A 509 ? VAL A 514 ? ILE A 509 VAL A 514 1 ? 6  
HELX_P HELX_P28 AD1 GLU A 527 ? VAL A 532 ? GLU A 527 VAL A 532 5 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 51 SG ? ? ? 1_555 A CYS 127 SG ? ? A CYS 51 A CYS 127 1_555 ? ? ? ? ? ? ? 2.029 ? ? 
disulf2 disulf ? ? A CYS 90 SG ? ? ? 1_555 A CYS 148 SG ? ? A CYS 90 A CYS 148 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 51 ? CYS A 127 ? CYS A 51 ? 1_555 CYS A 127 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 90 ? CYS A 148 ? CYS A 90 ? 1_555 CYS A 148 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 49  ? CYS A 51  ? TYR A 49  CYS A 51  
AA1 2 TRP A 131 ? TYR A 133 ? TRP A 131 TYR A 133 
AA2 1 GLN A 91  ? TYR A 93  ? GLN A 91  TYR A 93  
AA2 2 LEU A 124 ? PRO A 126 ? LEU A 124 PRO A 126 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TRP A 50 ? N TRP A 50 O ARG A 132 ? O ARG A 132 
AA2 1 2 N ARG A 92 ? N ARG A 92 O VAL A 125 ? O VAL A 125 
# 
_pdbx_entry_details.entry_id                   7ZH0 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OG1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   THR 
_pdbx_validate_close_contact.auth_seq_id_1    28 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   OH 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   TYR 
_pdbx_validate_close_contact.auth_seq_id_2    185 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLU A 13  ? ? 58.38   -111.53 
2  1 ARG A 120 ? ? 49.30   24.23   
3  1 LEU A 146 ? ? -101.39 74.48   
4  1 CYS A 148 ? ? 59.49   -121.73 
5  1 GLN A 238 ? ? 50.51   17.95   
6  1 TYR A 285 ? ? 49.93   -105.43 
7  1 SER A 291 ? ? -171.24 126.87  
8  1 SER A 334 ? ? 58.58   -126.25 
9  1 SER A 471 ? ? 74.01   -12.06  
10 1 GLU A 519 ? ? 75.57   -14.53  
11 1 THR A 520 ? ? 37.82   57.67   
12 1 ALA A 524 ? ? 59.27   -131.13 
13 1 THR A 528 ? ? 41.05   -126.92 
14 1 GLU A 533 ? ? -122.62 -55.38  
# 
_em_3d_fitting.entry_id          7ZH0 
_em_3d_fitting.id                1 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   80 
_em_3d_fitting.ref_protocol      'AB INITIO MODEL' 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.method            ? 
# 
_em_3d_reconstruction.entry_id                    7ZH0 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.num_particles               238702 
_em_3d_reconstruction.resolution                  3.2 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.symmetry_type               POINT 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.magnification_calibration   ? 
# 
_em_buffer.id            1 
_em_buffer.details       ? 
_em_buffer.pH            8.0 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.details              ? 
_em_entity_assembly.name                 'human OCT3 in lipid nanodisc' 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 CELL 
_em_entity_assembly.entity_id_list       1 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
# 
_em_imaging.id                              1 
_em_imaging.entry_id                        7ZH0 
_em_imaging.accelerating_voltage            300 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.cryogen                         ? 
_em_imaging.details                         ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.illumination_mode               'SPOT SCAN' 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_max             3000 
_em_imaging.nominal_defocus_min             500 
_em_imaging.nominal_magnification           ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.specimen_id                     1 
_em_imaging.citation_id                     ? 
_em_imaging.date                            ? 
_em_imaging.temperature                     ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.astigmatism                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.specimen_holder_type            ? 
# 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.details               ? 
_em_vitrification.humidity              ? 
_em_vitrification.instrument            ? 
_em_vitrification.entry_id              7ZH0 
_em_vitrification.citation_id           ? 
_em_vitrification.method                ? 
_em_vitrification.temp                  ? 
_em_vitrification.time_resolved_state   ? 
# 
_em_experiment.entry_id                7ZH0 
_em_experiment.id                      1 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 75  ? A ALA 75  
3  1 Y 1 A PRO 76  ? A PRO 76  
4  1 Y 1 A ALA 77  ? A ALA 77  
5  1 Y 1 A SER 78  ? A SER 78  
6  1 Y 1 A ARG 79  ? A ARG 79  
7  1 Y 1 A GLY 80  ? A GLY 80  
8  1 Y 1 A PRO 81  ? A PRO 81  
9  1 Y 1 A GLU 82  ? A GLU 82  
10 1 Y 1 A PRO 83  ? A PRO 83  
11 1 Y 1 A PRO 84  ? A PRO 84  
12 1 Y 1 A GLU 85  ? A GLU 85  
13 1 Y 1 A ARG 86  ? A ARG 86  
14 1 Y 1 A ARG 87  ? A ARG 87  
15 1 Y 1 A ASP 100 ? A ASP 100 
16 1 Y 1 A SER 101 ? A SER 101 
17 1 Y 1 A ALA 102 ? A ALA 102 
18 1 Y 1 A SER 103 ? A SER 103 
19 1 Y 1 A ALA 104 ? A ALA 104 
20 1 Y 1 A THR 105 ? A THR 105 
21 1 Y 1 A SER 106 ? A SER 106 
22 1 Y 1 A ALA 107 ? A ALA 107 
23 1 Y 1 A LEU 108 ? A LEU 108 
24 1 Y 1 A SER 109 ? A SER 109 
25 1 Y 1 A CYS 110 ? A CYS 110 
26 1 Y 1 A ALA 111 ? A ALA 111 
27 1 Y 1 A ASP 112 ? A ASP 112 
28 1 Y 1 A PRO 113 ? A PRO 113 
29 1 Y 1 A LYS 317 ? A LYS 317 
30 1 Y 1 A TYR 318 ? A TYR 318 
31 1 Y 1 A LEU 319 ? A LEU 319 
32 1 Y 1 A SER 320 ? A SER 320 
33 1 Y 1 A SER 321 ? A SER 321 
34 1 Y 1 A ASN 322 ? A ASN 322 
35 1 Y 1 A TYR 323 ? A TYR 323 
36 1 Y 1 A SER 324 ? A SER 324 
37 1 Y 1 A GLU 325 ? A GLU 325 
38 1 Y 1 A ILE 326 ? A ILE 326 
39 1 Y 1 A THR 327 ? A THR 327 
40 1 Y 1 A LEU 535 ? A LEU 535 
41 1 Y 1 A GLY 536 ? A GLY 536 
42 1 Y 1 A SER 537 ? A SER 537 
43 1 Y 1 A PRO 538 ? A PRO 538 
44 1 Y 1 A HIS 539 ? A HIS 539 
45 1 Y 1 A SER 540 ? A SER 540 
46 1 Y 1 A CYS 541 ? A CYS 541 
47 1 Y 1 A LYS 542 ? A LYS 542 
48 1 Y 1 A CYS 543 ? A CYS 543 
49 1 Y 1 A GLY 544 ? A GLY 544 
50 1 Y 1 A ARG 545 ? A ARG 545 
51 1 Y 1 A ASN 546 ? A ASN 546 
52 1 Y 1 A LYS 547 ? A LYS 547 
53 1 Y 1 A LYS 548 ? A LYS 548 
54 1 Y 1 A THR 549 ? A THR 549 
55 1 Y 1 A PRO 550 ? A PRO 550 
56 1 Y 1 A VAL 551 ? A VAL 551 
57 1 Y 1 A SER 552 ? A SER 552 
58 1 Y 1 A ARG 553 ? A ARG 553 
59 1 Y 1 A SER 554 ? A SER 554 
60 1 Y 1 A HIS 555 ? A HIS 555 
61 1 Y 1 A LEU 556 ? A LEU 556 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.entry_id           7ZH0 
_em_admin.current_status     REL 
_em_admin.deposition_date    2022-04-05 
_em_admin.deposition_site    PDBE 
_em_admin.last_update        2025-07-02 
_em_admin.map_release_date   2022-11-09 
_em_admin.title              'Structure of human OCT3 in lipid nanodisc' 
# 
_em_ctf_correction.id                       1 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
_em_ctf_correction.details                  ? 
# 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
# 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
_em_image_processing.details              ? 
# 
loop_
_em_image_recording.id 
_em_image_recording.imaging_id 
_em_image_recording.avg_electron_dose_per_image 
_em_image_recording.average_exposure_time 
_em_image_recording.details 
_em_image_recording.detector_mode 
_em_image_recording.film_or_detector_model 
_em_image_recording.num_diffraction_images 
_em_image_recording.num_grids_imaged 
_em_image_recording.num_real_images 
_em_image_recording.avg_electron_dose_per_subtomogram 
1 1 48 ? 'Data set 1, 2 and 3' ? 'GATAN K3 BIOQUANTUM (6k x 4k)' ? ? ? ? 
2 1 49 ? 'Data set 4'          ? 'GATAN K3 BIOQUANTUM (6k x 4k)' ? ? ? ? 
# 
loop_
_em_software.id 
_em_software.category 
_em_software.details 
_em_software.name 
_em_software.version 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
1  'PARTICLE SELECTION'       ? ?      ? 1 ? ? 
2  'IMAGE ACQUISITION'        ? ?      ? ? ? 1 
3  MASKING                    ? ?      ? ? ? ? 
4  'CTF CORRECTION'           ? ?      ? 1 ? ? 
5  'LAYERLINE INDEXING'       ? ?      ? ? ? ? 
6  'DIFFRACTION INDEXING'     ? ?      ? ? ? ? 
7  'MODEL FITTING'            ? ?      ? ? 1 ? 
8  OTHER                      ? ?      ? ? ? ? 
9  'INITIAL EULER ASSIGNMENT' ? ?      ? 1 ? ? 
10 'FINAL EULER ASSIGNMENT'   ? ?      ? 1 ? ? 
11 CLASSIFICATION             ? ?      ? 1 ? ? 
12 RECONSTRUCTION             ? ?      ? 1 ? ? 
13 'MODEL REFINEMENT'         ? PHENIX ? ? 1 ? 
# 
_em_specimen.id                      1 
_em_specimen.experiment_id           1 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Swiss National Science Foundation' 
_pdbx_audit_support.country                Switzerland 
_pdbx_audit_support.grant_number           198545 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    7ZH0 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . PRO A 1 2   ? 83.379  127.356 126.952 1.00 115.07 ? 2   PRO A N   1 
ATOM 2    C CA  . PRO A 1 2   ? 83.100  126.154 127.755 1.00 115.07 ? 2   PRO A CA  1 
ATOM 3    C C   . PRO A 1 2   ? 82.134  125.195 127.087 1.00 115.07 ? 2   PRO A C   1 
ATOM 4    O O   . PRO A 1 2   ? 82.184  123.991 127.371 1.00 115.07 ? 2   PRO A O   1 
ATOM 5    C CB  . PRO A 1 2   ? 82.516  126.724 129.055 1.00 115.07 ? 2   PRO A CB  1 
ATOM 6    C CG  . PRO A 1 2   ? 83.000  128.137 129.106 1.00 115.07 ? 2   PRO A CG  1 
ATOM 7    C CD  . PRO A 1 2   ? 83.058  128.594 127.682 1.00 115.07 ? 2   PRO A CD  1 
ATOM 8    N N   . SER A 1 3   ? 81.251  125.688 126.215 1.00 108.84 ? 3   SER A N   1 
ATOM 9    C CA  . SER A 1 3   ? 80.356  124.794 125.490 1.00 108.84 ? 3   SER A CA  1 
ATOM 10   C C   . SER A 1 3   ? 81.127  123.884 124.545 1.00 108.84 ? 3   SER A C   1 
ATOM 11   O O   . SER A 1 3   ? 80.680  122.768 124.257 1.00 108.84 ? 3   SER A O   1 
ATOM 12   C CB  . SER A 1 3   ? 79.309  125.602 124.724 1.00 108.84 ? 3   SER A CB  1 
ATOM 13   O OG  . SER A 1 3   ? 78.198  124.795 124.377 1.00 108.84 ? 3   SER A OG  1 
ATOM 14   N N   . PHE A 1 4   ? 82.282  124.339 124.051 1.00 101.07 ? 4   PHE A N   1 
ATOM 15   C CA  . PHE A 1 4   ? 83.124  123.468 123.239 1.00 101.07 ? 4   PHE A CA  1 
ATOM 16   C C   . PHE A 1 4   ? 83.613  122.278 124.050 1.00 101.07 ? 4   PHE A C   1 
ATOM 17   O O   . PHE A 1 4   ? 83.686  121.155 123.539 1.00 101.07 ? 4   PHE A O   1 
ATOM 18   C CB  . PHE A 1 4   ? 84.307  124.248 122.669 1.00 101.07 ? 4   PHE A CB  1 
ATOM 19   C CG  . PHE A 1 4   ? 85.121  123.471 121.674 1.00 101.07 ? 4   PHE A CG  1 
ATOM 20   C CD1 . PHE A 1 4   ? 86.170  122.670 122.089 1.00 101.07 ? 4   PHE A CD1 1 
ATOM 21   C CD2 . PHE A 1 4   ? 84.833  123.537 120.325 1.00 101.07 ? 4   PHE A CD2 1 
ATOM 22   C CE1 . PHE A 1 4   ? 86.915  121.952 121.175 1.00 101.07 ? 4   PHE A CE1 1 
ATOM 23   C CE2 . PHE A 1 4   ? 85.576  122.822 119.409 1.00 101.07 ? 4   PHE A CE2 1 
ATOM 24   C CZ  . PHE A 1 4   ? 86.617  122.029 119.835 1.00 101.07 ? 4   PHE A CZ  1 
ATOM 25   N N   . ASP A 1 5   ? 83.965  122.507 125.317 1.00 108.13 ? 5   ASP A N   1 
ATOM 26   C CA  . ASP A 1 5   ? 84.318  121.396 126.193 1.00 108.13 ? 5   ASP A CA  1 
ATOM 27   C C   . ASP A 1 5   ? 83.141  120.446 126.365 1.00 108.13 ? 5   ASP A C   1 
ATOM 28   O O   . ASP A 1 5   ? 83.297  119.223 126.266 1.00 108.13 ? 5   ASP A O   1 
ATOM 29   C CB  . ASP A 1 5   ? 84.785  121.930 127.545 1.00 108.13 ? 5   ASP A CB  1 
ATOM 30   C CG  . ASP A 1 5   ? 86.115  122.652 127.457 1.00 108.13 ? 5   ASP A CG  1 
ATOM 31   O OD1 . ASP A 1 5   ? 86.924  122.299 126.574 1.00 108.13 ? 5   ASP A OD1 1 
ATOM 32   O OD2 . ASP A 1 5   ? 86.349  123.574 128.265 1.00 108.13 ? 5   ASP A OD2 1 
ATOM 33   N N   . GLU A 1 6   ? 81.946  120.992 126.602 1.00 105.99 ? 6   GLU A N   1 
ATOM 34   C CA  . GLU A 1 6   ? 80.754  120.155 126.657 1.00 105.99 ? 6   GLU A CA  1 
ATOM 35   C C   . GLU A 1 6   ? 80.482  119.504 125.307 1.00 105.99 ? 6   GLU A C   1 
ATOM 36   O O   . GLU A 1 6   ? 80.001  118.367 125.243 1.00 105.99 ? 6   GLU A O   1 
ATOM 37   C CB  . GLU A 1 6   ? 79.550  120.982 127.109 1.00 105.99 ? 6   GLU A CB  1 
ATOM 38   C CG  . GLU A 1 6   ? 78.257  120.187 127.229 1.00 105.99 ? 6   GLU A CG  1 
ATOM 39   C CD  . GLU A 1 6   ? 77.099  121.024 127.736 1.00 105.99 ? 6   GLU A CD  1 
ATOM 40   O OE1 . GLU A 1 6   ? 77.223  122.266 127.751 1.00 105.99 ? 6   GLU A OE1 1 
ATOM 41   O OE2 . GLU A 1 6   ? 76.064  120.440 128.117 1.00 105.99 ? 6   GLU A OE2 1 
ATOM 42   N N   . ALA A 1 7   ? 80.784  120.211 124.215 1.00 103.12 ? 7   ALA A N   1 
ATOM 43   C CA  . ALA A 1 7   ? 80.580  119.645 122.886 1.00 103.12 ? 7   ALA A CA  1 
ATOM 44   C C   . ALA A 1 7   ? 81.451  118.416 122.672 1.00 103.12 ? 7   ALA A C   1 
ATOM 45   O O   . ALA A 1 7   ? 81.006  117.425 122.082 1.00 103.12 ? 7   ALA A O   1 
ATOM 46   C CB  . ALA A 1 7   ? 80.866  120.697 121.817 1.00 103.12 ? 7   ALA A CB  1 
ATOM 47   N N   . LEU A 1 8   ? 82.698  118.463 123.139 1.00 101.96 ? 8   LEU A N   1 
ATOM 48   C CA  . LEU A 1 8   ? 83.559  117.292 123.042 1.00 101.96 ? 8   LEU A CA  1 
ATOM 49   C C   . LEU A 1 8   ? 83.167  116.224 124.055 1.00 101.96 ? 8   LEU A C   1 
ATOM 50   O O   . LEU A 1 8   ? 83.408  115.033 123.823 1.00 101.96 ? 8   LEU A O   1 
ATOM 51   C CB  . LEU A 1 8   ? 85.020  117.693 123.229 1.00 101.96 ? 8   LEU A CB  1 
ATOM 52   C CG  . LEU A 1 8   ? 85.810  117.938 121.943 1.00 101.96 ? 8   LEU A CG  1 
ATOM 53   C CD1 . LEU A 1 8   ? 87.274  118.184 122.258 1.00 101.96 ? 8   LEU A CD1 1 
ATOM 54   C CD2 . LEU A 1 8   ? 85.651  116.777 120.977 1.00 101.96 ? 8   LEU A CD2 1 
ATOM 55   N N   . GLN A 1 9   ? 82.580  116.626 125.185 1.00 107.71 ? 9   GLN A N   1 
ATOM 56   C CA  . GLN A 1 9   ? 82.086  115.645 126.147 1.00 107.71 ? 9   GLN A CA  1 
ATOM 57   C C   . GLN A 1 9   ? 80.932  114.835 125.569 1.00 107.71 ? 9   GLN A C   1 
ATOM 58   O O   . GLN A 1 9   ? 80.861  113.616 125.764 1.00 107.71 ? 9   GLN A O   1 
ATOM 59   C CB  . GLN A 1 9   ? 81.654  116.342 127.436 1.00 107.71 ? 9   GLN A CB  1 
ATOM 60   C CG  . GLN A 1 9   ? 82.704  116.330 128.532 1.00 107.71 ? 9   GLN A CG  1 
ATOM 61   C CD  . GLN A 1 9   ? 82.137  116.721 129.881 1.00 107.71 ? 9   GLN A CD  1 
ATOM 62   O OE1 . GLN A 1 9   ? 81.229  116.070 130.397 1.00 107.71 ? 9   GLN A OE1 1 
ATOM 63   N NE2 . GLN A 1 9   ? 82.670  117.790 130.461 1.00 107.71 ? 9   GLN A NE2 1 
ATOM 64   N N   . ARG A 1 10  ? 80.012  115.498 124.863 1.00 104.44 ? 10  ARG A N   1 
ATOM 65   C CA  . ARG A 1 10  ? 78.875  114.796 124.274 1.00 104.44 ? 10  ARG A CA  1 
ATOM 66   C C   . ARG A 1 10  ? 79.335  113.804 123.215 1.00 104.44 ? 10  ARG A C   1 
ATOM 67   O O   . ARG A 1 10  ? 78.814  112.686 123.123 1.00 104.44 ? 10  ARG A O   1 
ATOM 68   C CB  . ARG A 1 10  ? 77.887  115.800 123.684 1.00 104.44 ? 10  ARG A CB  1 
ATOM 69   C CG  . ARG A 1 10  ? 77.338  116.786 124.695 1.00 104.44 ? 10  ARG A CG  1 
ATOM 70   C CD  . ARG A 1 10  ? 76.483  117.843 124.025 1.00 104.44 ? 10  ARG A CD  1 
ATOM 71   N NE  . ARG A 1 10  ? 75.463  118.366 124.926 1.00 104.44 ? 10  ARG A NE  1 
ATOM 72   C CZ  . ARG A 1 10  ? 75.286  119.654 125.187 1.00 104.44 ? 10  ARG A CZ  1 
ATOM 73   N NH1 . ARG A 1 10  ? 76.045  120.583 124.628 1.00 104.44 ? 10  ARG A NH1 1 
ATOM 74   N NH2 . ARG A 1 10  ? 74.324  120.019 126.029 1.00 104.44 ? 10  ARG A NH2 1 
ATOM 75   N N   . VAL A 1 11  ? 80.306  114.200 122.400 1.00 103.30 ? 11  VAL A N   1 
ATOM 76   C CA  . VAL A 1 11  ? 80.943  113.308 121.440 1.00 103.30 ? 11  VAL A CA  1 
ATOM 77   C C   . VAL A 1 11  ? 82.371  113.782 121.223 1.00 103.30 ? 11  VAL A C   1 
ATOM 78   O O   . VAL A 1 11  ? 82.615  114.982 121.064 1.00 103.30 ? 11  VAL A O   1 
ATOM 79   C CB  . VAL A 1 11  ? 80.179  113.247 120.103 1.00 103.30 ? 11  VAL A CB  1 
ATOM 80   C CG1 . VAL A 1 11  ? 80.021  114.636 119.501 1.00 103.30 ? 11  VAL A CG1 1 
ATOM 81   C CG2 . VAL A 1 11  ? 80.910  112.332 119.138 1.00 103.30 ? 11  VAL A CG2 1 
ATOM 82   N N   . GLY A 1 12  ? 83.307  112.855 121.235 1.00 100.28 ? 12  GLY A N   1 
ATOM 83   C CA  . GLY A 1 12  ? 84.685  113.202 120.996 1.00 100.28 ? 12  GLY A CA  1 
ATOM 84   C C   . GLY A 1 12  ? 85.602  112.393 121.902 1.00 100.28 ? 12  GLY A C   1 
ATOM 85   O O   . GLY A 1 12  ? 85.421  111.183 122.058 1.00 100.28 ? 12  GLY A O   1 
ATOM 86   N N   . GLU A 1 13  ? 86.581  113.087 122.482 1.00 101.85 ? 13  GLU A N   1 
ATOM 87   C CA  . GLU A 1 13  ? 87.635  112.467 123.287 1.00 101.85 ? 13  GLU A CA  1 
ATOM 88   C C   . GLU A 1 13  ? 88.335  111.460 122.383 1.00 101.85 ? 13  GLU A C   1 
ATOM 89   O O   . GLU A 1 13  ? 89.022  111.885 121.440 1.00 101.85 ? 13  GLU A O   1 
ATOM 90   C CB  . GLU A 1 13  ? 87.029  111.917 124.581 1.00 101.85 ? 13  GLU A CB  1 
ATOM 91   C CG  . GLU A 1 13  ? 86.307  112.935 125.494 1.00 101.85 ? 13  GLU A CG  1 
ATOM 92   C CD  . GLU A 1 13  ? 87.129  114.162 125.915 1.00 101.85 ? 13  GLU A CD  1 
ATOM 93   O OE1 . GLU A 1 13  ? 86.739  114.792 126.920 1.00 101.85 ? 13  GLU A OE1 1 
ATOM 94   O OE2 . GLU A 1 13  ? 88.149  114.505 125.283 1.00 101.85 ? 13  GLU A OE2 1 
ATOM 95   N N   . PHE A 1 14  ? 88.216  110.159 122.616 1.00 98.45  ? 14  PHE A N   1 
ATOM 96   C CA  . PHE A 1 14  ? 88.680  109.155 121.669 1.00 98.45  ? 14  PHE A CA  1 
ATOM 97   C C   . PHE A 1 14  ? 87.505  108.359 121.124 1.00 98.45  ? 14  PHE A C   1 
ATOM 98   O O   . PHE A 1 14  ? 86.747  107.755 121.888 1.00 98.45  ? 14  PHE A O   1 
ATOM 99   C CB  . PHE A 1 14  ? 89.705  108.215 122.303 1.00 98.45  ? 14  PHE A CB  1 
ATOM 100  C CG  . PHE A 1 14  ? 91.124  108.597 122.015 1.00 98.45  ? 14  PHE A CG  1 
ATOM 101  C CD1 . PHE A 1 14  ? 91.621  109.823 122.408 1.00 98.45  ? 14  PHE A CD1 1 
ATOM 102  C CD2 . PHE A 1 14  ? 91.957  107.730 121.332 1.00 98.45  ? 14  PHE A CD2 1 
ATOM 103  C CE1 . PHE A 1 14  ? 92.924  110.172 122.131 1.00 98.45  ? 14  PHE A CE1 1 
ATOM 104  C CE2 . PHE A 1 14  ? 93.261  108.073 121.055 1.00 98.45  ? 14  PHE A CE2 1 
ATOM 105  C CZ  . PHE A 1 14  ? 93.745  109.295 121.455 1.00 98.45  ? 14  PHE A CZ  1 
ATOM 106  N N   . GLY A 1 15  ? 87.364  108.367 119.804 1.00 97.89  ? 15  GLY A N   1 
ATOM 107  C CA  . GLY A 1 15  ? 86.443  107.490 119.116 1.00 97.89  ? 15  GLY A CA  1 
ATOM 108  C C   . GLY A 1 15  ? 87.183  106.703 118.057 1.00 97.89  ? 15  GLY A C   1 
ATOM 109  O O   . GLY A 1 15  ? 88.416  106.706 118.030 1.00 97.89  ? 15  GLY A O   1 
ATOM 110  N N   . ARG A 1 16  ? 86.449  106.012 117.187 1.00 100.90 ? 16  ARG A N   1 
ATOM 111  C CA  . ARG A 1 16  ? 87.091  105.347 116.059 1.00 100.90 ? 16  ARG A CA  1 
ATOM 112  C C   . ARG A 1 16  ? 87.652  106.367 115.075 1.00 100.90 ? 16  ARG A C   1 
ATOM 113  O O   . ARG A 1 16  ? 88.766  106.204 114.558 1.00 100.90 ? 16  ARG A O   1 
ATOM 114  C CB  . ARG A 1 16  ? 86.089  104.416 115.376 1.00 100.90 ? 16  ARG A CB  1 
ATOM 115  C CG  . ARG A 1 16  ? 86.581  103.760 114.103 1.00 100.90 ? 16  ARG A CG  1 
ATOM 116  C CD  . ARG A 1 16  ? 85.554  102.758 113.604 1.00 100.90 ? 16  ARG A CD  1 
ATOM 117  N NE  . ARG A 1 16  ? 84.196  103.180 113.927 1.00 100.90 ? 16  ARG A NE  1 
ATOM 118  C CZ  . ARG A 1 16  ? 83.099  102.639 113.416 1.00 100.90 ? 16  ARG A CZ  1 
ATOM 119  N NH1 . ARG A 1 16  ? 83.160  101.646 112.544 1.00 100.90 ? 16  ARG A NH1 1 
ATOM 120  N NH2 . ARG A 1 16  ? 81.911  103.105 113.790 1.00 100.90 ? 16  ARG A NH2 1 
ATOM 121  N N   . PHE A 1 17  ? 86.898  107.438 114.825 1.00 98.67  ? 17  PHE A N   1 
ATOM 122  C CA  . PHE A 1 17  ? 87.312  108.454 113.863 1.00 98.67  ? 17  PHE A CA  1 
ATOM 123  C C   . PHE A 1 17  ? 88.606  109.132 114.294 1.00 98.67  ? 17  PHE A C   1 
ATOM 124  O O   . PHE A 1 17  ? 89.542  109.279 113.497 1.00 98.67  ? 17  PHE A O   1 
ATOM 125  C CB  . PHE A 1 17  ? 86.186  109.476 113.695 1.00 98.67  ? 17  PHE A CB  1 
ATOM 126  C CG  . PHE A 1 17  ? 86.626  110.783 113.110 1.00 98.67  ? 17  PHE A CG  1 
ATOM 127  C CD1 . PHE A 1 17  ? 87.111  110.853 111.817 1.00 98.67  ? 17  PHE A CD1 1 
ATOM 128  C CD2 . PHE A 1 17  ? 86.540  111.947 113.853 1.00 98.67  ? 17  PHE A CD2 1 
ATOM 129  C CE1 . PHE A 1 17  ? 87.510  112.056 111.283 1.00 98.67  ? 17  PHE A CE1 1 
ATOM 130  C CE2 . PHE A 1 17  ? 86.938  113.153 113.323 1.00 98.67  ? 17  PHE A CE2 1 
ATOM 131  C CZ  . PHE A 1 17  ? 87.423  113.208 112.037 1.00 98.67  ? 17  PHE A CZ  1 
ATOM 132  N N   . GLN A 1 18  ? 88.681  109.543 115.561 1.00 94.69  ? 18  GLN A N   1 
ATOM 133  C CA  . GLN A 1 18  ? 89.869  110.241 116.036 1.00 94.69  ? 18  GLN A CA  1 
ATOM 134  C C   . GLN A 1 18  ? 91.067  109.309 116.132 1.00 94.69  ? 18  GLN A C   1 
ATOM 135  O O   . GLN A 1 18  ? 92.199  109.744 115.920 1.00 94.69  ? 18  GLN A O   1 
ATOM 136  C CB  . GLN A 1 18  ? 89.574  110.911 117.374 1.00 94.69  ? 18  GLN A CB  1 
ATOM 137  C CG  . GLN A 1 18  ? 88.331  111.779 117.317 1.00 94.69  ? 18  GLN A CG  1 
ATOM 138  C CD  . GLN A 1 18  ? 87.930  112.329 118.662 1.00 94.69  ? 18  GLN A CD  1 
ATOM 139  O OE1 . GLN A 1 18  ? 87.153  111.712 119.388 1.00 94.69  ? 18  GLN A OE1 1 
ATOM 140  N NE2 . GLN A 1 18  ? 88.451  113.502 119.003 1.00 94.69  ? 18  GLN A NE2 1 
ATOM 141  N N   . ARG A 1 19  ? 90.841  108.026 116.416 1.00 97.78  ? 19  ARG A N   1 
ATOM 142  C CA  . ARG A 1 19  ? 91.932  107.056 116.384 1.00 97.78  ? 19  ARG A CA  1 
ATOM 143  C C   . ARG A 1 19  ? 92.489  106.890 114.974 1.00 97.78  ? 19  ARG A C   1 
ATOM 144  O O   . ARG A 1 19  ? 93.715  106.857 114.777 1.00 97.78  ? 19  ARG A O   1 
ATOM 145  C CB  . ARG A 1 19  ? 91.442  105.717 116.928 1.00 97.78  ? 19  ARG A CB  1 
ATOM 146  C CG  . ARG A 1 19  ? 92.534  104.780 117.403 1.00 97.78  ? 19  ARG A CG  1 
ATOM 147  C CD  . ARG A 1 19  ? 91.982  103.737 118.366 1.00 97.78  ? 19  ARG A CD  1 
ATOM 148  N NE  . ARG A 1 19  ? 91.183  104.336 119.429 1.00 97.78  ? 19  ARG A NE  1 
ATOM 149  C CZ  . ARG A 1 19  ? 89.857  104.330 119.470 1.00 97.78  ? 19  ARG A CZ  1 
ATOM 150  N NH1 . ARG A 1 19  ? 89.140  103.747 118.525 1.00 97.78  ? 19  ARG A NH1 1 
ATOM 151  N NH2 . ARG A 1 19  ? 89.237  104.929 120.482 1.00 97.78  ? 19  ARG A NH2 1 
ATOM 152  N N   . ARG A 1 20  ? 91.605  106.778 113.979 1.00 98.35  ? 20  ARG A N   1 
ATOM 153  C CA  . ARG A 1 20  ? 92.070  106.670 112.600 1.00 98.35  ? 20  ARG A CA  1 
ATOM 154  C C   . ARG A 1 20  ? 92.835  107.921 112.181 1.00 98.35  ? 20  ARG A C   1 
ATOM 155  O O   . ARG A 1 20  ? 93.913  107.826 111.581 1.00 98.35  ? 20  ARG A O   1 
ATOM 156  C CB  . ARG A 1 20  ? 90.888  106.411 111.666 1.00 98.35  ? 20  ARG A CB  1 
ATOM 157  C CG  . ARG A 1 20  ? 90.164  105.098 111.943 1.00 98.35  ? 20  ARG A CG  1 
ATOM 158  C CD  . ARG A 1 20  ? 89.380  104.602 110.732 1.00 98.35  ? 20  ARG A CD  1 
ATOM 159  N NE  . ARG A 1 20  ? 88.159  105.368 110.507 1.00 98.35  ? 20  ARG A NE  1 
ATOM 160  C CZ  . ARG A 1 20  ? 87.908  106.077 109.415 1.00 98.35  ? 20  ARG A CZ  1 
ATOM 161  N NH1 . ARG A 1 20  ? 88.773  106.138 108.417 1.00 98.35  ? 20  ARG A NH1 1 
ATOM 162  N NH2 . ARG A 1 20  ? 86.758  106.739 109.322 1.00 98.35  ? 20  ARG A NH2 1 
ATOM 163  N N   . VAL A 1 21  ? 92.304  109.101 112.514 1.00 96.19  ? 21  VAL A N   1 
ATOM 164  C CA  . VAL A 1 21  ? 93.007  110.351 112.225 1.00 96.19  ? 21  VAL A CA  1 
ATOM 165  C C   . VAL A 1 21  ? 94.364  110.370 112.916 1.00 96.19  ? 21  VAL A C   1 
ATOM 166  O O   . VAL A 1 21  ? 95.366  110.825 112.350 1.00 96.19  ? 21  VAL A O   1 
ATOM 167  C CB  . VAL A 1 21  ? 92.138  111.550 112.647 1.00 96.19  ? 21  VAL A CB  1 
ATOM 168  C CG1 . VAL A 1 21  ? 92.935  112.839 112.610 1.00 96.19  ? 21  VAL A CG1 1 
ATOM 169  C CG2 . VAL A 1 21  ? 90.921  111.654 111.753 1.00 96.19  ? 21  VAL A CG2 1 
ATOM 170  N N   . PHE A 1 22  ? 94.412  109.875 114.152 1.00 91.79  ? 22  PHE A N   1 
ATOM 171  C CA  . PHE A 1 22  ? 95.648  109.829 114.920 1.00 91.79  ? 22  PHE A CA  1 
ATOM 172  C C   . PHE A 1 22  ? 96.718  109.032 114.189 1.00 91.79  ? 22  PHE A C   1 
ATOM 173  O O   . PHE A 1 22  ? 97.846  109.505 114.002 1.00 91.79  ? 22  PHE A O   1 
ATOM 174  C CB  . PHE A 1 22  ? 95.339  109.212 116.282 1.00 91.79  ? 22  PHE A CB  1 
ATOM 175  C CG  . PHE A 1 22  ? 96.415  109.383 117.298 1.00 91.79  ? 22  PHE A CG  1 
ATOM 176  C CD1 . PHE A 1 22  ? 97.599  108.677 117.213 1.00 91.79  ? 22  PHE A CD1 1 
ATOM 177  C CD2 . PHE A 1 22  ? 96.218  110.221 118.374 1.00 91.79  ? 22  PHE A CD2 1 
ATOM 178  C CE1 . PHE A 1 22  ? 98.573  108.833 118.165 1.00 91.79  ? 22  PHE A CE1 1 
ATOM 179  C CE2 . PHE A 1 22  ? 97.185  110.374 119.323 1.00 91.79  ? 22  PHE A CE2 1 
ATOM 180  C CZ  . PHE A 1 22  ? 98.366  109.685 119.223 1.00 91.79  ? 22  PHE A CZ  1 
ATOM 181  N N   . LEU A 1 23  ? 96.376  107.816 113.762 1.00 92.90  ? 23  LEU A N   1 
ATOM 182  C CA  . LEU A 1 23  ? 97.348  107.004 113.033 1.00 92.90  ? 23  LEU A CA  1 
ATOM 183  C C   . LEU A 1 23  ? 97.746  107.669 111.720 1.00 92.90  ? 23  LEU A C   1 
ATOM 184  O O   . LEU A 1 23  ? 98.930  107.670 111.341 1.00 92.90  ? 23  LEU A O   1 
ATOM 185  C CB  . LEU A 1 23  ? 96.790  105.605 112.777 1.00 92.90  ? 23  LEU A CB  1 
ATOM 186  C CG  . LEU A 1 23  ? 96.980  104.553 113.875 1.00 92.90  ? 23  LEU A CG  1 
ATOM 187  C CD1 . LEU A 1 23  ? 96.066  104.797 115.065 1.00 92.90  ? 23  LEU A CD1 1 
ATOM 188  C CD2 . LEU A 1 23  ? 96.770  103.159 113.311 1.00 92.90  ? 23  LEU A CD2 1 
ATOM 189  N N   . LEU A 1 24  ? 96.773  108.256 111.020 1.00 93.61  ? 24  LEU A N   1 
ATOM 190  C CA  . LEU A 1 24  ? 97.063  108.871 109.730 1.00 93.61  ? 24  LEU A CA  1 
ATOM 191  C C   . LEU A 1 24  ? 98.061  110.014 109.870 1.00 93.61  ? 24  LEU A C   1 
ATOM 192  O O   . LEU A 1 24  ? 98.971  110.156 109.045 1.00 93.61  ? 24  LEU A O   1 
ATOM 193  C CB  . LEU A 1 24  ? 95.768  109.356 109.082 1.00 93.61  ? 24  LEU A CB  1 
ATOM 194  C CG  . LEU A 1 24  ? 94.797  108.241 108.695 1.00 93.61  ? 24  LEU A CG  1 
ATOM 195  C CD1 . LEU A 1 24  ? 93.538  108.813 108.070 1.00 93.61  ? 24  LEU A CD1 1 
ATOM 196  C CD2 . LEU A 1 24  ? 95.461  107.239 107.768 1.00 93.61  ? 24  LEU A CD2 1 
ATOM 197  N N   . LEU A 1 25  ? 97.912  110.839 110.906 1.00 88.94  ? 25  LEU A N   1 
ATOM 198  C CA  . LEU A 1 25  ? 98.845  111.946 111.096 1.00 88.94  ? 25  LEU A CA  1 
ATOM 199  C C   . LEU A 1 25  ? 100.177 111.478 111.680 1.00 88.94  ? 25  LEU A C   1 
ATOM 200  O O   . LEU A 1 25  ? 101.223 112.095 111.424 1.00 88.94  ? 25  LEU A O   1 
ATOM 201  C CB  . LEU A 1 25  ? 98.216  113.022 111.982 1.00 88.94  ? 25  LEU A CB  1 
ATOM 202  C CG  . LEU A 1 25  ? 97.268  114.021 111.304 1.00 88.94  ? 25  LEU A CG  1 
ATOM 203  C CD1 . LEU A 1 25  ? 97.995  114.835 110.260 1.00 88.94  ? 25  LEU A CD1 1 
ATOM 204  C CD2 . LEU A 1 25  ? 96.052  113.364 110.687 1.00 88.94  ? 25  LEU A CD2 1 
ATOM 205  N N   . CYS A 1 26  ? 100.170 110.396 112.462 1.00 90.94  ? 26  CYS A N   1 
ATOM 206  C CA  . CYS A 1 26  ? 101.432 109.829 112.918 1.00 90.94  ? 26  CYS A CA  1 
ATOM 207  C C   . CYS A 1 26  ? 102.269 109.336 111.749 1.00 90.94  ? 26  CYS A C   1 
ATOM 208  O O   . CYS A 1 26  ? 103.505 109.352 111.812 1.00 90.94  ? 26  CYS A O   1 
ATOM 209  C CB  . CYS A 1 26  ? 101.169 108.699 113.909 1.00 90.94  ? 26  CYS A CB  1 
ATOM 210  S SG  . CYS A 1 26  ? 100.647 109.273 115.536 1.00 90.94  ? 26  CYS A SG  1 
ATOM 211  N N   . LEU A 1 27  ? 101.617 108.901 110.672 1.00 85.58  ? 27  LEU A N   1 
ATOM 212  C CA  . LEU A 1 27  ? 102.366 108.572 109.463 1.00 85.58  ? 27  LEU A CA  1 
ATOM 213  C C   . LEU A 1 27  ? 103.139 109.787 108.944 1.00 85.58  ? 27  LEU A C   1 
ATOM 214  O O   . LEU A 1 27  ? 104.310 109.675 108.547 1.00 85.58  ? 27  LEU A O   1 
ATOM 215  C CB  . LEU A 1 27  ? 101.414 108.034 108.398 1.00 85.58  ? 27  LEU A CB  1 
ATOM 216  C CG  . LEU A 1 27  ? 100.796 106.673 108.712 1.00 85.58  ? 27  LEU A CG  1 
ATOM 217  C CD1 . LEU A 1 27  ? 100.167 106.075 107.468 1.00 85.58  ? 27  LEU A CD1 1 
ATOM 218  C CD2 . LEU A 1 27  ? 101.839 105.737 109.292 1.00 85.58  ? 27  LEU A CD2 1 
ATOM 219  N N   . THR A 1 28  ? 102.499 110.959 108.945 1.00 84.53  ? 28  THR A N   1 
ATOM 220  C CA  . THR A 1 28  ? 103.182 112.182 108.533 1.00 84.53  ? 28  THR A CA  1 
ATOM 221  C C   . THR A 1 28  ? 104.330 112.515 109.473 1.00 84.53  ? 28  THR A C   1 
ATOM 222  O O   . THR A 1 28  ? 105.383 112.998 109.038 1.00 84.53  ? 28  THR A O   1 
ATOM 223  C CB  . THR A 1 28  ? 102.188 113.339 108.472 1.00 84.53  ? 28  THR A CB  1 
ATOM 224  O OG1 . THR A 1 28  ? 101.241 113.096 107.426 1.00 84.53  ? 28  THR A OG1 1 
ATOM 225  C CG2 . THR A 1 28  ? 102.901 114.656 108.212 1.00 84.53  ? 28  THR A CG2 1 
ATOM 226  N N   . GLY A 1 29  ? 104.135 112.290 110.771 1.00 84.14  ? 29  GLY A N   1 
ATOM 227  C CA  . GLY A 1 29  ? 105.242 112.450 111.705 1.00 84.14  ? 29  GLY A CA  1 
ATOM 228  C C   . GLY A 1 29  ? 106.429 111.568 111.356 1.00 84.14  ? 29  GLY A C   1 
ATOM 229  O O   . GLY A 1 29  ? 107.584 112.005 111.405 1.00 84.14  ? 29  GLY A O   1 
ATOM 230  N N   . VAL A 1 30  ? 106.155 110.316 110.982 1.00 82.90  ? 30  VAL A N   1 
ATOM 231  C CA  . VAL A 1 30  ? 107.218 109.402 110.568 1.00 82.90  ? 30  VAL A CA  1 
ATOM 232  C C   . VAL A 1 30  ? 107.950 109.948 109.349 1.00 82.90  ? 30  VAL A C   1 
ATOM 233  O O   . VAL A 1 30  ? 109.185 109.913 109.277 1.00 82.90  ? 30  VAL A O   1 
ATOM 234  C CB  . VAL A 1 30  ? 106.639 108.002 110.292 1.00 82.90  ? 30  VAL A CB  1 
ATOM 235  C CG1 . VAL A 1 30  ? 107.655 107.136 109.567 1.00 82.90  ? 30  VAL A CG1 1 
ATOM 236  C CG2 . VAL A 1 30  ? 106.203 107.344 111.584 1.00 82.90  ? 30  VAL A CG2 1 
ATOM 237  N N   . THR A 1 31  ? 107.201 110.446 108.364 1.00 80.58  ? 31  THR A N   1 
ATOM 238  C CA  . THR A 1 31  ? 107.842 110.970 107.157 1.00 80.58  ? 31  THR A CA  1 
ATOM 239  C C   . THR A 1 31  ? 108.681 112.212 107.455 1.00 80.58  ? 31  THR A C   1 
ATOM 240  O O   . THR A 1 31  ? 109.769 112.388 106.888 1.00 80.58  ? 31  THR A O   1 
ATOM 241  C CB  . THR A 1 31  ? 106.792 111.259 106.088 1.00 80.58  ? 31  THR A CB  1 
ATOM 242  O OG1 . THR A 1 31  ? 106.286 110.017 105.587 1.00 80.58  ? 31  THR A OG1 1 
ATOM 243  C CG2 . THR A 1 31  ? 107.389 112.050 104.939 1.00 80.58  ? 31  THR A CG2 1 
ATOM 244  N N   . PHE A 1 32  ? 108.203 113.084 108.342 1.00 78.87  ? 32  PHE A N   1 
ATOM 245  C CA  . PHE A 1 32  ? 109.014 114.235 108.727 1.00 78.87  ? 32  PHE A CA  1 
ATOM 246  C C   . PHE A 1 32  ? 110.298 113.792 109.414 1.00 78.87  ? 32  PHE A C   1 
ATOM 247  O O   . PHE A 1 32  ? 111.361 114.389 109.205 1.00 78.87  ? 32  PHE A O   1 
ATOM 248  C CB  . PHE A 1 32  ? 108.231 115.174 109.637 1.00 78.87  ? 32  PHE A CB  1 
ATOM 249  C CG  . PHE A 1 32  ? 109.074 116.258 110.238 1.00 78.87  ? 32  PHE A CG  1 
ATOM 250  C CD1 . PHE A 1 32  ? 109.450 117.354 109.487 1.00 78.87  ? 32  PHE A CD1 1 
ATOM 251  C CD2 . PHE A 1 32  ? 109.498 116.177 111.549 1.00 78.87  ? 32  PHE A CD2 1 
ATOM 252  C CE1 . PHE A 1 32  ? 110.228 118.352 110.035 1.00 78.87  ? 32  PHE A CE1 1 
ATOM 253  C CE2 . PHE A 1 32  ? 110.277 117.171 112.101 1.00 78.87  ? 32  PHE A CE2 1 
ATOM 254  C CZ  . PHE A 1 32  ? 110.642 118.259 111.343 1.00 78.87  ? 32  PHE A CZ  1 
ATOM 255  N N   . ALA A 1 33  ? 110.216 112.755 110.252 1.00 83.61  ? 33  ALA A N   1 
ATOM 256  C CA  . ALA A 1 33  ? 111.428 112.208 110.854 1.00 83.61  ? 33  ALA A CA  1 
ATOM 257  C C   . ALA A 1 33  ? 112.377 111.675 109.788 1.00 83.61  ? 33  ALA A C   1 
ATOM 258  O O   . ALA A 1 33  ? 113.598 111.830 109.899 1.00 83.61  ? 33  ALA A O   1 
ATOM 259  C CB  . ALA A 1 33  ? 111.074 111.109 111.853 1.00 83.61  ? 33  ALA A CB  1 
ATOM 260  N N   . PHE A 1 34  ? 111.830 111.030 108.756 1.00 82.81  ? 34  PHE A N   1 
ATOM 261  C CA  . PHE A 1 34  ? 112.644 110.609 107.619 1.00 82.81  ? 34  PHE A CA  1 
ATOM 262  C C   . PHE A 1 34  ? 113.395 111.793 107.030 1.00 82.81  ? 34  PHE A C   1 
ATOM 263  O O   . PHE A 1 34  ? 114.601 111.722 106.771 1.00 82.81  ? 34  PHE A O   1 
ATOM 264  C CB  . PHE A 1 34  ? 111.767 109.976 106.538 1.00 82.81  ? 34  PHE A CB  1 
ATOM 265  C CG  . PHE A 1 34  ? 111.389 108.555 106.803 1.00 82.81  ? 34  PHE A CG  1 
ATOM 266  C CD1 . PHE A 1 34  ? 111.534 108.002 108.058 1.00 82.81  ? 34  PHE A CD1 1 
ATOM 267  C CD2 . PHE A 1 34  ? 110.879 107.771 105.787 1.00 82.81  ? 34  PHE A CD2 1 
ATOM 268  C CE1 . PHE A 1 34  ? 111.179 106.695 108.292 1.00 82.81  ? 34  PHE A CE1 1 
ATOM 269  C CE2 . PHE A 1 34  ? 110.523 106.462 106.015 1.00 82.81  ? 34  PHE A CE2 1 
ATOM 270  C CZ  . PHE A 1 34  ? 110.673 105.923 107.269 1.00 82.81  ? 34  PHE A CZ  1 
ATOM 271  N N   . LEU A 1 35  ? 112.679 112.893 106.804 1.00 81.26  ? 35  LEU A N   1 
ATOM 272  C CA  . LEU A 1 35  ? 113.285 114.058 106.165 1.00 81.26  ? 35  LEU A CA  1 
ATOM 273  C C   . LEU A 1 35  ? 114.371 114.679 107.034 1.00 81.26  ? 35  LEU A C   1 
ATOM 274  O O   . LEU A 1 35  ? 115.433 115.063 106.531 1.00 81.26  ? 35  LEU A O   1 
ATOM 275  C CB  . LEU A 1 35  ? 112.213 115.096 105.840 1.00 81.26  ? 35  LEU A CB  1 
ATOM 276  C CG  . LEU A 1 35  ? 112.731 116.480 105.447 1.00 81.26  ? 35  LEU A CG  1 
ATOM 277  C CD1 . LEU A 1 35  ? 113.526 116.408 104.156 1.00 81.26  ? 35  LEU A CD1 1 
ATOM 278  C CD2 . LEU A 1 35  ? 111.584 117.466 105.324 1.00 81.26  ? 35  LEU A CD2 1 
ATOM 279  N N   . PHE A 1 36  ? 114.125 114.787 108.342 1.00 84.67  ? 36  PHE A N   1 
ATOM 280  C CA  . PHE A 1 36  ? 114.994 115.591 109.198 1.00 84.67  ? 36  PHE A CA  1 
ATOM 281  C C   . PHE A 1 36  ? 116.412 115.034 109.259 1.00 84.67  ? 36  PHE A C   1 
ATOM 282  O O   . PHE A 1 36  ? 117.383 115.797 109.272 1.00 84.67  ? 36  PHE A O   1 
ATOM 283  C CB  . PHE A 1 36  ? 114.402 115.690 110.603 1.00 84.67  ? 36  PHE A CB  1 
ATOM 284  C CG  . PHE A 1 36  ? 115.222 116.519 111.550 1.00 84.67  ? 36  PHE A CG  1 
ATOM 285  C CD1 . PHE A 1 36  ? 115.225 117.898 111.459 1.00 84.67  ? 36  PHE A CD1 1 
ATOM 286  C CD2 . PHE A 1 36  ? 115.982 115.921 112.538 1.00 84.67  ? 36  PHE A CD2 1 
ATOM 287  C CE1 . PHE A 1 36  ? 115.976 118.663 112.329 1.00 84.67  ? 36  PHE A CE1 1 
ATOM 288  C CE2 . PHE A 1 36  ? 116.734 116.679 113.410 1.00 84.67  ? 36  PHE A CE2 1 
ATOM 289  C CZ  . PHE A 1 36  ? 116.730 118.052 113.306 1.00 84.67  ? 36  PHE A CZ  1 
ATOM 290  N N   . VAL A 1 37  ? 116.556 113.713 109.306 1.00 85.31  ? 37  VAL A N   1 
ATOM 291  C CA  . VAL A 1 37  ? 117.854 113.100 109.551 1.00 85.31  ? 37  VAL A CA  1 
ATOM 292  C C   . VAL A 1 37  ? 118.438 112.419 108.317 1.00 85.31  ? 37  VAL A C   1 
ATOM 293  O O   . VAL A 1 37  ? 119.670 112.313 108.219 1.00 85.31  ? 37  VAL A O   1 
ATOM 294  C CB  . VAL A 1 37  ? 117.778 112.098 110.722 1.00 85.31  ? 37  VAL A CB  1 
ATOM 295  C CG1 . VAL A 1 37  ? 119.159 111.613 111.099 1.00 85.31  ? 37  VAL A CG1 1 
ATOM 296  C CG2 . VAL A 1 37  ? 117.093 112.725 111.916 1.00 85.31  ? 37  VAL A CG2 1 
ATOM 297  N N   . GLY A 1 38  ? 117.611 111.999 107.358 1.00 88.43  ? 38  GLY A N   1 
ATOM 298  C CA  . GLY A 1 38  ? 118.045 111.153 106.252 1.00 88.43  ? 38  GLY A CA  1 
ATOM 299  C C   . GLY A 1 38  ? 119.258 111.656 105.495 1.00 88.43  ? 38  GLY A C   1 
ATOM 300  O O   . GLY A 1 38  ? 119.809 110.908 104.679 1.00 88.43  ? 38  GLY A O   1 
ATOM 301  N N   . VAL A 1 39  ? 119.688 112.893 105.745 1.00 83.91  ? 39  VAL A N   1 
ATOM 302  C CA  . VAL A 1 39  ? 120.893 113.412 105.113 1.00 83.91  ? 39  VAL A CA  1 
ATOM 303  C C   . VAL A 1 39  ? 122.133 112.668 105.592 1.00 83.91  ? 39  VAL A C   1 
ATOM 304  O O   . VAL A 1 39  ? 123.119 112.559 104.856 1.00 83.91  ? 39  VAL A O   1 
ATOM 305  C CB  . VAL A 1 39  ? 121.001 114.925 105.369 1.00 83.91  ? 39  VAL A CB  1 
ATOM 306  C CG1 . VAL A 1 39  ? 121.094 115.203 106.859 1.00 83.91  ? 39  VAL A CG1 1 
ATOM 307  C CG2 . VAL A 1 39  ? 122.189 115.513 104.620 1.00 83.91  ? 39  VAL A CG2 1 
ATOM 308  N N   . VAL A 1 40  ? 122.116 112.145 106.821 1.00 85.20  ? 40  VAL A N   1 
ATOM 309  C CA  . VAL A 1 40  ? 123.275 111.408 107.313 1.00 85.20  ? 40  VAL A CA  1 
ATOM 310  C C   . VAL A 1 40  ? 123.509 110.158 106.476 1.00 85.20  ? 40  VAL A C   1 
ATOM 311  O O   . VAL A 1 40  ? 124.653 109.718 106.309 1.00 85.20  ? 40  VAL A O   1 
ATOM 312  C CB  . VAL A 1 40  ? 123.111 111.078 108.809 1.00 85.20  ? 40  VAL A CB  1 
ATOM 313  C CG1 . VAL A 1 40  ? 121.934 110.149 109.035 1.00 85.20  ? 40  VAL A CG1 1 
ATOM 314  C CG2 . VAL A 1 40  ? 124.387 110.471 109.364 1.00 85.20  ? 40  VAL A CG2 1 
ATOM 315  N N   . PHE A 1 41  ? 122.446 109.568 105.932 1.00 90.45  ? 41  PHE A N   1 
ATOM 316  C CA  . PHE A 1 41  ? 122.595 108.470 104.988 1.00 90.45  ? 41  PHE A CA  1 
ATOM 317  C C   . PHE A 1 41  ? 122.706 108.951 103.550 1.00 90.45  ? 41  PHE A C   1 
ATOM 318  O O   . PHE A 1 41  ? 122.936 108.131 102.654 1.00 90.45  ? 41  PHE A O   1 
ATOM 319  C CB  . PHE A 1 41  ? 121.428 107.492 105.136 1.00 90.45  ? 41  PHE A CB  1 
ATOM 320  C CG  . PHE A 1 41  ? 121.424 106.766 106.446 1.00 90.45  ? 41  PHE A CG  1 
ATOM 321  C CD1 . PHE A 1 41  ? 122.168 105.613 106.615 1.00 90.45  ? 41  PHE A CD1 1 
ATOM 322  C CD2 . PHE A 1 41  ? 120.697 107.250 107.517 1.00 90.45  ? 41  PHE A CD2 1 
ATOM 323  C CE1 . PHE A 1 41  ? 122.175 104.951 107.822 1.00 90.45  ? 41  PHE A CE1 1 
ATOM 324  C CE2 . PHE A 1 41  ? 120.701 106.592 108.727 1.00 90.45  ? 41  PHE A CE2 1 
ATOM 325  C CZ  . PHE A 1 41  ? 121.440 105.442 108.880 1.00 90.45  ? 41  PHE A CZ  1 
ATOM 326  N N   . LEU A 1 42  ? 122.542 110.249 103.312 1.00 88.61  ? 42  LEU A N   1 
ATOM 327  C CA  . LEU A 1 42  ? 122.853 110.836 102.018 1.00 88.61  ? 42  LEU A CA  1 
ATOM 328  C C   . LEU A 1 42  ? 124.310 111.274 102.002 1.00 88.61  ? 42  LEU A C   1 
ATOM 329  O O   . LEU A 1 42  ? 124.745 112.050 102.858 1.00 88.61  ? 42  LEU A O   1 
ATOM 330  C CB  . LEU A 1 42  ? 121.941 112.028 101.732 1.00 88.61  ? 42  LEU A CB  1 
ATOM 331  C CG  . LEU A 1 42  ? 120.458 111.762 101.489 1.00 88.61  ? 42  LEU A CG  1 
ATOM 332  C CD1 . LEU A 1 42  ? 119.854 112.892 100.683 1.00 88.61  ? 42  LEU A CD1 1 
ATOM 333  C CD2 . LEU A 1 42  ? 120.274 110.443 100.767 1.00 88.61  ? 42  LEU A CD2 1 
ATOM 334  N N   . GLY A 1 43  ? 125.064 110.785 101.028 1.00 97.09  ? 43  GLY A N   1 
ATOM 335  C CA  . GLY A 1 43  ? 126.463 111.145 100.955 1.00 97.09  ? 43  GLY A CA  1 
ATOM 336  C C   . GLY A 1 43  ? 127.297 110.639 102.111 1.00 97.09  ? 43  GLY A C   1 
ATOM 337  O O   . GLY A 1 43  ? 128.071 111.396 102.703 1.00 97.09  ? 43  GLY A O   1 
ATOM 338  N N   . THR A 1 44  ? 127.133 109.366 102.458 1.00 96.55  ? 44  THR A N   1 
ATOM 339  C CA  . THR A 1 44  ? 128.064 108.733 103.378 1.00 96.55  ? 44  THR A CA  1 
ATOM 340  C C   . THR A 1 44  ? 129.461 108.760 102.773 1.00 96.55  ? 44  THR A C   1 
ATOM 341  O O   . THR A 1 44  ? 129.627 108.634 101.557 1.00 96.55  ? 44  THR A O   1 
ATOM 342  C CB  . THR A 1 44  ? 127.639 107.295 103.668 1.00 96.55  ? 44  THR A CB  1 
ATOM 343  O OG1 . THR A 1 44  ? 127.642 106.539 102.451 1.00 96.55  ? 44  THR A OG1 1 
ATOM 344  C CG2 . THR A 1 44  ? 126.245 107.266 104.269 1.00 96.55  ? 44  THR A CG2 1 
ATOM 345  N N   . GLN A 1 45  ? 130.463 108.938 103.623 1.00 98.52  ? 45  GLN A N   1 
ATOM 346  C CA  . GLN A 1 45  ? 131.814 109.175 103.137 1.00 98.52  ? 45  GLN A CA  1 
ATOM 347  C C   . GLN A 1 45  ? 132.299 107.987 102.314 1.00 98.52  ? 45  GLN A C   1 
ATOM 348  O O   . GLN A 1 45  ? 132.215 106.841 102.776 1.00 98.52  ? 45  GLN A O   1 
ATOM 349  C CB  . GLN A 1 45  ? 132.765 109.433 104.303 1.00 98.52  ? 45  GLN A CB  1 
ATOM 350  C CG  . GLN A 1 45  ? 132.522 110.752 105.013 1.00 98.52  ? 45  GLN A CG  1 
ATOM 351  C CD  . GLN A 1 45  ? 132.943 111.947 104.183 1.00 98.52  ? 45  GLN A CD  1 
ATOM 352  O OE1 . GLN A 1 45  ? 133.639 111.805 103.178 1.00 98.52  ? 45  GLN A OE1 1 
ATOM 353  N NE2 . GLN A 1 45  ? 132.522 113.134 104.600 1.00 98.52  ? 45  GLN A NE2 1 
ATOM 354  N N   . PRO A 1 46  ? 132.794 108.210 101.100 1.00 102.01 ? 46  PRO A N   1 
ATOM 355  C CA  . PRO A 1 46  ? 133.303 107.098 100.296 1.00 102.01 ? 46  PRO A CA  1 
ATOM 356  C C   . PRO A 1 46  ? 134.530 106.476 100.936 1.00 102.01 ? 46  PRO A C   1 
ATOM 357  O O   . PRO A 1 46  ? 135.289 107.132 101.652 1.00 102.01 ? 46  PRO A O   1 
ATOM 358  C CB  . PRO A 1 46  ? 133.652 107.755 98.954  1.00 102.01 ? 46  PRO A CB  1 
ATOM 359  C CG  . PRO A 1 46  ? 132.965 109.085 98.973  1.00 102.01 ? 46  PRO A CG  1 
ATOM 360  C CD  . PRO A 1 46  ? 132.918 109.498 100.403 1.00 102.01 ? 46  PRO A CD  1 
ATOM 361  N N   . ASP A 1 47  ? 134.710 105.181 100.679 1.00 115.19 ? 47  ASP A N   1 
ATOM 362  C CA  . ASP A 1 47  ? 135.869 104.485 101.224 1.00 115.19 ? 47  ASP A CA  1 
ATOM 363  C C   . ASP A 1 47  ? 137.171 105.023 100.640 1.00 115.19 ? 47  ASP A C   1 
ATOM 364  O O   . ASP A 1 47  ? 138.166 105.167 101.361 1.00 115.19 ? 47  ASP A O   1 
ATOM 365  C CB  . ASP A 1 47  ? 135.729 102.978 100.994 1.00 115.19 ? 47  ASP A CB  1 
ATOM 366  C CG  . ASP A 1 47  ? 135.690 102.604 99.523  1.00 115.19 ? 47  ASP A CG  1 
ATOM 367  O OD1 . ASP A 1 47  ? 135.728 103.510 98.664  1.00 115.19 ? 47  ASP A OD1 1 
ATOM 368  O OD2 . ASP A 1 47  ? 135.614 101.393 99.226  1.00 115.19 ? 47  ASP A OD2 1 
ATOM 369  N N   . HIS A 1 48  ? 137.188 105.331 99.344  1.00 117.21 ? 48  HIS A N   1 
ATOM 370  C CA  . HIS A 1 48  ? 138.383 105.848 98.690  1.00 117.21 ? 48  HIS A CA  1 
ATOM 371  C C   . HIS A 1 48  ? 137.993 106.863 97.628  1.00 117.21 ? 48  HIS A C   1 
ATOM 372  O O   . HIS A 1 48  ? 137.066 106.624 96.849  1.00 117.21 ? 48  HIS A O   1 
ATOM 373  C CB  . HIS A 1 48  ? 139.203 104.717 98.055  1.00 117.21 ? 48  HIS A CB  1 
ATOM 374  C CG  . HIS A 1 48  ? 139.590 103.638 99.016  1.00 117.21 ? 48  HIS A CG  1 
ATOM 375  N ND1 . HIS A 1 48  ? 140.195 103.900 100.226 1.00 117.21 ? 48  HIS A ND1 1 
ATOM 376  C CD2 . HIS A 1 48  ? 139.457 102.292 98.947  1.00 117.21 ? 48  HIS A CD2 1 
ATOM 377  C CE1 . HIS A 1 48  ? 140.419 102.764 100.861 1.00 117.21 ? 48  HIS A CE1 1 
ATOM 378  N NE2 . HIS A 1 48  ? 139.981 101.772 100.106 1.00 117.21 ? 48  HIS A NE2 1 
ATOM 379  N N   . TYR A 1 49  ? 138.701 107.990 97.601  1.00 113.59 ? 49  TYR A N   1 
ATOM 380  C CA  . TYR A 1 49  ? 138.530 109.002 96.570  1.00 113.59 ? 49  TYR A CA  1 
ATOM 381  C C   . TYR A 1 49  ? 139.889 109.574 96.200  1.00 113.59 ? 49  TYR A C   1 
ATOM 382  O O   . TYR A 1 49  ? 140.728 109.812 97.072  1.00 113.59 ? 49  TYR A O   1 
ATOM 383  C CB  . TYR A 1 49  ? 137.580 110.120 97.024  1.00 113.59 ? 49  TYR A CB  1 
ATOM 384  C CG  . TYR A 1 49  ? 138.148 111.066 98.057  1.00 113.59 ? 49  TYR A CG  1 
ATOM 385  C CD1 . TYR A 1 49  ? 138.813 112.224 97.680  1.00 113.59 ? 49  TYR A CD1 1 
ATOM 386  C CD2 . TYR A 1 49  ? 138.000 110.810 99.411  1.00 113.59 ? 49  TYR A CD2 1 
ATOM 387  C CE1 . TYR A 1 49  ? 139.328 113.090 98.623  1.00 113.59 ? 49  TYR A CE1 1 
ATOM 388  C CE2 . TYR A 1 49  ? 138.508 111.672 100.361 1.00 113.59 ? 49  TYR A CE2 1 
ATOM 389  C CZ  . TYR A 1 49  ? 139.171 112.810 99.961  1.00 113.59 ? 49  TYR A CZ  1 
ATOM 390  O OH  . TYR A 1 49  ? 139.679 113.670 100.906 1.00 113.59 ? 49  TYR A OH  1 
ATOM 391  N N   . TRP A 1 50  ? 140.101 109.790 94.906  1.00 118.15 ? 50  TRP A N   1 
ATOM 392  C CA  . TRP A 1 50  ? 141.376 110.291 94.415  1.00 118.15 ? 50  TRP A CA  1 
ATOM 393  C C   . TRP A 1 50  ? 141.151 110.961 93.071  1.00 118.15 ? 50  TRP A C   1 
ATOM 394  O O   . TRP A 1 50  ? 140.124 110.754 92.420  1.00 118.15 ? 50  TRP A O   1 
ATOM 395  C CB  . TRP A 1 50  ? 142.405 109.169 94.282  1.00 118.15 ? 50  TRP A CB  1 
ATOM 396  C CG  . TRP A 1 50  ? 142.177 108.322 93.079  1.00 118.15 ? 50  TRP A CG  1 
ATOM 397  C CD1 . TRP A 1 50  ? 142.832 108.398 91.888  1.00 118.15 ? 50  TRP A CD1 1 
ATOM 398  C CD2 . TRP A 1 50  ? 141.219 107.269 92.944  1.00 118.15 ? 50  TRP A CD2 1 
ATOM 399  N NE1 . TRP A 1 50  ? 142.344 107.455 91.018  1.00 118.15 ? 50  TRP A NE1 1 
ATOM 400  C CE2 . TRP A 1 50  ? 141.352 106.748 91.644  1.00 118.15 ? 50  TRP A CE2 1 
ATOM 401  C CE3 . TRP A 1 50  ? 140.263 106.714 93.797  1.00 118.15 ? 50  TRP A CE3 1 
ATOM 402  C CZ2 . TRP A 1 50  ? 140.564 105.701 91.176  1.00 118.15 ? 50  TRP A CZ2 1 
ATOM 403  C CZ3 . TRP A 1 50  ? 139.484 105.675 93.331  1.00 118.15 ? 50  TRP A CZ3 1 
ATOM 404  C CH2 . TRP A 1 50  ? 139.639 105.179 92.034  1.00 118.15 ? 50  TRP A CH2 1 
ATOM 405  N N   . CYS A 1 51  ? 142.132 111.758 92.657  1.00 126.51 ? 51  CYS A N   1 
ATOM 406  C CA  . CYS A 1 51  ? 142.081 112.467 91.389  1.00 126.51 ? 51  CYS A CA  1 
ATOM 407  C C   . CYS A 1 51  ? 143.185 111.979 90.464  1.00 126.51 ? 51  CYS A C   1 
ATOM 408  O O   . CYS A 1 51  ? 144.283 111.635 90.908  1.00 126.51 ? 51  CYS A O   1 
ATOM 409  C CB  . CYS A 1 51  ? 142.193 113.980 91.594  1.00 126.51 ? 51  CYS A CB  1 
ATOM 410  S SG  . CYS A 1 51  ? 143.706 114.537 92.374  1.00 126.51 ? 51  CYS A SG  1 
ATOM 411  N N   . ARG A 1 52  ? 142.877 111.941 89.170  1.00 132.62 ? 52  ARG A N   1 
ATOM 412  C CA  . ARG A 1 52  ? 143.819 111.490 88.158  1.00 132.62 ? 52  ARG A CA  1 
ATOM 413  C C   . ARG A 1 52  ? 143.871 112.490 87.014  1.00 132.62 ? 52  ARG A C   1 
ATOM 414  O O   . ARG A 1 52  ? 142.868 113.123 86.673  1.00 132.62 ? 52  ARG A O   1 
ATOM 415  C CB  . ARG A 1 52  ? 143.451 110.105 87.613  1.00 132.62 ? 52  ARG A CB  1 
ATOM 416  C CG  . ARG A 1 52  ? 142.003 109.957 87.180  1.00 132.62 ? 52  ARG A CG  1 
ATOM 417  C CD  . ARG A 1 52  ? 141.767 108.570 86.612  1.00 132.62 ? 52  ARG A CD  1 
ATOM 418  N NE  . ARG A 1 52  ? 140.367 108.169 86.659  1.00 132.62 ? 52  ARG A NE  1 
ATOM 419  C CZ  . ARG A 1 52  ? 139.934 106.950 86.369  1.00 132.62 ? 52  ARG A CZ  1 
ATOM 420  N NH1 . ARG A 1 52  ? 140.767 105.989 86.009  1.00 132.62 ? 52  ARG A NH1 1 
ATOM 421  N NH2 . ARG A 1 52  ? 138.633 106.687 86.444  1.00 132.62 ? 52  ARG A NH2 1 
ATOM 422  N N   . GLY A 1 53  ? 145.054 112.622 86.424  1.00 145.35 ? 53  GLY A N   1 
ATOM 423  C CA  . GLY A 1 53  ? 145.248 113.507 85.300  1.00 145.35 ? 53  GLY A CA  1 
ATOM 424  C C   . GLY A 1 53  ? 144.719 112.913 84.016  1.00 145.35 ? 53  GLY A C   1 
ATOM 425  O O   . GLY A 1 53  ? 144.314 111.742 83.944  1.00 145.35 ? 53  GLY A O   1 
ATOM 426  N N   . PRO A 1 54  ? 144.703 113.738 82.965  1.00 151.86 ? 54  PRO A N   1 
ATOM 427  C CA  . PRO A 1 54  ? 144.208 113.246 81.668  1.00 151.86 ? 54  PRO A CA  1 
ATOM 428  C C   . PRO A 1 54  ? 144.986 112.053 81.144  1.00 151.86 ? 54  PRO A C   1 
ATOM 429  O O   . PRO A 1 54  ? 144.386 111.116 80.604  1.00 151.86 ? 54  PRO A O   1 
ATOM 430  C CB  . PRO A 1 54  ? 144.352 114.471 80.753  1.00 151.86 ? 54  PRO A CB  1 
ATOM 431  C CG  . PRO A 1 54  ? 145.383 115.328 81.416  1.00 151.86 ? 54  PRO A CG  1 
ATOM 432  C CD  . PRO A 1 54  ? 145.197 115.122 82.887  1.00 151.86 ? 54  PRO A CD  1 
ATOM 433  N N   . SER A 1 55  ? 146.311 112.054 81.301  1.00 153.04 ? 55  SER A N   1 
ATOM 434  C CA  . SER A 1 55  ? 147.103 110.906 80.875  1.00 153.04 ? 55  SER A CA  1 
ATOM 435  C C   . SER A 1 55  ? 146.783 109.675 81.713  1.00 153.04 ? 55  SER A C   1 
ATOM 436  O O   . SER A 1 55  ? 146.647 108.568 81.175  1.00 153.04 ? 55  SER A O   1 
ATOM 437  C CB  . SER A 1 55  ? 148.592 111.237 80.952  1.00 153.04 ? 55  SER A CB  1 
ATOM 438  O OG  . SER A 1 55  ? 149.062 111.155 82.286  1.00 153.04 ? 55  SER A OG  1 
ATOM 439  N N   . ALA A 1 56  ? 146.663 109.849 83.032  1.00 149.98 ? 56  ALA A N   1 
ATOM 440  C CA  . ALA A 1 56  ? 146.338 108.725 83.903  1.00 149.98 ? 56  ALA A CA  1 
ATOM 441  C C   . ALA A 1 56  ? 144.963 108.158 83.579  1.00 149.98 ? 56  ALA A C   1 
ATOM 442  O O   . ALA A 1 56  ? 144.788 106.936 83.507  1.00 149.98 ? 56  ALA A O   1 
ATOM 443  C CB  . ALA A 1 56  ? 146.411 109.156 85.367  1.00 149.98 ? 56  ALA A CB  1 
ATOM 444  N N   . ALA A 1 57  ? 143.977 109.031 83.371  1.00 150.61 ? 57  ALA A N   1 
ATOM 445  C CA  . ALA A 1 57  ? 142.645 108.565 83.002  1.00 150.61 ? 57  ALA A CA  1 
ATOM 446  C C   . ALA A 1 57  ? 142.668 107.850 81.658  1.00 150.61 ? 57  ALA A C   1 
ATOM 447  O O   . ALA A 1 57  ? 142.013 106.816 81.486  1.00 150.61 ? 57  ALA A O   1 
ATOM 448  C CB  . ALA A 1 57  ? 141.666 109.737 82.972  1.00 150.61 ? 57  ALA A CB  1 
ATOM 449  N N   . ALA A 1 58  ? 143.421 108.386 80.695  1.00 152.82 ? 58  ALA A N   1 
ATOM 450  C CA  . ALA A 1 58  ? 143.494 107.766 79.377  1.00 152.82 ? 58  ALA A CA  1 
ATOM 451  C C   . ALA A 1 58  ? 144.093 106.368 79.460  1.00 152.82 ? 58  ALA A C   1 
ATOM 452  O O   . ALA A 1 58  ? 143.560 105.416 78.877  1.00 152.82 ? 58  ALA A O   1 
ATOM 453  C CB  . ALA A 1 58  ? 144.308 108.647 78.429  1.00 152.82 ? 58  ALA A CB  1 
ATOM 454  N N   . LEU A 1 59  ? 145.199 106.220 80.193  1.00 153.48 ? 59  LEU A N   1 
ATOM 455  C CA  . LEU A 1 59  ? 145.825 104.905 80.296  1.00 153.48 ? 59  LEU A CA  1 
ATOM 456  C C   . LEU A 1 59  ? 144.953 103.938 81.089  1.00 153.48 ? 59  LEU A C   1 
ATOM 457  O O   . LEU A 1 59  ? 144.877 102.749 80.756  1.00 153.48 ? 59  LEU A O   1 
ATOM 458  C CB  . LEU A 1 59  ? 147.224 105.021 80.907  1.00 153.48 ? 59  LEU A CB  1 
ATOM 459  C CG  . LEU A 1 59  ? 147.441 105.693 82.264  1.00 153.48 ? 59  LEU A CG  1 
ATOM 460  C CD1 . LEU A 1 59  ? 147.362 104.691 83.401  1.00 153.48 ? 59  LEU A CD1 1 
ATOM 461  C CD2 . LEU A 1 59  ? 148.777 106.420 82.284  1.00 153.48 ? 59  LEU A CD2 1 
ATOM 462  N N   . ALA A 1 60  ? 144.277 104.429 82.131  1.00 154.05 ? 60  ALA A N   1 
ATOM 463  C CA  . ALA A 1 60  ? 143.380 103.568 82.895  1.00 154.05 ? 60  ALA A CA  1 
ATOM 464  C C   . ALA A 1 60  ? 142.229 103.068 82.034  1.00 154.05 ? 60  ALA A C   1 
ATOM 465  O O   . ALA A 1 60  ? 141.859 101.890 82.102  1.00 154.05 ? 60  ALA A O   1 
ATOM 466  C CB  . ALA A 1 60  ? 142.852 104.317 84.116  1.00 154.05 ? 60  ALA A CB  1 
ATOM 467  N N   . GLU A 1 61  ? 141.647 103.949 81.218  1.00 156.89 ? 61  GLU A N   1 
ATOM 468  C CA  . GLU A 1 61  ? 140.562 103.532 80.338  1.00 156.89 ? 61  GLU A CA  1 
ATOM 469  C C   . GLU A 1 61  ? 141.058 102.577 79.261  1.00 156.89 ? 61  GLU A C   1 
ATOM 470  O O   . GLU A 1 61  ? 140.367 101.612 78.915  1.00 156.89 ? 61  GLU A O   1 
ATOM 471  C CB  . GLU A 1 61  ? 139.895 104.757 79.708  1.00 156.89 ? 61  GLU A CB  1 
ATOM 472  C CG  . GLU A 1 61  ? 138.899 105.531 80.597  1.00 156.89 ? 61  GLU A CG  1 
ATOM 473  C CD  . GLU A 1 61  ? 137.759 104.698 81.197  1.00 156.89 ? 61  GLU A CD  1 
ATOM 474  O OE1 . GLU A 1 61  ? 136.835 105.314 81.769  1.00 156.89 ? 61  GLU A OE1 1 
ATOM 475  O OE2 . GLU A 1 61  ? 137.745 103.454 81.084  1.00 156.89 ? 61  GLU A OE2 1 
ATOM 476  N N   . ARG A 1 62  ? 142.254 102.824 78.719  1.00 157.61 ? 62  ARG A N   1 
ATOM 477  C CA  . ARG A 1 62  ? 142.776 101.951 77.674  1.00 157.61 ? 62  ARG A CA  1 
ATOM 478  C C   . ARG A 1 62  ? 143.184 100.591 78.226  1.00 157.61 ? 62  ARG A C   1 
ATOM 479  O O   . ARG A 1 62  ? 143.248 99.614  77.472  1.00 157.61 ? 62  ARG A O   1 
ATOM 480  C CB  . ARG A 1 62  ? 143.954 102.621 76.964  1.00 157.61 ? 62  ARG A CB  1 
ATOM 481  C CG  . ARG A 1 62  ? 145.317 102.336 77.571  1.00 157.61 ? 62  ARG A CG  1 
ATOM 482  C CD  . ARG A 1 62  ? 146.351 103.338 77.083  1.00 157.61 ? 62  ARG A CD  1 
ATOM 483  N NE  . ARG A 1 62  ? 147.559 103.316 77.899  1.00 157.61 ? 62  ARG A NE  1 
ATOM 484  C CZ  . ARG A 1 62  ? 148.616 104.090 77.694  1.00 157.61 ? 62  ARG A CZ  1 
ATOM 485  N NH1 . ARG A 1 62  ? 148.651 104.965 76.703  1.00 157.61 ? 62  ARG A NH1 1 
ATOM 486  N NH2 . ARG A 1 62  ? 149.665 103.983 78.504  1.00 157.61 ? 62  ARG A NH2 1 
ATOM 487  N N   . CYS A 1 63  ? 143.461 100.504 79.527  1.00 157.04 ? 63  CYS A N   1 
ATOM 488  C CA  . CYS A 1 63  ? 143.792 99.220  80.132  1.00 157.04 ? 63  CYS A CA  1 
ATOM 489  C C   . CYS A 1 63  ? 142.612 98.590  80.860  1.00 157.04 ? 63  CYS A C   1 
ATOM 490  O O   . CYS A 1 63  ? 142.563 97.362  80.995  1.00 157.04 ? 63  CYS A O   1 
ATOM 491  C CB  . CYS A 1 63  ? 144.967 99.380  81.094  1.00 157.04 ? 63  CYS A CB  1 
ATOM 492  S SG  . CYS A 1 63  ? 146.567 99.615  80.287  1.00 157.04 ? 63  CYS A SG  1 
ATOM 493  N N   . GLY A 1 64  ? 141.669 99.398  81.333  1.00 153.80 ? 64  GLY A N   1 
ATOM 494  C CA  . GLY A 1 64  ? 140.433 98.884  81.901  1.00 153.80 ? 64  GLY A CA  1 
ATOM 495  C C   . GLY A 1 64  ? 140.552 98.105  83.194  1.00 153.80 ? 64  GLY A C   1 
ATOM 496  O O   . GLY A 1 64  ? 139.924 97.047  83.332  1.00 153.80 ? 64  GLY A O   1 
ATOM 497  N N   . TRP A 1 65  ? 141.340 98.596  84.146  1.00 149.10 ? 65  TRP A N   1 
ATOM 498  C CA  . TRP A 1 65  ? 141.370 97.996  85.471  1.00 149.10 ? 65  TRP A CA  1 
ATOM 499  C C   . TRP A 1 65  ? 140.295 98.594  86.376  1.00 149.10 ? 65  TRP A C   1 
ATOM 500  O O   . TRP A 1 65  ? 139.794 99.700  86.154  1.00 149.10 ? 65  TRP A O   1 
ATOM 501  C CB  . TRP A 1 65  ? 142.743 98.164  86.121  1.00 149.10 ? 65  TRP A CB  1 
ATOM 502  C CG  . TRP A 1 65  ? 143.306 99.538  85.986  1.00 149.10 ? 65  TRP A CG  1 
ATOM 503  C CD1 . TRP A 1 65  ? 142.830 100.683 86.552  1.00 149.10 ? 65  TRP A CD1 1 
ATOM 504  C CD2 . TRP A 1 65  ? 144.508 99.900  85.299  1.00 149.10 ? 65  TRP A CD2 1 
ATOM 505  N NE1 . TRP A 1 65  ? 143.633 101.746 86.215  1.00 149.10 ? 65  TRP A NE1 1 
ATOM 506  C CE2 . TRP A 1 65  ? 144.674 101.288 85.450  1.00 149.10 ? 65  TRP A CE2 1 
ATOM 507  C CE3 . TRP A 1 65  ? 145.451 99.185  84.554  1.00 149.10 ? 65  TRP A CE3 1 
ATOM 508  C CZ2 . TRP A 1 65  ? 145.746 101.976 84.889  1.00 149.10 ? 65  TRP A CZ2 1 
ATOM 509  C CZ3 . TRP A 1 65  ? 146.515 99.871  83.999  1.00 149.10 ? 65  TRP A CZ3 1 
ATOM 510  C CH2 . TRP A 1 65  ? 146.651 101.252 84.166  1.00 149.10 ? 65  TRP A CH2 1 
ATOM 511  N N   . SER A 1 66  ? 139.949 97.836  87.415  1.00 144.67 ? 66  SER A N   1 
ATOM 512  C CA  . SER A 1 66  ? 138.962 98.277  88.385  1.00 144.67 ? 66  SER A CA  1 
ATOM 513  C C   . SER A 1 66  ? 139.528 99.408  89.246  1.00 144.67 ? 66  SER A C   1 
ATOM 514  O O   . SER A 1 66  ? 140.743 99.503  89.439  1.00 144.67 ? 66  SER A O   1 
ATOM 515  C CB  . SER A 1 66  ? 138.533 97.104  89.266  1.00 144.67 ? 66  SER A CB  1 
ATOM 516  O OG  . SER A 1 66  ? 137.598 97.494  90.255  1.00 144.67 ? 66  SER A OG  1 
ATOM 517  N N   . PRO A 1 67  ? 138.667 100.290 89.763  1.00 137.31 ? 67  PRO A N   1 
ATOM 518  C CA  . PRO A 1 67  ? 139.169 101.413 90.573  1.00 137.31 ? 67  PRO A CA  1 
ATOM 519  C C   . PRO A 1 67  ? 139.926 100.995 91.822  1.00 137.31 ? 67  PRO A C   1 
ATOM 520  O O   . PRO A 1 67  ? 140.770 101.762 92.303  1.00 137.31 ? 67  PRO A O   1 
ATOM 521  C CB  . PRO A 1 67  ? 137.891 102.186 90.925  1.00 137.31 ? 67  PRO A CB  1 
ATOM 522  C CG  . PRO A 1 67  ? 136.936 101.843 89.842  1.00 137.31 ? 67  PRO A CG  1 
ATOM 523  C CD  . PRO A 1 67  ? 137.228 100.423 89.474  1.00 137.31 ? 67  PRO A CD  1 
ATOM 524  N N   . GLU A 1 68  ? 139.648 99.810  92.370  1.00 136.69 ? 68  GLU A N   1 
ATOM 525  C CA  . GLU A 1 68  ? 140.271 99.417  93.631  1.00 136.69 ? 68  GLU A CA  1 
ATOM 526  C C   . GLU A 1 68  ? 141.785 99.307  93.493  1.00 136.69 ? 68  GLU A C   1 
ATOM 527  O O   . GLU A 1 68  ? 142.535 99.902  94.275  1.00 136.69 ? 68  GLU A O   1 
ATOM 528  C CB  . GLU A 1 68  ? 139.678 98.098  94.123  1.00 136.69 ? 68  GLU A CB  1 
ATOM 529  C CG  . GLU A 1 68  ? 140.313 97.587  95.403  1.00 136.69 ? 68  GLU A CG  1 
ATOM 530  C CD  . GLU A 1 68  ? 140.015 98.480  96.591  1.00 136.69 ? 68  GLU A CD  1 
ATOM 531  O OE1 . GLU A 1 68  ? 138.823 98.745  96.854  1.00 136.69 ? 68  GLU A OE1 1 
ATOM 532  O OE2 . GLU A 1 68  ? 140.972 98.921  97.260  1.00 136.69 ? 68  GLU A OE2 1 
ATOM 533  N N   . GLU A 1 69  ? 142.257 98.556  92.495  1.00 140.12 ? 69  GLU A N   1 
ATOM 534  C CA  . GLU A 1 69  ? 143.698 98.420  92.304  1.00 140.12 ? 69  GLU A CA  1 
ATOM 535  C C   . GLU A 1 69  ? 144.336 99.733  91.870  1.00 140.12 ? 69  GLU A C   1 
ATOM 536  O O   . GLU A 1 69  ? 145.492 100.003 92.219  1.00 140.12 ? 69  GLU A O   1 
ATOM 537  C CB  . GLU A 1 69  ? 143.999 97.314  91.291  1.00 140.12 ? 69  GLU A CB  1 
ATOM 538  C CG  . GLU A 1 69  ? 143.425 97.555  89.909  1.00 140.12 ? 69  GLU A CG  1 
ATOM 539  C CD  . GLU A 1 69  ? 142.127 96.808  89.699  1.00 140.12 ? 69  GLU A CD  1 
ATOM 540  O OE1 . GLU A 1 69  ? 141.290 96.821  90.624  1.00 140.12 ? 69  GLU A OE1 1 
ATOM 541  O OE2 . GLU A 1 69  ? 141.943 96.212  88.617  1.00 140.12 ? 69  GLU A OE2 1 
ATOM 542  N N   . GLU A 1 70  ? 143.608 100.558 91.115  1.00 136.11 ? 70  GLU A N   1 
ATOM 543  C CA  . GLU A 1 70  ? 144.136 101.860 90.726  1.00 136.11 ? 70  GLU A CA  1 
ATOM 544  C C   . GLU A 1 70  ? 144.396 102.726 91.951  1.00 136.11 ? 70  GLU A C   1 
ATOM 545  O O   . GLU A 1 70  ? 145.450 103.363 92.065  1.00 136.11 ? 70  GLU A O   1 
ATOM 546  C CB  . GLU A 1 70  ? 143.169 102.553 89.768  1.00 136.11 ? 70  GLU A CB  1 
ATOM 547  C CG  . GLU A 1 70  ? 143.281 104.065 89.772  1.00 136.11 ? 70  GLU A CG  1 
ATOM 548  C CD  . GLU A 1 70  ? 142.639 104.697 88.557  1.00 136.11 ? 70  GLU A CD  1 
ATOM 549  O OE1 . GLU A 1 70  ? 142.111 103.949 87.708  1.00 136.11 ? 70  GLU A OE1 1 
ATOM 550  O OE2 . GLU A 1 70  ? 142.659 105.940 88.453  1.00 136.11 ? 70  GLU A OE2 1 
ATOM 551  N N   . TRP A 1 71  ? 143.445 102.755 92.885  1.00 127.00 ? 71  TRP A N   1 
ATOM 552  C CA  . TRP A 1 71  ? 143.665 103.479 94.131  1.00 127.00 ? 71  TRP A CA  1 
ATOM 553  C C   . TRP A 1 71  ? 144.778 102.840 94.950  1.00 127.00 ? 71  TRP A C   1 
ATOM 554  O O   . TRP A 1 71  ? 145.563 103.544 95.595  1.00 127.00 ? 71  TRP A O   1 
ATOM 555  C CB  . TRP A 1 71  ? 142.376 103.536 94.944  1.00 127.00 ? 71  TRP A CB  1 
ATOM 556  C CG  . TRP A 1 71  ? 142.624 103.702 96.402  1.00 127.00 ? 71  TRP A CG  1 
ATOM 557  C CD1 . TRP A 1 71  ? 142.479 102.753 97.368  1.00 127.00 ? 71  TRP A CD1 1 
ATOM 558  C CD2 . TRP A 1 71  ? 143.079 104.884 97.064  1.00 127.00 ? 71  TRP A CD2 1 
ATOM 559  N NE1 . TRP A 1 71  ? 142.807 103.274 98.594  1.00 127.00 ? 71  TRP A NE1 1 
ATOM 560  C CE2 . TRP A 1 71  ? 143.179 104.582 98.435  1.00 127.00 ? 71  TRP A CE2 1 
ATOM 561  C CE3 . TRP A 1 71  ? 143.407 106.171 96.633  1.00 127.00 ? 71  TRP A CE3 1 
ATOM 562  C CZ2 . TRP A 1 71  ? 143.593 105.518 99.376  1.00 127.00 ? 71  TRP A CZ2 1 
ATOM 563  C CZ3 . TRP A 1 71  ? 143.817 107.099 97.569  1.00 127.00 ? 71  TRP A CZ3 1 
ATOM 564  C CH2 . TRP A 1 71  ? 143.907 106.769 98.924  1.00 127.00 ? 71  TRP A CH2 1 
ATOM 565  N N   . ASN A 1 72  ? 144.855 101.507 94.942  1.00 133.84 ? 72  ASN A N   1 
ATOM 566  C CA  . ASN A 1 72  ? 145.875 100.819 95.727  1.00 133.84 ? 72  ASN A CA  1 
ATOM 567  C C   . ASN A 1 72  ? 147.278 101.185 95.262  1.00 133.84 ? 72  ASN A C   1 
ATOM 568  O O   . ASN A 1 72  ? 148.171 101.413 96.086  1.00 133.84 ? 72  ASN A O   1 
ATOM 569  C CB  . ASN A 1 72  ? 145.665 99.308  95.651  1.00 133.84 ? 72  ASN A CB  1 
ATOM 570  C CG  . ASN A 1 72  ? 146.172 98.589  96.883  1.00 133.84 ? 72  ASN A CG  1 
ATOM 571  O OD1 . ASN A 1 72  ? 146.529 99.217  97.879  1.00 133.84 ? 72  ASN A OD1 1 
ATOM 572  N ND2 . ASN A 1 72  ? 146.209 97.263  96.822  1.00 133.84 ? 72  ASN A ND2 1 
ATOM 573  N N   . ARG A 1 73  ? 147.495 101.244 93.947  1.00 136.35 ? 73  ARG A N   1 
ATOM 574  C CA  . ARG A 1 73  ? 148.823 101.587 93.451  1.00 136.35 ? 73  ARG A CA  1 
ATOM 575  C C   . ARG A 1 73  ? 149.126 103.072 93.611  1.00 136.35 ? 73  ARG A C   1 
ATOM 576  O O   . ARG A 1 73  ? 150.299 103.456 93.668  1.00 136.35 ? 73  ARG A O   1 
ATOM 577  C CB  . ARG A 1 73  ? 148.970 101.192 91.983  1.00 136.35 ? 73  ARG A CB  1 
ATOM 578  C CG  . ARG A 1 73  ? 148.455 102.244 91.033  1.00 136.35 ? 73  ARG A CG  1 
ATOM 579  C CD  . ARG A 1 73  ? 148.359 101.750 89.613  1.00 136.35 ? 73  ARG A CD  1 
ATOM 580  N NE  . ARG A 1 73  ? 147.872 102.812 88.743  1.00 136.35 ? 73  ARG A NE  1 
ATOM 581  C CZ  . ARG A 1 73  ? 146.747 102.745 88.048  1.00 136.35 ? 73  ARG A CZ  1 
ATOM 582  N NH1 . ARG A 1 73  ? 145.981 101.668 88.081  1.00 136.35 ? 73  ARG A NH1 1 
ATOM 583  N NH2 . ARG A 1 73  ? 146.377 103.787 87.310  1.00 136.35 ? 73  ARG A NH2 1 
ATOM 584  N N   . THR A 1 74  ? 148.098 103.914 93.683  1.00 129.47 ? 74  THR A N   1 
ATOM 585  C CA  . THR A 1 74  ? 148.297 105.356 93.777  1.00 129.47 ? 74  THR A CA  1 
ATOM 586  C C   . THR A 1 74  ? 147.655 105.920 95.039  1.00 129.47 ? 74  THR A C   1 
ATOM 587  O O   . THR A 1 74  ? 146.536 106.430 95.003  1.00 129.47 ? 74  THR A O   1 
ATOM 588  C CB  . THR A 1 74  ? 147.722 106.086 92.550  1.00 129.47 ? 74  THR A CB  1 
ATOM 589  O OG1 . THR A 1 74  ? 148.117 105.404 91.355  1.00 129.47 ? 74  THR A OG1 1 
ATOM 590  C CG2 . THR A 1 74  ? 148.231 107.516 92.496  1.00 129.47 ? 74  THR A CG2 1 
ATOM 591  N N   . GLY A 1 88  ? 141.420 109.487 101.583 1.00 117.77 ? 88  GLY A N   1 
ATOM 592  C CA  . GLY A 1 88  ? 141.973 109.545 100.243 1.00 117.77 ? 88  GLY A CA  1 
ATOM 593  C C   . GLY A 1 88  ? 142.873 110.744 100.010 1.00 117.77 ? 88  GLY A C   1 
ATOM 594  O O   . GLY A 1 88  ? 142.678 111.804 100.603 1.00 117.77 ? 88  GLY A O   1 
ATOM 595  N N   . ARG A 1 89  ? 143.863 110.573 99.138  1.00 121.59 ? 89  ARG A N   1 
ATOM 596  C CA  . ARG A 1 89  ? 144.801 111.647 98.849  1.00 121.59 ? 89  ARG A CA  1 
ATOM 597  C C   . ARG A 1 89  ? 144.143 112.727 97.999  1.00 121.59 ? 89  ARG A C   1 
ATOM 598  O O   . ARG A 1 89  ? 143.331 112.438 97.117  1.00 121.59 ? 89  ARG A O   1 
ATOM 599  C CB  . ARG A 1 89  ? 146.035 111.096 98.136  1.00 121.59 ? 89  ARG A CB  1 
ATOM 600  C CG  . ARG A 1 89  ? 145.727 110.330 96.864  1.00 121.59 ? 89  ARG A CG  1 
ATOM 601  C CD  . ARG A 1 89  ? 146.897 109.456 96.448  1.00 121.59 ? 89  ARG A CD  1 
ATOM 602  N NE  . ARG A 1 89  ? 148.179 110.114 96.670  1.00 121.59 ? 89  ARG A NE  1 
ATOM 603  C CZ  . ARG A 1 89  ? 149.355 109.511 96.578  1.00 121.59 ? 89  ARG A CZ  1 
ATOM 604  N NH1 . ARG A 1 89  ? 149.452 108.230 96.264  1.00 121.59 ? 89  ARG A NH1 1 
ATOM 605  N NH2 . ARG A 1 89  ? 150.463 110.211 96.806  1.00 121.59 ? 89  ARG A NH2 1 
ATOM 606  N N   . CYS A 1 90  ? 144.497 113.980 98.275  1.00 121.87 ? 90  CYS A N   1 
ATOM 607  C CA  . CYS A 1 90  ? 143.989 115.121 97.528  1.00 121.87 ? 90  CYS A CA  1 
ATOM 608  C C   . CYS A 1 90  ? 144.948 115.597 96.446  1.00 121.87 ? 90  CYS A C   1 
ATOM 609  O O   . CYS A 1 90  ? 144.629 116.553 95.734  1.00 121.87 ? 90  CYS A O   1 
ATOM 610  C CB  . CYS A 1 90  ? 143.676 116.278 98.480  1.00 121.87 ? 90  CYS A CB  1 
ATOM 611  S SG  . CYS A 1 90  ? 142.073 116.149 99.301  1.00 121.87 ? 90  CYS A SG  1 
ATOM 612  N N   . GLN A 1 91  ? 146.108 114.960 96.306  1.00 130.73 ? 91  GLN A N   1 
ATOM 613  C CA  . GLN A 1 91  ? 147.105 115.340 95.316  1.00 130.73 ? 91  GLN A CA  1 
ATOM 614  C C   . GLN A 1 91  ? 147.573 114.095 94.579  1.00 130.73 ? 91  GLN A C   1 
ATOM 615  O O   . GLN A 1 91  ? 147.593 113.000 95.147  1.00 130.73 ? 91  GLN A O   1 
ATOM 616  C CB  . GLN A 1 91  ? 148.293 116.056 95.972  1.00 130.73 ? 91  GLN A CB  1 
ATOM 617  C CG  . GLN A 1 91  ? 147.889 117.253 96.822  1.00 130.73 ? 91  GLN A CG  1 
ATOM 618  C CD  . GLN A 1 91  ? 148.980 117.699 97.772  1.00 130.73 ? 91  GLN A CD  1 
ATOM 619  O OE1 . GLN A 1 91  ? 150.161 117.681 97.432  1.00 130.73 ? 91  GLN A OE1 1 
ATOM 620  N NE2 . GLN A 1 91  ? 148.588 118.104 98.974  1.00 130.73 ? 91  GLN A NE2 1 
ATOM 621  N N   . ARG A 1 92  ? 147.948 114.266 93.313  1.00 138.71 ? 92  ARG A N   1 
ATOM 622  C CA  . ARG A 1 92  ? 148.267 113.145 92.443  1.00 138.71 ? 92  ARG A CA  1 
ATOM 623  C C   . ARG A 1 92  ? 149.575 113.386 91.708  1.00 138.71 ? 92  ARG A C   1 
ATOM 624  O O   . ARG A 1 92  ? 149.965 114.527 91.451  1.00 138.71 ? 92  ARG A O   1 
ATOM 625  C CB  . ARG A 1 92  ? 147.152 112.903 91.425  1.00 138.71 ? 92  ARG A CB  1 
ATOM 626  C CG  . ARG A 1 92  ? 146.704 114.160 90.697  1.00 138.71 ? 92  ARG A CG  1 
ATOM 627  C CD  . ARG A 1 92  ? 147.260 114.244 89.288  1.00 138.71 ? 92  ARG A CD  1 
ATOM 628  N NE  . ARG A 1 92  ? 146.630 115.319 88.530  1.00 138.71 ? 92  ARG A NE  1 
ATOM 629  C CZ  . ARG A 1 92  ? 146.976 115.672 87.300  1.00 138.71 ? 92  ARG A CZ  1 
ATOM 630  N NH1 . ARG A 1 92  ? 147.948 115.053 86.650  1.00 138.71 ? 92  ARG A NH1 1 
ATOM 631  N NH2 . ARG A 1 92  ? 146.329 116.670 86.706  1.00 138.71 ? 92  ARG A NH2 1 
ATOM 632  N N   . TYR A 1 93  ? 150.249 112.289 91.375  1.00 145.55 ? 93  TYR A N   1 
ATOM 633  C CA  . TYR A 1 93  ? 151.404 112.353 90.495  1.00 145.55 ? 93  TYR A CA  1 
ATOM 634  C C   . TYR A 1 93  ? 150.951 112.658 89.072  1.00 145.55 ? 93  TYR A C   1 
ATOM 635  O O   . TYR A 1 93  ? 149.883 112.226 88.633  1.00 145.55 ? 93  TYR A O   1 
ATOM 636  C CB  . TYR A 1 93  ? 152.178 111.033 90.514  1.00 145.55 ? 93  TYR A CB  1 
ATOM 637  C CG  . TYR A 1 93  ? 152.345 110.403 91.880  1.00 145.55 ? 93  TYR A CG  1 
ATOM 638  C CD1 . TYR A 1 93  ? 152.572 111.181 93.009  1.00 145.55 ? 93  TYR A CD1 1 
ATOM 639  C CD2 . TYR A 1 93  ? 152.280 109.026 92.038  1.00 145.55 ? 93  TYR A CD2 1 
ATOM 640  C CE1 . TYR A 1 93  ? 152.723 110.603 94.253  1.00 145.55 ? 93  TYR A CE1 1 
ATOM 641  C CE2 . TYR A 1 93  ? 152.431 108.440 93.277  1.00 145.55 ? 93  TYR A CE2 1 
ATOM 642  C CZ  . TYR A 1 93  ? 152.652 109.233 94.380  1.00 145.55 ? 93  TYR A CZ  1 
ATOM 643  O OH  . TYR A 1 93  ? 152.803 108.652 95.616  1.00 145.55 ? 93  TYR A OH  1 
ATOM 644  N N   . LEU A 1 94  ? 151.773 113.408 88.347  1.00 153.72 ? 94  LEU A N   1 
ATOM 645  C CA  . LEU A 1 94  ? 151.484 113.753 86.962  1.00 153.72 ? 94  LEU A CA  1 
ATOM 646  C C   . LEU A 1 94  ? 152.489 113.072 86.044  1.00 153.72 ? 94  LEU A C   1 
ATOM 647  O O   . LEU A 1 94  ? 153.703 113.188 86.244  1.00 153.72 ? 94  LEU A O   1 
ATOM 648  C CB  . LEU A 1 94  ? 151.489 115.273 86.750  1.00 153.72 ? 94  LEU A CB  1 
ATOM 649  C CG  . LEU A 1 94  ? 152.779 116.097 86.745  1.00 153.72 ? 94  LEU A CG  1 
ATOM 650  C CD1 . LEU A 1 94  ? 152.518 117.464 86.138  1.00 153.72 ? 94  LEU A CD1 1 
ATOM 651  C CD2 . LEU A 1 94  ? 153.338 116.249 88.145  1.00 153.72 ? 94  LEU A CD2 1 
ATOM 652  N N   . LEU A 1 95  ? 151.975 112.340 85.054  1.00 162.34 ? 95  LEU A N   1 
ATOM 653  C CA  . LEU A 1 95  ? 152.824 111.708 84.053  1.00 162.34 ? 95  LEU A CA  1 
ATOM 654  C C   . LEU A 1 95  ? 153.279 112.692 82.984  1.00 162.34 ? 95  LEU A C   1 
ATOM 655  O O   . LEU A 1 95  ? 154.259 112.418 82.282  1.00 162.34 ? 95  LEU A O   1 
ATOM 656  C CB  . LEU A 1 95  ? 152.079 110.522 83.424  1.00 162.34 ? 95  LEU A CB  1 
ATOM 657  C CG  . LEU A 1 95  ? 152.760 109.546 82.457  1.00 162.34 ? 95  LEU A CG  1 
ATOM 658  C CD1 . LEU A 1 95  ? 152.067 108.199 82.528  1.00 162.34 ? 95  LEU A CD1 1 
ATOM 659  C CD2 . LEU A 1 95  ? 152.722 110.049 81.021  1.00 162.34 ? 95  LEU A CD2 1 
ATOM 660  N N   . GLU A 1 96  ? 152.605 113.838 82.864  1.00 163.00 ? 96  GLU A N   1 
ATOM 661  C CA  . GLU A 1 96  ? 152.991 114.827 81.864  1.00 163.00 ? 96  GLU A CA  1 
ATOM 662  C C   . GLU A 1 96  ? 154.394 115.357 82.128  1.00 163.00 ? 96  GLU A C   1 
ATOM 663  O O   . GLU A 1 96  ? 155.163 115.597 81.190  1.00 163.00 ? 96  GLU A O   1 
ATOM 664  C CB  . GLU A 1 96  ? 151.980 115.973 81.842  1.00 163.00 ? 96  GLU A CB  1 
ATOM 665  C CG  . GLU A 1 96  ? 150.556 115.546 81.517  1.00 163.00 ? 96  GLU A CG  1 
ATOM 666  C CD  . GLU A 1 96  ? 149.793 115.069 82.740  1.00 163.00 ? 96  GLU A CD  1 
ATOM 667  O OE1 . GLU A 1 96  ? 149.915 115.708 83.806  1.00 163.00 ? 96  GLU A OE1 1 
ATOM 668  O OE2 . GLU A 1 96  ? 149.072 114.055 82.635  1.00 163.00 ? 96  GLU A OE2 1 
ATOM 669  N N   . ALA A 1 97  ? 154.742 115.553 83.402  1.00 165.00 ? 97  ALA A N   1 
ATOM 670  C CA  . ALA A 1 97  ? 156.095 115.982 83.741  1.00 165.00 ? 97  ALA A CA  1 
ATOM 671  C C   . ALA A 1 97  ? 157.121 114.932 83.335  1.00 165.00 ? 97  ALA A C   1 
ATOM 672  O O   . ALA A 1 97  ? 158.231 115.271 82.909  1.00 165.00 ? 97  ALA A O   1 
ATOM 673  C CB  . ALA A 1 97  ? 156.194 116.279 85.237  1.00 165.00 ? 97  ALA A CB  1 
ATOM 674  N N   . ALA A 1 98  ? 156.768 113.651 83.467  1.00 166.57 ? 98  ALA A N   1 
ATOM 675  C CA  . ALA A 1 98  ? 157.685 112.585 83.075  1.00 166.57 ? 98  ALA A CA  1 
ATOM 676  C C   . ALA A 1 98  ? 157.978 112.628 81.580  1.00 166.57 ? 98  ALA A C   1 
ATOM 677  O O   . ALA A 1 98  ? 159.124 112.428 81.161  1.00 166.57 ? 98  ALA A O   1 
ATOM 678  C CB  . ALA A 1 98  ? 157.110 111.225 83.472  1.00 166.57 ? 98  ALA A CB  1 
ATOM 679  N N   . ASN A 1 99  ? 156.955 112.886 80.766  1.00 165.20 ? 99  ASN A N   1 
ATOM 680  C CA  . ASN A 1 99  ? 157.096 112.980 79.314  1.00 165.20 ? 99  ASN A CA  1 
ATOM 681  C C   . ASN A 1 99  ? 157.713 111.714 78.723  1.00 165.20 ? 99  ASN A C   1 
ATOM 682  O O   . ASN A 1 99  ? 157.246 111.200 77.708  1.00 165.20 ? 99  ASN A O   1 
ATOM 683  C CB  . ASN A 1 99  ? 157.935 114.204 78.933  1.00 165.20 ? 99  ASN A CB  1 
ATOM 684  C CG  . ASN A 1 99  ? 157.808 114.567 77.465  1.00 165.20 ? 99  ASN A CG  1 
ATOM 685  O OD1 . ASN A 1 99  ? 157.066 113.932 76.716  1.00 165.20 ? 99  ASN A OD1 1 
ATOM 686  N ND2 . ASN A 1 99  ? 158.536 115.596 77.046  1.00 165.20 ? 99  ASN A ND2 1 
ATOM 687  N N   . LEU A 1 114 ? 153.450 97.401  85.299  1.00 161.65 ? 114 LEU A N   1 
ATOM 688  C CA  . LEU A 1 114 ? 152.313 98.199  84.854  1.00 161.65 ? 114 LEU A CA  1 
ATOM 689  C C   . LEU A 1 114 ? 152.263 99.533  85.590  1.00 161.65 ? 114 LEU A C   1 
ATOM 690  O O   . LEU A 1 114 ? 151.483 100.418 85.237  1.00 161.65 ? 114 LEU A O   1 
ATOM 691  C CB  . LEU A 1 114 ? 151.006 97.432  85.061  1.00 161.65 ? 114 LEU A CB  1 
ATOM 692  C CG  . LEU A 1 114 ? 149.826 97.846  84.180  1.00 161.65 ? 114 LEU A CG  1 
ATOM 693  C CD1 . LEU A 1 114 ? 150.281 98.086  82.749  1.00 161.65 ? 114 LEU A CD1 1 
ATOM 694  C CD2 . LEU A 1 114 ? 148.727 96.797  84.227  1.00 161.65 ? 114 LEU A CD2 1 
ATOM 695  N N   . ALA A 1 115 ? 153.099 99.668  86.618  1.00 166.68 ? 115 ALA A N   1 
ATOM 696  C CA  . ALA A 1 115 ? 153.165 100.901 87.392  1.00 166.68 ? 115 ALA A CA  1 
ATOM 697  C C   . ALA A 1 115 ? 153.633 102.059 86.521  1.00 166.68 ? 115 ALA A C   1 
ATOM 698  O O   . ALA A 1 115 ? 154.635 101.943 85.809  1.00 166.68 ? 115 ALA A O   1 
ATOM 699  C CB  . ALA A 1 115 ? 154.093 100.731 88.596  1.00 166.68 ? 115 ALA A CB  1 
ATOM 700  N N   . ALA A 1 116 ? 152.906 103.179 86.568  1.00 168.77 ? 116 ALA A N   1 
ATOM 701  C CA  . ALA A 1 116 ? 153.280 104.338 85.765  1.00 168.77 ? 116 ALA A CA  1 
ATOM 702  C C   . ALA A 1 116 ? 154.620 104.909 86.206  1.00 168.77 ? 116 ALA A C   1 
ATOM 703  O O   . ALA A 1 116 ? 155.460 105.262 85.370  1.00 168.77 ? 116 ALA A O   1 
ATOM 704  C CB  . ALA A 1 116 ? 152.188 105.405 85.846  1.00 168.77 ? 116 ALA A CB  1 
ATOM 705  N N   . PHE A 1 117 ? 154.841 105.006 87.517  1.00 167.09 ? 117 PHE A N   1 
ATOM 706  C CA  . PHE A 1 117 ? 156.081 105.553 88.045  1.00 167.09 ? 117 PHE A CA  1 
ATOM 707  C C   . PHE A 1 117 ? 157.097 104.439 88.225  1.00 167.09 ? 117 PHE A C   1 
ATOM 708  O O   . PHE A 1 117 ? 156.797 103.441 88.899  1.00 167.09 ? 117 PHE A O   1 
ATOM 709  C CB  . PHE A 1 117 ? 155.837 106.276 89.368  1.00 167.09 ? 117 PHE A CB  1 
ATOM 710  C CG  . PHE A 1 117 ? 155.116 105.449 90.399  1.00 167.09 ? 117 PHE A CG  1 
ATOM 711  C CD1 . PHE A 1 117 ? 153.733 105.374 90.402  1.00 167.09 ? 117 PHE A CD1 1 
ATOM 712  C CD2 . PHE A 1 117 ? 155.819 104.768 91.379  1.00 167.09 ? 117 PHE A CD2 1 
ATOM 713  C CE1 . PHE A 1 117 ? 153.069 104.622 91.349  1.00 167.09 ? 117 PHE A CE1 1 
ATOM 714  C CE2 . PHE A 1 117 ? 155.160 104.013 92.328  1.00 167.09 ? 117 PHE A CE2 1 
ATOM 715  C CZ  . PHE A 1 117 ? 153.783 103.941 92.314  1.00 167.09 ? 117 PHE A CZ  1 
ATOM 716  N N   . PRO A 1 118 ? 158.282 104.538 87.623  1.00 167.16 ? 118 PRO A N   1 
ATOM 717  C CA  . PRO A 1 118 ? 159.299 103.498 87.825  1.00 167.16 ? 118 PRO A CA  1 
ATOM 718  C C   . PRO A 1 118 ? 159.850 103.495 89.243  1.00 167.16 ? 118 PRO A C   1 
ATOM 719  O O   . PRO A 1 118 ? 159.973 102.436 89.868  1.00 167.16 ? 118 PRO A O   1 
ATOM 720  C CB  . PRO A 1 118 ? 160.379 103.859 86.797  1.00 167.16 ? 118 PRO A CB  1 
ATOM 721  C CG  . PRO A 1 118 ? 160.193 105.319 86.545  1.00 167.16 ? 118 PRO A CG  1 
ATOM 722  C CD  . PRO A 1 118 ? 158.723 105.580 86.680  1.00 167.16 ? 118 PRO A CD  1 
ATOM 723  N N   . ASN A 1 119 ? 160.180 104.679 89.762  1.00 167.65 ? 119 ASN A N   1 
ATOM 724  C CA  . ASN A 1 119 ? 160.719 104.832 91.108  1.00 167.65 ? 119 ASN A CA  1 
ATOM 725  C C   . ASN A 1 119 ? 160.086 106.025 91.817  1.00 167.65 ? 119 ASN A C   1 
ATOM 726  O O   . ASN A 1 119 ? 160.740 106.691 92.623  1.00 167.65 ? 119 ASN A O   1 
ATOM 727  C CB  . ASN A 1 119 ? 162.241 104.968 91.074  1.00 167.65 ? 119 ASN A CB  1 
ATOM 728  C CG  . ASN A 1 119 ? 162.697 106.267 90.438  1.00 167.65 ? 119 ASN A CG  1 
ATOM 729  O OD1 . ASN A 1 119 ? 162.202 106.661 89.382  1.00 167.65 ? 119 ASN A OD1 1 
ATOM 730  N ND2 . ASN A 1 119 ? 163.643 106.941 91.081  1.00 167.65 ? 119 ASN A ND2 1 
ATOM 731  N N   . ARG A 1 120 ? 158.816 106.304 91.504  1.00 167.73 ? 120 ARG A N   1 
ATOM 732  C CA  . ARG A 1 120 ? 158.051 107.435 92.050  1.00 167.73 ? 120 ARG A CA  1 
ATOM 733  C C   . ARG A 1 120 ? 158.821 108.753 91.952  1.00 167.73 ? 120 ARG A C   1 
ATOM 734  O O   . ARG A 1 120 ? 158.551 109.708 92.685  1.00 167.73 ? 120 ARG A O   1 
ATOM 735  C CB  . ARG A 1 120 ? 157.587 107.161 93.491  1.00 167.73 ? 120 ARG A CB  1 
ATOM 736  C CG  . ARG A 1 120 ? 158.612 107.365 94.601  1.00 167.73 ? 120 ARG A CG  1 
ATOM 737  C CD  . ARG A 1 120 ? 157.956 107.907 95.863  1.00 167.73 ? 120 ARG A CD  1 
ATOM 738  N NE  . ARG A 1 120 ? 157.332 109.206 95.646  1.00 167.73 ? 120 ARG A NE  1 
ATOM 739  C CZ  . ARG A 1 120 ? 157.992 110.353 95.556  1.00 167.73 ? 120 ARG A CZ  1 
ATOM 740  N NH1 . ARG A 1 120 ? 159.310 110.402 95.663  1.00 167.73 ? 120 ARG A NH1 1 
ATOM 741  N NH2 . ARG A 1 120 ? 157.314 111.478 95.351  1.00 167.73 ? 120 ARG A NH2 1 
ATOM 742  N N   . SER A 1 121 ? 159.762 108.829 91.007  1.00 163.55 ? 121 SER A N   1 
ATOM 743  C CA  . SER A 1 121 ? 160.504 110.065 90.793  1.00 163.55 ? 121 SER A CA  1 
ATOM 744  C C   . SER A 1 121 ? 159.622 111.179 90.248  1.00 163.55 ? 121 SER A C   1 
ATOM 745  O O   . SER A 1 121 ? 160.001 112.352 90.337  1.00 163.55 ? 121 SER A O   1 
ATOM 746  C CB  . SER A 1 121 ? 161.679 109.816 89.847  1.00 163.55 ? 121 SER A CB  1 
ATOM 747  O OG  . SER A 1 121 ? 161.290 108.998 88.757  1.00 163.55 ? 121 SER A OG  1 
ATOM 748  N N   . ALA A 1 122 ? 158.466 110.842 89.688  1.00 157.87 ? 122 ALA A N   1 
ATOM 749  C CA  . ALA A 1 122 ? 157.549 111.862 89.199  1.00 157.87 ? 122 ALA A CA  1 
ATOM 750  C C   . ALA A 1 122 ? 156.992 112.659 90.373  1.00 157.87 ? 122 ALA A C   1 
ATOM 751  O O   . ALA A 1 122 ? 156.502 112.066 91.341  1.00 157.87 ? 122 ALA A O   1 
ATOM 752  C CB  . ALA A 1 122 ? 156.413 111.224 88.405  1.00 157.87 ? 122 ALA A CB  1 
ATOM 753  N N   . PRO A 1 123 ? 157.054 113.986 90.334  1.00 152.06 ? 123 PRO A N   1 
ATOM 754  C CA  . PRO A 1 123 ? 156.552 114.783 91.454  1.00 152.06 ? 123 PRO A CA  1 
ATOM 755  C C   . PRO A 1 123 ? 155.039 114.714 91.571  1.00 152.06 ? 123 PRO A C   1 
ATOM 756  O O   . PRO A 1 123 ? 154.321 114.472 90.599  1.00 152.06 ? 123 PRO A O   1 
ATOM 757  C CB  . PRO A 1 123 ? 157.013 116.203 91.106  1.00 152.06 ? 123 PRO A CB  1 
ATOM 758  C CG  . PRO A 1 123 ? 157.081 116.211 89.620  1.00 152.06 ? 123 PRO A CG  1 
ATOM 759  C CD  . PRO A 1 123 ? 157.510 114.826 89.213  1.00 152.06 ? 123 PRO A CD  1 
ATOM 760  N N   . LEU A 1 124 ? 154.563 114.921 92.793  1.00 143.08 ? 124 LEU A N   1 
ATOM 761  C CA  . LEU A 1 124 ? 153.133 114.996 93.046  1.00 143.08 ? 124 LEU A CA  1 
ATOM 762  C C   . LEU A 1 124 ? 152.646 116.431 92.883  1.00 143.08 ? 124 LEU A C   1 
ATOM 763  O O   . LEU A 1 124 ? 153.347 117.384 93.233  1.00 143.08 ? 124 LEU A O   1 
ATOM 764  C CB  . LEU A 1 124 ? 152.815 114.459 94.443  1.00 143.08 ? 124 LEU A CB  1 
ATOM 765  C CG  . LEU A 1 124 ? 153.475 115.094 95.673  1.00 143.08 ? 124 LEU A CG  1 
ATOM 766  C CD1 . LEU A 1 124 ? 152.710 116.303 96.190  1.00 143.08 ? 124 LEU A CD1 1 
ATOM 767  C CD2 . LEU A 1 124 ? 153.643 114.056 96.772  1.00 143.08 ? 124 LEU A CD2 1 
ATOM 768  N N   . VAL A 1 125 ? 151.444 116.579 92.336  1.00 141.64 ? 125 VAL A N   1 
ATOM 769  C CA  . VAL A 1 125 ? 150.873 117.899 92.078  1.00 141.64 ? 125 VAL A CA  1 
ATOM 770  C C   . VAL A 1 125 ? 149.437 117.938 92.590  1.00 141.64 ? 125 VAL A C   1 
ATOM 771  O O   . VAL A 1 125 ? 148.693 116.959 92.430  1.00 141.64 ? 125 VAL A O   1 
ATOM 772  C CB  . VAL A 1 125 ? 150.959 118.253 90.582  1.00 141.64 ? 125 VAL A CB  1 
ATOM 773  C CG1 . VAL A 1 125 ? 150.113 117.307 89.742  1.00 141.64 ? 125 VAL A CG1 1 
ATOM 774  C CG2 . VAL A 1 125 ? 150.539 119.695 90.344  1.00 141.64 ? 125 VAL A CG2 1 
ATOM 775  N N   . PRO A 1 126 ? 149.016 119.020 93.242  1.00 138.70 ? 126 PRO A N   1 
ATOM 776  C CA  . PRO A 1 126 ? 147.608 119.137 93.633  1.00 138.70 ? 126 PRO A CA  1 
ATOM 777  C C   . PRO A 1 126 ? 146.707 119.259 92.416  1.00 138.70 ? 126 PRO A C   1 
ATOM 778  O O   . PRO A 1 126 ? 147.112 119.742 91.357  1.00 138.70 ? 126 PRO A O   1 
ATOM 779  C CB  . PRO A 1 126 ? 147.576 120.414 94.482  1.00 138.70 ? 126 PRO A CB  1 
ATOM 780  C CG  . PRO A 1 126 ? 148.804 121.168 94.091  1.00 138.70 ? 126 PRO A CG  1 
ATOM 781  C CD  . PRO A 1 126 ? 149.829 120.128 93.768  1.00 138.70 ? 126 PRO A CD  1 
ATOM 782  N N   . CYS A 1 127 ? 145.467 118.806 92.579  1.00 137.98 ? 127 CYS A N   1 
ATOM 783  C CA  . CYS A 1 127 ? 144.495 118.761 91.496  1.00 137.98 ? 127 CYS A CA  1 
ATOM 784  C C   . CYS A 1 127 ? 143.315 119.666 91.818  1.00 137.98 ? 127 CYS A C   1 
ATOM 785  O O   . CYS A 1 127 ? 142.741 119.585 92.909  1.00 137.98 ? 127 CYS A O   1 
ATOM 786  C CB  . CYS A 1 127 ? 144.017 117.327 91.253  1.00 137.98 ? 127 CYS A CB  1 
ATOM 787  S SG  . CYS A 1 127 ? 143.359 116.506 92.718  1.00 137.98 ? 127 CYS A SG  1 
ATOM 788  N N   . ARG A 1 128 ? 142.965 120.533 90.867  1.00 136.58 ? 128 ARG A N   1 
ATOM 789  C CA  . ARG A 1 128 ? 141.774 121.362 91.004  1.00 136.58 ? 128 ARG A CA  1 
ATOM 790  C C   . ARG A 1 128 ? 140.500 120.577 90.718  1.00 136.58 ? 128 ARG A C   1 
ATOM 791  O O   . ARG A 1 128 ? 139.466 120.834 91.344  1.00 136.58 ? 128 ARG A O   1 
ATOM 792  C CB  . ARG A 1 128 ? 141.872 122.576 90.075  1.00 136.58 ? 128 ARG A CB  1 
ATOM 793  C CG  . ARG A 1 128 ? 140.642 123.474 90.072  1.00 136.58 ? 128 ARG A CG  1 
ATOM 794  C CD  . ARG A 1 128 ? 140.451 124.173 91.408  1.00 136.58 ? 128 ARG A CD  1 
ATOM 795  N NE  . ARG A 1 128 ? 139.259 125.012 91.415  1.00 136.58 ? 128 ARG A NE  1 
ATOM 796  C CZ  . ARG A 1 128 ? 138.043 124.583 91.725  1.00 136.58 ? 128 ARG A CZ  1 
ATOM 797  N NH1 . ARG A 1 128 ? 137.820 123.325 92.068  1.00 136.58 ? 128 ARG A NH1 1 
ATOM 798  N NH2 . ARG A 1 128 ? 137.024 125.438 91.692  1.00 136.58 ? 128 ARG A NH2 1 
ATOM 799  N N   . GLY A 1 129 ? 140.554 119.623 89.792  1.00 126.72 ? 129 GLY A N   1 
ATOM 800  C CA  . GLY A 1 129 ? 139.377 118.855 89.439  1.00 126.72 ? 129 GLY A CA  1 
ATOM 801  C C   . GLY A 1 129 ? 139.756 117.577 88.724  1.00 126.72 ? 129 GLY A C   1 
ATOM 802  O O   . GLY A 1 129 ? 140.929 117.314 88.449  1.00 126.72 ? 129 GLY A O   1 
ATOM 803  N N   . GLY A 1 130 ? 138.735 116.781 88.423  1.00 121.17 ? 130 GLY A N   1 
ATOM 804  C CA  . GLY A 1 130 ? 138.915 115.528 87.724  1.00 121.17 ? 130 GLY A CA  1 
ATOM 805  C C   . GLY A 1 130 ? 138.971 114.290 88.590  1.00 121.17 ? 130 GLY A C   1 
ATOM 806  O O   . GLY A 1 130 ? 139.321 113.219 88.080  1.00 121.17 ? 130 GLY A O   1 
ATOM 807  N N   . TRP A 1 131 ? 138.646 114.396 89.875  1.00 116.02 ? 131 TRP A N   1 
ATOM 808  C CA  . TRP A 1 131 ? 138.683 113.243 90.762  1.00 116.02 ? 131 TRP A CA  1 
ATOM 809  C C   . TRP A 1 131 ? 137.476 112.330 90.581  1.00 116.02 ? 131 TRP A C   1 
ATOM 810  O O   . TRP A 1 131 ? 136.366 112.775 90.281  1.00 116.02 ? 131 TRP A O   1 
ATOM 811  C CB  . TRP A 1 131 ? 138.787 113.684 92.221  1.00 116.02 ? 131 TRP A CB  1 
ATOM 812  C CG  . TRP A 1 131 ? 137.671 114.534 92.674  1.00 116.02 ? 131 TRP A CG  1 
ATOM 813  C CD1 . TRP A 1 131 ? 136.479 114.126 93.182  1.00 116.02 ? 131 TRP A CD1 1 
ATOM 814  C CD2 . TRP A 1 131 ? 137.679 115.960 92.761  1.00 116.02 ? 131 TRP A CD2 1 
ATOM 815  N NE1 . TRP A 1 131 ? 135.715 115.214 93.524  1.00 116.02 ? 131 TRP A NE1 1 
ATOM 816  C CE2 . TRP A 1 131 ? 136.435 116.354 93.283  1.00 116.02 ? 131 TRP A CE2 1 
ATOM 817  C CE3 . TRP A 1 131 ? 138.611 116.944 92.426  1.00 116.02 ? 131 TRP A CE3 1 
ATOM 818  C CZ2 . TRP A 1 131 ? 136.099 117.690 93.481  1.00 116.02 ? 131 TRP A CZ2 1 
ATOM 819  C CZ3 . TRP A 1 131 ? 138.275 118.268 92.623  1.00 116.02 ? 131 TRP A CZ3 1 
ATOM 820  C CH2 . TRP A 1 131 ? 137.031 118.630 93.142  1.00 116.02 ? 131 TRP A CH2 1 
ATOM 821  N N   . ARG A 1 132 ? 137.717 111.034 90.779  1.00 110.14 ? 132 ARG A N   1 
ATOM 822  C CA  . ARG A 1 132 ? 136.700 109.999 90.688  1.00 110.14 ? 132 ARG A CA  1 
ATOM 823  C C   . ARG A 1 132 ? 136.654 109.218 91.993  1.00 110.14 ? 132 ARG A C   1 
ATOM 824  O O   . ARG A 1 132 ? 137.379 109.516 92.945  1.00 110.14 ? 132 ARG A O   1 
ATOM 825  C CB  . ARG A 1 132 ? 136.963 109.052 89.513  1.00 110.14 ? 132 ARG A CB  1 
ATOM 826  C CG  . ARG A 1 132 ? 137.305 109.763 88.221  1.00 110.14 ? 132 ARG A CG  1 
ATOM 827  C CD  . ARG A 1 132 ? 136.608 109.109 87.040  1.00 110.14 ? 132 ARG A CD  1 
ATOM 828  N NE  . ARG A 1 132 ? 135.155 109.137 87.168  1.00 110.14 ? 132 ARG A NE  1 
ATOM 829  C CZ  . ARG A 1 132 ? 134.407 110.227 87.057  1.00 110.14 ? 132 ARG A CZ  1 
ATOM 830  N NH1 . ARG A 1 132 ? 134.939 111.408 86.786  1.00 110.14 ? 132 ARG A NH1 1 
ATOM 831  N NH2 . ARG A 1 132 ? 133.090 110.128 87.214  1.00 110.14 ? 132 ARG A NH2 1 
ATOM 832  N N   . TYR A 1 133 ? 135.785 108.210 92.031  1.00 105.40 ? 133 TYR A N   1 
ATOM 833  C CA  . TYR A 1 133 ? 135.496 107.465 93.246  1.00 105.40 ? 133 TYR A CA  1 
ATOM 834  C C   . TYR A 1 133 ? 135.507 105.968 92.966  1.00 105.40 ? 133 TYR A C   1 
ATOM 835  O O   . TYR A 1 133 ? 135.321 105.533 91.826  1.00 105.40 ? 133 TYR A O   1 
ATOM 836  C CB  . TYR A 1 133 ? 134.146 107.887 93.820  1.00 105.40 ? 133 TYR A CB  1 
ATOM 837  C CG  . TYR A 1 133 ? 134.092 109.359 94.143  1.00 105.40 ? 133 TYR A CG  1 
ATOM 838  C CD1 . TYR A 1 133 ? 134.517 109.835 95.371  1.00 105.40 ? 133 TYR A CD1 1 
ATOM 839  C CD2 . TYR A 1 133 ? 133.647 110.276 93.204  1.00 105.40 ? 133 TYR A CD2 1 
ATOM 840  C CE1 . TYR A 1 133 ? 134.478 111.181 95.664  1.00 105.40 ? 133 TYR A CE1 1 
ATOM 841  C CE2 . TYR A 1 133 ? 133.608 111.620 93.486  1.00 105.40 ? 133 TYR A CE2 1 
ATOM 842  C CZ  . TYR A 1 133 ? 134.023 112.068 94.717  1.00 105.40 ? 133 TYR A CZ  1 
ATOM 843  O OH  . TYR A 1 133 ? 133.984 113.411 95.003  1.00 105.40 ? 133 TYR A OH  1 
ATOM 844  N N   . ALA A 1 134 ? 135.731 105.181 94.019  1.00 108.13 ? 134 ALA A N   1 
ATOM 845  C CA  . ALA A 1 134 ? 135.881 103.737 93.872  1.00 108.13 ? 134 ALA A CA  1 
ATOM 846  C C   . ALA A 1 134 ? 134.680 102.952 94.389  1.00 108.13 ? 134 ALA A C   1 
ATOM 847  O O   . ALA A 1 134 ? 134.303 101.940 93.790  1.00 108.13 ? 134 ALA A O   1 
ATOM 848  C CB  . ALA A 1 134 ? 137.146 103.265 94.592  1.00 108.13 ? 134 ALA A CB  1 
ATOM 849  N N   . GLN A 1 135 ? 134.079 103.388 95.492  1.00 110.68 ? 135 GLN A N   1 
ATOM 850  C CA  . GLN A 1 135 ? 133.000 102.628 96.110  1.00 110.68 ? 135 GLN A CA  1 
ATOM 851  C C   . GLN A 1 135 ? 131.750 102.631 95.234  1.00 110.68 ? 135 GLN A C   1 
ATOM 852  O O   . GLN A 1 135 ? 131.385 103.649 94.641  1.00 110.68 ? 135 GLN A O   1 
ATOM 853  C CB  . GLN A 1 135 ? 132.685 103.195 97.492  1.00 110.68 ? 135 GLN A CB  1 
ATOM 854  C CG  . GLN A 1 135 ? 132.474 104.693 97.507  1.00 110.68 ? 135 GLN A CG  1 
ATOM 855  C CD  . GLN A 1 135 ? 131.013 105.068 97.543  1.00 110.68 ? 135 GLN A CD  1 
ATOM 856  O OE1 . GLN A 1 135 ? 130.206 104.390 98.177  1.00 110.68 ? 135 GLN A OE1 1 
ATOM 857  N NE2 . GLN A 1 135 ? 130.659 106.149 96.859  1.00 110.68 ? 135 GLN A NE2 1 
ATOM 858  N N   . ALA A 1 136 ? 131.090 101.471 95.161  1.00 114.57 ? 136 ALA A N   1 
ATOM 859  C CA  . ALA A 1 136 ? 129.952 101.300 94.265  1.00 114.57 ? 136 ALA A CA  1 
ATOM 860  C C   . ALA A 1 136 ? 128.694 101.990 94.775  1.00 114.57 ? 136 ALA A C   1 
ATOM 861  O O   . ALA A 1 136 ? 127.848 102.393 93.969  1.00 114.57 ? 136 ALA A O   1 
ATOM 862  C CB  . ALA A 1 136 ? 129.676 99.812  94.048  1.00 114.57 ? 136 ALA A CB  1 
ATOM 863  N N   . HIS A 1 137 ? 128.543 102.119 96.091  1.00 108.66 ? 137 HIS A N   1 
ATOM 864  C CA  . HIS A 1 137 ? 127.380 102.794 96.652  1.00 108.66 ? 137 HIS A CA  1 
ATOM 865  C C   . HIS A 1 137 ? 127.325 104.240 96.172  1.00 108.66 ? 137 HIS A C   1 
ATOM 866  O O   . HIS A 1 137 ? 128.347 104.929 96.105  1.00 108.66 ? 137 HIS A O   1 
ATOM 867  C CB  . HIS A 1 137 ? 127.438 102.733 98.179  1.00 108.66 ? 137 HIS A CB  1 
ATOM 868  C CG  . HIS A 1 137 ? 126.231 103.295 98.860  1.00 108.66 ? 137 HIS A CG  1 
ATOM 869  N ND1 . HIS A 1 137 ? 126.020 104.648 99.007  1.00 108.66 ? 137 HIS A ND1 1 
ATOM 870  C CD2 . HIS A 1 137 ? 125.176 102.684 99.448  1.00 108.66 ? 137 HIS A CD2 1 
ATOM 871  C CE1 . HIS A 1 137 ? 124.884 104.848 99.651  1.00 108.66 ? 137 HIS A CE1 1 
ATOM 872  N NE2 . HIS A 1 137 ? 124.351 103.672 99.929  1.00 108.66 ? 137 HIS A NE2 1 
ATOM 873  N N   . SER A 1 138 ? 126.127 104.700 95.825  1.00 102.82 ? 138 SER A N   1 
ATOM 874  C CA  . SER A 1 138 ? 125.941 106.034 95.270  1.00 102.82 ? 138 SER A CA  1 
ATOM 875  C C   . SER A 1 138 ? 125.702 107.029 96.396  1.00 102.82 ? 138 SER A C   1 
ATOM 876  O O   . SER A 1 138 ? 124.896 106.774 97.296  1.00 102.82 ? 138 SER A O   1 
ATOM 877  C CB  . SER A 1 138 ? 124.771 106.066 94.287  1.00 102.82 ? 138 SER A CB  1 
ATOM 878  O OG  . SER A 1 138 ? 123.535 106.050 94.975  1.00 102.82 ? 138 SER A OG  1 
ATOM 879  N N   . THR A 1 139 ? 126.400 108.159 96.339  1.00 96.62  ? 139 THR A N   1 
ATOM 880  C CA  . THR A 1 139 ? 126.320 109.186 97.366  1.00 96.62  ? 139 THR A CA  1 
ATOM 881  C C   . THR A 1 139 ? 126.326 110.552 96.698  1.00 96.62  ? 139 THR A C   1 
ATOM 882  O O   . THR A 1 139 ? 126.779 110.703 95.562  1.00 96.62  ? 139 THR A O   1 
ATOM 883  C CB  . THR A 1 139 ? 127.485 109.081 98.357  1.00 96.62  ? 139 THR A CB  1 
ATOM 884  O OG1 . THR A 1 139 ? 128.724 109.063 97.638  1.00 96.62  ? 139 THR A OG1 1 
ATOM 885  C CG2 . THR A 1 139 ? 127.371 107.823 99.201  1.00 96.62  ? 139 THR A CG2 1 
ATOM 886  N N   . ILE A 1 140 ? 125.814 111.558 97.414  1.00 91.76  ? 140 ILE A N   1 
ATOM 887  C CA  . ILE A 1 140 ? 125.843 112.914 96.873  1.00 91.76  ? 140 ILE A CA  1 
ATOM 888  C C   . ILE A 1 140 ? 127.277 113.400 96.742  1.00 91.76  ? 140 ILE A C   1 
ATOM 889  O O   . ILE A 1 140 ? 127.571 114.277 95.921  1.00 91.76  ? 140 ILE A O   1 
ATOM 890  C CB  . ILE A 1 140 ? 125.000 113.876 97.732  1.00 91.76  ? 140 ILE A CB  1 
ATOM 891  C CG1 . ILE A 1 140 ? 125.615 114.056 99.116  1.00 91.76  ? 140 ILE A CG1 1 
ATOM 892  C CG2 . ILE A 1 140 ? 123.581 113.371 97.853  1.00 91.76  ? 140 ILE A CG2 1 
ATOM 893  C CD1 . ILE A 1 140 ? 124.955 115.142 99.929  1.00 91.76  ? 140 ILE A CD1 1 
ATOM 894  N N   . VAL A 1 141 ? 128.189 112.844 97.540  1.00 90.50  ? 141 VAL A N   1 
ATOM 895  C CA  . VAL A 1 141 ? 129.602 113.186 97.416  1.00 90.50  ? 141 VAL A CA  1 
ATOM 896  C C   . VAL A 1 141 ? 130.123 112.788 96.043  1.00 90.50  ? 141 VAL A C   1 
ATOM 897  O O   . VAL A 1 141 ? 130.865 113.540 95.401  1.00 90.50  ? 141 VAL A O   1 
ATOM 898  C CB  . VAL A 1 141 ? 130.409 112.515 98.541  1.00 90.50  ? 141 VAL A CB  1 
ATOM 899  C CG1 . VAL A 1 141 ? 131.892 112.778 98.362  1.00 90.50  ? 141 VAL A CG1 1 
ATOM 900  C CG2 . VAL A 1 141 ? 129.931 112.999 99.892  1.00 90.50  ? 141 VAL A CG2 1 
ATOM 901  N N   . SER A 1 142 ? 129.748 111.599 95.574  1.00 95.25  ? 142 SER A N   1 
ATOM 902  C CA  . SER A 1 142 ? 130.190 111.150 94.259  1.00 95.25  ? 142 SER A CA  1 
ATOM 903  C C   . SER A 1 142 ? 129.626 112.029 93.150  1.00 95.25  ? 142 SER A C   1 
ATOM 904  O O   . SER A 1 142 ? 130.333 112.355 92.189  1.00 95.25  ? 142 SER A O   1 
ATOM 905  C CB  . SER A 1 142 ? 129.790 109.692 94.045  1.00 95.25  ? 142 SER A CB  1 
ATOM 906  O OG  . SER A 1 142 ? 129.891 109.330 92.680  1.00 95.25  ? 142 SER A OG  1 
ATOM 907  N N   . GLU A 1 143 ? 128.354 112.418 93.258  1.00 94.55  ? 143 GLU A N   1 
ATOM 908  C CA  . GLU A 1 143 ? 127.720 113.166 92.178  1.00 94.55  ? 143 GLU A CA  1 
ATOM 909  C C   . GLU A 1 143 ? 128.188 114.617 92.142  1.00 94.55  ? 143 GLU A C   1 
ATOM 910  O O   . GLU A 1 143 ? 128.449 115.161 91.063  1.00 94.55  ? 143 GLU A O   1 
ATOM 911  C CB  . GLU A 1 143 ? 126.200 113.097 92.313  1.00 94.55  ? 143 GLU A CB  1 
ATOM 912  C CG  . GLU A 1 143 ? 125.626 111.692 92.214  1.00 94.55  ? 143 GLU A CG  1 
ATOM 913  C CD  . GLU A 1 143 ? 126.328 110.844 91.173  1.00 94.55  ? 143 GLU A CD  1 
ATOM 914  O OE1 . GLU A 1 143 ? 125.987 110.966 89.978  1.00 94.55  ? 143 GLU A OE1 1 
ATOM 915  O OE2 . GLU A 1 143 ? 127.215 110.048 91.549  1.00 94.55  ? 143 GLU A OE2 1 
ATOM 916  N N   . PHE A 1 144 ? 128.297 115.262 93.300  1.00 89.03  ? 144 PHE A N   1 
ATOM 917  C CA  . PHE A 1 144 ? 128.587 116.687 93.359  1.00 89.03  ? 144 PHE A CA  1 
ATOM 918  C C   . PHE A 1 144 ? 130.047 116.992 93.662  1.00 89.03  ? 144 PHE A C   1 
ATOM 919  O O   . PHE A 1 144 ? 130.416 118.169 93.722  1.00 89.03  ? 144 PHE A O   1 
ATOM 920  C CB  . PHE A 1 144 ? 127.692 117.363 94.400  1.00 89.03  ? 144 PHE A CB  1 
ATOM 921  C CG  . PHE A 1 144 ? 126.224 117.166 94.156  1.00 89.03  ? 144 PHE A CG  1 
ATOM 922  C CD1 . PHE A 1 144 ? 125.746 116.894 92.887  1.00 89.03  ? 144 PHE A CD1 1 
ATOM 923  C CD2 . PHE A 1 144 ? 125.323 117.249 95.200  1.00 89.03  ? 144 PHE A CD2 1 
ATOM 924  C CE1 . PHE A 1 144 ? 124.400 116.709 92.665  1.00 89.03  ? 144 PHE A CE1 1 
ATOM 925  C CE2 . PHE A 1 144 ? 123.976 117.067 94.982  1.00 89.03  ? 144 PHE A CE2 1 
ATOM 926  C CZ  . PHE A 1 144 ? 123.513 116.797 93.714  1.00 89.03  ? 144 PHE A CZ  1 
ATOM 927  N N   . ASP A 1 145 ? 130.878 115.969 93.860  1.00 97.66  ? 145 ASP A N   1 
ATOM 928  C CA  . ASP A 1 145 ? 132.324 116.127 94.015  1.00 97.66  ? 145 ASP A CA  1 
ATOM 929  C C   . ASP A 1 145 ? 132.665 117.025 95.207  1.00 97.66  ? 145 ASP A C   1 
ATOM 930  O O   . ASP A 1 145 ? 133.309 118.066 95.074  1.00 97.66  ? 145 ASP A O   1 
ATOM 931  C CB  . ASP A 1 145 ? 132.943 116.664 92.721  1.00 97.66  ? 145 ASP A CB  1 
ATOM 932  C CG  . ASP A 1 145 ? 133.162 115.579 91.689  1.00 97.66  ? 145 ASP A CG  1 
ATOM 933  O OD1 . ASP A 1 145 ? 133.247 114.397 92.078  1.00 97.66  ? 145 ASP A OD1 1 
ATOM 934  O OD2 . ASP A 1 145 ? 133.250 115.907 90.489  1.00 97.66  ? 145 ASP A OD2 1 
ATOM 935  N N   . LEU A 1 146 ? 132.214 116.602 96.389  1.00 95.03  ? 146 LEU A N   1 
ATOM 936  C CA  . LEU A 1 146 ? 132.433 117.359 97.622  1.00 95.03  ? 146 LEU A CA  1 
ATOM 937  C C   . LEU A 1 146 ? 133.579 116.725 98.408  1.00 95.03  ? 146 LEU A C   1 
ATOM 938  O O   . LEU A 1 146 ? 133.380 116.069 99.429  1.00 95.03  ? 146 LEU A O   1 
ATOM 939  C CB  . LEU A 1 146 ? 131.155 117.411 98.453  1.00 95.03  ? 146 LEU A CB  1 
ATOM 940  C CG  . LEU A 1 146 ? 129.824 117.669 97.750  1.00 95.03  ? 146 LEU A CG  1 
ATOM 941  C CD1 . LEU A 1 146 ? 128.712 117.817 98.774  1.00 95.03  ? 146 LEU A CD1 1 
ATOM 942  C CD2 . LEU A 1 146 ? 129.903 118.894 96.871  1.00 95.03  ? 146 LEU A CD2 1 
ATOM 943  N N   . VAL A 1 147 ? 134.806 116.940 97.928  1.00 107.50 ? 147 VAL A N   1 
ATOM 944  C CA  . VAL A 1 147 ? 136.007 116.458 98.601  1.00 107.50 ? 147 VAL A CA  1 
ATOM 945  C C   . VAL A 1 147 ? 137.089 117.529 98.522  1.00 107.50 ? 147 VAL A C   1 
ATOM 946  O O   . VAL A 1 147 ? 136.998 118.483 97.747  1.00 107.50 ? 147 VAL A O   1 
ATOM 947  C CB  . VAL A 1 147 ? 136.533 115.135 98.006  1.00 107.50 ? 147 VAL A CB  1 
ATOM 948  C CG1 . VAL A 1 147 ? 135.578 113.990 98.295  1.00 107.50 ? 147 VAL A CG1 1 
ATOM 949  C CG2 . VAL A 1 147 ? 136.772 115.286 96.525  1.00 107.50 ? 147 VAL A CG2 1 
ATOM 950  N N   . CYS A 1 148 ? 138.125 117.351 99.344  1.00 110.35 ? 148 CYS A N   1 
ATOM 951  C CA  . CYS A 1 148 ? 139.308 118.218 99.373  1.00 110.35 ? 148 CYS A CA  1 
ATOM 952  C C   . CYS A 1 148 ? 138.853 119.635 99.698  1.00 110.35 ? 148 CYS A C   1 
ATOM 953  O O   . CYS A 1 148 ? 138.245 119.835 100.763 1.00 110.35 ? 148 CYS A O   1 
ATOM 954  C CB  . CYS A 1 148 ? 140.080 118.052 98.063  1.00 110.35 ? 148 CYS A CB  1 
ATOM 955  S SG  . CYS A 1 148 ? 140.727 116.392 97.800  1.00 110.35 ? 148 CYS A SG  1 
ATOM 956  N N   . VAL A 1 149 ? 139.119 120.631 98.850  1.00 107.18 ? 149 VAL A N   1 
ATOM 957  C CA  . VAL A 1 149 ? 138.653 121.984 99.131  1.00 107.18 ? 149 VAL A CA  1 
ATOM 958  C C   . VAL A 1 149 ? 137.131 122.043 99.107  1.00 107.18 ? 149 VAL A C   1 
ATOM 959  O O   . VAL A 1 149 ? 136.523 122.865 99.804  1.00 107.18 ? 149 VAL A O   1 
ATOM 960  C CB  . VAL A 1 149 ? 139.279 122.980 98.138  1.00 107.18 ? 149 VAL A CB  1 
ATOM 961  C CG1 . VAL A 1 149 ? 140.772 123.094 98.382  1.00 107.18 ? 149 VAL A CG1 1 
ATOM 962  C CG2 . VAL A 1 149 ? 139.013 122.544 96.709  1.00 107.18 ? 149 VAL A CG2 1 
ATOM 963  N N   . ASN A 1 150 ? 136.493 121.182 98.315  1.00 103.65 ? 150 ASN A N   1 
ATOM 964  C CA  . ASN A 1 150 ? 135.040 121.110 98.277  1.00 103.65 ? 150 ASN A CA  1 
ATOM 965  C C   . ASN A 1 150 ? 134.457 120.288 99.418  1.00 103.65 ? 150 ASN A C   1 
ATOM 966  O O   . ASN A 1 150 ? 133.239 120.317 99.617  1.00 103.65 ? 150 ASN A O   1 
ATOM 967  C CB  . ASN A 1 150 ? 134.580 120.533 96.938  1.00 103.65 ? 150 ASN A CB  1 
ATOM 968  C CG  . ASN A 1 150 ? 134.898 121.445 95.775  1.00 103.65 ? 150 ASN A CG  1 
ATOM 969  O OD1 . ASN A 1 150 ? 134.757 122.663 95.872  1.00 103.65 ? 150 ASN A OD1 1 
ATOM 970  N ND2 . ASN A 1 150 ? 135.332 120.861 94.667  1.00 103.65 ? 150 ASN A ND2 1 
ATOM 971  N N   . ALA A 1 151 ? 135.287 119.561 100.170 1.00 100.60 ? 151 ALA A N   1 
ATOM 972  C CA  . ALA A 1 151 ? 134.786 118.847 101.337 1.00 100.60 ? 151 ALA A CA  1 
ATOM 973  C C   . ALA A 1 151 ? 134.258 119.800 102.395 1.00 100.60 ? 151 ALA A C   1 
ATOM 974  O O   . ALA A 1 151 ? 133.544 119.369 103.305 1.00 100.60 ? 151 ALA A O   1 
ATOM 975  C CB  . ALA A 1 151 ? 135.883 117.964 101.931 1.00 100.60 ? 151 ALA A CB  1 
ATOM 976  N N   . TRP A 1 152 ? 134.603 121.084 102.295 1.00 102.64 ? 152 TRP A N   1 
ATOM 977  C CA  . TRP A 1 152 ? 134.035 122.086 103.187 1.00 102.64 ? 152 TRP A CA  1 
ATOM 978  C C   . TRP A 1 152 ? 132.518 122.123 103.091 1.00 102.64 ? 152 TRP A C   1 
ATOM 979  O O   . TRP A 1 152 ? 131.823 122.177 104.113 1.00 102.64 ? 152 TRP A O   1 
ATOM 980  C CB  . TRP A 1 152 ? 134.602 123.460 102.848 1.00 102.64 ? 152 TRP A CB  1 
ATOM 981  C CG  . TRP A 1 152 ? 134.086 124.536 103.730 1.00 102.64 ? 152 TRP A CG  1 
ATOM 982  C CD1 . TRP A 1 152 ? 134.292 124.672 105.070 1.00 102.64 ? 152 TRP A CD1 1 
ATOM 983  C CD2 . TRP A 1 152 ? 133.219 125.605 103.344 1.00 102.64 ? 152 TRP A CD2 1 
ATOM 984  N NE1 . TRP A 1 152 ? 133.634 125.784 105.539 1.00 102.64 ? 152 TRP A NE1 1 
ATOM 985  C CE2 . TRP A 1 152 ? 132.964 126.372 104.498 1.00 102.64 ? 152 TRP A CE2 1 
ATOM 986  C CE3 . TRP A 1 152 ? 132.646 125.998 102.131 1.00 102.64 ? 152 TRP A CE3 1 
ATOM 987  C CZ2 . TRP A 1 152 ? 132.159 127.508 104.475 1.00 102.64 ? 152 TRP A CZ2 1 
ATOM 988  C CZ3 . TRP A 1 152 ? 131.848 127.124 102.109 1.00 102.64 ? 152 TRP A CZ3 1 
ATOM 989  C CH2 . TRP A 1 152 ? 131.612 127.867 103.274 1.00 102.64 ? 152 TRP A CH2 1 
ATOM 990  N N   . MET A 1 153 ? 131.988 122.099 101.874 1.00 97.88  ? 153 MET A N   1 
ATOM 991  C CA  . MET A 1 153 ? 130.575 122.342 101.635 1.00 97.88  ? 153 MET A CA  1 
ATOM 992  C C   . MET A 1 153 ? 129.727 121.079 101.687 1.00 97.88  ? 153 MET A C   1 
ATOM 993  O O   . MET A 1 153 ? 128.595 121.088 101.194 1.00 97.88  ? 153 MET A O   1 
ATOM 994  C CB  . MET A 1 153 ? 130.399 123.073 100.300 1.00 97.88  ? 153 MET A CB  1 
ATOM 995  C CG  . MET A 1 153 ? 130.806 122.293 99.068  1.00 97.88  ? 153 MET A CG  1 
ATOM 996  S SD  . MET A 1 153 ? 130.597 123.307 97.592  1.00 97.88  ? 153 MET A SD  1 
ATOM 997  C CE  . MET A 1 153 ? 131.155 122.191 96.311  1.00 97.88  ? 153 MET A CE  1 
ATOM 998  N N   . LEU A 1 154 ? 130.241 119.996 102.275 1.00 95.44  ? 154 LEU A N   1 
ATOM 999  C CA  . LEU A 1 154 ? 129.373 118.875 102.617 1.00 95.44  ? 154 LEU A CA  1 
ATOM 1000 C C   . LEU A 1 154 ? 128.461 119.228 103.783 1.00 95.44  ? 154 LEU A C   1 
ATOM 1001 O O   . LEU A 1 154 ? 127.283 118.856 103.782 1.00 95.44  ? 154 LEU A O   1 
ATOM 1002 C CB  . LEU A 1 154 ? 130.208 117.640 102.950 1.00 95.44  ? 154 LEU A CB  1 
ATOM 1003 C CG  . LEU A 1 154 ? 129.495 116.288 103.017 1.00 95.44  ? 154 LEU A CG  1 
ATOM 1004 C CD1 . LEU A 1 154 ? 130.458 115.195 102.612 1.00 95.44  ? 154 LEU A CD1 1 
ATOM 1005 C CD2 . LEU A 1 154 ? 128.938 116.008 104.403 1.00 95.44  ? 154 LEU A CD2 1 
ATOM 1006 N N   . ASP A 1 155 ? 128.987 119.933 104.785 1.00 95.66  ? 155 ASP A N   1 
ATOM 1007 C CA  . ASP A 1 155 ? 128.167 120.475 105.859 1.00 95.66  ? 155 ASP A CA  1 
ATOM 1008 C C   . ASP A 1 155 ? 127.360 121.685 105.411 1.00 95.66  ? 155 ASP A C   1 
ATOM 1009 O O   . ASP A 1 155 ? 126.439 122.104 106.126 1.00 95.66  ? 155 ASP A O   1 
ATOM 1010 C CB  . ASP A 1 155 ? 129.052 120.845 107.053 1.00 95.66  ? 155 ASP A CB  1 
ATOM 1011 C CG  . ASP A 1 155 ? 128.249 121.285 108.263 1.00 95.66  ? 155 ASP A CG  1 
ATOM 1012 O OD1 . ASP A 1 155 ? 127.641 120.418 108.925 1.00 95.66  ? 155 ASP A OD1 1 
ATOM 1013 O OD2 . ASP A 1 155 ? 128.228 122.500 108.553 1.00 95.66  ? 155 ASP A OD2 1 
ATOM 1014 N N   . LEU A 1 156 ? 127.680 122.254 104.247 1.00 88.00  ? 156 LEU A N   1 
ATOM 1015 C CA  . LEU A 1 156 ? 126.839 123.304 103.690 1.00 88.00  ? 156 LEU A CA  1 
ATOM 1016 C C   . LEU A 1 156 ? 125.424 122.794 103.464 1.00 88.00  ? 156 LEU A C   1 
ATOM 1017 O O   . LEU A 1 156 ? 124.456 123.536 103.645 1.00 88.00  ? 156 LEU A O   1 
ATOM 1018 C CB  . LEU A 1 156 ? 127.439 123.829 102.388 1.00 88.00  ? 156 LEU A CB  1 
ATOM 1019 C CG  . LEU A 1 156 ? 126.535 124.686 101.503 1.00 88.00  ? 156 LEU A CG  1 
ATOM 1020 C CD1 . LEU A 1 156 ? 126.368 126.070 102.102 1.00 88.00  ? 156 LEU A CD1 1 
ATOM 1021 C CD2 . LEU A 1 156 ? 127.092 124.772 100.094 1.00 88.00  ? 156 LEU A CD2 1 
ATOM 1022 N N   . THR A 1 157 ? 125.283 121.524 103.078 1.00 89.15  ? 157 THR A N   1 
ATOM 1023 C CA  . THR A 1 157 ? 123.954 120.933 102.976 1.00 89.15  ? 157 THR A CA  1 
ATOM 1024 C C   . THR A 1 157 ? 123.246 120.926 104.324 1.00 89.15  ? 157 THR A C   1 
ATOM 1025 O O   . THR A 1 157 ? 122.050 121.227 104.394 1.00 89.15  ? 157 THR A O   1 
ATOM 1026 C CB  . THR A 1 157 ? 124.046 119.514 102.423 1.00 89.15  ? 157 THR A CB  1 
ATOM 1027 O OG1 . THR A 1 157 ? 124.806 118.699 103.322 1.00 89.15  ? 157 THR A OG1 1 
ATOM 1028 C CG2 . THR A 1 157 ? 124.723 119.519 101.067 1.00 89.15  ? 157 THR A CG2 1 
ATOM 1029 N N   . GLN A 1 158 ? 123.966 120.594 105.398 1.00 87.58  ? 158 GLN A N   1 
ATOM 1030 C CA  . GLN A 1 158 ? 123.389 120.658 106.737 1.00 87.58  ? 158 GLN A CA  1 
ATOM 1031 C C   . GLN A 1 158 ? 122.889 122.062 107.042 1.00 87.58  ? 158 GLN A C   1 
ATOM 1032 O O   . GLN A 1 158 ? 121.752 122.253 107.494 1.00 87.58  ? 158 GLN A O   1 
ATOM 1033 C CB  . GLN A 1 158 ? 124.434 120.250 107.778 1.00 87.58  ? 158 GLN A CB  1 
ATOM 1034 C CG  . GLN A 1 158 ? 124.753 118.766 107.896 1.00 87.58  ? 158 GLN A CG  1 
ATOM 1035 C CD  . GLN A 1 158 ? 123.565 117.847 107.708 1.00 87.58  ? 158 GLN A CD  1 
ATOM 1036 O OE1 . GLN A 1 158 ? 123.685 116.812 107.061 1.00 87.58  ? 158 GLN A OE1 1 
ATOM 1037 N NE2 . GLN A 1 158 ? 122.432 118.186 108.319 1.00 87.58  ? 158 GLN A NE2 1 
ATOM 1038 N N   . ALA A 1 159 ? 123.741 123.060 106.800 1.00 87.43  ? 159 ALA A N   1 
ATOM 1039 C CA  . ALA A 1 159 ? 123.387 124.436 107.125 1.00 87.43  ? 159 ALA A CA  1 
ATOM 1040 C C   . ALA A 1 159 ? 122.193 124.909 106.308 1.00 87.43  ? 159 ALA A C   1 
ATOM 1041 O O   . ALA A 1 159 ? 121.297 125.573 106.836 1.00 87.43  ? 159 ALA A O   1 
ATOM 1042 C CB  . ALA A 1 159 ? 124.587 125.353 106.902 1.00 87.43  ? 159 ALA A CB  1 
ATOM 1043 N N   . ILE A 1 160 ? 122.160 124.573 105.018 1.00 84.28  ? 160 ILE A N   1 
ATOM 1044 C CA  . ILE A 1 160 ? 121.061 125.009 104.165 1.00 84.28  ? 160 ILE A CA  1 
ATOM 1045 C C   . ILE A 1 160 ? 119.763 124.315 104.554 1.00 84.28  ? 160 ILE A C   1 
ATOM 1046 O O   . ILE A 1 160 ? 118.699 124.939 104.570 1.00 84.28  ? 160 ILE A O   1 
ATOM 1047 C CB  . ILE A 1 160 ? 121.410 124.791 102.683 1.00 84.28  ? 160 ILE A CB  1 
ATOM 1048 C CG1 . ILE A 1 160 ? 122.667 125.576 102.321 1.00 84.28  ? 160 ILE A CG1 1 
ATOM 1049 C CG2 . ILE A 1 160 ? 120.271 125.221 101.797 1.00 84.28  ? 160 ILE A CG2 1 
ATOM 1050 C CD1 . ILE A 1 160 ? 122.517 127.067 102.507 1.00 84.28  ? 160 ILE A CD1 1 
ATOM 1051 N N   . LEU A 1 161 ? 119.821 123.021 104.878 1.00 81.35  ? 161 LEU A N   1 
ATOM 1052 C CA  . LEU A 1 161 ? 118.612 122.334 105.320 1.00 81.35  ? 161 LEU A CA  1 
ATOM 1053 C C   . LEU A 1 161 ? 118.074 122.943 106.605 1.00 81.35  ? 161 LEU A C   1 
ATOM 1054 O O   . LEU A 1 161 ? 116.864 123.158 106.741 1.00 81.35  ? 161 LEU A O   1 
ATOM 1055 C CB  . LEU A 1 161 ? 118.885 120.847 105.518 1.00 81.35  ? 161 LEU A CB  1 
ATOM 1056 C CG  . LEU A 1 161 ? 117.677 120.040 105.995 1.00 81.35  ? 161 LEU A CG  1 
ATOM 1057 C CD1 . LEU A 1 161 ? 116.589 120.041 104.941 1.00 81.35  ? 161 LEU A CD1 1 
ATOM 1058 C CD2 . LEU A 1 161 ? 118.072 118.621 106.360 1.00 81.35  ? 161 LEU A CD2 1 
ATOM 1059 N N   . ASN A 1 162 ? 118.957 123.239 107.559 1.00 85.23  ? 162 ASN A N   1 
ATOM 1060 C CA  . ASN A 1 162 ? 118.490 123.806 108.818 1.00 85.23  ? 162 ASN A CA  1 
ATOM 1061 C C   . ASN A 1 162 ? 117.986 125.235 108.633 1.00 85.23  ? 162 ASN A C   1 
ATOM 1062 O O   . ASN A 1 162 ? 117.027 125.651 109.293 1.00 85.23  ? 162 ASN A O   1 
ATOM 1063 C CB  . ASN A 1 162 ? 119.601 123.743 109.859 1.00 85.23  ? 162 ASN A CB  1 
ATOM 1064 C CG  . ASN A 1 162 ? 119.825 122.342 110.386 1.00 85.23  ? 162 ASN A CG  1 
ATOM 1065 O OD1 . ASN A 1 162 ? 119.334 121.983 111.455 1.00 85.23  ? 162 ASN A OD1 1 
ATOM 1066 N ND2 . ASN A 1 162 ? 120.569 121.540 109.635 1.00 85.23  ? 162 ASN A ND2 1 
ATOM 1067 N N   . LEU A 1 163 ? 118.608 125.999 107.733 1.00 85.13  ? 163 LEU A N   1 
ATOM 1068 C CA  . LEU A 1 163 ? 118.111 127.337 107.432 1.00 85.13  ? 163 LEU A CA  1 
ATOM 1069 C C   . LEU A 1 163 ? 116.746 127.276 106.760 1.00 85.13  ? 163 LEU A C   1 
ATOM 1070 O O   . LEU A 1 163 ? 115.873 128.113 107.026 1.00 85.13  ? 163 LEU A O   1 
ATOM 1071 C CB  . LEU A 1 163 ? 119.116 128.079 106.552 1.00 85.13  ? 163 LEU A CB  1 
ATOM 1072 C CG  . LEU A 1 163 ? 118.882 129.577 106.358 1.00 85.13  ? 163 LEU A CG  1 
ATOM 1073 C CD1 . LEU A 1 163 ? 119.431 130.364 107.536 1.00 85.13  ? 163 LEU A CD1 1 
ATOM 1074 C CD2 . LEU A 1 163 ? 119.515 130.044 105.060 1.00 85.13  ? 163 LEU A CD2 1 
ATOM 1075 N N   . GLY A 1 164 ? 116.552 126.299 105.873 1.00 82.86  ? 164 GLY A N   1 
ATOM 1076 C CA  . GLY A 1 164 ? 115.237 126.083 105.301 1.00 82.86  ? 164 GLY A CA  1 
ATOM 1077 C C   . GLY A 1 164 ? 114.212 125.727 106.355 1.00 82.86  ? 164 GLY A C   1 
ATOM 1078 O O   . GLY A 1 164 ? 113.083 126.214 106.319 1.00 82.86  ? 164 GLY A O   1 
ATOM 1079 N N   . PHE A 1 165 ? 114.595 124.881 107.312 1.00 83.19  ? 165 PHE A N   1 
ATOM 1080 C CA  . PHE A 1 165 ? 113.710 124.584 108.434 1.00 83.19  ? 165 PHE A CA  1 
ATOM 1081 C C   . PHE A 1 165 ? 113.331 125.859 109.174 1.00 83.19  ? 165 PHE A C   1 
ATOM 1082 O O   . PHE A 1 165 ? 112.154 126.095 109.468 1.00 83.19  ? 165 PHE A O   1 
ATOM 1083 C CB  . PHE A 1 165 ? 114.378 123.596 109.390 1.00 83.19  ? 165 PHE A CB  1 
ATOM 1084 C CG  . PHE A 1 165 ? 114.307 122.170 108.940 1.00 83.19  ? 165 PHE A CG  1 
ATOM 1085 C CD1 . PHE A 1 165 ? 113.184 121.687 108.298 1.00 83.19  ? 165 PHE A CD1 1 
ATOM 1086 C CD2 . PHE A 1 165 ? 115.365 121.310 109.164 1.00 83.19  ? 165 PHE A CD2 1 
ATOM 1087 C CE1 . PHE A 1 165 ? 113.120 120.375 107.884 1.00 83.19  ? 165 PHE A CE1 1 
ATOM 1088 C CE2 . PHE A 1 165 ? 115.306 119.998 108.751 1.00 83.19  ? 165 PHE A CE2 1 
ATOM 1089 C CZ  . PHE A 1 165 ? 114.182 119.530 108.111 1.00 83.19  ? 165 PHE A CZ  1 
ATOM 1090 N N   . LEU A 1 166 ? 114.322 126.704 109.465 1.00 85.48  ? 166 LEU A N   1 
ATOM 1091 C CA  . LEU A 1 166 ? 114.063 127.931 110.212 1.00 85.48  ? 166 LEU A CA  1 
ATOM 1092 C C   . LEU A 1 166 ? 113.089 128.836 109.468 1.00 85.48  ? 166 LEU A C   1 
ATOM 1093 O O   . LEU A 1 166 ? 112.067 129.261 110.022 1.00 85.48  ? 166 LEU A O   1 
ATOM 1094 C CB  . LEU A 1 166 ? 115.380 128.664 110.477 1.00 85.48  ? 166 LEU A CB  1 
ATOM 1095 C CG  . LEU A 1 166 ? 115.371 129.911 111.367 1.00 85.48  ? 166 LEU A CG  1 
ATOM 1096 C CD1 . LEU A 1 166 ? 116.677 130.016 112.127 1.00 85.48  ? 166 LEU A CD1 1 
ATOM 1097 C CD2 . LEU A 1 166 ? 115.139 131.179 110.561 1.00 85.48  ? 166 LEU A CD2 1 
ATOM 1098 N N   . THR A 1 167 ? 113.388 129.137 108.203 1.00 87.36  ? 167 THR A N   1 
ATOM 1099 C CA  . THR A 1 167 ? 112.549 130.077 107.465 1.00 87.36  ? 167 THR A CA  1 
ATOM 1100 C C   . THR A 1 167 ? 111.174 129.487 107.173 1.00 87.36  ? 167 THR A C   1 
ATOM 1101 O O   . THR A 1 167 ? 110.165 130.203 107.218 1.00 87.36  ? 167 THR A O   1 
ATOM 1102 C CB  . THR A 1 167 ? 113.249 130.518 106.178 1.00 87.36  ? 167 THR A CB  1 
ATOM 1103 O OG1 . THR A 1 167 ? 112.491 131.560 105.552 1.00 87.36  ? 167 THR A OG1 1 
ATOM 1104 C CG2 . THR A 1 167 ? 113.418 129.362 105.215 1.00 87.36  ? 167 THR A CG2 1 
ATOM 1105 N N   . GLY A 1 168 ? 111.109 128.184 106.884 1.00 88.65  ? 168 GLY A N   1 
ATOM 1106 C CA  . GLY A 1 168 ? 109.827 127.548 106.668 1.00 88.65  ? 168 GLY A CA  1 
ATOM 1107 C C   . GLY A 1 168 ? 108.964 127.584 107.907 1.00 88.65  ? 168 GLY A C   1 
ATOM 1108 O O   . GLY A 1 168 ? 107.769 127.851 107.828 1.00 88.65  ? 168 GLY A O   1 
ATOM 1109 N N   . ALA A 1 169 ? 109.560 127.339 109.071 1.00 90.81  ? 169 ALA A N   1 
ATOM 1110 C CA  . ALA A 1 169 ? 108.823 127.509 110.313 1.00 90.81  ? 169 ALA A CA  1 
ATOM 1111 C C   . ALA A 1 169 ? 108.311 128.937 110.443 1.00 90.81  ? 169 ALA A C   1 
ATOM 1112 O O   . ALA A 1 169 ? 107.109 129.167 110.643 1.00 90.81  ? 169 ALA A O   1 
ATOM 1113 C CB  . ALA A 1 169 ? 109.721 127.144 111.490 1.00 90.81  ? 169 ALA A CB  1 
ATOM 1114 N N   . PHE A 1 170 ? 109.209 129.909 110.255 1.00 92.21  ? 170 PHE A N   1 
ATOM 1115 C CA  . PHE A 1 170 ? 108.876 131.306 110.511 1.00 92.21  ? 170 PHE A CA  1 
ATOM 1116 C C   . PHE A 1 170 ? 107.724 131.779 109.634 1.00 92.21  ? 170 PHE A C   1 
ATOM 1117 O O   . PHE A 1 170 ? 106.850 132.521 110.097 1.00 92.21  ? 170 PHE A O   1 
ATOM 1118 C CB  . PHE A 1 170 ? 110.108 132.184 110.290 1.00 92.21  ? 170 PHE A CB  1 
ATOM 1119 C CG  . PHE A 1 170 ? 109.873 133.642 110.570 1.00 92.21  ? 170 PHE A CG  1 
ATOM 1120 C CD1 . PHE A 1 170 ? 109.799 134.106 111.872 1.00 92.21  ? 170 PHE A CD1 1 
ATOM 1121 C CD2 . PHE A 1 170 ? 109.722 134.546 109.533 1.00 92.21  ? 170 PHE A CD2 1 
ATOM 1122 C CE1 . PHE A 1 170 ? 109.582 135.446 112.135 1.00 92.21  ? 170 PHE A CE1 1 
ATOM 1123 C CE2 . PHE A 1 170 ? 109.504 135.888 109.790 1.00 92.21  ? 170 PHE A CE2 1 
ATOM 1124 C CZ  . PHE A 1 170 ? 109.433 136.337 111.093 1.00 92.21  ? 170 PHE A CZ  1 
ATOM 1125 N N   . THR A 1 171 ? 107.700 131.368 108.367 1.00 91.75  ? 171 THR A N   1 
ATOM 1126 C CA  . THR A 1 171 ? 106.634 131.849 107.494 1.00 91.75  ? 171 THR A CA  1 
ATOM 1127 C C   . THR A 1 171 ? 105.408 130.936 107.485 1.00 91.75  ? 171 THR A C   1 
ATOM 1128 O O   . THR A 1 171 ? 104.275 131.429 107.428 1.00 91.75  ? 171 THR A O   1 
ATOM 1129 C CB  . THR A 1 171 ? 107.160 132.055 106.068 1.00 91.75  ? 171 THR A CB  1 
ATOM 1130 O OG1 . THR A 1 171 ? 106.121 132.603 105.248 1.00 91.75  ? 171 THR A OG1 1 
ATOM 1131 C CG2 . THR A 1 171 ? 107.648 130.755 105.460 1.00 91.75  ? 171 THR A CG2 1 
ATOM 1132 N N   . LEU A 1 172 ? 105.590 129.614 107.556 1.00 86.15  ? 172 LEU A N   1 
ATOM 1133 C CA  . LEU A 1 172 ? 104.459 128.700 107.542 1.00 86.15  ? 172 LEU A CA  1 
ATOM 1134 C C   . LEU A 1 172 ? 103.630 128.770 108.813 1.00 86.15  ? 172 LEU A C   1 
ATOM 1135 O O   . LEU A 1 172 ? 102.457 128.400 108.772 1.00 86.15  ? 172 LEU A O   1 
ATOM 1136 C CB  . LEU A 1 172 ? 104.929 127.261 107.319 1.00 86.15  ? 172 LEU A CB  1 
ATOM 1137 C CG  . LEU A 1 172 ? 105.107 126.751 105.885 1.00 86.15  ? 172 LEU A CG  1 
ATOM 1138 C CD1 . LEU A 1 172 ? 103.778 126.768 105.155 1.00 86.15  ? 172 LEU A CD1 1 
ATOM 1139 C CD2 . LEU A 1 172 ? 106.141 127.537 105.112 1.00 86.15  ? 172 LEU A CD2 1 
ATOM 1140 N N   . GLY A 1 173 ? 104.183 129.239 109.934 1.00 90.71  ? 173 GLY A N   1 
ATOM 1141 C CA  . GLY A 1 173 ? 103.325 129.477 111.085 1.00 90.71  ? 173 GLY A CA  1 
ATOM 1142 C C   . GLY A 1 173 ? 102.232 130.483 110.775 1.00 90.71  ? 173 GLY A C   1 
ATOM 1143 O O   . GLY A 1 173 ? 101.039 130.222 110.983 1.00 90.71  ? 173 GLY A O   1 
ATOM 1144 N N   . TYR A 1 174 ? 102.624 131.634 110.225 1.00 95.53  ? 174 TYR A N   1 
ATOM 1145 C CA  . TYR A 1 174 ? 101.648 132.634 109.812 1.00 95.53  ? 174 TYR A CA  1 
ATOM 1146 C C   . TYR A 1 174 ? 100.776 132.115 108.678 1.00 95.53  ? 174 TYR A C   1 
ATOM 1147 O O   . TYR A 1 174 ? 99.582  132.426 108.618 1.00 95.53  ? 174 TYR A O   1 
ATOM 1148 C CB  . TYR A 1 174 ? 102.360 133.919 109.398 1.00 95.53  ? 174 TYR A CB  1 
ATOM 1149 C CG  . TYR A 1 174 ? 101.430 135.035 108.993 1.00 95.53  ? 174 TYR A CG  1 
ATOM 1150 C CD1 . TYR A 1 174 ? 100.972 135.147 107.688 1.00 95.53  ? 174 TYR A CD1 1 
ATOM 1151 C CD2 . TYR A 1 174 ? 101.006 135.974 109.918 1.00 95.53  ? 174 TYR A CD2 1 
ATOM 1152 C CE1 . TYR A 1 174 ? 100.122 136.164 107.317 1.00 95.53  ? 174 TYR A CE1 1 
ATOM 1153 C CE2 . TYR A 1 174 ? 100.156 136.996 109.555 1.00 95.53  ? 174 TYR A CE2 1 
ATOM 1154 C CZ  . TYR A 1 174 ? 99.717  137.086 108.254 1.00 95.53  ? 174 TYR A CZ  1 
ATOM 1155 O OH  . TYR A 1 174 ? 98.869  138.103 107.887 1.00 95.53  ? 174 TYR A OH  1 
ATOM 1156 N N   . ALA A 1 175 ? 101.356 131.341 107.759 1.00 93.33  ? 175 ALA A N   1 
ATOM 1157 C CA  . ALA A 1 175 ? 100.566 130.798 106.659 1.00 93.33  ? 175 ALA A CA  1 
ATOM 1158 C C   . ALA A 1 175 ? 99.453  129.893 107.171 1.00 93.33  ? 175 ALA A C   1 
ATOM 1159 O O   . ALA A 1 175 ? 98.316  129.964 106.693 1.00 93.33  ? 175 ALA A O   1 
ATOM 1160 C CB  . ALA A 1 175 ? 101.467 130.040 105.687 1.00 93.33  ? 175 ALA A CB  1 
ATOM 1161 N N   . ALA A 1 176 ? 99.759  129.039 108.149 1.00 91.18  ? 176 ALA A N   1 
ATOM 1162 C CA  . ALA A 1 176 ? 98.774  128.103 108.671 1.00 91.18  ? 176 ALA A CA  1 
ATOM 1163 C C   . ALA A 1 176 ? 97.797  128.761 109.631 1.00 91.18  ? 176 ALA A C   1 
ATOM 1164 O O   . ALA A 1 176 ? 96.714  128.217 109.866 1.00 91.18  ? 176 ALA A O   1 
ATOM 1165 C CB  . ALA A 1 176 ? 99.473  126.930 109.355 1.00 91.18  ? 176 ALA A CB  1 
ATOM 1166 N N   . ASP A 1 177 ? 98.152  129.909 110.210 1.00 95.75  ? 177 ASP A N   1 
ATOM 1167 C CA  . ASP A 1 177 ? 97.170  130.600 111.041 1.00 95.75  ? 177 ASP A CA  1 
ATOM 1168 C C   . ASP A 1 177 ? 96.259  131.505 110.217 1.00 95.75  ? 177 ASP A C   1 
ATOM 1169 O O   . ASP A 1 177 ? 95.088  131.688 110.565 1.00 95.75  ? 177 ASP A O   1 
ATOM 1170 C CB  . ASP A 1 177 ? 97.865  131.381 112.150 1.00 95.75  ? 177 ASP A CB  1 
ATOM 1171 C CG  . ASP A 1 177 ? 98.492  130.473 113.176 1.00 95.75  ? 177 ASP A CG  1 
ATOM 1172 O OD1 . ASP A 1 177 ? 97.970  129.356 113.371 1.00 95.75  ? 177 ASP A OD1 1 
ATOM 1173 O OD2 . ASP A 1 177 ? 99.493  130.867 113.796 1.00 95.75  ? 177 ASP A OD2 1 
ATOM 1174 N N   . ARG A 1 178 ? 96.772  132.099 109.139 1.00 96.19  ? 178 ARG A N   1 
ATOM 1175 C CA  . ARG A 1 178 ? 95.926  132.941 108.298 1.00 96.19  ? 178 ARG A CA  1 
ATOM 1176 C C   . ARG A 1 178 ? 94.835  132.116 107.623 1.00 96.19  ? 178 ARG A C   1 
ATOM 1177 O O   . ARG A 1 178 ? 93.647  132.444 107.713 1.00 96.19  ? 178 ARG A O   1 
ATOM 1178 C CB  . ARG A 1 178 ? 96.785  133.679 107.270 1.00 96.19  ? 178 ARG A CB  1 
ATOM 1179 C CG  . ARG A 1 178 ? 96.087  134.014 105.966 1.00 96.19  ? 178 ARG A CG  1 
ATOM 1180 C CD  . ARG A 1 178 ? 95.100  135.156 106.107 1.00 96.19  ? 178 ARG A CD  1 
ATOM 1181 N NE  . ARG A 1 178 ? 95.770  136.448 106.180 1.00 96.19  ? 178 ARG A NE  1 
ATOM 1182 C CZ  . ARG A 1 178 ? 96.190  137.133 105.125 1.00 96.19  ? 178 ARG A CZ  1 
ATOM 1183 N NH1 . ARG A 1 178 ? 96.032  136.673 103.896 1.00 96.19  ? 178 ARG A NH1 1 
ATOM 1184 N NH2 . ARG A 1 178 ? 96.783  138.309 105.309 1.00 96.19  ? 178 ARG A NH2 1 
ATOM 1185 N N   . TYR A 1 179 ? 95.219  131.034 106.954 1.00 93.68  ? 179 TYR A N   1 
ATOM 1186 C CA  . TYR A 1 179 ? 94.268  130.053 106.454 1.00 93.68  ? 179 TYR A CA  1 
ATOM 1187 C C   . TYR A 1 179 ? 94.007  129.010 107.538 1.00 93.68  ? 179 TYR A C   1 
ATOM 1188 O O   . TYR A 1 179 ? 94.369  129.188 108.704 1.00 93.68  ? 179 TYR A O   1 
ATOM 1189 C CB  . TYR A 1 179 ? 94.769  129.403 105.163 1.00 93.68  ? 179 TYR A CB  1 
ATOM 1190 C CG  . TYR A 1 179 ? 95.306  130.344 104.104 1.00 93.68  ? 179 TYR A CG  1 
ATOM 1191 C CD1 . TYR A 1 179 ? 94.820  131.638 103.977 1.00 93.68  ? 179 TYR A CD1 1 
ATOM 1192 C CD2 . TYR A 1 179 ? 96.301  129.933 103.228 1.00 93.68  ? 179 TYR A CD2 1 
ATOM 1193 C CE1 . TYR A 1 179 ? 95.309  132.493 103.006 1.00 93.68  ? 179 TYR A CE1 1 
ATOM 1194 C CE2 . TYR A 1 179 ? 96.797  130.780 102.259 1.00 93.68  ? 179 TYR A CE2 1 
ATOM 1195 C CZ  . TYR A 1 179 ? 96.298  132.059 102.153 1.00 93.68  ? 179 TYR A CZ  1 
ATOM 1196 O OH  . TYR A 1 179 ? 96.790  132.906 101.188 1.00 93.68  ? 179 TYR A OH  1 
ATOM 1197 N N   . GLY A 1 180 ? 93.361  127.911 107.165 1.00 89.39  ? 180 GLY A N   1 
ATOM 1198 C CA  . GLY A 1 180 ? 93.150  126.824 108.094 1.00 89.39  ? 180 GLY A CA  1 
ATOM 1199 C C   . GLY A 1 180 ? 94.361  125.923 108.214 1.00 89.39  ? 180 GLY A C   1 
ATOM 1200 O O   . GLY A 1 180 ? 95.342  126.043 107.483 1.00 89.39  ? 180 GLY A O   1 
ATOM 1201 N N   . ARG A 1 181 ? 94.284  124.998 109.171 1.00 89.33  ? 181 ARG A N   1 
ATOM 1202 C CA  . ARG A 1 181 ? 95.383  124.059 109.365 1.00 89.33  ? 181 ARG A CA  1 
ATOM 1203 C C   . ARG A 1 181 ? 95.452  123.042 108.234 1.00 89.33  ? 181 ARG A C   1 
ATOM 1204 O O   . ARG A 1 181 ? 96.543  122.713 107.755 1.00 89.33  ? 181 ARG A O   1 
ATOM 1205 C CB  . ARG A 1 181 ? 95.244  123.349 110.709 1.00 89.33  ? 181 ARG A CB  1 
ATOM 1206 C CG  . ARG A 1 181 ? 95.814  124.112 111.887 1.00 89.33  ? 181 ARG A CG  1 
ATOM 1207 C CD  . ARG A 1 181 ? 94.770  125.024 112.496 1.00 89.33  ? 181 ARG A CD  1 
ATOM 1208 N NE  . ARG A 1 181 ? 95.124  125.449 113.844 1.00 89.33  ? 181 ARG A NE  1 
ATOM 1209 C CZ  . ARG A 1 181 ? 95.753  126.579 114.133 1.00 89.33  ? 181 ARG A CZ  1 
ATOM 1210 N NH1 . ARG A 1 181 ? 96.133  127.420 113.186 1.00 89.33  ? 181 ARG A NH1 1 
ATOM 1211 N NH2 . ARG A 1 181 ? 96.000  126.877 115.405 1.00 89.33  ? 181 ARG A NH2 1 
ATOM 1212 N N   . ILE A 1 182 ? 94.301  122.526 107.794 1.00 86.76  ? 182 ILE A N   1 
ATOM 1213 C CA  . ILE A 1 182 ? 94.316  121.417 106.843 1.00 86.76  ? 182 ILE A CA  1 
ATOM 1214 C C   . ILE A 1 182 ? 94.792  121.879 105.470 1.00 86.76  ? 182 ILE A C   1 
ATOM 1215 O O   . ILE A 1 182 ? 95.507  121.149 104.775 1.00 86.76  ? 182 ILE A O   1 
ATOM 1216 C CB  . ILE A 1 182 ? 92.938  120.731 106.776 1.00 86.76  ? 182 ILE A CB  1 
ATOM 1217 C CG1 . ILE A 1 182 ? 93.079  119.329 106.188 1.00 86.76  ? 182 ILE A CG1 1 
ATOM 1218 C CG2 . ILE A 1 182 ? 91.947  121.534 105.948 1.00 86.76  ? 182 ILE A CG2 1 
ATOM 1219 C CD1 . ILE A 1 182 ? 93.913  118.404 107.032 1.00 86.76  ? 182 ILE A CD1 1 
ATOM 1220 N N   . VAL A 1 183 ? 94.411  123.088 105.051 1.00 83.61  ? 183 VAL A N   1 
ATOM 1221 C CA  . VAL A 1 183 ? 94.815  123.554 103.728 1.00 83.61  ? 183 VAL A CA  1 
ATOM 1222 C C   . VAL A 1 183 ? 96.327  123.730 103.663 1.00 83.61  ? 183 VAL A C   1 
ATOM 1223 O O   . VAL A 1 183 ? 96.974  123.301 102.699 1.00 83.61  ? 183 VAL A O   1 
ATOM 1224 C CB  . VAL A 1 183 ? 94.061  124.846 103.358 1.00 83.61  ? 183 VAL A CB  1 
ATOM 1225 C CG1 . VAL A 1 183 ? 92.581  124.558 103.215 1.00 83.61  ? 183 VAL A CG1 1 
ATOM 1226 C CG2 . VAL A 1 183 ? 94.271  125.918 104.407 1.00 83.61  ? 183 VAL A CG2 1 
ATOM 1227 N N   . ILE A 1 184 ? 96.916  124.334 104.695 1.00 84.05  ? 184 ILE A N   1 
ATOM 1228 C CA  . ILE A 1 184 ? 98.361  124.521 104.725 1.00 84.05  ? 184 ILE A CA  1 
ATOM 1229 C C   . ILE A 1 184 ? 99.072  123.187 104.885 1.00 84.05  ? 184 ILE A C   1 
ATOM 1230 O O   . ILE A 1 184 ? 100.129 122.962 104.289 1.00 84.05  ? 184 ILE A O   1 
ATOM 1231 C CB  . ILE A 1 184 ? 98.741  125.516 105.833 1.00 84.05  ? 184 ILE A CB  1 
ATOM 1232 C CG1 . ILE A 1 184 ? 98.100  126.867 105.533 1.00 84.05  ? 184 ILE A CG1 1 
ATOM 1233 C CG2 . ILE A 1 184 ? 100.244 125.650 105.944 1.00 84.05  ? 184 ILE A CG2 1 
ATOM 1234 C CD1 . ILE A 1 184 ? 98.565  127.468 104.234 1.00 84.05  ? 184 ILE A CD1 1 
ATOM 1235 N N   . TYR A 1 185 ? 98.504  122.278 105.677 1.00 84.28  ? 185 TYR A N   1 
ATOM 1236 C CA  . TYR A 1 185 ? 99.060  120.934 105.780 1.00 84.28  ? 185 TYR A CA  1 
ATOM 1237 C C   . TYR A 1 185 ? 99.131  120.258 104.416 1.00 84.28  ? 185 TYR A C   1 
ATOM 1238 O O   . TYR A 1 185 ? 100.168 119.705 104.034 1.00 84.28  ? 185 TYR A O   1 
ATOM 1239 C CB  . TYR A 1 185 ? 98.225  120.099 106.748 1.00 84.28  ? 185 TYR A CB  1 
ATOM 1240 C CG  . TYR A 1 185 ? 98.659  118.659 106.808 1.00 84.28  ? 185 TYR A CG  1 
ATOM 1241 C CD1 . TYR A 1 185 ? 99.797  118.281 107.499 1.00 84.28  ? 185 TYR A CD1 1 
ATOM 1242 C CD2 . TYR A 1 185 ? 97.937  117.678 106.150 1.00 84.28  ? 185 TYR A CD2 1 
ATOM 1243 C CE1 . TYR A 1 185 ? 100.196 116.964 107.540 1.00 84.28  ? 185 TYR A CE1 1 
ATOM 1244 C CE2 . TYR A 1 185 ? 98.326  116.365 106.184 1.00 84.28  ? 185 TYR A CE2 1 
ATOM 1245 C CZ  . TYR A 1 185 ? 99.455  116.012 106.880 1.00 84.28  ? 185 TYR A CZ  1 
ATOM 1246 O OH  . TYR A 1 185 ? 99.836  114.696 106.909 1.00 84.28  ? 185 TYR A OH  1 
ATOM 1247 N N   . LEU A 1 186 ? 98.029  120.299 103.666 1.00 84.32  ? 186 LEU A N   1 
ATOM 1248 C CA  . LEU A 1 186 ? 97.989  119.643 102.364 1.00 84.32  ? 186 LEU A CA  1 
ATOM 1249 C C   . LEU A 1 186 ? 98.939  120.310 101.376 1.00 84.32  ? 186 LEU A C   1 
ATOM 1250 O O   . LEU A 1 186 ? 99.647  119.626 100.623 1.00 84.32  ? 186 LEU A O   1 
ATOM 1251 C CB  . LEU A 1 186 ? 96.559  119.648 101.825 1.00 84.32  ? 186 LEU A CB  1 
ATOM 1252 C CG  . LEU A 1 186 ? 95.669  118.450 102.166 1.00 84.32  ? 186 LEU A CG  1 
ATOM 1253 C CD1 . LEU A 1 186 ? 96.209  117.209 101.508 1.00 84.32  ? 186 LEU A CD1 1 
ATOM 1254 C CD2 . LEU A 1 186 ? 95.539  118.234 103.659 1.00 84.32  ? 186 LEU A CD2 1 
ATOM 1255 N N   . LEU A 1 187 ? 98.967  121.646 101.365 1.00 79.17  ? 187 LEU A N   1 
ATOM 1256 C CA  . LEU A 1 187 ? 99.864  122.359 100.463 1.00 79.17  ? 187 LEU A CA  1 
ATOM 1257 C C   . LEU A 1 187 ? 101.319 122.052 100.783 1.00 79.17  ? 187 LEU A C   1 
ATOM 1258 O O   . LEU A 1 187 ? 102.134 121.858 99.875  1.00 79.17  ? 187 LEU A O   1 
ATOM 1259 C CB  . LEU A 1 187 ? 99.601  123.861 100.542 1.00 79.17  ? 187 LEU A CB  1 
ATOM 1260 C CG  . LEU A 1 187 ? 98.317  124.359 99.879  1.00 79.17  ? 187 LEU A CG  1 
ATOM 1261 C CD1 . LEU A 1 187 ? 98.339  125.870 99.739  1.00 79.17  ? 187 LEU A CD1 1 
ATOM 1262 C CD2 . LEU A 1 187 ? 98.123  123.696 98.527  1.00 79.17  ? 187 LEU A CD2 1 
ATOM 1263 N N   . SER A 1 188 ? 101.662 121.999 102.071 1.00 81.92  ? 188 SER A N   1 
ATOM 1264 C CA  . SER A 1 188 ? 103.027 121.682 102.465 1.00 81.92  ? 188 SER A CA  1 
ATOM 1265 C C   . SER A 1 188 ? 103.382 120.245 102.112 1.00 81.92  ? 188 SER A C   1 
ATOM 1266 O O   . SER A 1 188 ? 104.519 119.964 101.728 1.00 81.92  ? 188 SER A O   1 
ATOM 1267 C CB  . SER A 1 188 ? 103.209 121.936 103.958 1.00 81.92  ? 188 SER A CB  1 
ATOM 1268 O OG  . SER A 1 188 ? 103.083 123.315 104.253 1.00 81.92  ? 188 SER A OG  1 
ATOM 1269 N N   . CYS A 1 189 ? 102.427 119.321 102.235 1.00 83.80  ? 189 CYS A N   1 
ATOM 1270 C CA  . CYS A 1 189 ? 102.685 117.948 101.810 1.00 83.80  ? 189 CYS A CA  1 
ATOM 1271 C C   . CYS A 1 189 ? 102.982 117.883 100.317 1.00 83.80  ? 189 CYS A C   1 
ATOM 1272 O O   . CYS A 1 189 ? 103.940 117.222 99.889  1.00 83.80  ? 189 CYS A O   1 
ATOM 1273 C CB  . CYS A 1 189 ? 101.493 117.061 102.160 1.00 83.80  ? 189 CYS A CB  1 
ATOM 1274 S SG  . CYS A 1 189 ? 101.466 116.486 103.871 1.00 83.80  ? 189 CYS A SG  1 
ATOM 1275 N N   . LEU A 1 190 ? 102.178 118.578 99.508  1.00 80.19  ? 190 LEU A N   1 
ATOM 1276 C CA  . LEU A 1 190 ? 102.427 118.609 98.069  1.00 80.19  ? 190 LEU A CA  1 
ATOM 1277 C C   . LEU A 1 190 ? 103.782 119.231 97.758  1.00 80.19  ? 190 LEU A C   1 
ATOM 1278 O O   . LEU A 1 190 ? 104.527 118.730 96.904  1.00 80.19  ? 190 LEU A O   1 
ATOM 1279 C CB  . LEU A 1 190 ? 101.314 119.379 97.362  1.00 80.19  ? 190 LEU A CB  1 
ATOM 1280 C CG  . LEU A 1 190 ? 101.517 119.654 95.872  1.00 80.19  ? 190 LEU A CG  1 
ATOM 1281 C CD1 . LEU A 1 190 ? 101.603 118.355 95.089  1.00 80.19  ? 190 LEU A CD1 1 
ATOM 1282 C CD2 . LEU A 1 190 ? 100.401 120.534 95.340  1.00 80.19  ? 190 LEU A CD2 1 
ATOM 1283 N N   . GLY A 1 191 ? 104.112 120.330 98.438  1.00 75.29  ? 191 GLY A N   1 
ATOM 1284 C CA  . GLY A 1 191 ? 105.395 120.970 98.215  1.00 75.29  ? 191 GLY A CA  1 
ATOM 1285 C C   . GLY A 1 191 ? 106.562 120.074 98.575  1.00 75.29  ? 191 GLY A C   1 
ATOM 1286 O O   . GLY A 1 191 ? 107.544 119.994 97.836  1.00 75.29  ? 191 GLY A O   1 
ATOM 1287 N N   . VAL A 1 192 ? 106.467 119.380 99.710  1.00 76.99  ? 192 VAL A N   1 
ATOM 1288 C CA  . VAL A 1 192 ? 107.524 118.456 100.104 1.00 76.99  ? 192 VAL A CA  1 
ATOM 1289 C C   . VAL A 1 192 ? 107.695 117.379 99.048  1.00 76.99  ? 192 VAL A C   1 
ATOM 1290 O O   . VAL A 1 192 ? 108.816 117.065 98.635  1.00 76.99  ? 192 VAL A O   1 
ATOM 1291 C CB  . VAL A 1 192 ? 107.223 117.843 101.482 1.00 76.99  ? 192 VAL A CB  1 
ATOM 1292 C CG1 . VAL A 1 192 ? 108.128 116.652 101.736 1.00 76.99  ? 192 VAL A CG1 1 
ATOM 1293 C CG2 . VAL A 1 192 ? 107.407 118.875 102.562 1.00 76.99  ? 192 VAL A CG2 1 
ATOM 1294 N N   . GLY A 1 193 ? 106.582 116.814 98.575  1.00 78.46  ? 193 GLY A N   1 
ATOM 1295 C CA  . GLY A 1 193 ? 106.681 115.774 97.564  1.00 78.46  ? 193 GLY A CA  1 
ATOM 1296 C C   . GLY A 1 193 ? 107.358 116.257 96.295  1.00 78.46  ? 193 GLY A C   1 
ATOM 1297 O O   . GLY A 1 193 ? 108.298 115.627 95.795  1.00 78.46  ? 193 GLY A O   1 
ATOM 1298 N N   . VAL A 1 194 ? 106.916 117.405 95.776  1.00 75.04  ? 194 VAL A N   1 
ATOM 1299 C CA  . VAL A 1 194 ? 107.435 117.861 94.489  1.00 75.04  ? 194 VAL A CA  1 
ATOM 1300 C C   . VAL A 1 194 ? 108.889 118.309 94.614  1.00 75.04  ? 194 VAL A C   1 
ATOM 1301 O O   . VAL A 1 194 ? 109.718 118.011 93.744  1.00 75.04  ? 194 VAL A O   1 
ATOM 1302 C CB  . VAL A 1 194 ? 106.533 118.962 93.897  1.00 75.04  ? 194 VAL A CB  1 
ATOM 1303 C CG1 . VAL A 1 194 ? 106.519 120.204 94.773  1.00 75.04  ? 194 VAL A CG1 1 
ATOM 1304 C CG2 . VAL A 1 194 ? 106.978 119.300 92.485  1.00 75.04  ? 194 VAL A CG2 1 
ATOM 1305 N N   . THR A 1 195 ? 109.236 119.008 95.701  1.00 73.52  ? 195 THR A N   1 
ATOM 1306 C CA  . THR A 1 195 ? 110.619 119.433 95.881  1.00 73.52  ? 195 THR A CA  1 
ATOM 1307 C C   . THR A 1 195 ? 111.539 118.245 96.116  1.00 73.52  ? 195 THR A C   1 
ATOM 1308 O O   . THR A 1 195 ? 112.688 118.252 95.666  1.00 73.52  ? 195 THR A O   1 
ATOM 1309 C CB  . THR A 1 195 ? 110.730 120.433 97.030  1.00 73.52  ? 195 THR A CB  1 
ATOM 1310 O OG1 . THR A 1 195 ? 110.298 119.817 98.248  1.00 73.52  ? 195 THR A OG1 1 
ATOM 1311 C CG2 . THR A 1 195 ? 109.904 121.679 96.747  1.00 73.52  ? 195 THR A CG2 1 
ATOM 1312 N N   . GLY A 1 196 ? 111.064 117.215 96.817  1.00 73.77  ? 196 GLY A N   1 
ATOM 1313 C CA  . GLY A 1 196 ? 111.867 116.015 96.965  1.00 73.77  ? 196 GLY A CA  1 
ATOM 1314 C C   . GLY A 1 196 ? 112.102 115.312 95.644  1.00 73.77  ? 196 GLY A C   1 
ATOM 1315 O O   . GLY A 1 196 ? 113.204 114.824 95.379  1.00 73.77  ? 196 GLY A O   1 
ATOM 1316 N N   . VAL A 1 197 ? 111.074 115.255 94.793  1.00 72.77  ? 197 VAL A N   1 
ATOM 1317 C CA  . VAL A 1 197 ? 111.264 114.668 93.469  1.00 72.77  ? 197 VAL A CA  1 
ATOM 1318 C C   . VAL A 1 197 ? 112.279 115.478 92.671  1.00 72.77  ? 197 VAL A C   1 
ATOM 1319 O O   . VAL A 1 197 ? 113.135 114.917 91.977  1.00 72.77  ? 197 VAL A O   1 
ATOM 1320 C CB  . VAL A 1 197 ? 109.921 114.549 92.728  1.00 72.77  ? 197 VAL A CB  1 
ATOM 1321 C CG1 . VAL A 1 197 ? 110.142 114.038 91.316  1.00 72.77  ? 197 VAL A CG1 1 
ATOM 1322 C CG2 . VAL A 1 197 ? 108.989 113.615 93.473  1.00 72.77  ? 197 VAL A CG2 1 
ATOM 1323 N N   . VAL A 1 198 ? 112.205 116.808 92.762  1.00 71.38  ? 198 VAL A N   1 
ATOM 1324 C CA  . VAL A 1 198 ? 113.148 117.657 92.034  1.00 71.38  ? 198 VAL A CA  1 
ATOM 1325 C C   . VAL A 1 198 ? 114.571 117.443 92.540  1.00 71.38  ? 198 VAL A C   1 
ATOM 1326 O O   . VAL A 1 198 ? 115.515 117.319 91.749  1.00 71.38  ? 198 VAL A O   1 
ATOM 1327 C CB  . VAL A 1 198 ? 112.726 119.134 92.136  1.00 71.38  ? 198 VAL A CB  1 
ATOM 1328 C CG1 . VAL A 1 198 ? 113.853 120.035 91.679  1.00 71.38  ? 198 VAL A CG1 1 
ATOM 1329 C CG2 . VAL A 1 198 ? 111.482 119.384 91.306  1.00 71.38  ? 198 VAL A CG2 1 
ATOM 1330 N N   . VAL A 1 199 ? 114.748 117.396 93.863  1.00 74.28  ? 199 VAL A N   1 
ATOM 1331 C CA  . VAL A 1 199 ? 116.072 117.175 94.442  1.00 74.28  ? 199 VAL A CA  1 
ATOM 1332 C C   . VAL A 1 199 ? 116.625 115.825 94.012  1.00 74.28  ? 199 VAL A C   1 
ATOM 1333 O O   . VAL A 1 199 ? 117.815 115.697 93.701  1.00 74.28  ? 199 VAL A O   1 
ATOM 1334 C CB  . VAL A 1 199 ? 116.013 117.298 95.976  1.00 74.28  ? 199 VAL A CB  1 
ATOM 1335 C CG1 . VAL A 1 199 ? 117.297 116.795 96.598  1.00 74.28  ? 199 VAL A CG1 1 
ATOM 1336 C CG2 . VAL A 1 199 ? 115.779 118.738 96.379  1.00 74.28  ? 199 VAL A CG2 1 
ATOM 1337 N N   . ALA A 1 200 ? 115.773 114.798 93.985  1.00 74.11  ? 200 ALA A N   1 
ATOM 1338 C CA  . ALA A 1 200 ? 116.226 113.481 93.551  1.00 74.11  ? 200 ALA A CA  1 
ATOM 1339 C C   . ALA A 1 200 ? 116.754 113.508 92.124  1.00 74.11  ? 200 ALA A C   1 
ATOM 1340 O O   . ALA A 1 200 ? 117.579 112.666 91.752  1.00 74.11  ? 200 ALA A O   1 
ATOM 1341 C CB  . ALA A 1 200 ? 115.089 112.469 93.675  1.00 74.11  ? 200 ALA A CB  1 
ATOM 1342 N N   . PHE A 1 201 ? 116.301 114.465 91.315  1.00 75.93  ? 201 PHE A N   1 
ATOM 1343 C CA  . PHE A 1 201 ? 116.721 114.590 89.925  1.00 75.93  ? 201 PHE A CA  1 
ATOM 1344 C C   . PHE A 1 201 ? 117.401 115.929 89.662  1.00 75.93  ? 201 PHE A C   1 
ATOM 1345 O O   . PHE A 1 201 ? 117.307 116.476 88.562  1.00 75.93  ? 201 PHE A O   1 
ATOM 1346 C CB  . PHE A 1 201 ? 115.531 114.399 88.986  1.00 75.93  ? 201 PHE A CB  1 
ATOM 1347 C CG  . PHE A 1 201 ? 114.956 113.014 89.016  1.00 75.93  ? 201 PHE A CG  1 
ATOM 1348 C CD1 . PHE A 1 201 ? 115.607 111.968 88.388  1.00 75.93  ? 201 PHE A CD1 1 
ATOM 1349 C CD2 . PHE A 1 201 ? 113.771 112.757 89.680  1.00 75.93  ? 201 PHE A CD2 1 
ATOM 1350 C CE1 . PHE A 1 201 ? 115.083 110.693 88.417  1.00 75.93  ? 201 PHE A CE1 1 
ATOM 1351 C CE2 . PHE A 1 201 ? 113.243 111.484 89.712  1.00 75.93  ? 201 PHE A CE2 1 
ATOM 1352 C CZ  . PHE A 1 201 ? 113.900 110.450 89.079  1.00 75.93  ? 201 PHE A CZ  1 
ATOM 1353 N N   . ALA A 1 202 ? 118.085 116.469 90.662  1.00 81.16  ? 202 ALA A N   1 
ATOM 1354 C CA  . ALA A 1 202 ? 118.780 117.739 90.488  1.00 81.16  ? 202 ALA A CA  1 
ATOM 1355 C C   . ALA A 1 202 ? 119.971 117.557 89.554  1.00 81.16  ? 202 ALA A C   1 
ATOM 1356 O O   . ALA A 1 202 ? 120.811 116.682 89.791  1.00 81.16  ? 202 ALA A O   1 
ATOM 1357 C CB  . ALA A 1 202 ? 119.243 118.283 91.835  1.00 81.16  ? 202 ALA A CB  1 
ATOM 1358 N N   . PRO A 1 203 ? 120.080 118.354 88.487  1.00 82.61  ? 203 PRO A N   1 
ATOM 1359 C CA  . PRO A 1 203 ? 121.206 118.163 87.561  1.00 82.61  ? 203 PRO A CA  1 
ATOM 1360 C C   . PRO A 1 203 ? 122.532 118.647 88.115  1.00 82.61  ? 203 PRO A C   1 
ATOM 1361 O O   . PRO A 1 203 ? 123.557 117.983 87.916  1.00 82.61  ? 203 PRO A O   1 
ATOM 1362 C CB  . PRO A 1 203 ? 120.774 118.964 86.327  1.00 82.61  ? 203 PRO A CB  1 
ATOM 1363 C CG  . PRO A 1 203 ? 119.897 120.034 86.875  1.00 82.61  ? 203 PRO A CG  1 
ATOM 1364 C CD  . PRO A 1 203 ? 119.173 119.428 88.048  1.00 82.61  ? 203 PRO A CD  1 
ATOM 1365 N N   . ASN A 1 204 ? 122.549 119.785 88.805  1.00 80.72  ? 204 ASN A N   1 
ATOM 1366 C CA  . ASN A 1 204 ? 123.780 120.373 89.310  1.00 80.72  ? 204 ASN A CA  1 
ATOM 1367 C C   . ASN A 1 204 ? 123.616 120.742 90.777  1.00 80.72  ? 204 ASN A C   1 
ATOM 1368 O O   . ASN A 1 204 ? 122.508 120.768 91.319  1.00 80.72  ? 204 ASN A O   1 
ATOM 1369 C CB  . ASN A 1 204 ? 124.186 121.605 88.494  1.00 80.72  ? 204 ASN A CB  1 
ATOM 1370 C CG  . ASN A 1 204 ? 123.029 122.544 88.249  1.00 80.72  ? 204 ASN A CG  1 
ATOM 1371 O OD1 . ASN A 1 204 ? 122.517 123.169 89.176  1.00 80.72  ? 204 ASN A OD1 1 
ATOM 1372 N ND2 . ASN A 1 204 ? 122.609 122.652 86.996  1.00 80.72  ? 204 ASN A ND2 1 
ATOM 1373 N N   . PHE A 1 205 ? 124.748 121.032 91.415  1.00 78.57  ? 205 PHE A N   1 
ATOM 1374 C CA  . PHE A 1 205 ? 124.756 121.304 92.851  1.00 78.57  ? 205 PHE A CA  1 
ATOM 1375 C C   . PHE A 1 205 ? 123.908 122.503 93.257  1.00 78.57  ? 205 PHE A C   1 
ATOM 1376 O O   . PHE A 1 205 ? 123.188 122.401 94.265  1.00 78.57  ? 205 PHE A O   1 
ATOM 1377 C CB  . PHE A 1 205 ? 126.203 121.464 93.327  1.00 78.57  ? 205 PHE A CB  1 
ATOM 1378 C CG  . PHE A 1 205 ? 126.342 121.590 94.816  1.00 78.57  ? 205 PHE A CG  1 
ATOM 1379 C CD1 . PHE A 1 205 ? 126.230 120.479 95.630  1.00 78.57  ? 205 PHE A CD1 1 
ATOM 1380 C CD2 . PHE A 1 205 ? 126.592 122.819 95.399  1.00 78.57  ? 205 PHE A CD2 1 
ATOM 1381 C CE1 . PHE A 1 205 ? 126.359 120.591 96.998  1.00 78.57  ? 205 PHE A CE1 1 
ATOM 1382 C CE2 . PHE A 1 205 ? 126.723 122.937 96.765  1.00 78.57  ? 205 PHE A CE2 1 
ATOM 1383 C CZ  . PHE A 1 205 ? 126.607 121.822 97.565  1.00 78.57  ? 205 PHE A CZ  1 
ATOM 1384 N N   . PRO A 1 206 ? 123.963 123.660 92.581  1.00 73.30  ? 206 PRO A N   1 
ATOM 1385 C CA  . PRO A 1 206 ? 123.111 124.780 93.022  1.00 73.30  ? 206 PRO A CA  1 
ATOM 1386 C C   . PRO A 1 206 ? 121.626 124.457 93.009  1.00 73.30  ? 206 PRO A C   1 
ATOM 1387 O O   . PRO A 1 206 ? 120.898 124.877 93.918  1.00 73.30  ? 206 PRO A O   1 
ATOM 1388 C CB  . PRO A 1 206 ? 123.459 125.895 92.027  1.00 73.30  ? 206 PRO A CB  1 
ATOM 1389 C CG  . PRO A 1 206 ? 124.816 125.556 91.545  1.00 73.30  ? 206 PRO A CG  1 
ATOM 1390 C CD  . PRO A 1 206 ? 124.854 124.065 91.479  1.00 73.30  ? 206 PRO A CD  1 
ATOM 1391 N N   . VAL A 1 207 ? 121.157 123.713 92.005  1.00 75.75  ? 207 VAL A N   1 
ATOM 1392 C CA  . VAL A 1 207 ? 119.753 123.311 91.968  1.00 75.75  ? 207 VAL A CA  1 
ATOM 1393 C C   . VAL A 1 207 ? 119.431 122.415 93.154  1.00 75.75  ? 207 VAL A C   1 
ATOM 1394 O O   . VAL A 1 207 ? 118.404 122.587 93.824  1.00 75.75  ? 207 VAL A O   1 
ATOM 1395 C CB  . VAL A 1 207 ? 119.432 122.619 90.630  1.00 75.75  ? 207 VAL A CB  1 
ATOM 1396 C CG1 . VAL A 1 207 ? 118.189 121.758 90.759  1.00 75.75  ? 207 VAL A CG1 1 
ATOM 1397 C CG2 . VAL A 1 207 ? 119.253 123.651 89.533  1.00 75.75  ? 207 VAL A CG2 1 
ATOM 1398 N N   . PHE A 1 208 ? 120.308 121.448 93.431  1.00 74.58  ? 208 PHE A N   1 
ATOM 1399 C CA  . PHE A 1 208 ? 120.123 120.577 94.585  1.00 74.58  ? 208 PHE A CA  1 
ATOM 1400 C C   . PHE A 1 208 ? 119.997 121.393 95.861  1.00 74.58  ? 208 PHE A C   1 
ATOM 1401 O O   . PHE A 1 208 ? 119.082 121.175 96.660  1.00 74.58  ? 208 PHE A O   1 
ATOM 1402 C CB  . PHE A 1 208 ? 121.291 119.592 94.681  1.00 74.58  ? 208 PHE A CB  1 
ATOM 1403 C CG  . PHE A 1 208 ? 121.352 118.832 95.979  1.00 74.58  ? 208 PHE A CG  1 
ATOM 1404 C CD1 . PHE A 1 208 ? 122.028 119.342 97.073  1.00 74.58  ? 208 PHE A CD1 1 
ATOM 1405 C CD2 . PHE A 1 208 ? 120.753 117.592 96.095  1.00 74.58  ? 208 PHE A CD2 1 
ATOM 1406 C CE1 . PHE A 1 208 ? 122.084 118.642 98.258  1.00 74.58  ? 208 PHE A CE1 1 
ATOM 1407 C CE2 . PHE A 1 208 ? 120.811 116.885 97.278  1.00 74.58  ? 208 PHE A CE2 1 
ATOM 1408 C CZ  . PHE A 1 208 ? 121.477 117.411 98.359  1.00 74.58  ? 208 PHE A CZ  1 
ATOM 1409 N N   . VAL A 1 209 ? 120.898 122.355 96.058  1.00 75.26  ? 209 VAL A N   1 
ATOM 1410 C CA  . VAL A 1 209 ? 120.905 123.118 97.301  1.00 75.26  ? 209 VAL A CA  1 
ATOM 1411 C C   . VAL A 1 209 ? 119.656 123.983 97.417  1.00 75.26  ? 209 VAL A C   1 
ATOM 1412 O O   . VAL A 1 209 ? 119.020 124.031 98.475  1.00 75.26  ? 209 VAL A O   1 
ATOM 1413 C CB  . VAL A 1 209 ? 122.188 123.957 97.407  1.00 75.26  ? 209 VAL A CB  1 
ATOM 1414 C CG1 . VAL A 1 209 ? 122.030 125.036 98.463  1.00 75.26  ? 209 VAL A CG1 1 
ATOM 1415 C CG2 . VAL A 1 209 ? 123.358 123.064 97.741  1.00 75.26  ? 209 VAL A CG2 1 
ATOM 1416 N N   . ILE A 1 210 ? 119.279 124.675 96.339  1.00 74.17  ? 210 ILE A N   1 
ATOM 1417 C CA  . ILE A 1 210 ? 118.112 125.554 96.399  1.00 74.17  ? 210 ILE A CA  1 
ATOM 1418 C C   . ILE A 1 210 ? 116.850 124.747 96.674  1.00 74.17  ? 210 ILE A C   1 
ATOM 1419 O O   . ILE A 1 210 ? 116.035 125.100 97.538  1.00 74.17  ? 210 ILE A O   1 
ATOM 1420 C CB  . ILE A 1 210 ? 117.982 126.372 95.102  1.00 74.17  ? 210 ILE A CB  1 
ATOM 1421 C CG1 . ILE A 1 210 ? 119.187 127.291 94.923  1.00 74.17  ? 210 ILE A CG1 1 
ATOM 1422 C CG2 . ILE A 1 210 ? 116.704 127.188 95.119  1.00 74.17  ? 210 ILE A CG2 1 
ATOM 1423 C CD1 . ILE A 1 210 ? 119.258 127.929 93.557  1.00 74.17  ? 210 ILE A CD1 1 
ATOM 1424 N N   . PHE A 1 211 ? 116.671 123.639 95.954  1.00 74.69  ? 211 PHE A N   1 
ATOM 1425 C CA  . PHE A 1 211 ? 115.438 122.884 96.120  1.00 74.69  ? 211 PHE A CA  1 
ATOM 1426 C C   . PHE A 1 211 ? 115.425 122.102 97.424  1.00 74.69  ? 211 PHE A C   1 
ATOM 1427 O O   . PHE A 1 211 ? 114.351 121.839 97.967  1.00 74.69  ? 211 PHE A O   1 
ATOM 1428 C CB  . PHE A 1 211 ? 115.220 121.969 94.921  1.00 74.69  ? 211 PHE A CB  1 
ATOM 1429 C CG  . PHE A 1 211 ? 114.603 122.669 93.751  1.00 74.69  ? 211 PHE A CG  1 
ATOM 1430 C CD1 . PHE A 1 211 ? 113.245 122.922 93.722  1.00 74.69  ? 211 PHE A CD1 1 
ATOM 1431 C CD2 . PHE A 1 211 ? 115.382 123.096 92.692  1.00 74.69  ? 211 PHE A CD2 1 
ATOM 1432 C CE1 . PHE A 1 211 ? 112.673 123.574 92.653  1.00 74.69  ? 211 PHE A CE1 1 
ATOM 1433 C CE2 . PHE A 1 211 ? 114.816 123.748 91.620  1.00 74.69  ? 211 PHE A CE2 1 
ATOM 1434 C CZ  . PHE A 1 211 ? 113.459 123.988 91.601  1.00 74.69  ? 211 PHE A CZ  1 
ATOM 1435 N N   . ARG A 1 212 ? 116.590 121.756 97.971  1.00 77.12  ? 212 ARG A N   1 
ATOM 1436 C CA  . ARG A 1 212 ? 116.605 121.125 99.282  1.00 77.12  ? 212 ARG A CA  1 
ATOM 1437 C C   . ARG A 1 212 ? 116.344 122.144 100.382 1.00 77.12  ? 212 ARG A C   1 
ATOM 1438 O O   . ARG A 1 212 ? 115.720 121.816 101.397 1.00 77.12  ? 212 ARG A O   1 
ATOM 1439 C CB  . ARG A 1 212 ? 117.935 120.402 99.484  1.00 77.12  ? 212 ARG A CB  1 
ATOM 1440 C CG  . ARG A 1 212 ? 118.153 119.806 100.850 1.00 77.12  ? 212 ARG A CG  1 
ATOM 1441 C CD  . ARG A 1 212 ? 119.242 118.754 100.749 1.00 77.12  ? 212 ARG A CD  1 
ATOM 1442 N NE  . ARG A 1 212 ? 118.939 117.568 101.540 1.00 77.12  ? 212 ARG A NE  1 
ATOM 1443 C CZ  . ARG A 1 212 ? 119.113 117.475 102.849 1.00 77.12  ? 212 ARG A CZ  1 
ATOM 1444 N NH1 . ARG A 1 212 ? 119.649 118.461 103.546 1.00 77.12  ? 212 ARG A NH1 1 
ATOM 1445 N NH2 . ARG A 1 212 ? 118.750 116.358 103.473 1.00 77.12  ? 212 ARG A NH2 1 
ATOM 1446 N N   . PHE A 1 213 ? 116.775 123.390 100.179 1.00 78.35  ? 213 PHE A N   1 
ATOM 1447 C CA  . PHE A 1 213 ? 116.339 124.482 101.041 1.00 78.35  ? 213 PHE A CA  1 
ATOM 1448 C C   . PHE A 1 213 ? 114.823 124.618 101.015 1.00 78.35  ? 213 PHE A C   1 
ATOM 1449 O O   . PHE A 1 213 ? 114.178 124.749 102.061 1.00 78.35  ? 213 PHE A O   1 
ATOM 1450 C CB  . PHE A 1 213 ? 117.005 125.782 100.592 1.00 78.35  ? 213 PHE A CB  1 
ATOM 1451 C CG  . PHE A 1 213 ? 116.474 127.009 101.268 1.00 78.35  ? 213 PHE A CG  1 
ATOM 1452 C CD1 . PHE A 1 213 ? 116.920 127.374 102.523 1.00 78.35  ? 213 PHE A CD1 1 
ATOM 1453 C CD2 . PHE A 1 213 ? 115.537 127.807 100.640 1.00 78.35  ? 213 PHE A CD2 1 
ATOM 1454 C CE1 . PHE A 1 213 ? 116.435 128.507 103.139 1.00 78.35  ? 213 PHE A CE1 1 
ATOM 1455 C CE2 . PHE A 1 213 ? 115.048 128.938 101.253 1.00 78.35  ? 213 PHE A CE2 1 
ATOM 1456 C CZ  . PHE A 1 213 ? 115.499 129.288 102.502 1.00 78.35  ? 213 PHE A CZ  1 
ATOM 1457 N N   . LEU A 1 214 ? 114.234 124.578 99.819  1.00 76.61  ? 214 LEU A N   1 
ATOM 1458 C CA  . LEU A 1 214 ? 112.780 124.672 99.714  1.00 76.61  ? 214 LEU A CA  1 
ATOM 1459 C C   . LEU A 1 214 ? 112.097 123.479 100.374 1.00 76.61  ? 214 LEU A C   1 
ATOM 1460 O O   . LEU A 1 214 ? 111.044 123.626 101.007 1.00 76.61  ? 214 LEU A O   1 
ATOM 1461 C CB  . LEU A 1 214 ? 112.365 124.789 98.250  1.00 76.61  ? 214 LEU A CB  1 
ATOM 1462 C CG  . LEU A 1 214 ? 112.677 126.137 97.603  1.00 76.61  ? 214 LEU A CG  1 
ATOM 1463 C CD1 . LEU A 1 214 ? 112.280 126.131 96.139  1.00 76.61  ? 214 LEU A CD1 1 
ATOM 1464 C CD2 . LEU A 1 214 ? 111.974 127.255 98.349  1.00 76.61  ? 214 LEU A CD2 1 
ATOM 1465 N N   . GLN A 1 215 ? 112.675 122.286 100.224 1.00 76.98  ? 215 GLN A N   1 
ATOM 1466 C CA  . GLN A 1 215 ? 112.137 121.101 100.882 1.00 76.98  ? 215 GLN A CA  1 
ATOM 1467 C C   . GLN A 1 215 ? 112.158 121.261 102.394 1.00 76.98  ? 215 GLN A C   1 
ATOM 1468 O O   . GLN A 1 215 ? 111.212 120.865 103.083 1.00 76.98  ? 215 GLN A O   1 
ATOM 1469 C CB  . GLN A 1 215 ? 112.932 119.867 100.466 1.00 76.98  ? 215 GLN A CB  1 
ATOM 1470 C CG  . GLN A 1 215 ? 112.331 118.557 100.923 1.00 76.98  ? 215 GLN A CG  1 
ATOM 1471 C CD  . GLN A 1 215 ? 113.139 117.362 100.470 1.00 76.98  ? 215 GLN A CD  1 
ATOM 1472 O OE1 . GLN A 1 215 ? 114.280 117.500 100.034 1.00 76.98  ? 215 GLN A OE1 1 
ATOM 1473 N NE2 . GLN A 1 215 ? 112.546 116.179 100.560 1.00 76.98  ? 215 GLN A NE2 1 
ATOM 1474 N N   . GLY A 1 216 ? 113.238 121.829 102.929 1.00 79.37  ? 216 GLY A N   1 
ATOM 1475 C CA  . GLY A 1 216 ? 113.259 122.155 104.344 1.00 79.37  ? 216 GLY A CA  1 
ATOM 1476 C C   . GLY A 1 216 ? 112.206 123.181 104.715 1.00 79.37  ? 216 GLY A C   1 
ATOM 1477 O O   . GLY A 1 216 ? 111.636 123.132 105.807 1.00 79.37  ? 216 GLY A O   1 
ATOM 1478 N N   . VAL A 1 217 ? 111.942 124.131 103.816 1.00 78.16  ? 217 VAL A N   1 
ATOM 1479 C CA  . VAL A 1 217 ? 110.900 125.128 104.065 1.00 78.16  ? 217 VAL A CA  1 
ATOM 1480 C C   . VAL A 1 217 ? 109.542 124.455 104.213 1.00 78.16  ? 217 VAL A C   1 
ATOM 1481 O O   . VAL A 1 217 ? 108.794 124.719 105.162 1.00 78.16  ? 217 VAL A O   1 
ATOM 1482 C CB  . VAL A 1 217 ? 110.876 126.180 102.942 1.00 78.16  ? 217 VAL A CB  1 
ATOM 1483 C CG1 . VAL A 1 217 ? 109.723 127.143 103.151 1.00 78.16  ? 217 VAL A CG1 1 
ATOM 1484 C CG2 . VAL A 1 217 ? 112.182 126.935 102.895 1.00 78.16  ? 217 VAL A CG2 1 
ATOM 1485 N N   . PHE A 1 218 ? 109.200 123.581 103.267 1.00 77.88  ? 218 PHE A N   1 
ATOM 1486 C CA  . PHE A 1 218 ? 107.899 122.924 103.297 1.00 77.88  ? 218 PHE A CA  1 
ATOM 1487 C C   . PHE A 1 218 ? 107.843 121.798 104.318 1.00 77.88  ? 218 PHE A C   1 
ATOM 1488 O O   . PHE A 1 218 ? 106.779 121.541 104.890 1.00 77.88  ? 218 PHE A O   1 
ATOM 1489 C CB  . PHE A 1 218 ? 107.550 122.394 101.907 1.00 77.88  ? 218 PHE A CB  1 
ATOM 1490 C CG  . PHE A 1 218 ? 107.225 123.471 100.918 1.00 77.88  ? 218 PHE A CG  1 
ATOM 1491 C CD1 . PHE A 1 218 ? 106.491 124.577 101.300 1.00 77.88  ? 218 PHE A CD1 1 
ATOM 1492 C CD2 . PHE A 1 218 ? 107.661 123.382 99.610  1.00 77.88  ? 218 PHE A CD2 1 
ATOM 1493 C CE1 . PHE A 1 218 ? 106.193 125.570 100.396 1.00 77.88  ? 218 PHE A CE1 1 
ATOM 1494 C CE2 . PHE A 1 218 ? 107.366 124.373 98.702  1.00 77.88  ? 218 PHE A CE2 1 
ATOM 1495 C CZ  . PHE A 1 218 ? 106.631 125.469 99.096  1.00 77.88  ? 218 PHE A CZ  1 
ATOM 1496 N N   . GLY A 1 219 ? 108.965 121.118 104.557 1.00 79.05  ? 219 GLY A N   1 
ATOM 1497 C CA  . GLY A 1 219 ? 108.970 120.024 105.513 1.00 79.05  ? 219 GLY A CA  1 
ATOM 1498 C C   . GLY A 1 219 ? 108.624 120.457 106.922 1.00 79.05  ? 219 GLY A C   1 
ATOM 1499 O O   . GLY A 1 219 ? 108.052 119.681 107.690 1.00 79.05  ? 219 GLY A O   1 
ATOM 1500 N N   . LYS A 1 220 ? 108.967 121.692 107.283 1.00 82.84  ? 220 LYS A N   1 
ATOM 1501 C CA  . LYS A 1 220 ? 108.663 122.177 108.623 1.00 82.84  ? 220 LYS A CA  1 
ATOM 1502 C C   . LYS A 1 220 ? 107.173 122.415 108.816 1.00 82.84  ? 220 LYS A C   1 
ATOM 1503 O O   . LYS A 1 220 ? 106.659 122.240 109.926 1.00 82.84  ? 220 LYS A O   1 
ATOM 1504 C CB  . LYS A 1 220 ? 109.438 123.459 108.903 1.00 82.84  ? 220 LYS A CB  1 
ATOM 1505 C CG  . LYS A 1 220 ? 109.458 123.850 110.360 1.00 82.84  ? 220 LYS A CG  1 
ATOM 1506 C CD  . LYS A 1 220 ? 110.393 122.960 111.151 1.00 82.84  ? 220 LYS A CD  1 
ATOM 1507 C CE  . LYS A 1 220 ? 110.655 123.535 112.527 1.00 82.84  ? 220 LYS A CE  1 
ATOM 1508 N NZ  . LYS A 1 220 ? 111.536 122.650 113.336 1.00 82.84  ? 220 LYS A NZ  1 
ATOM 1509 N N   . GLY A 1 221 ? 106.467 122.823 107.761 1.00 78.49  ? 221 GLY A N   1 
ATOM 1510 C CA  . GLY A 1 221 ? 105.047 123.102 107.899 1.00 78.49  ? 221 GLY A CA  1 
ATOM 1511 C C   . GLY A 1 221 ? 104.228 121.863 108.198 1.00 78.49  ? 221 GLY A C   1 
ATOM 1512 O O   . GLY A 1 221 ? 103.305 121.901 109.016 1.00 78.49  ? 221 GLY A O   1 
ATOM 1513 N N   . THR A 1 222 ? 104.553 120.746 107.543 1.00 80.10  ? 222 THR A N   1 
ATOM 1514 C CA  . THR A 1 222 ? 103.768 119.528 107.719 1.00 80.10  ? 222 THR A CA  1 
ATOM 1515 C C   . THR A 1 222 ? 103.784 119.067 109.169 1.00 80.10  ? 222 THR A C   1 
ATOM 1516 O O   . THR A 1 222 ? 102.734 118.769 109.748 1.00 80.10  ? 222 THR A O   1 
ATOM 1517 C CB  . THR A 1 222 ? 104.298 118.418 106.812 1.00 80.10  ? 222 THR A CB  1 
ATOM 1518 O OG1 . THR A 1 222 ? 105.623 118.058 107.220 1.00 80.10  ? 222 THR A OG1 1 
ATOM 1519 C CG2 . THR A 1 222 ? 104.330 118.875 105.372 1.00 80.10  ? 222 THR A CG2 1 
ATOM 1520 N N   . TRP A 1 223 ? 104.971 119.002 109.772 1.00 81.83  ? 223 TRP A N   1 
ATOM 1521 C CA  . TRP A 1 223 ? 105.087 118.469 111.125 1.00 81.83  ? 223 TRP A CA  1 
ATOM 1522 C C   . TRP A 1 223 ? 104.379 119.361 112.138 1.00 81.83  ? 223 TRP A C   1 
ATOM 1523 O O   . TRP A 1 223 ? 103.619 118.870 112.983 1.00 81.83  ? 223 TRP A O   1 
ATOM 1524 C CB  . TRP A 1 223 ? 106.561 118.292 111.481 1.00 81.83  ? 223 TRP A CB  1 
ATOM 1525 C CG  . TRP A 1 223 ? 106.828 118.052 112.930 1.00 81.83  ? 223 TRP A CG  1 
ATOM 1526 C CD1 . TRP A 1 223 ? 107.185 118.980 113.859 1.00 81.83  ? 223 TRP A CD1 1 
ATOM 1527 C CD2 . TRP A 1 223 ? 106.773 116.797 113.617 1.00 81.83  ? 223 TRP A CD2 1 
ATOM 1528 N NE1 . TRP A 1 223 ? 107.353 118.385 115.083 1.00 81.83  ? 223 TRP A NE1 1 
ATOM 1529 C CE2 . TRP A 1 223 ? 107.103 117.045 114.962 1.00 81.83  ? 223 TRP A CE2 1 
ATOM 1530 C CE3 . TRP A 1 223 ? 106.472 115.491 113.227 1.00 81.83  ? 223 TRP A CE3 1 
ATOM 1531 C CZ2 . TRP A 1 223 ? 107.143 116.036 115.917 1.00 81.83  ? 223 TRP A CZ2 1 
ATOM 1532 C CZ3 . TRP A 1 223 ? 106.513 114.492 114.177 1.00 81.83  ? 223 TRP A CZ3 1 
ATOM 1533 C CH2 . TRP A 1 223 ? 106.845 114.769 115.505 1.00 81.83  ? 223 TRP A CH2 1 
ATOM 1534 N N   . MET A 1 224 ? 104.599 120.673 112.062 1.00 85.05  ? 224 MET A N   1 
ATOM 1535 C CA  . MET A 1 224 ? 103.944 121.574 113.003 1.00 85.05  ? 224 MET A CA  1 
ATOM 1536 C C   . MET A 1 224 ? 102.430 121.545 112.834 1.00 85.05  ? 224 MET A C   1 
ATOM 1537 O O   . MET A 1 224 ? 101.689 121.490 113.825 1.00 85.05  ? 224 MET A O   1 
ATOM 1538 C CB  . MET A 1 224 ? 104.476 122.992 112.824 1.00 85.05  ? 224 MET A CB  1 
ATOM 1539 C CG  . MET A 1 224 ? 105.971 123.109 113.027 1.00 85.05  ? 224 MET A CG  1 
ATOM 1540 S SD  . MET A 1 224 ? 106.443 123.015 114.761 1.00 85.05  ? 224 MET A SD  1 
ATOM 1541 C CE  . MET A 1 224 ? 108.041 122.224 114.630 1.00 85.05  ? 224 MET A CE  1 
ATOM 1542 N N   . THR A 1 225 ? 101.952 121.568 111.587 1.00 86.83  ? 225 THR A N   1 
ATOM 1543 C CA  . THR A 1 225 ? 100.513 121.551 111.354 1.00 86.83  ? 225 THR A CA  1 
ATOM 1544 C C   . THR A 1 225 ? 99.886  120.256 111.849 1.00 86.83  ? 225 THR A C   1 
ATOM 1545 O O   . THR A 1 225 ? 98.819  120.280 112.472 1.00 86.83  ? 225 THR A O   1 
ATOM 1546 C CB  . THR A 1 225 ? 100.213 121.756 109.872 1.00 86.83  ? 225 THR A CB  1 
ATOM 1547 O OG1 . THR A 1 225 ? 101.122 120.975 109.088 1.00 86.83  ? 225 THR A OG1 1 
ATOM 1548 C CG2 . THR A 1 225 ? 100.357 123.220 109.503 1.00 86.83  ? 225 THR A CG2 1 
ATOM 1549 N N   . CYS A 1 226 ? 100.525 119.112 111.581 1.00 85.61  ? 226 CYS A N   1 
ATOM 1550 C CA  . CYS A 1 226 ? 99.944  117.845 112.011 1.00 85.61  ? 226 CYS A CA  1 
ATOM 1551 C C   . CYS A 1 226 ? 99.930  117.745 113.528 1.00 85.61  ? 226 CYS A C   1 
ATOM 1552 O O   . CYS A 1 226 ? 98.947  117.279 114.119 1.00 85.61  ? 226 CYS A O   1 
ATOM 1553 C CB  . CYS A 1 226 ? 100.696 116.662 111.398 1.00 85.61  ? 226 CYS A CB  1 
ATOM 1554 S SG  . CYS A 1 226 ? 102.365 116.364 111.986 1.00 85.61  ? 226 CYS A SG  1 
ATOM 1555 N N   . TYR A 1 227 ? 101.001 118.196 114.182 1.00 85.11  ? 227 TYR A N   1 
ATOM 1556 C CA  . TYR A 1 227 ? 101.012 118.184 115.638 1.00 85.11  ? 227 TYR A CA  1 
ATOM 1557 C C   . TYR A 1 227 ? 99.906  119.066 116.202 1.00 85.11  ? 227 TYR A C   1 
ATOM 1558 O O   . TYR A 1 227 ? 99.188  118.660 117.124 1.00 85.11  ? 227 TYR A O   1 
ATOM 1559 C CB  . TYR A 1 227 ? 102.375 118.633 116.155 1.00 85.11  ? 227 TYR A CB  1 
ATOM 1560 C CG  . TYR A 1 227 ? 102.635 118.242 117.587 1.00 85.11  ? 227 TYR A CG  1 
ATOM 1561 C CD1 . TYR A 1 227 ? 103.183 117.007 117.898 1.00 85.11  ? 227 TYR A CD1 1 
ATOM 1562 C CD2 . TYR A 1 227 ? 102.338 119.108 118.629 1.00 85.11  ? 227 TYR A CD2 1 
ATOM 1563 C CE1 . TYR A 1 227 ? 103.428 116.648 119.202 1.00 85.11  ? 227 TYR A CE1 1 
ATOM 1564 C CE2 . TYR A 1 227 ? 102.577 118.752 119.937 1.00 85.11  ? 227 TYR A CE2 1 
ATOM 1565 C CZ  . TYR A 1 227 ? 103.121 117.520 120.217 1.00 85.11  ? 227 TYR A CZ  1 
ATOM 1566 O OH  . TYR A 1 227 ? 103.364 117.156 121.519 1.00 85.11  ? 227 TYR A OH  1 
ATOM 1567 N N   . VAL A 1 228 ? 99.733  120.266 115.644 1.00 82.68  ? 228 VAL A N   1 
ATOM 1568 C CA  . VAL A 1 228 ? 98.728  121.179 116.178 1.00 82.68  ? 228 VAL A CA  1 
ATOM 1569 C C   . VAL A 1 228 ? 97.322  120.633 115.954 1.00 82.68  ? 228 VAL A C   1 
ATOM 1570 O O   . VAL A 1 228 ? 96.469  120.708 116.845 1.00 82.68  ? 228 VAL A O   1 
ATOM 1571 C CB  . VAL A 1 228 ? 98.900  122.582 115.572 1.00 82.68  ? 228 VAL A CB  1 
ATOM 1572 C CG1 . VAL A 1 228 ? 97.637  123.401 115.766 1.00 82.68  ? 228 VAL A CG1 1 
ATOM 1573 C CG2 . VAL A 1 228 ? 100.086 123.278 116.213 1.00 82.68  ? 228 VAL A CG2 1 
ATOM 1574 N N   . ILE A 1 229 ? 97.051  120.073 114.774 1.00 86.49  ? 229 ILE A N   1 
ATOM 1575 C CA  . ILE A 1 229 ? 95.714  119.545 114.519 1.00 86.49  ? 229 ILE A CA  1 
ATOM 1576 C C   . ILE A 1 229 ? 95.425  118.351 115.423 1.00 86.49  ? 229 ILE A C   1 
ATOM 1577 O O   . ILE A 1 229 ? 94.324  118.233 115.979 1.00 86.49  ? 229 ILE A O   1 
ATOM 1578 C CB  . ILE A 1 229 ? 95.525  119.200 113.028 1.00 86.49  ? 229 ILE A CB  1 
ATOM 1579 C CG1 . ILE A 1 229 ? 94.107  118.703 112.770 1.00 86.49  ? 229 ILE A CG1 1 
ATOM 1580 C CG2 . ILE A 1 229 ? 96.486  118.141 112.560 1.00 86.49  ? 229 ILE A CG2 1 
ATOM 1581 C CD1 . ILE A 1 229 ? 93.865  118.307 111.330 1.00 86.49  ? 229 ILE A CD1 1 
ATOM 1582 N N   . VAL A 1 230 ? 96.400  117.453 115.603 1.00 86.58  ? 230 VAL A N   1 
ATOM 1583 C CA  . VAL A 1 230 ? 96.131  116.272 116.415 1.00 86.58  ? 230 VAL A CA  1 
ATOM 1584 C C   . VAL A 1 230 ? 96.040  116.647 117.888 1.00 86.58  ? 230 VAL A C   1 
ATOM 1585 O O   . VAL A 1 230 ? 95.425  115.925 118.681 1.00 86.58  ? 230 VAL A O   1 
ATOM 1586 C CB  . VAL A 1 230 ? 97.192  115.185 116.163 1.00 86.58  ? 230 VAL A CB  1 
ATOM 1587 C CG1 . VAL A 1 230 ? 98.495  115.523 116.864 1.00 86.58  ? 230 VAL A CG1 1 
ATOM 1588 C CG2 . VAL A 1 230 ? 96.669  113.820 116.577 1.00 86.58  ? 230 VAL A CG2 1 
ATOM 1589 N N   . THR A 1 231 ? 96.640  117.772 118.285 1.00 85.22  ? 231 THR A N   1 
ATOM 1590 C CA  . THR A 1 231 ? 96.440  118.259 119.646 1.00 85.22  ? 231 THR A CA  1 
ATOM 1591 C C   . THR A 1 231 ? 95.074  118.916 119.801 1.00 85.22  ? 231 THR A C   1 
ATOM 1592 O O   . THR A 1 231 ? 94.429  118.786 120.848 1.00 85.22  ? 231 THR A O   1 
ATOM 1593 C CB  . THR A 1 231 ? 97.556  119.236 120.019 1.00 85.22  ? 231 THR A CB  1 
ATOM 1594 O OG1 . THR A 1 231 ? 98.808  118.542 120.045 1.00 85.22  ? 231 THR A OG1 1 
ATOM 1595 C CG2 . THR A 1 231 ? 97.302  119.858 121.381 1.00 85.22  ? 231 THR A CG2 1 
ATOM 1596 N N   . GLU A 1 232 ? 94.611  119.618 118.764 1.00 89.76  ? 232 GLU A N   1 
ATOM 1597 C CA  . GLU A 1 232 ? 93.338  120.327 118.849 1.00 89.76  ? 232 GLU A CA  1 
ATOM 1598 C C   . GLU A 1 232 ? 92.154  119.370 118.837 1.00 89.76  ? 232 GLU A C   1 
ATOM 1599 O O   . GLU A 1 232 ? 91.154  119.604 119.525 1.00 89.76  ? 232 GLU A O   1 
ATOM 1600 C CB  . GLU A 1 232 ? 93.221  121.322 117.696 1.00 89.76  ? 232 GLU A CB  1 
ATOM 1601 C CG  . GLU A 1 232 ? 94.106  122.543 117.824 1.00 89.76  ? 232 GLU A CG  1 
ATOM 1602 C CD  . GLU A 1 232 ? 93.396  123.684 118.508 1.00 89.76  ? 232 GLU A CD  1 
ATOM 1603 O OE1 . GLU A 1 232 ? 92.287  123.451 119.028 1.00 89.76  ? 232 GLU A OE1 1 
ATOM 1604 O OE2 . GLU A 1 232 ? 93.936  124.809 118.519 1.00 89.76  ? 232 GLU A OE2 1 
ATOM 1605 N N   . ILE A 1 233 ? 92.242  118.294 118.052 1.00 89.51  ? 233 ILE A N   1 
ATOM 1606 C CA  . ILE A 1 233 ? 91.082  117.432 117.841 1.00 89.51  ? 233 ILE A CA  1 
ATOM 1607 C C   . ILE A 1 233 ? 90.702  116.676 119.112 1.00 89.51  ? 233 ILE A C   1 
ATOM 1608 O O   . ILE A 1 233 ? 89.531  116.325 119.305 1.00 89.51  ? 233 ILE A O   1 
ATOM 1609 C CB  . ILE A 1 233 ? 91.347  116.478 116.660 1.00 89.51  ? 233 ILE A CB  1 
ATOM 1610 C CG1 . ILE A 1 233 ? 90.051  115.793 116.223 1.00 89.51  ? 233 ILE A CG1 1 
ATOM 1611 C CG2 . ILE A 1 233 ? 92.422  115.460 117.008 1.00 89.51  ? 233 ILE A CG2 1 
ATOM 1612 C CD1 . ILE A 1 233 ? 89.032  116.743 115.636 1.00 89.51  ? 233 ILE A CD1 1 
ATOM 1613 N N   . VAL A 1 234 ? 91.662  116.415 119.994 1.00 95.80  ? 234 VAL A N   1 
ATOM 1614 C CA  . VAL A 1 234 ? 91.419  115.670 121.224 1.00 95.80  ? 234 VAL A CA  1 
ATOM 1615 C C   . VAL A 1 234 ? 91.143  116.649 122.357 1.00 95.80  ? 234 VAL A C   1 
ATOM 1616 O O   . VAL A 1 234 ? 91.592  117.799 122.340 1.00 95.80  ? 234 VAL A O   1 
ATOM 1617 C CB  . VAL A 1 234 ? 92.614  114.747 121.544 1.00 95.80  ? 234 VAL A CB  1 
ATOM 1618 C CG1 . VAL A 1 234 ? 92.248  113.745 122.618 1.00 95.80  ? 234 VAL A CG1 1 
ATOM 1619 C CG2 . VAL A 1 234 ? 93.071  114.027 120.292 1.00 95.80  ? 234 VAL A CG2 1 
ATOM 1620 N N   . GLY A 1 235 ? 90.396  116.190 123.357 1.00 101.48 ? 235 GLY A N   1 
ATOM 1621 C CA  . GLY A 1 235 ? 90.023  117.020 124.481 1.00 101.48 ? 235 GLY A CA  1 
ATOM 1622 C C   . GLY A 1 235 ? 91.159  117.204 125.469 1.00 101.48 ? 235 GLY A C   1 
ATOM 1623 O O   . GLY A 1 235 ? 92.318  116.875 125.212 1.00 101.48 ? 235 GLY A O   1 
ATOM 1624 N N   . SER A 1 236 ? 90.804  117.757 126.632 1.00 102.64 ? 236 SER A N   1 
ATOM 1625 C CA  . SER A 1 236 ? 91.802  118.040 127.659 1.00 102.64 ? 236 SER A CA  1 
ATOM 1626 C C   . SER A 1 236 ? 92.468  116.761 128.153 1.00 102.64 ? 236 SER A C   1 
ATOM 1627 O O   . SER A 1 236 ? 93.692  116.705 128.312 1.00 102.64 ? 236 SER A O   1 
ATOM 1628 C CB  . SER A 1 236 ? 91.155  118.788 128.823 1.00 102.64 ? 236 SER A CB  1 
ATOM 1629 O OG  . SER A 1 236 ? 92.096  119.023 129.855 1.00 102.64 ? 236 SER A OG  1 
ATOM 1630 N N   . LYS A 1 237 ? 91.677  115.723 128.402 1.00 101.80 ? 237 LYS A N   1 
ATOM 1631 C CA  . LYS A 1 237 ? 92.237  114.449 128.819 1.00 101.80 ? 237 LYS A CA  1 
ATOM 1632 C C   . LYS A 1 237 ? 92.929  113.769 127.640 1.00 101.80 ? 237 LYS A C   1 
ATOM 1633 O O   . LYS A 1 237 ? 92.719  114.121 126.475 1.00 101.80 ? 237 LYS A O   1 
ATOM 1634 C CB  . LYS A 1 237 ? 91.140  113.550 129.398 1.00 101.80 ? 237 LYS A CB  1 
ATOM 1635 C CG  . LYS A 1 237 ? 91.640  112.434 130.304 1.00 101.80 ? 237 LYS A CG  1 
ATOM 1636 C CD  . LYS A 1 237 ? 92.257  112.990 131.573 1.00 101.80 ? 237 LYS A CD  1 
ATOM 1637 C CE  . LYS A 1 237 ? 91.236  113.771 132.381 1.00 101.80 ? 237 LYS A CE  1 
ATOM 1638 N NZ  . LYS A 1 237 ? 90.157  112.888 132.900 1.00 101.80 ? 237 LYS A NZ  1 
ATOM 1639 N N   . GLN A 1 238 ? 93.802  112.812 127.968 1.00 96.01  ? 238 GLN A N   1 
ATOM 1640 C CA  . GLN A 1 238 ? 94.524  111.956 127.025 1.00 96.01  ? 238 GLN A CA  1 
ATOM 1641 C C   . GLN A 1 238 ? 95.227  112.733 125.915 1.00 96.01  ? 238 GLN A C   1 
ATOM 1642 O O   . GLN A 1 238 ? 95.608  112.153 124.894 1.00 96.01  ? 238 GLN A O   1 
ATOM 1643 C CB  . GLN A 1 238 ? 93.598  110.887 126.419 1.00 96.01  ? 238 GLN A CB  1 
ATOM 1644 C CG  . GLN A 1 238 ? 92.617  111.339 125.356 1.00 96.01  ? 238 GLN A CG  1 
ATOM 1645 C CD  . GLN A 1 238 ? 91.213  111.503 125.888 1.00 96.01  ? 238 GLN A CD  1 
ATOM 1646 O OE1 . GLN A 1 238 ? 90.987  111.479 127.096 1.00 96.01  ? 238 GLN A OE1 1 
ATOM 1647 N NE2 . GLN A 1 238 ? 90.257  111.664 124.986 1.00 96.01  ? 238 GLN A NE2 1 
ATOM 1648 N N   . ARG A 1 239 ? 95.428  114.037 126.113 1.00 93.27  ? 239 ARG A N   1 
ATOM 1649 C CA  . ARG A 1 239 ? 96.234  114.822 125.185 1.00 93.27  ? 239 ARG A CA  1 
ATOM 1650 C C   . ARG A 1 239 ? 97.711  114.468 125.303 1.00 93.27  ? 239 ARG A C   1 
ATOM 1651 O O   . ARG A 1 239 ? 98.441  114.468 124.301 1.00 93.27  ? 239 ARG A O   1 
ATOM 1652 C CB  . ARG A 1 239 ? 96.001  116.308 125.451 1.00 93.27  ? 239 ARG A CB  1 
ATOM 1653 C CG  . ARG A 1 239 ? 97.019  117.242 124.852 1.00 93.27  ? 239 ARG A CG  1 
ATOM 1654 C CD  . ARG A 1 239 ? 96.552  118.673 125.000 1.00 93.27  ? 239 ARG A CD  1 
ATOM 1655 N NE  . ARG A 1 239 ? 96.789  119.184 126.344 1.00 93.27  ? 239 ARG A NE  1 
ATOM 1656 C CZ  . ARG A 1 239 ? 95.855  119.714 127.121 1.00 93.27  ? 239 ARG A CZ  1 
ATOM 1657 N NH1 . ARG A 1 239 ? 94.595  119.794 126.731 1.00 93.27  ? 239 ARG A NH1 1 
ATOM 1658 N NH2 . ARG A 1 239 ? 96.196  120.178 128.320 1.00 93.27  ? 239 ARG A NH2 1 
ATOM 1659 N N   . ARG A 1 240 ? 98.161  114.161 126.521 1.00 89.19  ? 240 ARG A N   1 
ATOM 1660 C CA  . ARG A 1 240 ? 99.527  113.697 126.727 1.00 89.19  ? 240 ARG A CA  1 
ATOM 1661 C C   . ARG A 1 240 ? 99.805  112.416 125.952 1.00 89.19  ? 240 ARG A C   1 
ATOM 1662 O O   . ARG A 1 240 ? 100.894 112.254 125.390 1.00 89.19  ? 240 ARG A O   1 
ATOM 1663 C CB  . ARG A 1 240 ? 99.789  113.540 128.230 1.00 89.19  ? 240 ARG A CB  1 
ATOM 1664 C CG  . ARG A 1 240 ? 98.865  112.579 128.977 1.00 89.19  ? 240 ARG A CG  1 
ATOM 1665 C CD  . ARG A 1 240 ? 99.326  111.136 128.985 1.00 89.19  ? 240 ARG A CD  1 
ATOM 1666 N NE  . ARG A 1 240 ? 98.465  110.330 129.841 1.00 89.19  ? 240 ARG A NE  1 
ATOM 1667 C CZ  . ARG A 1 240 ? 98.534  109.012 129.954 1.00 89.19  ? 240 ARG A CZ  1 
ATOM 1668 N NH1 . ARG A 1 240 ? 99.422  108.307 129.276 1.00 89.19  ? 240 ARG A NH1 1 
ATOM 1669 N NH2 . ARG A 1 240 ? 97.688  108.386 130.766 1.00 89.19  ? 240 ARG A NH2 1 
ATOM 1670 N N   . ILE A 1 241 ? 98.833  111.503 125.889 1.00 86.20  ? 241 ILE A N   1 
ATOM 1671 C CA  . ILE A 1 241 ? 99.010  110.323 125.047 1.00 86.20  ? 241 ILE A CA  1 
ATOM 1672 C C   . ILE A 1 241 ? 99.204  110.734 123.597 1.00 86.20  ? 241 ILE A C   1 
ATOM 1673 O O   . ILE A 1 241 ? 100.091 110.219 122.908 1.00 86.20  ? 241 ILE A O   1 
ATOM 1674 C CB  . ILE A 1 241 ? 97.838  109.336 125.207 1.00 86.20  ? 241 ILE A CB  1 
ATOM 1675 C CG1 . ILE A 1 241 ? 97.450  109.199 126.679 1.00 86.20  ? 241 ILE A CG1 1 
ATOM 1676 C CG2 . ILE A 1 241 ? 98.188  107.987 124.604 1.00 86.20  ? 241 ILE A CG2 1 
ATOM 1677 C CD1 . ILE A 1 241 ? 96.093  108.597 126.908 1.00 86.20  ? 241 ILE A CD1 1 
ATOM 1678 N N   . VAL A 1 242 ? 98.402  111.686 123.121 1.00 87.46  ? 242 VAL A N   1 
ATOM 1679 C CA  . VAL A 1 242 ? 98.534  112.154 121.743 1.00 87.46  ? 242 VAL A CA  1 
ATOM 1680 C C   . VAL A 1 242 ? 99.956  112.628 121.474 1.00 87.46  ? 242 VAL A C   1 
ATOM 1681 O O   . VAL A 1 242 ? 100.638 112.131 120.565 1.00 87.46  ? 242 VAL A O   1 
ATOM 1682 C CB  . VAL A 1 242 ? 97.512  113.265 121.454 1.00 87.46  ? 242 VAL A CB  1 
ATOM 1683 C CG1 . VAL A 1 242 ? 97.583  113.670 120.006 1.00 87.46  ? 242 VAL A CG1 1 
ATOM 1684 C CG2 . VAL A 1 242 ? 96.116  112.794 121.802 1.00 87.46  ? 242 VAL A CG2 1 
ATOM 1685 N N   . GLY A 1 243 ? 100.423 113.589 122.273 1.00 83.89  ? 243 GLY A N   1 
ATOM 1686 C CA  . GLY A 1 243 ? 101.737 114.163 122.024 1.00 83.89  ? 243 GLY A CA  1 
ATOM 1687 C C   . GLY A 1 243 ? 102.855 113.144 122.136 1.00 83.89  ? 243 GLY A C   1 
ATOM 1688 O O   . GLY A 1 243 ? 103.726 113.055 121.264 1.00 83.89  ? 243 GLY A O   1 
ATOM 1689 N N   . ILE A 1 244 ? 102.842 112.349 123.204 1.00 82.96  ? 244 ILE A N   1 
ATOM 1690 C CA  . ILE A 1 244 ? 103.945 111.424 123.412 1.00 82.96  ? 244 ILE A CA  1 
ATOM 1691 C C   . ILE A 1 244 ? 103.947 110.342 122.342 1.00 82.96  ? 244 ILE A C   1 
ATOM 1692 O O   . ILE A 1 244 ? 105.011 109.907 121.895 1.00 82.96  ? 244 ILE A O   1 
ATOM 1693 C CB  . ILE A 1 244 ? 103.900 110.839 124.833 1.00 82.96  ? 244 ILE A CB  1 
ATOM 1694 C CG1 . ILE A 1 244 ? 103.930 111.968 125.863 1.00 82.96  ? 244 ILE A CG1 1 
ATOM 1695 C CG2 . ILE A 1 244 ? 105.077 109.915 125.061 1.00 82.96  ? 244 ILE A CG2 1 
ATOM 1696 C CD1 . ILE A 1 244 ? 104.956 113.044 125.570 1.00 82.96  ? 244 ILE A CD1 1 
ATOM 1697 N N   . VAL A 1 245 ? 102.769 109.905 121.888 1.00 83.09  ? 245 VAL A N   1 
ATOM 1698 C CA  . VAL A 1 245 ? 102.733 108.849 120.882 1.00 83.09  ? 245 VAL A CA  1 
ATOM 1699 C C   . VAL A 1 245 ? 103.171 109.377 119.520 1.00 83.09  ? 245 VAL A C   1 
ATOM 1700 O O   . VAL A 1 245 ? 103.842 108.670 118.759 1.00 83.09  ? 245 VAL A O   1 
ATOM 1701 C CB  . VAL A 1 245 ? 101.342 108.195 120.832 1.00 83.09  ? 245 VAL A CB  1 
ATOM 1702 C CG1 . VAL A 1 245 ? 101.257 107.230 119.670 1.00 83.09  ? 245 VAL A CG1 1 
ATOM 1703 C CG2 . VAL A 1 245 ? 101.076 107.444 122.123 1.00 83.09  ? 245 VAL A CG2 1 
ATOM 1704 N N   . ILE A 1 246 ? 102.817 110.619 119.176 1.00 82.89  ? 246 ILE A N   1 
ATOM 1705 C CA  . ILE A 1 246 ? 103.309 111.140 117.900 1.00 82.89  ? 246 ILE A CA  1 
ATOM 1706 C C   . ILE A 1 246 ? 104.824 111.338 117.954 1.00 82.89  ? 246 ILE A C   1 
ATOM 1707 O O   . ILE A 1 246 ? 105.534 111.102 116.965 1.00 82.89  ? 246 ILE A O   1 
ATOM 1708 C CB  . ILE A 1 246 ? 102.558 112.422 117.488 1.00 82.89  ? 246 ILE A CB  1 
ATOM 1709 C CG1 . ILE A 1 246 ? 103.176 113.036 116.232 1.00 82.89  ? 246 ILE A CG1 1 
ATOM 1710 C CG2 . ILE A 1 246 ? 102.573 113.443 118.572 1.00 82.89  ? 246 ILE A CG2 1 
ATOM 1711 C CD1 . ILE A 1 246 ? 103.050 112.177 115.013 1.00 82.89  ? 246 ILE A CD1 1 
ATOM 1712 N N   . GLN A 1 247 ? 105.354 111.736 119.117 1.00 84.11  ? 247 GLN A N   1 
ATOM 1713 C CA  . GLN A 1 247 ? 106.809 111.780 119.267 1.00 84.11  ? 247 GLN A CA  1 
ATOM 1714 C C   . GLN A 1 247 ? 107.422 110.389 119.147 1.00 84.11  ? 247 GLN A C   1 
ATOM 1715 O O   . GLN A 1 247 ? 108.504 110.224 118.568 1.00 84.11  ? 247 GLN A O   1 
ATOM 1716 C CB  . GLN A 1 247 ? 107.185 112.410 120.603 1.00 84.11  ? 247 GLN A CB  1 
ATOM 1717 C CG  . GLN A 1 247 ? 106.659 113.809 120.786 1.00 84.11  ? 247 GLN A CG  1 
ATOM 1718 C CD  . GLN A 1 247 ? 107.657 114.853 120.374 1.00 84.11  ? 247 GLN A CD  1 
ATOM 1719 O OE1 . GLN A 1 247 ? 108.781 114.538 119.991 1.00 84.11  ? 247 GLN A OE1 1 
ATOM 1720 N NE2 . GLN A 1 247 ? 107.256 116.109 120.455 1.00 84.11  ? 247 GLN A NE2 1 
ATOM 1721 N N   . MET A 1 248 ? 106.759 109.377 119.710 1.00 87.07  ? 248 MET A N   1 
ATOM 1722 C CA  . MET A 1 248 ? 107.224 108.006 119.539 1.00 87.07  ? 248 MET A CA  1 
ATOM 1723 C C   . MET A 1 248 ? 107.212 107.594 118.078 1.00 87.07  ? 248 MET A C   1 
ATOM 1724 O O   . MET A 1 248 ? 108.059 106.810 117.652 1.00 87.07  ? 248 MET A O   1 
ATOM 1725 C CB  . MET A 1 248 ? 106.372 107.035 120.356 1.00 87.07  ? 248 MET A CB  1 
ATOM 1726 C CG  . MET A 1 248 ? 106.503 107.171 121.858 1.00 87.07  ? 248 MET A CG  1 
ATOM 1727 S SD  . MET A 1 248 ? 105.451 105.983 122.712 1.00 87.07  ? 248 MET A SD  1 
ATOM 1728 C CE  . MET A 1 248 ? 105.733 106.434 124.418 1.00 87.07  ? 248 MET A CE  1 
ATOM 1729 N N   . PHE A 1 249 ? 106.258 108.100 117.299 1.00 86.93  ? 249 PHE A N   1 
ATOM 1730 C CA  . PHE A 1 249 ? 106.248 107.803 115.870 1.00 86.93  ? 249 PHE A CA  1 
ATOM 1731 C C   . PHE A 1 249 ? 107.409 108.489 115.159 1.00 86.93  ? 249 PHE A C   1 
ATOM 1732 O O   . PHE A 1 249 ? 107.996 107.928 114.227 1.00 86.93  ? 249 PHE A O   1 
ATOM 1733 C CB  . PHE A 1 249 ? 104.913 108.212 115.257 1.00 86.93  ? 249 PHE A CB  1 
ATOM 1734 C CG  . PHE A 1 249 ? 103.935 107.080 115.138 1.00 86.93  ? 249 PHE A CG  1 
ATOM 1735 C CD1 . PHE A 1 249 ? 103.937 106.260 114.024 1.00 86.93  ? 249 PHE A CD1 1 
ATOM 1736 C CD2 . PHE A 1 249 ? 103.019 106.831 116.143 1.00 86.93  ? 249 PHE A CD2 1 
ATOM 1737 C CE1 . PHE A 1 249 ? 103.041 105.218 113.913 1.00 86.93  ? 249 PHE A CE1 1 
ATOM 1738 C CE2 . PHE A 1 249 ? 102.118 105.793 116.036 1.00 86.93  ? 249 PHE A CE2 1 
ATOM 1739 C CZ  . PHE A 1 249 ? 102.130 104.984 114.920 1.00 86.93  ? 249 PHE A CZ  1 
ATOM 1740 N N   . PHE A 1 250 ? 107.750 109.705 115.585 1.00 85.11  ? 250 PHE A N   1 
ATOM 1741 C CA  . PHE A 1 250 ? 108.964 110.358 115.093 1.00 85.11  ? 250 PHE A CA  1 
ATOM 1742 C C   . PHE A 1 250 ? 110.194 109.494 115.368 1.00 85.11  ? 250 PHE A C   1 
ATOM 1743 O O   . PHE A 1 250 ? 111.023 109.244 114.477 1.00 85.11  ? 250 PHE A O   1 
ATOM 1744 C CB  . PHE A 1 250 ? 109.096 111.732 115.756 1.00 85.11  ? 250 PHE A CB  1 
ATOM 1745 C CG  . PHE A 1 250 ? 110.252 112.553 115.260 1.00 85.11  ? 250 PHE A CG  1 
ATOM 1746 C CD1 . PHE A 1 250 ? 111.514 112.405 115.808 1.00 85.11  ? 250 PHE A CD1 1 
ATOM 1747 C CD2 . PHE A 1 250 ? 110.069 113.495 114.264 1.00 85.11  ? 250 PHE A CD2 1 
ATOM 1748 C CE1 . PHE A 1 250 ? 112.573 113.166 115.357 1.00 85.11  ? 250 PHE A CE1 1 
ATOM 1749 C CE2 . PHE A 1 250 ? 111.126 114.257 113.812 1.00 85.11  ? 250 PHE A CE2 1 
ATOM 1750 C CZ  . PHE A 1 250 ? 112.378 114.093 114.358 1.00 85.11  ? 250 PHE A CZ  1 
ATOM 1751 N N   . THR A 1 251 ? 110.316 109.016 116.606 1.00 84.48  ? 251 THR A N   1 
ATOM 1752 C CA  . THR A 1 251 ? 111.430 108.144 116.964 1.00 84.48  ? 251 THR A CA  1 
ATOM 1753 C C   . THR A 1 251 ? 111.388 106.841 116.174 1.00 84.48  ? 251 THR A C   1 
ATOM 1754 O O   . THR A 1 251 ? 112.433 106.291 115.813 1.00 84.48  ? 251 THR A O   1 
ATOM 1755 C CB  . THR A 1 251 ? 111.414 107.867 118.466 1.00 84.48  ? 251 THR A CB  1 
ATOM 1756 O OG1 . THR A 1 251 ? 111.589 109.098 119.179 1.00 84.48  ? 251 THR A OG1 1 
ATOM 1757 C CG2 . THR A 1 251 ? 112.522 106.906 118.845 1.00 84.48  ? 251 THR A CG2 1 
ATOM 1758 N N   . LEU A 1 252 ? 110.188 106.330 115.898 1.00 85.63  ? 252 LEU A N   1 
ATOM 1759 C CA  . LEU A 1 252 ? 110.050 105.133 115.077 1.00 85.63  ? 252 LEU A CA  1 
ATOM 1760 C C   . LEU A 1 252 ? 110.568 105.370 113.669 1.00 85.63  ? 252 LEU A C   1 
ATOM 1761 O O   . LEU A 1 252 ? 111.203 104.493 113.075 1.00 85.63  ? 252 LEU A O   1 
ATOM 1762 C CB  . LEU A 1 252 ? 108.590 104.691 115.030 1.00 85.63  ? 252 LEU A CB  1 
ATOM 1763 C CG  . LEU A 1 252 ? 108.334 103.406 114.243 1.00 85.63  ? 252 LEU A CG  1 
ATOM 1764 C CD1 . LEU A 1 252 ? 109.050 102.226 114.877 1.00 85.63  ? 252 LEU A CD1 1 
ATOM 1765 C CD2 . LEU A 1 252 ? 106.845 103.139 114.115 1.00 85.63  ? 252 LEU A CD2 1 
ATOM 1766 N N   . GLY A 1 253 ? 110.276 106.540 113.106 1.00 84.51  ? 253 GLY A N   1 
ATOM 1767 C CA  . GLY A 1 253 ? 110.832 106.876 111.808 1.00 84.51  ? 253 GLY A CA  1 
ATOM 1768 C C   . GLY A 1 253 ? 112.346 106.908 111.833 1.00 84.51  ? 253 GLY A C   1 
ATOM 1769 O O   . GLY A 1 253 ? 113.005 106.390 110.926 1.00 84.51  ? 253 GLY A O   1 
ATOM 1770 N N   . ILE A 1 254 ? 112.917 107.503 112.884 1.00 85.80  ? 254 ILE A N   1 
ATOM 1771 C CA  . ILE A 1 254 ? 114.373 107.493 113.034 1.00 85.80  ? 254 ILE A CA  1 
ATOM 1772 C C   . ILE A 1 254 ? 114.896 106.062 113.110 1.00 85.80  ? 254 ILE A C   1 
ATOM 1773 O O   . ILE A 1 254 ? 115.916 105.723 112.499 1.00 85.80  ? 254 ILE A O   1 
ATOM 1774 C CB  . ILE A 1 254 ? 114.799 108.314 114.265 1.00 85.80  ? 254 ILE A CB  1 
ATOM 1775 C CG1 . ILE A 1 254 ? 114.676 109.810 113.980 1.00 85.80  ? 254 ILE A CG1 1 
ATOM 1776 C CG2 . ILE A 1 254 ? 116.217 107.969 114.676 1.00 85.80  ? 254 ILE A CG2 1 
ATOM 1777 C CD1 . ILE A 1 254 ? 115.024 110.677 115.162 1.00 85.80  ? 254 ILE A CD1 1 
ATOM 1778 N N   . ILE A 1 255 ? 114.205 105.203 113.860 1.00 87.55  ? 255 ILE A N   1 
ATOM 1779 C CA  . ILE A 1 255 ? 114.635 103.817 114.026 1.00 87.55  ? 255 ILE A CA  1 
ATOM 1780 C C   . ILE A 1 255 ? 114.600 103.076 112.698 1.00 87.55  ? 255 ILE A C   1 
ATOM 1781 O O   . ILE A 1 255 ? 115.511 102.305 112.374 1.00 87.55  ? 255 ILE A O   1 
ATOM 1782 C CB  . ILE A 1 255 ? 113.761 103.112 115.080 1.00 87.55  ? 255 ILE A CB  1 
ATOM 1783 C CG1 . ILE A 1 255 ? 114.079 103.632 116.478 1.00 87.55  ? 255 ILE A CG1 1 
ATOM 1784 C CG2 . ILE A 1 255 ? 113.946 101.608 115.016 1.00 87.55  ? 255 ILE A CG2 1 
ATOM 1785 C CD1 . ILE A 1 255 ? 113.092 103.188 117.526 1.00 87.55  ? 255 ILE A CD1 1 
ATOM 1786 N N   . ILE A 1 256 ? 113.542 103.284 111.914 1.00 87.48  ? 256 ILE A N   1 
ATOM 1787 C CA  . ILE A 1 256 ? 113.340 102.486 110.710 1.00 87.48  ? 256 ILE A CA  1 
ATOM 1788 C C   . ILE A 1 256 ? 114.102 103.039 109.511 1.00 87.48  ? 256 ILE A C   1 
ATOM 1789 O O   . ILE A 1 256 ? 114.302 102.312 108.529 1.00 87.48  ? 256 ILE A O   1 
ATOM 1790 C CB  . ILE A 1 256 ? 111.835 102.373 110.408 1.00 87.48  ? 256 ILE A CB  1 
ATOM 1791 C CG1 . ILE A 1 256 ? 111.566 101.299 109.354 1.00 87.48  ? 256 ILE A CG1 1 
ATOM 1792 C CG2 . ILE A 1 256 ? 111.279 103.704 109.962 1.00 87.48  ? 256 ILE A CG2 1 
ATOM 1793 C CD1 . ILE A 1 256 ? 111.898 99.902  109.818 1.00 87.48  ? 256 ILE A CD1 1 
ATOM 1794 N N   . LEU A 1 257 ? 114.551 104.292 109.568 1.00 88.34  ? 257 LEU A N   1 
ATOM 1795 C CA  . LEU A 1 257 ? 115.347 104.849 108.476 1.00 88.34  ? 257 LEU A CA  1 
ATOM 1796 C C   . LEU A 1 257 ? 116.565 104.005 108.105 1.00 88.34  ? 257 LEU A C   1 
ATOM 1797 O O   . LEU A 1 257 ? 116.836 103.867 106.899 1.00 88.34  ? 257 LEU A O   1 
ATOM 1798 C CB  . LEU A 1 257 ? 115.764 106.282 108.837 1.00 88.34  ? 257 LEU A CB  1 
ATOM 1799 C CG  . LEU A 1 257 ? 116.610 107.036 107.815 1.00 88.34  ? 257 LEU A CG  1 
ATOM 1800 C CD1 . LEU A 1 257 ? 115.873 107.140 106.494 1.00 88.34  ? 257 LEU A CD1 1 
ATOM 1801 C CD2 . LEU A 1 257 ? 116.958 108.412 108.348 1.00 88.34  ? 257 LEU A CD2 1 
ATOM 1802 N N   . PRO A 1 258 ? 117.334 103.440 109.044 1.00 88.40  ? 258 PRO A N   1 
ATOM 1803 C CA  . PRO A 1 258 ? 118.403 102.519 108.634 1.00 88.40  ? 258 PRO A CA  1 
ATOM 1804 C C   . PRO A 1 258 ? 117.913 101.343 107.815 1.00 88.40  ? 258 PRO A C   1 
ATOM 1805 O O   . PRO A 1 258 ? 118.654 100.865 106.952 1.00 88.40  ? 258 PRO A O   1 
ATOM 1806 C CB  . PRO A 1 258 ? 118.996 102.056 109.969 1.00 88.40  ? 258 PRO A CB  1 
ATOM 1807 C CG  . PRO A 1 258 ? 118.749 103.167 110.880 1.00 88.40  ? 258 PRO A CG  1 
ATOM 1808 C CD  . PRO A 1 258 ? 117.449 103.788 110.472 1.00 88.40  ? 258 PRO A CD  1 
ATOM 1809 N N   . GLY A 1 259 ? 116.692 100.861 108.049 1.00 89.73  ? 259 GLY A N   1 
ATOM 1810 C CA  . GLY A 1 259 ? 116.203 99.732  107.274 1.00 89.73  ? 259 GLY A CA  1 
ATOM 1811 C C   . GLY A 1 259 ? 116.121 100.035 105.790 1.00 89.73  ? 259 GLY A C   1 
ATOM 1812 O O   . GLY A 1 259 ? 116.687 99.315  104.961 1.00 89.73  ? 259 GLY A O   1 
ATOM 1813 N N   . ILE A 1 260 ? 115.436 101.124 105.436 1.00 88.52  ? 260 ILE A N   1 
ATOM 1814 C CA  . ILE A 1 260 ? 115.333 101.504 104.031 1.00 88.52  ? 260 ILE A CA  1 
ATOM 1815 C C   . ILE A 1 260 ? 116.693 101.926 103.491 1.00 88.52  ? 260 ILE A C   1 
ATOM 1816 O O   . ILE A 1 260 ? 117.033 101.634 102.339 1.00 88.52  ? 260 ILE A O   1 
ATOM 1817 C CB  . ILE A 1 260 ? 114.277 102.610 103.844 1.00 88.52  ? 260 ILE A CB  1 
ATOM 1818 C CG1 . ILE A 1 260 ? 114.458 103.714 104.884 1.00 88.52  ? 260 ILE A CG1 1 
ATOM 1819 C CG2 . ILE A 1 260 ? 112.879 102.028 103.929 1.00 88.52  ? 260 ILE A CG2 1 
ATOM 1820 C CD1 . ILE A 1 260 ? 113.419 104.801 104.807 1.00 88.52  ? 260 ILE A CD1 1 
ATOM 1821 N N   . ALA A 1 261 ? 117.496 102.611 104.312 1.00 90.61  ? 261 ALA A N   1 
ATOM 1822 C CA  . ALA A 1 261 ? 118.811 103.047 103.853 1.00 90.61  ? 261 ALA A CA  1 
ATOM 1823 C C   . ALA A 1 261 ? 119.686 101.859 103.474 1.00 90.61  ? 261 ALA A C   1 
ATOM 1824 O O   . ALA A 1 261 ? 120.395 101.896 102.462 1.00 90.61  ? 261 ALA A O   1 
ATOM 1825 C CB  . ALA A 1 261 ? 119.489 103.892 104.929 1.00 90.61  ? 261 ALA A CB  1 
ATOM 1826 N N   . TYR A 1 262 ? 119.648 100.792 104.273 1.00 94.40  ? 262 TYR A N   1 
ATOM 1827 C CA  . TYR A 1 262 ? 120.453 99.614  103.981 1.00 94.40  ? 262 TYR A CA  1 
ATOM 1828 C C   . TYR A 1 262 ? 119.867 98.814  102.826 1.00 94.40  ? 262 TYR A C   1 
ATOM 1829 O O   . TYR A 1 262 ? 120.610 98.301  101.982 1.00 94.40  ? 262 TYR A O   1 
ATOM 1830 C CB  . TYR A 1 262 ? 120.572 98.746  105.234 1.00 94.40  ? 262 TYR A CB  1 
ATOM 1831 C CG  . TYR A 1 262 ? 121.274 97.426  105.012 1.00 94.40  ? 262 TYR A CG  1 
ATOM 1832 C CD1 . TYR A 1 262 ? 122.466 97.360  104.305 1.00 94.40  ? 262 TYR A CD1 1 
ATOM 1833 C CD2 . TYR A 1 262 ? 120.744 96.246  105.510 1.00 94.40  ? 262 TYR A CD2 1 
ATOM 1834 C CE1 . TYR A 1 262 ? 123.108 96.156  104.099 1.00 94.40  ? 262 TYR A CE1 1 
ATOM 1835 C CE2 . TYR A 1 262 ? 121.379 95.037  105.309 1.00 94.40  ? 262 TYR A CE2 1 
ATOM 1836 C CZ  . TYR A 1 262 ? 122.561 94.998  104.604 1.00 94.40  ? 262 TYR A CZ  1 
ATOM 1837 O OH  . TYR A 1 262 ? 123.199 93.797  104.400 1.00 94.40  ? 262 TYR A OH  1 
ATOM 1838 N N   . PHE A 1 263 ? 118.538 98.694  102.769 1.00 95.96  ? 263 PHE A N   1 
ATOM 1839 C CA  . PHE A 1 263 ? 117.924 97.829  101.766 1.00 95.96  ? 263 PHE A CA  1 
ATOM 1840 C C   . PHE A 1 263 ? 118.136 98.368  100.356 1.00 95.96  ? 263 PHE A C   1 
ATOM 1841 O O   . PHE A 1 263 ? 118.585 97.637  99.465  1.00 95.96  ? 263 PHE A O   1 
ATOM 1842 C CB  . PHE A 1 263 ? 116.437 97.657  102.066 1.00 95.96  ? 263 PHE A CB  1 
ATOM 1843 C CG  . PHE A 1 263 ? 116.158 96.689  103.175 1.00 95.96  ? 263 PHE A CG  1 
ATOM 1844 C CD1 . PHE A 1 263 ? 117.040 95.655  103.441 1.00 95.96  ? 263 PHE A CD1 1 
ATOM 1845 C CD2 . PHE A 1 263 ? 115.025 96.818  103.959 1.00 95.96  ? 263 PHE A CD2 1 
ATOM 1846 C CE1 . PHE A 1 263 ? 116.794 94.765  104.461 1.00 95.96  ? 263 PHE A CE1 1 
ATOM 1847 C CE2 . PHE A 1 263 ? 114.774 95.930  104.983 1.00 95.96  ? 263 PHE A CE2 1 
ATOM 1848 C CZ  . PHE A 1 263 ? 115.660 94.902  105.235 1.00 95.96  ? 263 PHE A CZ  1 
ATOM 1849 N N   . ILE A 1 264 ? 117.826 99.640  100.133 1.00 96.42  ? 264 ILE A N   1 
ATOM 1850 C CA  . ILE A 1 264 ? 118.041 100.285 98.844  1.00 96.42  ? 264 ILE A CA  1 
ATOM 1851 C C   . ILE A 1 264 ? 119.254 101.207 98.977  1.00 96.42  ? 264 ILE A C   1 
ATOM 1852 O O   . ILE A 1 264 ? 119.225 102.173 99.754  1.00 96.42  ? 264 ILE A O   1 
ATOM 1853 C CB  . ILE A 1 264 ? 116.786 101.025 98.354  1.00 96.42  ? 264 ILE A CB  1 
ATOM 1854 C CG1 . ILE A 1 264 ? 116.365 102.148 99.302  1.00 96.42  ? 264 ILE A CG1 1 
ATOM 1855 C CG2 . ILE A 1 264 ? 115.636 100.049 98.171  1.00 96.42  ? 264 ILE A CG2 1 
ATOM 1856 C CD1 . ILE A 1 264 ? 115.287 103.034 98.746  1.00 96.42  ? 264 ILE A CD1 1 
ATOM 1857 N N   . PRO A 1 265 ? 120.354 100.921 98.287  1.00 101.35 ? 265 PRO A N   1 
ATOM 1858 C CA  . PRO A 1 265 ? 121.588 101.680 98.520  1.00 101.35 ? 265 PRO A CA  1 
ATOM 1859 C C   . PRO A 1 265 ? 121.637 102.999 97.769  1.00 101.35 ? 265 PRO A C   1 
ATOM 1860 O O   . PRO A 1 265 ? 122.262 103.960 98.229  1.00 101.35 ? 265 PRO A O   1 
ATOM 1861 C CB  . PRO A 1 265 ? 122.674 100.719 98.026  1.00 101.35 ? 265 PRO A CB  1 
ATOM 1862 C CG  . PRO A 1 265 ? 122.002 99.957  96.931  1.00 101.35 ? 265 PRO A CG  1 
ATOM 1863 C CD  . PRO A 1 265 ? 120.555 99.812  97.338  1.00 101.35 ? 265 PRO A CD  1 
ATOM 1864 N N   . ASN A 1 266 ? 120.980 103.055 96.615  1.00 95.42  ? 266 ASN A N   1 
ATOM 1865 C CA  . ASN A 1 266 ? 121.136 104.188 95.715  1.00 95.42  ? 266 ASN A CA  1 
ATOM 1866 C C   . ASN A 1 266 ? 120.589 105.466 96.340  1.00 95.42  ? 266 ASN A C   1 
ATOM 1867 O O   . ASN A 1 266 ? 119.539 105.460 96.987  1.00 95.42  ? 266 ASN A O   1 
ATOM 1868 C CB  . ASN A 1 266 ? 120.433 103.905 94.389  1.00 95.42  ? 266 ASN A CB  1 
ATOM 1869 C CG  . ASN A 1 266 ? 120.737 104.947 93.341  1.00 95.42  ? 266 ASN A CG  1 
ATOM 1870 O OD1 . ASN A 1 266 ? 120.121 106.010 93.311  1.00 95.42  ? 266 ASN A OD1 1 
ATOM 1871 N ND2 . ASN A 1 266 ? 121.695 104.649 92.472  1.00 95.42  ? 266 ASN A ND2 1 
ATOM 1872 N N   . TRP A 1 267 ? 121.316 106.567 96.140  1.00 91.34  ? 267 TRP A N   1 
ATOM 1873 C CA  . TRP A 1 267 ? 120.879 107.860 96.659  1.00 91.34  ? 267 TRP A CA  1 
ATOM 1874 C C   . TRP A 1 267 ? 119.512 108.244 96.108  1.00 91.34  ? 267 TRP A C   1 
ATOM 1875 O O   . TRP A 1 267 ? 118.612 108.642 96.862  1.00 91.34  ? 267 TRP A O   1 
ATOM 1876 C CB  . TRP A 1 267 ? 121.914 108.930 96.310  1.00 91.34  ? 267 TRP A CB  1 
ATOM 1877 C CG  . TRP A 1 267 ? 121.378 110.332 96.333  1.00 91.34  ? 267 TRP A CG  1 
ATOM 1878 C CD1 . TRP A 1 267 ? 120.540 110.883 97.261  1.00 91.34  ? 267 TRP A CD1 1 
ATOM 1879 C CD2 . TRP A 1 267 ? 121.612 111.349 95.354  1.00 91.34  ? 267 TRP A CD2 1 
ATOM 1880 N NE1 . TRP A 1 267 ? 120.254 112.182 96.928  1.00 91.34  ? 267 TRP A NE1 1 
ATOM 1881 C CE2 . TRP A 1 267 ? 120.899 112.493 95.761  1.00 91.34  ? 267 TRP A CE2 1 
ATOM 1882 C CE3 . TRP A 1 267 ? 122.362 111.406 94.178  1.00 91.34  ? 267 TRP A CE3 1 
ATOM 1883 C CZ2 . TRP A 1 267 ? 120.916 113.678 95.035  1.00 91.34  ? 267 TRP A CZ2 1 
ATOM 1884 C CZ3 . TRP A 1 267 ? 122.377 112.581 93.459  1.00 91.34  ? 267 TRP A CZ3 1 
ATOM 1885 C CH2 . TRP A 1 267 ? 121.659 113.702 93.889  1.00 91.34  ? 267 TRP A CH2 1 
ATOM 1886 N N   . GLN A 1 268 ? 119.342 108.145 94.788  1.00 90.85  ? 268 GLN A N   1 
ATOM 1887 C CA  . GLN A 1 268 ? 118.074 108.529 94.180  1.00 90.85  ? 268 GLN A CA  1 
ATOM 1888 C C   . GLN A 1 268 ? 116.936 107.684 94.728  1.00 90.85  ? 268 GLN A C   1 
ATOM 1889 O O   . GLN A 1 268 ? 115.860 108.206 95.041  1.00 90.85  ? 268 GLN A O   1 
ATOM 1890 C CB  . GLN A 1 268 ? 118.155 108.400 92.660  1.00 90.85  ? 268 GLN A CB  1 
ATOM 1891 C CG  . GLN A 1 268 ? 118.969 109.487 91.982  1.00 90.85  ? 268 GLN A CG  1 
ATOM 1892 C CD  . GLN A 1 268 ? 120.376 109.032 91.649  1.00 90.85  ? 268 GLN A CD  1 
ATOM 1893 O OE1 . GLN A 1 268 ? 121.104 108.546 92.514  1.00 90.85  ? 268 GLN A OE1 1 
ATOM 1894 N NE2 . GLN A 1 268 ? 120.766 109.183 90.389  1.00 90.85  ? 268 GLN A NE2 1 
ATOM 1895 N N   . GLY A 1 269 ? 117.162 106.377 94.867  1.00 85.62  ? 269 GLY A N   1 
ATOM 1896 C CA  . GLY A 1 269 ? 116.140 105.517 95.434  1.00 85.62  ? 269 GLY A CA  1 
ATOM 1897 C C   . GLY A 1 269 ? 115.780 105.896 96.857  1.00 85.62  ? 269 GLY A C   1 
ATOM 1898 O O   . GLY A 1 269 ? 114.604 105.910 97.225  1.00 85.62  ? 269 GLY A O   1 
ATOM 1899 N N   . ILE A 1 270 ? 116.785 106.213 97.675  1.00 87.15  ? 270 ILE A N   1 
ATOM 1900 C CA  . ILE A 1 270 ? 116.524 106.562 99.070  1.00 87.15  ? 270 ILE A CA  1 
ATOM 1901 C C   . ILE A 1 270 ? 115.703 107.841 99.154  1.00 87.15  ? 270 ILE A C   1 
ATOM 1902 O O   . ILE A 1 270 ? 114.705 107.913 99.882  1.00 87.15  ? 270 ILE A O   1 
ATOM 1903 C CB  . ILE A 1 270 ? 117.843 106.686 99.853  1.00 87.15  ? 270 ILE A CB  1 
ATOM 1904 C CG1 . ILE A 1 270 ? 118.477 105.312 100.058 1.00 87.15  ? 270 ILE A CG1 1 
ATOM 1905 C CG2 . ILE A 1 270 ? 117.606 107.353 101.191 1.00 87.15  ? 270 ILE A CG2 1 
ATOM 1906 C CD1 . ILE A 1 270 ? 119.979 105.352 100.209 1.00 87.15  ? 270 ILE A CD1 1 
ATOM 1907 N N   . GLN A 1 271 ? 116.104 108.870 98.402  1.00 81.82  ? 271 GLN A N   1 
ATOM 1908 C CA  . GLN A 1 271 ? 115.362 110.128 98.449  1.00 81.82  ? 271 GLN A CA  1 
ATOM 1909 C C   . GLN A 1 271 ? 113.950 109.956 97.902  1.00 81.82  ? 271 GLN A C   1 
ATOM 1910 O O   . GLN A 1 271 ? 112.990 110.518 98.446  1.00 81.82  ? 271 GLN A O   1 
ATOM 1911 C CB  . GLN A 1 271 ? 116.111 111.216 97.681  1.00 81.82  ? 271 GLN A CB  1 
ATOM 1912 C CG  . GLN A 1 271 ? 115.408 112.568 97.672  1.00 81.82  ? 271 GLN A CG  1 
ATOM 1913 C CD  . GLN A 1 271 ? 115.477 113.295 99.004  1.00 81.82  ? 271 GLN A CD  1 
ATOM 1914 O OE1 . GLN A 1 271 ? 115.920 112.743 100.009 1.00 81.82  ? 271 GLN A OE1 1 
ATOM 1915 N NE2 . GLN A 1 271 ? 115.034 114.545 99.015  1.00 81.82  ? 271 GLN A NE2 1 
ATOM 1916 N N   . LEU A 1 272 ? 113.800 109.174 96.833  1.00 83.13  ? 272 LEU A N   1 
ATOM 1917 C CA  . LEU A 1 272 ? 112.480 108.927 96.270  1.00 83.13  ? 272 LEU A CA  1 
ATOM 1918 C C   . LEU A 1 272 ? 111.585 108.210 97.274  1.00 83.13  ? 272 LEU A C   1 
ATOM 1919 O O   . LEU A 1 272 ? 110.419 108.581 97.459  1.00 83.13  ? 272 LEU A O   1 
ATOM 1920 C CB  . LEU A 1 272 ? 112.628 108.108 94.988  1.00 83.13  ? 272 LEU A CB  1 
ATOM 1921 C CG  . LEU A 1 272 ? 111.549 108.176 93.914  1.00 83.13  ? 272 LEU A CG  1 
ATOM 1922 C CD1 . LEU A 1 272 ? 111.579 109.538 93.247  1.00 83.13  ? 272 LEU A CD1 1 
ATOM 1923 C CD2 . LEU A 1 272 ? 111.747 107.074 92.893  1.00 83.13  ? 272 LEU A CD2 1 
ATOM 1924 N N   . ALA A 1 273 ? 112.117 107.185 97.943  1.00 83.04  ? 273 ALA A N   1 
ATOM 1925 C CA  . ALA A 1 273 ? 111.333 106.457 98.932  1.00 83.04  ? 273 ALA A CA  1 
ATOM 1926 C C   . ALA A 1 273 ? 110.981 107.332 100.125 1.00 83.04  ? 273 ALA A C   1 
ATOM 1927 O O   . ALA A 1 273 ? 109.924 107.145 100.735 1.00 83.04  ? 273 ALA A O   1 
ATOM 1928 C CB  . ALA A 1 273 ? 112.091 105.213 99.390  1.00 83.04  ? 273 ALA A CB  1 
ATOM 1929 N N   . ILE A 1 274 ? 111.851 108.278 100.482 1.00 83.92  ? 274 ILE A N   1 
ATOM 1930 C CA  . ILE A 1 274 ? 111.524 109.191 101.572 1.00 83.92  ? 274 ILE A CA  1 
ATOM 1931 C C   . ILE A 1 274 ? 110.408 110.144 101.161 1.00 83.92  ? 274 ILE A C   1 
ATOM 1932 O O   . ILE A 1 274 ? 109.499 110.430 101.950 1.00 83.92  ? 274 ILE A O   1 
ATOM 1933 C CB  . ILE A 1 274 ? 112.776 109.959 102.029 1.00 83.92  ? 274 ILE A CB  1 
ATOM 1934 C CG1 . ILE A 1 274 ? 113.770 109.018 102.707 1.00 83.92  ? 274 ILE A CG1 1 
ATOM 1935 C CG2 . ILE A 1 274 ? 112.397 111.088 102.973 1.00 83.92  ? 274 ILE A CG2 1 
ATOM 1936 C CD1 . ILE A 1 274 ? 115.184 109.550 102.725 1.00 83.92  ? 274 ILE A CD1 1 
ATOM 1937 N N   . THR A 1 275 ? 110.448 110.647 99.926  1.00 85.24  ? 275 THR A N   1 
ATOM 1938 C CA  . THR A 1 275 ? 109.582 111.762 99.555  1.00 85.24  ? 275 THR A CA  1 
ATOM 1939 C C   . THR A 1 275 ? 108.227 111.354 98.984  1.00 85.24  ? 275 THR A C   1 
ATOM 1940 O O   . THR A 1 275 ? 107.257 112.099 99.157  1.00 85.24  ? 275 THR A O   1 
ATOM 1941 C CB  . THR A 1 275 ? 110.297 112.666 98.552  1.00 85.24  ? 275 THR A CB  1 
ATOM 1942 O OG1 . THR A 1 275 ? 110.601 111.920 97.367  1.00 85.24  ? 275 THR A OG1 1 
ATOM 1943 C CG2 . THR A 1 275 ? 111.576 113.215 99.159  1.00 85.24  ? 275 THR A CG2 1 
ATOM 1944 N N   . LEU A 1 276 ? 108.123 110.213 98.302  1.00 85.82  ? 276 LEU A N   1 
ATOM 1945 C CA  . LEU A 1 276 ? 106.833 109.815 97.736  1.00 85.82  ? 276 LEU A CA  1 
ATOM 1946 C C   . LEU A 1 276 ? 105.690 109.688 98.742  1.00 85.82  ? 276 LEU A C   1 
ATOM 1947 O O   . LEU A 1 276 ? 104.566 110.087 98.391  1.00 85.82  ? 276 LEU A O   1 
ATOM 1948 C CB  . LEU A 1 276 ? 106.984 108.522 96.925  1.00 85.82  ? 276 LEU A CB  1 
ATOM 1949 C CG  . LEU A 1 276 ? 107.348 108.694 95.447  1.00 85.82  ? 276 LEU A CG  1 
ATOM 1950 C CD1 . LEU A 1 276 ? 106.190 109.369 94.742  1.00 85.82  ? 276 LEU A CD1 1 
ATOM 1951 C CD2 . LEU A 1 276 ? 108.580 109.532 95.247  1.00 85.82  ? 276 LEU A CD2 1 
ATOM 1952 N N   . PRO A 1 277 ? 105.868 109.151 99.954  1.00 85.54  ? 277 PRO A N   1 
ATOM 1953 C CA  . PRO A 1 277 ? 104.728 109.078 100.888 1.00 85.54  ? 277 PRO A CA  1 
ATOM 1954 C C   . PRO A 1 277 ? 104.050 110.413 101.156 1.00 85.54  ? 277 PRO A C   1 
ATOM 1955 O O   . PRO A 1 277 ? 102.920 110.428 101.667 1.00 85.54  ? 277 PRO A O   1 
ATOM 1956 C CB  . PRO A 1 277 ? 105.360 108.504 102.160 1.00 85.54  ? 277 PRO A CB  1 
ATOM 1957 C CG  . PRO A 1 277 ? 106.481 107.683 101.659 1.00 85.54  ? 277 PRO A CG  1 
ATOM 1958 C CD  . PRO A 1 277 ? 107.039 108.429 100.484 1.00 85.54  ? 277 PRO A CD  1 
ATOM 1959 N N   . SER A 1 278 ? 104.692 111.534 100.822 1.00 86.17  ? 278 SER A N   1 
ATOM 1960 C CA  . SER A 1 278 ? 104.037 112.826 100.978 1.00 86.17  ? 278 SER A CA  1 
ATOM 1961 C C   . SER A 1 278 ? 102.805 112.933 100.088 1.00 86.17  ? 278 SER A C   1 
ATOM 1962 O O   . SER A 1 278 ? 101.800 113.529 100.483 1.00 86.17  ? 278 SER A O   1 
ATOM 1963 C CB  . SER A 1 278 ? 105.017 113.956 100.676 1.00 86.17  ? 278 SER A CB  1 
ATOM 1964 O OG  . SER A 1 278 ? 104.375 115.212 100.787 1.00 86.17  ? 278 SER A OG  1 
ATOM 1965 N N   . PHE A 1 279 ? 102.861 112.363 98.881  1.00 87.67  ? 279 PHE A N   1 
ATOM 1966 C CA  . PHE A 1 279 ? 101.684 112.363 98.014  1.00 87.67  ? 279 PHE A CA  1 
ATOM 1967 C C   . PHE A 1 279 ? 100.552 111.538 98.616  1.00 87.67  ? 279 PHE A C   1 
ATOM 1968 O O   . PHE A 1 279 ? 99.386  111.961 98.608  1.00 87.67  ? 279 PHE A O   1 
ATOM 1969 C CB  . PHE A 1 279 ? 102.056 111.831 96.632  1.00 87.67  ? 279 PHE A CB  1 
ATOM 1970 C CG  . PHE A 1 279 ? 102.992 112.724 95.873  1.00 87.67  ? 279 PHE A CG  1 
ATOM 1971 C CD1 . PHE A 1 279 ? 102.829 114.097 95.892  1.00 87.67  ? 279 PHE A CD1 1 
ATOM 1972 C CD2 . PHE A 1 279 ? 104.040 112.190 95.145  1.00 87.67  ? 279 PHE A CD2 1 
ATOM 1973 C CE1 . PHE A 1 279 ? 103.690 114.920 95.197  1.00 87.67  ? 279 PHE A CE1 1 
ATOM 1974 C CE2 . PHE A 1 279 ? 104.905 113.008 94.447  1.00 87.67  ? 279 PHE A CE2 1 
ATOM 1975 C CZ  . PHE A 1 279 ? 104.729 114.375 94.473  1.00 87.67  ? 279 PHE A CZ  1 
ATOM 1976 N N   . LEU A 1 280 ? 100.876 110.358 99.147  1.00 87.56  ? 280 LEU A N   1 
ATOM 1977 C CA  . LEU A 1 280 ? 99.858  109.532 99.782  1.00 87.56  ? 280 LEU A CA  1 
ATOM 1978 C C   . LEU A 1 280 ? 99.225  110.260 100.958 1.00 87.56  ? 280 LEU A C   1 
ATOM 1979 O O   . LEU A 1 280 ? 98.021  110.132 101.202 1.00 87.56  ? 280 LEU A O   1 
ATOM 1980 C CB  . LEU A 1 280 ? 100.462 108.202 100.230 1.00 87.56  ? 280 LEU A CB  1 
ATOM 1981 C CG  . LEU A 1 280 ? 100.494 107.071 99.200  1.00 87.56  ? 280 LEU A CG  1 
ATOM 1982 C CD1 . LEU A 1 280 ? 101.553 107.320 98.143  1.00 87.56  ? 280 LEU A CD1 1 
ATOM 1983 C CD2 . LEU A 1 280 ? 100.733 105.741 99.888  1.00 87.56  ? 280 LEU A CD2 1 
ATOM 1984 N N   . PHE A 1 281 ? 100.020 111.027 101.703 1.00 85.80  ? 281 PHE A N   1 
ATOM 1985 C CA  . PHE A 1 281 ? 99.436  111.827 102.775 1.00 85.80  ? 281 PHE A CA  1 
ATOM 1986 C C   . PHE A 1 281 ? 98.618  112.984 102.221 1.00 85.80  ? 281 PHE A C   1 
ATOM 1987 O O   . PHE A 1 281 ? 97.640  113.407 102.845 1.00 85.80  ? 281 PHE A O   1 
ATOM 1988 C CB  . PHE A 1 281 ? 100.523 112.337 103.716 1.00 85.80  ? 281 PHE A CB  1 
ATOM 1989 C CG  . PHE A 1 281 ? 101.356 111.248 104.319 1.00 85.80  ? 281 PHE A CG  1 
ATOM 1990 C CD1 . PHE A 1 281 ? 100.878 109.950 104.392 1.00 85.80  ? 281 PHE A CD1 1 
ATOM 1991 C CD2 . PHE A 1 281 ? 102.614 111.519 104.814 1.00 85.80  ? 281 PHE A CD2 1 
ATOM 1992 C CE1 . PHE A 1 281 ? 101.642 108.947 104.940 1.00 85.80  ? 281 PHE A CE1 1 
ATOM 1993 C CE2 . PHE A 1 281 ? 103.379 110.521 105.365 1.00 85.80  ? 281 PHE A CE2 1 
ATOM 1994 C CZ  . PHE A 1 281 ? 102.896 109.233 105.428 1.00 85.80  ? 281 PHE A CZ  1 
ATOM 1995 N N   . LEU A 1 282 ? 99.004  113.508 101.060 1.00 90.29  ? 282 LEU A N   1 
ATOM 1996 C CA  . LEU A 1 282 ? 98.220  114.502 100.340 1.00 90.29  ? 282 LEU A CA  1 
ATOM 1997 C C   . LEU A 1 282 ? 96.879  113.953 99.879  1.00 90.29  ? 282 LEU A C   1 
ATOM 1998 O O   . LEU A 1 282 ? 95.955  114.731 99.616  1.00 90.29  ? 282 LEU A O   1 
ATOM 1999 C CB  . LEU A 1 282 ? 99.030  115.016 99.145  1.00 90.29  ? 282 LEU A CB  1 
ATOM 2000 C CG  . LEU A 1 282 ? 98.355  115.767 97.999  1.00 90.29  ? 282 LEU A CG  1 
ATOM 2001 C CD1 . LEU A 1 282 ? 98.074  117.201 98.403  1.00 90.29  ? 282 LEU A CD1 1 
ATOM 2002 C CD2 . LEU A 1 282 ? 99.219  115.713 96.753  1.00 90.29  ? 282 LEU A CD2 1 
ATOM 2003 N N   . LEU A 1 283 ? 96.744  112.635 99.802  1.00 91.99  ? 283 LEU A N   1 
ATOM 2004 C CA  . LEU A 1 283 ? 95.486  112.002 99.431  1.00 91.99  ? 283 LEU A CA  1 
ATOM 2005 C C   . LEU A 1 283 ? 94.388  112.188 100.477 1.00 91.99  ? 283 LEU A C   1 
ATOM 2006 O O   . LEU A 1 283 ? 93.226  111.887 100.188 1.00 91.99  ? 283 LEU A O   1 
ATOM 2007 C CB  . LEU A 1 283 ? 95.725  110.508 99.166  1.00 91.99  ? 283 LEU A CB  1 
ATOM 2008 C CG  . LEU A 1 283 ? 94.593  109.531 98.851  1.00 91.99  ? 283 LEU A CG  1 
ATOM 2009 C CD1 . LEU A 1 283 ? 95.059  108.518 97.825  1.00 91.99  ? 283 LEU A CD1 1 
ATOM 2010 C CD2 . LEU A 1 283 ? 94.138  108.825 100.112 1.00 91.99  ? 283 LEU A CD2 1 
ATOM 2011 N N   . TYR A 1 284 ? 94.716  112.691 101.672 1.00 94.00  ? 284 TYR A N   1 
ATOM 2012 C CA  . TYR A 1 284 ? 93.724  112.767 102.745 1.00 94.00  ? 284 TYR A CA  1 
ATOM 2013 C C   . TYR A 1 284 ? 92.521  113.605 102.332 1.00 94.00  ? 284 TYR A C   1 
ATOM 2014 O O   . TYR A 1 284 ? 91.418  113.078 102.148 1.00 94.00  ? 284 TYR A O   1 
ATOM 2015 C CB  . TYR A 1 284 ? 94.356  113.353 104.009 1.00 94.00  ? 284 TYR A CB  1 
ATOM 2016 C CG  . TYR A 1 284 ? 95.301  112.427 104.741 1.00 94.00  ? 284 TYR A CG  1 
ATOM 2017 C CD1 . TYR A 1 284 ? 95.564  111.151 104.266 1.00 94.00  ? 284 TYR A CD1 1 
ATOM 2018 C CD2 . TYR A 1 284 ? 95.936  112.836 105.904 1.00 94.00  ? 284 TYR A CD2 1 
ATOM 2019 C CE1 . TYR A 1 284 ? 96.431  110.309 104.929 1.00 94.00  ? 284 TYR A CE1 1 
ATOM 2020 C CE2 . TYR A 1 284 ? 96.805  112.001 106.573 1.00 94.00  ? 284 TYR A CE2 1 
ATOM 2021 C CZ  . TYR A 1 284 ? 97.048  110.738 106.081 1.00 94.00  ? 284 TYR A CZ  1 
ATOM 2022 O OH  . TYR A 1 284 ? 97.911  109.898 106.740 1.00 94.00  ? 284 TYR A OH  1 
ATOM 2023 N N   . TYR A 1 285 ? 92.725  114.911 102.156 1.00 100.91 ? 285 TYR A N   1 
ATOM 2024 C CA  . TYR A 1 285 ? 91.685  115.865 101.737 1.00 100.91 ? 285 TYR A CA  1 
ATOM 2025 C C   . TYR A 1 285 ? 90.455  115.674 102.627 1.00 100.91 ? 285 TYR A C   1 
ATOM 2026 O O   . TYR A 1 285 ? 90.473  116.105 103.788 1.00 100.91 ? 285 TYR A O   1 
ATOM 2027 C CB  . TYR A 1 285 ? 91.439  115.723 100.242 1.00 100.91 ? 285 TYR A CB  1 
ATOM 2028 C CG  . TYR A 1 285 ? 90.374  116.662 99.722  1.00 100.91 ? 285 TYR A CG  1 
ATOM 2029 C CD1 . TYR A 1 285 ? 90.555  118.037 99.761  1.00 100.91 ? 285 TYR A CD1 1 
ATOM 2030 C CD2 . TYR A 1 285 ? 89.187  116.173 99.193  1.00 100.91 ? 285 TYR A CD2 1 
ATOM 2031 C CE1 . TYR A 1 285 ? 89.583  118.898 99.294  1.00 100.91 ? 285 TYR A CE1 1 
ATOM 2032 C CE2 . TYR A 1 285 ? 88.211  117.026 98.723  1.00 100.91 ? 285 TYR A CE2 1 
ATOM 2033 C CZ  . TYR A 1 285 ? 88.415  118.388 98.775  1.00 100.91 ? 285 TYR A CZ  1 
ATOM 2034 O OH  . TYR A 1 285 ? 87.446  119.243 98.306  1.00 100.91 ? 285 TYR A OH  1 
ATOM 2035 N N   . TRP A 1 286 ? 89.380  115.060 102.131 1.00 108.05 ? 286 TRP A N   1 
ATOM 2036 C CA  . TRP A 1 286 ? 88.116  115.002 102.856 1.00 108.05 ? 286 TRP A CA  1 
ATOM 2037 C C   . TRP A 1 286 ? 88.153  114.058 104.050 1.00 108.05 ? 286 TRP A C   1 
ATOM 2038 O O   . TRP A 1 286 ? 87.204  114.047 104.842 1.00 108.05 ? 286 TRP A O   1 
ATOM 2039 C CB  . TRP A 1 286 ? 87.001  114.585 101.897 1.00 108.05 ? 286 TRP A CB  1 
ATOM 2040 C CG  . TRP A 1 286 ? 87.226  113.241 101.273 1.00 108.05 ? 286 TRP A CG  1 
ATOM 2041 C CD1 . TRP A 1 286 ? 88.028  112.958 100.205 1.00 108.05 ? 286 TRP A CD1 1 
ATOM 2042 C CD2 . TRP A 1 286 ? 86.637  111.997 101.672 1.00 108.05 ? 286 TRP A CD2 1 
ATOM 2043 N NE1 . TRP A 1 286 ? 87.980  111.616 99.918  1.00 108.05 ? 286 TRP A NE1 1 
ATOM 2044 C CE2 . TRP A 1 286 ? 87.132  111.003 100.804 1.00 108.05 ? 286 TRP A CE2 1 
ATOM 2045 C CE3 . TRP A 1 286 ? 85.741  111.626 102.680 1.00 108.05 ? 286 TRP A CE3 1 
ATOM 2046 C CZ2 . TRP A 1 286 ? 86.760  109.663 100.912 1.00 108.05 ? 286 TRP A CZ2 1 
ATOM 2047 C CZ3 . TRP A 1 286 ? 85.373  110.295 102.786 1.00 108.05 ? 286 TRP A CZ3 1 
ATOM 2048 C CH2 . TRP A 1 286 ? 85.882  109.330 101.907 1.00 108.05 ? 286 TRP A CH2 1 
ATOM 2049 N N   . VAL A 1 287 ? 89.212  113.261 104.195 1.00 100.10 ? 287 VAL A N   1 
ATOM 2050 C CA  . VAL A 1 287 ? 89.278  112.307 105.300 1.00 100.10 ? 287 VAL A CA  1 
ATOM 2051 C C   . VAL A 1 287 ? 89.333  113.034 106.639 1.00 100.10 ? 287 VAL A C   1 
ATOM 2052 O O   . VAL A 1 287 ? 88.656  112.648 107.599 1.00 100.10 ? 287 VAL A O   1 
ATOM 2053 C CB  . VAL A 1 287 ? 90.480  111.363 105.117 1.00 100.10 ? 287 VAL A CB  1 
ATOM 2054 C CG1 . VAL A 1 287 ? 90.754  110.595 106.396 1.00 100.10 ? 287 VAL A CG1 1 
ATOM 2055 C CG2 . VAL A 1 287 ? 90.235  110.412 103.958 1.00 100.10 ? 287 VAL A CG2 1 
ATOM 2056 N N   . VAL A 1 288 ? 90.129  114.096 106.725 1.00 90.63  ? 288 VAL A N   1 
ATOM 2057 C CA  . VAL A 1 288 ? 90.377  114.771 107.996 1.00 90.63  ? 288 VAL A CA  1 
ATOM 2058 C C   . VAL A 1 288 ? 89.885  116.212 107.948 1.00 90.63  ? 288 VAL A C   1 
ATOM 2059 O O   . VAL A 1 288 ? 90.418  117.021 107.176 1.00 90.63  ? 288 VAL A O   1 
ATOM 2060 C CB  . VAL A 1 288 ? 91.869  114.728 108.352 1.00 90.63  ? 288 VAL A CB  1 
ATOM 2061 C CG1 . VAL A 1 288 ? 92.129  115.512 109.625 1.00 90.63  ? 288 VAL A CG1 1 
ATOM 2062 C CG2 . VAL A 1 288 ? 92.341  113.293 108.486 1.00 90.63  ? 288 VAL A CG2 1 
ATOM 2063 N N   . PRO A 1 289 ? 88.883  116.583 108.747 1.00 90.83  ? 289 PRO A N   1 
ATOM 2064 C CA  . PRO A 1 289 ? 88.487  117.997 108.858 1.00 90.83  ? 289 PRO A CA  1 
ATOM 2065 C C   . PRO A 1 289 ? 89.570  118.783 109.581 1.00 90.83  ? 289 PRO A C   1 
ATOM 2066 O O   . PRO A 1 289 ? 90.327  118.221 110.374 1.00 90.83  ? 289 PRO A O   1 
ATOM 2067 C CB  . PRO A 1 289 ? 87.187  117.939 109.672 1.00 90.83  ? 289 PRO A CB  1 
ATOM 2068 C CG  . PRO A 1 289 ? 86.776  116.486 109.662 1.00 90.83  ? 289 PRO A CG  1 
ATOM 2069 C CD  . PRO A 1 289 ? 88.057  115.726 109.607 1.00 90.83  ? 289 PRO A CD  1 
ATOM 2070 N N   . GLU A 1 290 ? 89.654  120.086 109.299 1.00 96.53  ? 290 GLU A N   1 
ATOM 2071 C CA  . GLU A 1 290 ? 90.774  120.870 109.815 1.00 96.53  ? 290 GLU A CA  1 
ATOM 2072 C C   . GLU A 1 290 ? 90.762  120.945 111.343 1.00 96.53  ? 290 GLU A C   1 
ATOM 2073 O O   . GLU A 1 290 ? 91.630  120.365 112.002 1.00 96.53  ? 290 GLU A O   1 
ATOM 2074 C CB  . GLU A 1 290 ? 90.790  122.259 109.156 1.00 96.53  ? 290 GLU A CB  1 
ATOM 2075 C CG  . GLU A 1 290 ? 89.684  123.236 109.513 1.00 96.53  ? 290 GLU A CG  1 
ATOM 2076 C CD  . GLU A 1 290 ? 88.431  123.025 108.694 1.00 96.53  ? 290 GLU A CD  1 
ATOM 2077 O OE1 . GLU A 1 290 ? 88.117  121.860 108.371 1.00 96.53  ? 290 GLU A OE1 1 
ATOM 2078 O OE2 . GLU A 1 290 ? 87.757  124.025 108.372 1.00 96.53  ? 290 GLU A OE2 1 
ATOM 2079 N N   . SER A 1 291 ? 89.780  121.623 111.926 1.00 99.14  ? 291 SER A N   1 
ATOM 2080 C CA  . SER A 1 291 ? 89.693  121.725 113.376 1.00 99.14  ? 291 SER A CA  1 
ATOM 2081 C C   . SER A 1 291 ? 88.373  122.363 113.782 1.00 99.14  ? 291 SER A C   1 
ATOM 2082 O O   . SER A 1 291 ? 88.034  123.448 113.292 1.00 99.14  ? 291 SER A O   1 
ATOM 2083 C CB  . SER A 1 291 ? 90.859  122.540 113.939 1.00 99.14  ? 291 SER A CB  1 
ATOM 2084 O OG  . SER A 1 291 ? 90.558  123.029 115.234 1.00 99.14  ? 291 SER A OG  1 
ATOM 2085 N N   . PRO A 1 292 ? 87.601  121.730 114.663 1.00 98.71  ? 292 PRO A N   1 
ATOM 2086 C CA  . PRO A 1 292 ? 86.466  122.446 115.258 1.00 98.71  ? 292 PRO A CA  1 
ATOM 2087 C C   . PRO A 1 292 ? 86.878  123.711 115.990 1.00 98.71  ? 292 PRO A C   1 
ATOM 2088 O O   . PRO A 1 292 ? 86.240  124.756 115.814 1.00 98.71  ? 292 PRO A O   1 
ATOM 2089 C CB  . PRO A 1 292 ? 85.872  121.409 116.224 1.00 98.71  ? 292 PRO A CB  1 
ATOM 2090 C CG  . PRO A 1 292 ? 86.591  120.094 115.930 1.00 98.71  ? 292 PRO A CG  1 
ATOM 2091 C CD  . PRO A 1 292 ? 87.382  120.279 114.683 1.00 98.71  ? 292 PRO A CD  1 
ATOM 2092 N N   . ARG A 1 293 ? 87.939  123.651 116.799 1.00 99.05  ? 293 ARG A N   1 
ATOM 2093 C CA  . ARG A 1 293 ? 88.272  124.783 117.660 1.00 99.05  ? 293 ARG A CA  1 
ATOM 2094 C C   . ARG A 1 293 ? 88.915  125.912 116.869 1.00 99.05  ? 293 ARG A C   1 
ATOM 2095 O O   . ARG A 1 293 ? 88.893  127.071 117.298 1.00 99.05  ? 293 ARG A O   1 
ATOM 2096 C CB  . ARG A 1 293 ? 89.190  124.337 118.800 1.00 99.05  ? 293 ARG A CB  1 
ATOM 2097 C CG  . ARG A 1 293 ? 89.310  125.359 119.927 1.00 99.05  ? 293 ARG A CG  1 
ATOM 2098 C CD  . ARG A 1 293 ? 90.425  125.030 120.920 1.00 99.05  ? 293 ARG A CD  1 
ATOM 2099 N NE  . ARG A 1 293 ? 90.058  124.006 121.892 1.00 99.05  ? 293 ARG A NE  1 
ATOM 2100 C CZ  . ARG A 1 293 ? 90.252  122.704 121.728 1.00 99.05  ? 293 ARG A CZ  1 
ATOM 2101 N NH1 . ARG A 1 293 ? 90.825  122.221 120.637 1.00 99.05  ? 293 ARG A NH1 1 
ATOM 2102 N NH2 . ARG A 1 293 ? 89.871  121.866 122.687 1.00 99.05  ? 293 ARG A NH2 1 
ATOM 2103 N N   . TRP A 1 294 ? 89.517  125.596 115.722 1.00 98.92  ? 294 TRP A N   1 
ATOM 2104 C CA  . TRP A 1 294 ? 90.057  126.654 114.877 1.00 98.92  ? 294 TRP A CA  1 
ATOM 2105 C C   . TRP A 1 294 ? 88.945  127.550 114.350 1.00 98.92  ? 294 TRP A C   1 
ATOM 2106 O O   . TRP A 1 294 ? 89.090  128.778 114.309 1.00 98.92  ? 294 TRP A O   1 
ATOM 2107 C CB  . TRP A 1 294 ? 90.860  126.060 113.721 1.00 98.92  ? 294 TRP A CB  1 
ATOM 2108 C CG  . TRP A 1 294 ? 91.250  127.068 112.682 1.00 98.92  ? 294 TRP A CG  1 
ATOM 2109 C CD1 . TRP A 1 294 ? 91.096  126.951 111.332 1.00 98.92  ? 294 TRP A CD1 1 
ATOM 2110 C CD2 . TRP A 1 294 ? 91.854  128.350 112.906 1.00 98.92  ? 294 TRP A CD2 1 
ATOM 2111 N NE1 . TRP A 1 294 ? 91.564  128.078 110.702 1.00 98.92  ? 294 TRP A NE1 1 
ATOM 2112 C CE2 . TRP A 1 294 ? 92.035  128.950 111.648 1.00 98.92  ? 294 TRP A CE2 1 
ATOM 2113 C CE3 . TRP A 1 294 ? 92.259  129.047 114.049 1.00 98.92  ? 294 TRP A CE3 1 
ATOM 2114 C CZ2 . TRP A 1 294 ? 92.603  130.209 111.501 1.00 98.92  ? 294 TRP A CZ2 1 
ATOM 2115 C CZ3 . TRP A 1 294 ? 92.819  130.296 113.900 1.00 98.92  ? 294 TRP A CZ3 1 
ATOM 2116 C CH2 . TRP A 1 294 ? 92.986  130.865 112.637 1.00 98.92  ? 294 TRP A CH2 1 
ATOM 2117 N N   . LEU A 1 295 ? 87.826  126.957 113.955 1.00 103.17 ? 295 LEU A N   1 
ATOM 2118 C CA  . LEU A 1 295 ? 86.719  127.692 113.366 1.00 103.17 ? 295 LEU A CA  1 
ATOM 2119 C C   . LEU A 1 295 ? 85.732  128.211 114.400 1.00 103.17 ? 295 LEU A C   1 
ATOM 2120 O O   . LEU A 1 295 ? 84.834  128.979 114.043 1.00 103.17 ? 295 LEU A O   1 
ATOM 2121 C CB  . LEU A 1 295 ? 85.984  126.810 112.354 1.00 103.17 ? 295 LEU A CB  1 
ATOM 2122 C CG  . LEU A 1 295 ? 86.613  126.649 110.970 1.00 103.17 ? 295 LEU A CG  1 
ATOM 2123 C CD1 . LEU A 1 295 ? 87.867  125.815 111.038 1.00 103.17 ? 295 LEU A CD1 1 
ATOM 2124 C CD2 . LEU A 1 295 ? 85.625  126.011 110.020 1.00 103.17 ? 295 LEU A CD2 1 
ATOM 2125 N N   . ILE A 1 296 ? 85.876  127.827 115.673 1.00 106.16 ? 296 ILE A N   1 
ATOM 2126 C CA  . ILE A 1 296 ? 84.962  128.293 116.710 1.00 106.16 ? 296 ILE A CA  1 
ATOM 2127 C C   . ILE A 1 296 ? 85.261  129.730 117.118 1.00 106.16 ? 296 ILE A C   1 
ATOM 2128 O O   . ILE A 1 296 ? 84.640  130.253 118.053 1.00 106.16 ? 296 ILE A O   1 
ATOM 2129 C CB  . ILE A 1 296 ? 85.001  127.340 117.926 1.00 106.16 ? 296 ILE A CB  1 
ATOM 2130 C CG1 . ILE A 1 296 ? 83.728  127.473 118.761 1.00 106.16 ? 296 ILE A CG1 1 
ATOM 2131 C CG2 . ILE A 1 296 ? 86.211  127.625 118.797 1.00 106.16 ? 296 ILE A CG2 1 
ATOM 2132 C CD1 . ILE A 1 296 ? 82.487  127.007 118.035 1.00 106.16 ? 296 ILE A CD1 1 
ATOM 2133 N N   . THR A 1 297 ? 86.175  130.397 116.419 1.00 111.45 ? 297 THR A N   1 
ATOM 2134 C CA  . THR A 1 297 ? 86.537  131.783 116.674 1.00 111.45 ? 297 THR A CA  1 
ATOM 2135 C C   . THR A 1 297 ? 85.532  132.741 116.032 1.00 111.45 ? 297 THR A C   1 
ATOM 2136 O O   . THR A 1 297 ? 85.868  133.894 115.751 1.00 111.45 ? 297 THR A O   1 
ATOM 2137 C CB  . THR A 1 297 ? 87.966  132.035 116.158 1.00 111.45 ? 297 THR A CB  1 
ATOM 2138 O OG1 . THR A 1 297 ? 88.827  131.008 116.662 1.00 111.45 ? 297 THR A OG1 1 
ATOM 2139 C CG2 . THR A 1 297 ? 88.529  133.356 116.682 1.00 111.45 ? 297 THR A CG2 1 
ATOM 2140 N N   . ARG A 1 298 ? 84.317  132.257 115.761 1.00 120.58 ? 298 ARG A N   1 
ATOM 2141 C CA  . ARG A 1 298 ? 83.198  132.911 115.070 1.00 120.58 ? 298 ARG A CA  1 
ATOM 2142 C C   . ARG A 1 298 ? 83.572  133.263 113.637 1.00 120.58 ? 298 ARG A C   1 
ATOM 2143 O O   . ARG A 1 298 ? 82.852  134.030 112.979 1.00 120.58 ? 298 ARG A O   1 
ATOM 2144 C CB  . ARG A 1 298 ? 82.660  134.148 115.806 1.00 120.58 ? 298 ARG A CB  1 
ATOM 2145 C CG  . ARG A 1 298 ? 83.391  135.471 115.602 1.00 120.58 ? 298 ARG A CG  1 
ATOM 2146 C CD  . ARG A 1 298 ? 82.693  136.572 116.382 1.00 120.58 ? 298 ARG A CD  1 
ATOM 2147 N NE  . ARG A 1 298 ? 83.371  137.858 116.279 1.00 120.58 ? 298 ARG A NE  1 
ATOM 2148 C CZ  . ARG A 1 298 ? 83.142  138.749 115.323 1.00 120.58 ? 298 ARG A CZ  1 
ATOM 2149 N NH1 . ARG A 1 298 ? 82.279  138.511 114.349 1.00 120.58 ? 298 ARG A NH1 1 
ATOM 2150 N NH2 . ARG A 1 298 ? 83.789  139.910 115.350 1.00 120.58 ? 298 ARG A NH2 1 
ATOM 2151 N N   . LYS A 1 299 ? 84.664  132.701 113.119 1.00 111.10 ? 299 LYS A N   1 
ATOM 2152 C CA  . LYS A 1 299 ? 84.977  132.869 111.707 1.00 111.10 ? 299 LYS A CA  1 
ATOM 2153 C C   . LYS A 1 299 ? 83.923  132.204 110.833 1.00 111.10 ? 299 LYS A C   1 
ATOM 2154 O O   . LYS A 1 299 ? 83.388  132.826 109.908 1.00 111.10 ? 299 LYS A O   1 
ATOM 2155 C CB  . LYS A 1 299 ? 86.359  132.294 111.406 1.00 111.10 ? 299 LYS A CB  1 
ATOM 2156 C CG  . LYS A 1 299 ? 87.504  133.073 112.018 1.00 111.10 ? 299 LYS A CG  1 
ATOM 2157 C CD  . LYS A 1 299 ? 88.822  132.368 111.767 1.00 111.10 ? 299 LYS A CD  1 
ATOM 2158 C CE  . LYS A 1 299 ? 89.197  132.460 110.300 1.00 111.10 ? 299 LYS A CE  1 
ATOM 2159 N NZ  . LYS A 1 299 ? 90.534  131.888 110.015 1.00 111.10 ? 299 LYS A NZ  1 
ATOM 2160 N N   . LYS A 1 300 ? 83.608  130.940 111.112 1.00 108.07 ? 300 LYS A N   1 
ATOM 2161 C CA  . LYS A 1 300 ? 82.626  130.190 110.342 1.00 108.07 ? 300 LYS A CA  1 
ATOM 2162 C C   . LYS A 1 300 ? 81.438  129.737 111.176 1.00 108.07 ? 300 LYS A C   1 
ATOM 2163 O O   . LYS A 1 300 ? 80.292  130.056 110.845 1.00 108.07 ? 300 LYS A O   1 
ATOM 2164 C CB  . LYS A 1 300 ? 83.300  128.974 109.691 1.00 108.07 ? 300 LYS A CB  1 
ATOM 2165 C CG  . LYS A 1 300 ? 84.630  129.294 109.031 1.00 108.07 ? 300 LYS A CG  1 
ATOM 2166 C CD  . LYS A 1 300 ? 84.441  129.973 107.687 1.00 108.07 ? 300 LYS A CD  1 
ATOM 2167 C CE  . LYS A 1 300 ? 85.750  130.044 106.917 1.00 108.07 ? 300 LYS A CE  1 
ATOM 2168 N NZ  . LYS A 1 300 ? 86.402  128.712 106.800 1.00 108.07 ? 300 LYS A NZ  1 
ATOM 2169 N N   . GLY A 1 301 ? 81.681  129.004 112.258 1.00 105.52 ? 301 GLY A N   1 
ATOM 2170 C CA  . GLY A 1 301 ? 80.606  128.560 113.124 1.00 105.52 ? 301 GLY A CA  1 
ATOM 2171 C C   . GLY A 1 301 ? 79.792  127.410 112.566 1.00 105.52 ? 301 GLY A C   1 
ATOM 2172 O O   . GLY A 1 301 ? 79.827  126.300 113.103 1.00 105.52 ? 301 GLY A O   1 
ATOM 2173 N N   . ASP A 1 302 ? 79.048  127.669 111.488 1.00 103.88 ? 302 ASP A N   1 
ATOM 2174 C CA  . ASP A 1 302 ? 78.189  126.638 110.912 1.00 103.88 ? 302 ASP A CA  1 
ATOM 2175 C C   . ASP A 1 302 ? 79.005  125.465 110.386 1.00 103.88 ? 302 ASP A C   1 
ATOM 2176 O O   . ASP A 1 302 ? 78.616  124.303 110.556 1.00 103.88 ? 302 ASP A O   1 
ATOM 2177 C CB  . ASP A 1 302 ? 77.328  127.237 109.802 1.00 103.88 ? 302 ASP A CB  1 
ATOM 2178 C CG  . ASP A 1 302 ? 76.289  128.200 110.332 1.00 103.88 ? 302 ASP A CG  1 
ATOM 2179 O OD1 . ASP A 1 302 ? 75.846  128.019 111.486 1.00 103.88 ? 302 ASP A OD1 1 
ATOM 2180 O OD2 . ASP A 1 302 ? 75.918  129.140 109.599 1.00 103.88 ? 302 ASP A OD2 1 
ATOM 2181 N N   . LYS A 1 303 ? 80.135  125.749 109.738 1.00 101.96 ? 303 LYS A N   1 
ATOM 2182 C CA  . LYS A 1 303 ? 81.023  124.674 109.309 1.00 101.96 ? 303 LYS A CA  1 
ATOM 2183 C C   . LYS A 1 303 ? 81.539  123.889 110.507 1.00 101.96 ? 303 LYS A C   1 
ATOM 2184 O O   . LYS A 1 303 ? 81.669  122.661 110.447 1.00 101.96 ? 303 LYS A O   1 
ATOM 2185 C CB  . LYS A 1 303 ? 82.182  125.246 108.495 1.00 101.96 ? 303 LYS A CB  1 
ATOM 2186 C CG  . LYS A 1 303 ? 83.216  124.221 108.062 1.00 101.96 ? 303 LYS A CG  1 
ATOM 2187 C CD  . LYS A 1 303 ? 82.585  123.063 107.316 1.00 101.96 ? 303 LYS A CD  1 
ATOM 2188 C CE  . LYS A 1 303 ? 83.648  122.150 106.732 1.00 101.96 ? 303 LYS A CE  1 
ATOM 2189 N NZ  . LYS A 1 303 ? 84.821  122.917 106.232 1.00 101.96 ? 303 LYS A NZ  1 
ATOM 2190 N N   . ALA A 1 304 ? 81.831  124.581 111.611 1.00 100.91 ? 304 ALA A N   1 
ATOM 2191 C CA  . ALA A 1 304 ? 82.260  123.889 112.821 1.00 100.91 ? 304 ALA A CA  1 
ATOM 2192 C C   . ALA A 1 304 ? 81.174  122.951 113.334 1.00 100.91 ? 304 ALA A C   1 
ATOM 2193 O O   . ALA A 1 304 ? 81.455  121.800 113.686 1.00 100.91 ? 304 ALA A O   1 
ATOM 2194 C CB  . ALA A 1 304 ? 82.645  124.903 113.897 1.00 100.91 ? 304 ALA A CB  1 
ATOM 2195 N N   . LEU A 1 305 ? 79.927  123.423 113.377 1.00 99.23  ? 305 LEU A N   1 
ATOM 2196 C CA  . LEU A 1 305 ? 78.836  122.571 113.838 1.00 99.23  ? 305 LEU A CA  1 
ATOM 2197 C C   . LEU A 1 305 ? 78.645  121.379 112.910 1.00 99.23  ? 305 LEU A C   1 
ATOM 2198 O O   . LEU A 1 305 ? 78.355  120.267 113.366 1.00 99.23  ? 305 LEU A O   1 
ATOM 2199 C CB  . LEU A 1 305 ? 77.547  123.382 113.949 1.00 99.23  ? 305 LEU A CB  1 
ATOM 2200 C CG  . LEU A 1 305 ? 76.325  122.636 114.486 1.00 99.23  ? 305 LEU A CG  1 
ATOM 2201 C CD1 . LEU A 1 305 ? 76.569  122.166 115.909 1.00 99.23  ? 305 LEU A CD1 1 
ATOM 2202 C CD2 . LEU A 1 305 ? 75.083  123.509 114.412 1.00 99.23  ? 305 LEU A CD2 1 
ATOM 2203 N N   . GLN A 1 306 ? 78.806  121.593 111.602 1.00 103.04 ? 306 GLN A N   1 
ATOM 2204 C CA  . GLN A 1 306 ? 78.731  120.482 110.660 1.00 103.04 ? 306 GLN A CA  1 
ATOM 2205 C C   . GLN A 1 306 ? 79.829  119.463 110.925 1.00 103.04 ? 306 GLN A C   1 
ATOM 2206 O O   . GLN A 1 306 ? 79.585  118.254 110.851 1.00 103.04 ? 306 GLN A O   1 
ATOM 2207 C CB  . GLN A 1 306 ? 78.792  121.018 109.223 1.00 103.04 ? 306 GLN A CB  1 
ATOM 2208 C CG  . GLN A 1 306 ? 78.653  119.983 108.096 1.00 103.04 ? 306 GLN A CG  1 
ATOM 2209 C CD  . GLN A 1 306 ? 79.908  119.156 107.838 1.00 103.04 ? 306 GLN A CD  1 
ATOM 2210 O OE1 . GLN A 1 306 ? 80.985  119.449 108.357 1.00 103.04 ? 306 GLN A OE1 1 
ATOM 2211 N NE2 . GLN A 1 306 ? 79.768  118.114 107.027 1.00 103.04 ? 306 GLN A NE2 1 
ATOM 2212 N N   . ILE A 1 307 ? 81.043  119.928 111.222 1.00 97.82  ? 307 ILE A N   1 
ATOM 2213 C CA  . ILE A 1 307 ? 82.136  119.006 111.517 1.00 97.82  ? 307 ILE A CA  1 
ATOM 2214 C C   . ILE A 1 307 ? 81.846  118.220 112.791 1.00 97.82  ? 307 ILE A C   1 
ATOM 2215 O O   . ILE A 1 307 ? 82.101  117.012 112.861 1.00 97.82  ? 307 ILE A O   1 
ATOM 2216 C CB  . ILE A 1 307 ? 83.470  119.765 111.606 1.00 97.82  ? 307 ILE A CB  1 
ATOM 2217 C CG1 . ILE A 1 307 ? 83.808  120.404 110.261 1.00 97.82  ? 307 ILE A CG1 1 
ATOM 2218 C CG2 . ILE A 1 307 ? 84.583  118.829 112.027 1.00 97.82  ? 307 ILE A CG2 1 
ATOM 2219 C CD1 . ILE A 1 307 ? 84.957  121.376 110.322 1.00 97.82  ? 307 ILE A CD1 1 
ATOM 2220 N N   . LEU A 1 308 ? 81.316  118.888 113.818 1.00 96.29  ? 308 LEU A N   1 
ATOM 2221 C CA  . LEU A 1 308 ? 80.937  118.175 115.037 1.00 96.29  ? 308 LEU A CA  1 
ATOM 2222 C C   . LEU A 1 308 ? 79.868  117.125 114.762 1.00 96.29  ? 308 LEU A C   1 
ATOM 2223 O O   . LEU A 1 308 ? 79.945  116.004 115.276 1.00 96.29  ? 308 LEU A O   1 
ATOM 2224 C CB  . LEU A 1 308 ? 80.458  119.151 116.113 1.00 96.29  ? 308 LEU A CB  1 
ATOM 2225 C CG  . LEU A 1 308 ? 81.486  119.789 117.053 1.00 96.29  ? 308 LEU A CG  1 
ATOM 2226 C CD1 . LEU A 1 308 ? 82.383  120.780 116.364 1.00 96.29  ? 308 LEU A CD1 1 
ATOM 2227 C CD2 . LEU A 1 308 ? 80.766  120.459 118.206 1.00 96.29  ? 308 LEU A CD2 1 
ATOM 2228 N N   . ARG A 1 309 ? 78.859  117.468 113.958 1.00 100.41 ? 309 ARG A N   1 
ATOM 2229 C CA  . ARG A 1 309 ? 77.818  116.498 113.633 1.00 100.41 ? 309 ARG A CA  1 
ATOM 2230 C C   . ARG A 1 309 ? 78.386  115.315 112.858 1.00 100.41 ? 309 ARG A C   1 
ATOM 2231 O O   . ARG A 1 309 ? 77.986  114.166 113.083 1.00 100.41 ? 309 ARG A O   1 
ATOM 2232 C CB  . ARG A 1 309 ? 76.697  117.168 112.841 1.00 100.41 ? 309 ARG A CB  1 
ATOM 2233 C CG  . ARG A 1 309 ? 75.362  116.454 112.955 1.00 100.41 ? 309 ARG A CG  1 
ATOM 2234 C CD  . ARG A 1 309 ? 74.230  117.307 112.414 1.00 100.41 ? 309 ARG A CD  1 
ATOM 2235 N NE  . ARG A 1 309 ? 74.309  118.682 112.890 1.00 100.41 ? 309 ARG A NE  1 
ATOM 2236 C CZ  . ARG A 1 309 ? 73.700  119.132 113.978 1.00 100.41 ? 309 ARG A CZ  1 
ATOM 2237 N NH1 . ARG A 1 309 ? 72.962  118.337 114.735 1.00 100.41 ? 309 ARG A NH1 1 
ATOM 2238 N NH2 . ARG A 1 309 ? 73.834  120.411 114.314 1.00 100.41 ? 309 ARG A NH2 1 
ATOM 2239 N N   . ARG A 1 310 ? 79.312  115.577 111.935 1.00 99.63  ? 310 ARG A N   1 
ATOM 2240 C CA  . ARG A 1 310 ? 79.942  114.494 111.187 1.00 99.63  ? 310 ARG A CA  1 
ATOM 2241 C C   . ARG A 1 310 ? 80.808  113.632 112.095 1.00 99.63  ? 310 ARG A C   1 
ATOM 2242 O O   . ARG A 1 310 ? 80.977  112.433 111.847 1.00 99.63  ? 310 ARG A O   1 
ATOM 2243 C CB  . ARG A 1 310 ? 80.765  115.071 110.035 1.00 99.63  ? 310 ARG A CB  1 
ATOM 2244 C CG  . ARG A 1 310 ? 81.238  114.054 109.010 1.00 99.63  ? 310 ARG A CG  1 
ATOM 2245 C CD  . ARG A 1 310 ? 82.690  113.671 109.233 1.00 99.63  ? 310 ARG A CD  1 
ATOM 2246 N NE  . ARG A 1 310 ? 83.233  112.933 108.100 1.00 99.63  ? 310 ARG A NE  1 
ATOM 2247 C CZ  . ARG A 1 310 ? 84.428  112.360 108.085 1.00 99.63  ? 310 ARG A CZ  1 
ATOM 2248 N NH1 . ARG A 1 310 ? 85.232  112.412 109.132 1.00 99.63  ? 310 ARG A NH1 1 
ATOM 2249 N NH2 . ARG A 1 310 ? 84.827  111.721 106.990 1.00 99.63  ? 310 ARG A NH2 1 
ATOM 2250 N N   . ILE A 1 311 ? 81.378  114.230 113.142 1.00 100.33 ? 311 ILE A N   1 
ATOM 2251 C CA  . ILE A 1 311 ? 82.145  113.463 114.119 1.00 100.33 ? 311 ILE A CA  1 
ATOM 2252 C C   . ILE A 1 311 ? 81.238  112.490 114.859 1.00 100.33 ? 311 ILE A C   1 
ATOM 2253 O O   . ILE A 1 311 ? 81.591  111.324 115.073 1.00 100.33 ? 311 ILE A O   1 
ATOM 2254 C CB  . ILE A 1 311 ? 82.868  114.414 115.092 1.00 100.33 ? 311 ILE A CB  1 
ATOM 2255 C CG1 . ILE A 1 311 ? 84.165  114.936 114.472 1.00 100.33 ? 311 ILE A CG1 1 
ATOM 2256 C CG2 . ILE A 1 311 ? 83.150  113.722 116.417 1.00 100.33 ? 311 ILE A CG2 1 
ATOM 2257 C CD1 . ILE A 1 311 ? 84.882  115.956 115.329 1.00 100.33 ? 311 ILE A CD1 1 
ATOM 2258 N N   . ALA A 1 312 ? 80.049  112.949 115.246 1.00 101.86 ? 312 ALA A N   1 
ATOM 2259 C CA  . ALA A 1 312 ? 79.142  112.169 116.085 1.00 101.86 ? 312 ALA A CA  1 
ATOM 2260 C C   . ALA A 1 312 ? 78.476  111.067 115.260 1.00 101.86 ? 312 ALA A C   1 
ATOM 2261 O O   . ALA A 1 312 ? 77.268  111.056 115.020 1.00 101.86 ? 312 ALA A O   1 
ATOM 2262 C CB  . ALA A 1 312 ? 78.114  113.083 116.737 1.00 101.86 ? 312 ALA A CB  1 
ATOM 2263 N N   . LYS A 1 313 ? 79.308  110.121 114.818 1.00 101.81 ? 313 LYS A N   1 
ATOM 2264 C CA  . LYS A 1 313 ? 78.778  108.941 114.142 1.00 101.81 ? 313 LYS A CA  1 
ATOM 2265 C C   . LYS A 1 313 ? 78.163  107.971 115.142 1.00 101.81 ? 313 LYS A C   1 
ATOM 2266 O O   . LYS A 1 313 ? 77.124  107.358 114.868 1.00 101.81 ? 313 LYS A O   1 
ATOM 2267 C CB  . LYS A 1 313 ? 79.880  108.244 113.344 1.00 101.81 ? 313 LYS A CB  1 
ATOM 2268 C CG  . LYS A 1 313 ? 81.244  108.269 114.010 1.00 101.81 ? 313 LYS A CG  1 
ATOM 2269 C CD  . LYS A 1 313 ? 82.252  107.443 113.228 1.00 101.81 ? 313 LYS A CD  1 
ATOM 2270 C CE  . LYS A 1 313 ? 82.810  108.208 112.045 1.00 101.81 ? 313 LYS A CE  1 
ATOM 2271 N NZ  . LYS A 1 313 ? 83.904  107.450 111.380 1.00 101.81 ? 313 LYS A NZ  1 
ATOM 2272 N N   . CYS A 1 314 ? 78.795  107.817 116.309 1.00 105.18 ? 314 CYS A N   1 
ATOM 2273 C CA  . CYS A 1 314 ? 78.348  106.819 117.275 1.00 105.18 ? 314 CYS A CA  1 
ATOM 2274 C C   . CYS A 1 314 ? 77.045  107.232 117.947 1.00 105.18 ? 314 CYS A C   1 
ATOM 2275 O O   . CYS A 1 314 ? 76.149  106.402 118.141 1.00 105.18 ? 314 CYS A O   1 
ATOM 2276 C CB  . CYS A 1 314 ? 79.439  106.584 118.318 1.00 105.18 ? 314 CYS A CB  1 
ATOM 2277 S SG  . CYS A 1 314 ? 81.102  106.431 117.623 1.00 105.18 ? 314 CYS A SG  1 
ATOM 2278 N N   . ASN A 1 315 ? 76.919  108.505 118.313 1.00 105.03 ? 315 ASN A N   1 
ATOM 2279 C CA  . ASN A 1 315 ? 75.752  109.004 119.030 1.00 105.03 ? 315 ASN A CA  1 
ATOM 2280 C C   . ASN A 1 315 ? 75.204  110.227 118.311 1.00 105.03 ? 315 ASN A C   1 
ATOM 2281 O O   . ASN A 1 315 ? 75.974  111.034 117.781 1.00 105.03 ? 315 ASN A O   1 
ATOM 2282 C CB  . ASN A 1 315 ? 76.102  109.338 120.482 1.00 105.03 ? 315 ASN A CB  1 
ATOM 2283 C CG  . ASN A 1 315 ? 77.364  110.164 120.600 1.00 105.03 ? 315 ASN A CG  1 
ATOM 2284 O OD1 . ASN A 1 315 ? 77.990  110.506 119.599 1.00 105.03 ? 315 ASN A OD1 1 
ATOM 2285 N ND2 . ASN A 1 315 ? 77.747  110.490 121.829 1.00 105.03 ? 315 ASN A ND2 1 
ATOM 2286 N N   . GLY A 1 316 ? 73.882  110.357 118.284 1.00 106.96 ? 316 GLY A N   1 
ATOM 2287 C CA  . GLY A 1 316 ? 73.241  111.491 117.646 1.00 106.96 ? 316 GLY A CA  1 
ATOM 2288 C C   . GLY A 1 316 ? 73.202  112.727 118.522 1.00 106.96 ? 316 GLY A C   1 
ATOM 2289 O O   . GLY A 1 316 ? 73.200  113.854 118.026 1.00 106.96 ? 316 GLY A O   1 
ATOM 2290 N N   . VAL A 1 328 ? 80.583  130.821 121.340 1.00 127.11 ? 328 VAL A N   1 
ATOM 2291 C CA  . VAL A 1 328 ? 80.228  132.176 121.738 1.00 127.11 ? 328 VAL A CA  1 
ATOM 2292 C C   . VAL A 1 328 ? 80.822  133.180 120.758 1.00 127.11 ? 328 VAL A C   1 
ATOM 2293 O O   . VAL A 1 328 ? 81.309  132.805 119.692 1.00 127.11 ? 328 VAL A O   1 
ATOM 2294 C CB  . VAL A 1 328 ? 80.692  132.475 123.172 1.00 127.11 ? 328 VAL A CB  1 
ATOM 2295 C CG1 . VAL A 1 328 ? 80.007  131.539 124.155 1.00 127.11 ? 328 VAL A CG1 1 
ATOM 2296 C CG2 . VAL A 1 328 ? 82.204  132.354 123.275 1.00 127.11 ? 328 VAL A CG2 1 
ATOM 2297 N N   . THR A 1 329 ? 80.782  134.459 121.123 1.00 131.60 ? 329 THR A N   1 
ATOM 2298 C CA  . THR A 1 329 ? 81.278  135.537 120.279 1.00 131.60 ? 329 THR A CA  1 
ATOM 2299 C C   . THR A 1 329 ? 82.475  136.202 120.943 1.00 131.60 ? 329 THR A C   1 
ATOM 2300 O O   . THR A 1 329 ? 82.509  136.355 122.169 1.00 131.60 ? 329 THR A O   1 
ATOM 2301 C CB  . THR A 1 329 ? 80.181  136.572 119.997 1.00 131.60 ? 329 THR A CB  1 
ATOM 2302 O OG1 . THR A 1 329 ? 80.715  137.629 119.189 1.00 131.60 ? 329 THR A OG1 1 
ATOM 2303 C CG2 . THR A 1 329 ? 79.628  137.149 121.293 1.00 131.60 ? 329 THR A CG2 1 
ATOM 2304 N N   . ASP A 1 330 ? 83.461  136.575 120.131 1.00 130.59 ? 330 ASP A N   1 
ATOM 2305 C CA  . ASP A 1 330 ? 84.649  137.268 120.604 1.00 130.59 ? 330 ASP A CA  1 
ATOM 2306 C C   . ASP A 1 330 ? 85.299  138.000 119.437 1.00 130.59 ? 330 ASP A C   1 
ATOM 2307 O O   . ASP A 1 330 ? 84.994  137.743 118.270 1.00 130.59 ? 330 ASP A O   1 
ATOM 2308 C CB  . ASP A 1 330 ? 85.637  136.300 121.279 1.00 130.59 ? 330 ASP A CB  1 
ATOM 2309 C CG  . ASP A 1 330 ? 86.170  135.233 120.333 1.00 130.59 ? 330 ASP A CG  1 
ATOM 2310 O OD1 . ASP A 1 330 ? 85.757  135.192 119.155 1.00 130.59 ? 330 ASP A OD1 1 
ATOM 2311 O OD2 . ASP A 1 330 ? 87.011  134.423 120.777 1.00 130.59 ? 330 ASP A OD2 1 
ATOM 2312 N N   . GLU A 1 331 ? 86.193  138.928 119.768 1.00 132.37 ? 331 GLU A N   1 
ATOM 2313 C CA  . GLU A 1 331 ? 86.889  139.687 118.738 1.00 132.37 ? 331 GLU A CA  1 
ATOM 2314 C C   . GLU A 1 331 ? 87.750  138.761 117.888 1.00 132.37 ? 331 GLU A C   1 
ATOM 2315 O O   . GLU A 1 331 ? 88.386  137.835 118.398 1.00 132.37 ? 331 GLU A O   1 
ATOM 2316 C CB  . GLU A 1 331 ? 87.753  140.774 119.377 1.00 132.37 ? 331 GLU A CB  1 
ATOM 2317 C CG  . GLU A 1 331 ? 86.965  141.797 120.178 1.00 132.37 ? 331 GLU A CG  1 
ATOM 2318 C CD  . GLU A 1 331 ? 86.033  142.622 119.314 1.00 132.37 ? 331 GLU A CD  1 
ATOM 2319 O OE1 . GLU A 1 331 ? 86.374  142.873 118.139 1.00 132.37 ? 331 GLU A OE1 1 
ATOM 2320 O OE2 . GLU A 1 331 ? 84.958  143.018 119.811 1.00 132.37 ? 331 GLU A OE2 1 
ATOM 2321 N N   . GLU A 1 332 ? 87.769  139.015 116.581 1.00 127.23 ? 332 GLU A N   1 
ATOM 2322 C CA  . GLU A 1 332 ? 88.505  138.170 115.643 1.00 127.23 ? 332 GLU A CA  1 
ATOM 2323 C C   . GLU A 1 332 ? 89.968  138.595 115.656 1.00 127.23 ? 332 GLU A C   1 
ATOM 2324 O O   . GLU A 1 332 ? 90.319  139.688 115.206 1.00 127.23 ? 332 GLU A O   1 
ATOM 2325 C CB  . GLU A 1 332 ? 87.900  138.246 114.243 1.00 127.23 ? 332 GLU A CB  1 
ATOM 2326 C CG  . GLU A 1 332 ? 87.765  139.645 113.642 1.00 127.23 ? 332 GLU A CG  1 
ATOM 2327 C CD  . GLU A 1 332 ? 86.547  140.400 114.138 1.00 127.23 ? 332 GLU A CD  1 
ATOM 2328 O OE1 . GLU A 1 332 ? 86.119  140.169 115.289 1.00 127.23 ? 332 GLU A OE1 1 
ATOM 2329 O OE2 . GLU A 1 332 ? 86.012  141.229 113.372 1.00 127.23 ? 332 GLU A OE2 1 
ATOM 2330 N N   . VAL A 1 333 ? 90.827  137.732 116.202 1.00 121.16 ? 333 VAL A N   1 
ATOM 2331 C CA  . VAL A 1 333 ? 92.263  137.981 116.135 1.00 121.16 ? 333 VAL A CA  1 
ATOM 2332 C C   . VAL A 1 333 ? 92.720  138.000 114.684 1.00 121.16 ? 333 VAL A C   1 
ATOM 2333 O O   . VAL A 1 333 ? 93.541  138.835 114.286 1.00 121.16 ? 333 VAL A O   1 
ATOM 2334 C CB  . VAL A 1 333 ? 93.030  136.932 116.961 1.00 121.16 ? 333 VAL A CB  1 
ATOM 2335 C CG1 . VAL A 1 333 ? 94.508  137.285 117.030 1.00 121.16 ? 333 VAL A CG1 1 
ATOM 2336 C CG2 . VAL A 1 333 ? 92.438  136.824 118.357 1.00 121.16 ? 333 VAL A CG2 1 
ATOM 2337 N N   . SER A 1 334 ? 92.189  137.085 113.877 1.00 118.37 ? 334 SER A N   1 
ATOM 2338 C CA  . SER A 1 334 ? 92.434  137.028 112.432 1.00 118.37 ? 334 SER A CA  1 
ATOM 2339 C C   . SER A 1 334 ? 93.940  136.879 112.230 1.00 118.37 ? 334 SER A C   1 
ATOM 2340 O O   . SER A 1 334 ? 94.537  135.958 112.808 1.00 118.37 ? 334 SER A O   1 
ATOM 2341 C CB  . SER A 1 334 ? 91.789  138.238 111.769 1.00 118.37 ? 334 SER A CB  1 
ATOM 2342 O OG  . SER A 1 334 ? 90.429  138.356 112.148 1.00 118.37 ? 334 SER A OG  1 
ATOM 2343 N N   . ASN A 1 335 ? 94.582  137.733 111.447 1.00 109.36 ? 335 ASN A N   1 
ATOM 2344 C CA  . ASN A 1 335 ? 96.007  137.586 111.203 1.00 109.36 ? 335 ASN A CA  1 
ATOM 2345 C C   . ASN A 1 335 ? 96.788  137.807 112.494 1.00 109.36 ? 335 ASN A C   1 
ATOM 2346 O O   . ASN A 1 335 ? 96.597  138.833 113.162 1.00 109.36 ? 335 ASN A O   1 
ATOM 2347 C CB  . ASN A 1 335 ? 96.465  138.574 110.135 1.00 109.36 ? 335 ASN A CB  1 
ATOM 2348 C CG  . ASN A 1 335 ? 95.989  138.191 108.756 1.00 109.36 ? 335 ASN A CG  1 
ATOM 2349 O OD1 . ASN A 1 335 ? 96.010  137.018 108.391 1.00 109.36 ? 335 ASN A OD1 1 
ATOM 2350 N ND2 . ASN A 1 335 ? 95.556  139.177 107.979 1.00 109.36 ? 335 ASN A ND2 1 
ATOM 2351 N N   . PRO A 1 336 ? 97.659  136.883 112.880 1.00 104.70 ? 336 PRO A N   1 
ATOM 2352 C CA  . PRO A 1 336 ? 98.502  137.101 114.055 1.00 104.70 ? 336 PRO A CA  1 
ATOM 2353 C C   . PRO A 1 336 ? 99.646  138.058 113.756 1.00 104.70 ? 336 PRO A C   1 
ATOM 2354 O O   . PRO A 1 336 ? 100.058 138.249 112.611 1.00 104.70 ? 336 PRO A O   1 
ATOM 2355 C CB  . PRO A 1 336 ? 99.023  135.696 114.369 1.00 104.70 ? 336 PRO A CB  1 
ATOM 2356 C CG  . PRO A 1 336 ? 99.085  135.031 113.038 1.00 104.70 ? 336 PRO A CG  1 
ATOM 2357 C CD  . PRO A 1 336 ? 97.945  135.595 112.223 1.00 104.70 ? 336 PRO A CD  1 
ATOM 2358 N N   . SER A 1 337 ? 100.164 138.661 114.823 1.00 101.69 ? 337 SER A N   1 
ATOM 2359 C CA  . SER A 1 337 ? 101.248 139.626 114.722 1.00 101.69 ? 337 SER A CA  1 
ATOM 2360 C C   . SER A 1 337 ? 102.417 139.171 115.582 1.00 101.69 ? 337 SER A C   1 
ATOM 2361 O O   . SER A 1 337 ? 102.228 138.742 116.724 1.00 101.69 ? 337 SER A O   1 
ATOM 2362 C CB  . SER A 1 337 ? 100.788 141.024 115.152 1.00 101.69 ? 337 SER A CB  1 
ATOM 2363 O OG  . SER A 1 337 ? 101.696 142.019 114.713 1.00 101.69 ? 337 SER A OG  1 
ATOM 2364 N N   . PHE A 1 338 ? 103.626 139.269 115.024 1.00 98.16  ? 338 PHE A N   1 
ATOM 2365 C CA  . PHE A 1 338 ? 104.821 138.866 115.760 1.00 98.16  ? 338 PHE A CA  1 
ATOM 2366 C C   . PHE A 1 338 ? 105.004 139.717 117.010 1.00 98.16  ? 338 PHE A C   1 
ATOM 2367 O O   . PHE A 1 338 ? 105.360 139.201 118.074 1.00 98.16  ? 338 PHE A O   1 
ATOM 2368 C CB  . PHE A 1 338 ? 106.044 138.955 114.841 1.00 98.16  ? 338 PHE A CB  1 
ATOM 2369 C CG  . PHE A 1 338 ? 107.332 138.474 115.464 1.00 98.16  ? 338 PHE A CG  1 
ATOM 2370 C CD1 . PHE A 1 338 ? 107.988 139.218 116.434 1.00 98.16  ? 338 PHE A CD1 1 
ATOM 2371 C CD2 . PHE A 1 338 ? 107.919 137.299 115.028 1.00 98.16  ? 338 PHE A CD2 1 
ATOM 2372 C CE1 . PHE A 1 338 ? 109.175 138.774 116.986 1.00 98.16  ? 338 PHE A CE1 1 
ATOM 2373 C CE2 . PHE A 1 338 ? 109.105 136.852 115.576 1.00 98.16  ? 338 PHE A CE2 1 
ATOM 2374 C CZ  . PHE A 1 338 ? 109.734 137.591 116.554 1.00 98.16  ? 338 PHE A CZ  1 
ATOM 2375 N N   . LEU A 1 339 ? 104.775 141.027 116.900 1.00 101.11 ? 339 LEU A N   1 
ATOM 2376 C CA  . LEU A 1 339 ? 104.834 141.880 118.082 1.00 101.11 ? 339 LEU A CA  1 
ATOM 2377 C C   . LEU A 1 339 ? 103.732 141.515 119.068 1.00 101.11 ? 339 LEU A C   1 
ATOM 2378 O O   . LEU A 1 339 ? 103.951 141.531 120.284 1.00 101.11 ? 339 LEU A O   1 
ATOM 2379 C CB  . LEU A 1 339 ? 104.752 143.353 117.669 1.00 101.11 ? 339 LEU A CB  1 
ATOM 2380 C CG  . LEU A 1 339 ? 104.825 144.499 118.689 1.00 101.11 ? 339 LEU A CG  1 
ATOM 2381 C CD1 . LEU A 1 339 ? 105.143 145.792 117.958 1.00 101.11 ? 339 LEU A CD1 1 
ATOM 2382 C CD2 . LEU A 1 339 ? 103.542 144.682 119.491 1.00 101.11 ? 339 LEU A CD2 1 
ATOM 2383 N N   . ASP A 1 340 ? 102.540 141.187 118.563 1.00 99.67  ? 340 ASP A N   1 
ATOM 2384 C CA  . ASP A 1 340 ? 101.458 140.754 119.441 1.00 99.67  ? 340 ASP A CA  1 
ATOM 2385 C C   . ASP A 1 340 ? 101.767 139.412 120.091 1.00 99.67  ? 340 ASP A C   1 
ATOM 2386 O O   . ASP A 1 340 ? 101.195 139.082 121.136 1.00 99.67  ? 340 ASP A O   1 
ATOM 2387 C CB  . ASP A 1 340 ? 100.148 140.678 118.659 1.00 99.67  ? 340 ASP A CB  1 
ATOM 2388 C CG  . ASP A 1 340 ? 98.959  140.370 119.544 1.00 99.67  ? 340 ASP A CG  1 
ATOM 2389 O OD1 . ASP A 1 340 ? 98.518  141.273 120.287 1.00 99.67  ? 340 ASP A OD1 1 
ATOM 2390 O OD2 . ASP A 1 340 ? 98.463  139.225 119.495 1.00 99.67  ? 340 ASP A OD2 1 
ATOM 2391 N N   . LEU A 1 341 ? 102.660 138.625 119.487 1.00 95.10  ? 341 LEU A N   1 
ATOM 2392 C CA  . LEU A 1 341 ? 103.082 137.374 120.106 1.00 95.10  ? 341 LEU A CA  1 
ATOM 2393 C C   . LEU A 1 341 ? 103.796 137.619 121.428 1.00 95.10  ? 341 LEU A C   1 
ATOM 2394 O O   . LEU A 1 341 ? 103.756 136.766 122.321 1.00 95.10  ? 341 LEU A O   1 
ATOM 2395 C CB  . LEU A 1 341 ? 103.983 136.596 119.148 1.00 95.10  ? 341 LEU A CB  1 
ATOM 2396 C CG  . LEU A 1 341 ? 104.518 135.236 119.588 1.00 95.10  ? 341 LEU A CG  1 
ATOM 2397 C CD1 . LEU A 1 341 ? 104.451 134.253 118.440 1.00 95.10  ? 341 LEU A CD1 1 
ATOM 2398 C CD2 . LEU A 1 341 ? 105.943 135.376 120.074 1.00 95.10  ? 341 LEU A CD2 1 
ATOM 2399 N N   . VAL A 1 342 ? 104.453 138.767 121.573 1.00 94.64  ? 342 VAL A N   1 
ATOM 2400 C CA  . VAL A 1 342 ? 105.139 139.138 122.810 1.00 94.64  ? 342 VAL A CA  1 
ATOM 2401 C C   . VAL A 1 342 ? 104.650 140.529 123.218 1.00 94.64  ? 342 VAL A C   1 
ATOM 2402 O O   . VAL A 1 342 ? 105.199 141.557 122.814 1.00 94.64  ? 342 VAL A O   1 
ATOM 2403 C CB  . VAL A 1 342 ? 106.667 139.061 122.679 1.00 94.64  ? 342 VAL A CB  1 
ATOM 2404 C CG1 . VAL A 1 342 ? 107.220 139.993 121.600 1.00 94.64  ? 342 VAL A CG1 1 
ATOM 2405 C CG2 . VAL A 1 342 ? 107.317 139.373 124.001 1.00 94.64  ? 342 VAL A CG2 1 
ATOM 2406 N N   . ARG A 1 343 ? 103.591 140.566 124.024 1.00 100.21 ? 343 ARG A N   1 
ATOM 2407 C CA  . ARG A 1 343 ? 103.072 141.815 124.569 1.00 100.21 ? 343 ARG A CA  1 
ATOM 2408 C C   . ARG A 1 343 ? 102.689 141.740 126.036 1.00 100.21 ? 343 ARG A C   1 
ATOM 2409 O O   . ARG A 1 343 ? 102.730 142.774 126.714 1.00 100.21 ? 343 ARG A O   1 
ATOM 2410 C CB  . ARG A 1 343 ? 101.846 142.287 123.774 1.00 100.21 ? 343 ARG A CB  1 
ATOM 2411 C CG  . ARG A 1 343 ? 102.170 142.988 122.468 1.00 100.21 ? 343 ARG A CG  1 
ATOM 2412 C CD  . ARG A 1 343 ? 100.916 143.569 121.834 1.00 100.21 ? 343 ARG A CD  1 
ATOM 2413 N NE  . ARG A 1 343 ? 100.350 144.642 122.643 1.00 100.21 ? 343 ARG A NE  1 
ATOM 2414 C CZ  . ARG A 1 343 ? 99.233  144.538 123.350 1.00 100.21 ? 343 ARG A CZ  1 
ATOM 2415 N NH1 . ARG A 1 343 ? 98.528  143.418 123.368 1.00 100.21 ? 343 ARG A NH1 1 
ATOM 2416 N NH2 . ARG A 1 343 ? 98.815  145.581 124.060 1.00 100.21 ? 343 ARG A NH2 1 
ATOM 2417 N N   . THR A 1 344 ? 102.320 140.575 126.546 1.00 103.17 ? 344 THR A N   1 
ATOM 2418 C CA  . THR A 1 344 ? 101.870 140.390 127.911 1.00 103.17 ? 344 THR A CA  1 
ATOM 2419 C C   . THR A 1 344 ? 102.966 139.713 128.727 1.00 103.17 ? 344 THR A C   1 
ATOM 2420 O O   . THR A 1 344 ? 103.592 138.763 128.244 1.00 103.17 ? 344 THR A O   1 
ATOM 2421 C CB  . THR A 1 344 ? 100.592 139.539 127.936 1.00 103.17 ? 344 THR A CB  1 
ATOM 2422 O OG1 . THR A 1 344 ? 99.569  140.204 127.185 1.00 103.17 ? 344 THR A OG1 1 
ATOM 2423 C CG2 . THR A 1 344 ? 100.091 139.338 129.353 1.00 103.17 ? 344 THR A CG2 1 
ATOM 2424 N N   . PRO A 1 345 ? 103.239 140.190 129.948 1.00 104.50 ? 345 PRO A N   1 
ATOM 2425 C CA  . PRO A 1 345 ? 104.407 139.676 130.683 1.00 104.50 ? 345 PRO A CA  1 
ATOM 2426 C C   . PRO A 1 345 ? 104.422 138.168 130.860 1.00 104.50 ? 345 PRO A C   1 
ATOM 2427 O O   . PRO A 1 345 ? 105.488 137.557 130.740 1.00 104.50 ? 345 PRO A O   1 
ATOM 2428 C CB  . PRO A 1 345 ? 104.320 140.410 132.030 1.00 104.50 ? 345 PRO A CB  1 
ATOM 2429 C CG  . PRO A 1 345 ? 102.917 140.931 132.109 1.00 104.50 ? 345 PRO A CG  1 
ATOM 2430 C CD  . PRO A 1 345 ? 102.552 141.252 130.700 1.00 104.50 ? 345 PRO A CD  1 
ATOM 2431 N N   . GLN A 1 346 ? 103.276 137.542 131.129 1.00 103.29 ? 346 GLN A N   1 
ATOM 2432 C CA  . GLN A 1 346 ? 103.255 136.085 131.219 1.00 103.29 ? 346 GLN A CA  1 
ATOM 2433 C C   . GLN A 1 346 ? 103.454 135.462 129.842 1.00 103.29 ? 346 GLN A C   1 
ATOM 2434 O O   . GLN A 1 346 ? 104.188 134.475 129.692 1.00 103.29 ? 346 GLN A O   1 
ATOM 2435 C CB  . GLN A 1 346 ? 101.941 135.631 131.859 1.00 103.29 ? 346 GLN A CB  1 
ATOM 2436 C CG  . GLN A 1 346 ? 102.017 134.373 132.724 1.00 103.29 ? 346 GLN A CG  1 
ATOM 2437 C CD  . GLN A 1 346 ? 102.335 133.108 131.951 1.00 103.29 ? 346 GLN A CD  1 
ATOM 2438 O OE1 . GLN A 1 346 ? 102.149 133.040 130.740 1.00 103.29 ? 346 GLN A OE1 1 
ATOM 2439 N NE2 . GLN A 1 346 ? 102.810 132.091 132.659 1.00 103.29 ? 346 GLN A NE2 1 
ATOM 2440 N N   . MET A 1 347 ? 102.827 136.050 128.821 1.00 99.79  ? 347 MET A N   1 
ATOM 2441 C CA  . MET A 1 347 ? 103.023 135.597 127.450 1.00 99.79  ? 347 MET A CA  1 
ATOM 2442 C C   . MET A 1 347 ? 104.486 135.734 127.040 1.00 99.79  ? 347 MET A C   1 
ATOM 2443 O O   . MET A 1 347 ? 105.073 134.808 126.461 1.00 99.79  ? 347 MET A O   1 
ATOM 2444 C CB  . MET A 1 347 ? 102.119 136.415 126.525 1.00 99.79  ? 347 MET A CB  1 
ATOM 2445 C CG  . MET A 1 347 ? 102.168 136.049 125.063 1.00 99.79  ? 347 MET A CG  1 
ATOM 2446 S SD  . MET A 1 347 ? 101.526 134.395 124.788 1.00 99.79  ? 347 MET A SD  1 
ATOM 2447 C CE  . MET A 1 347 ? 103.015 133.564 124.294 1.00 99.79  ? 347 MET A CE  1 
ATOM 2448 N N   . ARG A 1 348 ? 105.095 136.880 127.359 1.00 101.22 ? 348 ARG A N   1 
ATOM 2449 C CA  . ARG A 1 348 ? 106.500 137.111 127.041 1.00 101.22 ? 348 ARG A CA  1 
ATOM 2450 C C   . ARG A 1 348 ? 107.401 136.132 127.781 1.00 101.22 ? 348 ARG A C   1 
ATOM 2451 O O   . ARG A 1 348 ? 108.373 135.614 127.217 1.00 101.22 ? 348 ARG A O   1 
ATOM 2452 C CB  . ARG A 1 348 ? 106.874 138.553 127.387 1.00 101.22 ? 348 ARG A CB  1 
ATOM 2453 C CG  . ARG A 1 348 ? 108.362 138.842 127.362 1.00 101.22 ? 348 ARG A CG  1 
ATOM 2454 C CD  . ARG A 1 348 ? 108.663 140.182 128.007 1.00 101.22 ? 348 ARG A CD  1 
ATOM 2455 N NE  . ARG A 1 348 ? 107.992 141.282 127.324 1.00 101.22 ? 348 ARG A NE  1 
ATOM 2456 C CZ  . ARG A 1 348 ? 107.095 142.078 127.888 1.00 101.22 ? 348 ARG A CZ  1 
ATOM 2457 N NH1 . ARG A 1 348 ? 106.727 141.919 129.149 1.00 101.22 ? 348 ARG A NH1 1 
ATOM 2458 N NH2 . ARG A 1 348 ? 106.553 143.057 127.171 1.00 101.22 ? 348 ARG A NH2 1 
ATOM 2459 N N   . LYS A 1 349 ? 107.105 135.888 129.058 1.00 99.72  ? 349 LYS A N   1 
ATOM 2460 C CA  . LYS A 1 349 ? 107.893 134.947 129.843 1.00 99.72  ? 349 LYS A CA  1 
ATOM 2461 C C   . LYS A 1 349 ? 107.853 133.557 129.230 1.00 99.72  ? 349 LYS A C   1 
ATOM 2462 O O   . LYS A 1 349 ? 108.895 132.909 129.070 1.00 99.72  ? 349 LYS A O   1 
ATOM 2463 C CB  . LYS A 1 349 ? 107.373 134.912 131.280 1.00 99.72  ? 349 LYS A CB  1 
ATOM 2464 C CG  . LYS A 1 349 ? 108.019 133.859 132.157 1.00 99.72  ? 349 LYS A CG  1 
ATOM 2465 C CD  . LYS A 1 349 ? 106.988 133.145 133.012 1.00 99.72  ? 349 LYS A CD  1 
ATOM 2466 C CE  . LYS A 1 349 ? 106.407 134.066 134.069 1.00 99.72  ? 349 LYS A CE  1 
ATOM 2467 N NZ  . LYS A 1 349 ? 105.636 133.313 135.094 1.00 99.72  ? 349 LYS A NZ  1 
ATOM 2468 N N   . CYS A 1 350 ? 106.656 133.088 128.870 1.00 96.71  ? 350 CYS A N   1 
ATOM 2469 C CA  . CYS A 1 350 ? 106.538 131.774 128.250 1.00 96.71  ? 350 CYS A CA  1 
ATOM 2470 C C   . CYS A 1 350 ? 107.313 131.719 126.942 1.00 96.71  ? 350 CYS A C   1 
ATOM 2471 O O   . CYS A 1 350 ? 108.059 130.766 126.690 1.00 96.71  ? 350 CYS A O   1 
ATOM 2472 C CB  . CYS A 1 350 ? 105.067 131.428 128.020 1.00 96.71  ? 350 CYS A CB  1 
ATOM 2473 S SG  . CYS A 1 350 ? 104.151 131.037 129.520 1.00 96.71  ? 350 CYS A SG  1 
ATOM 2474 N N   . THR A 1 351 ? 107.172 132.752 126.108 1.00 93.98  ? 351 THR A N   1 
ATOM 2475 C CA  . THR A 1 351 ? 107.866 132.759 124.825 1.00 93.98  ? 351 THR A CA  1 
ATOM 2476 C C   . THR A 1 351 ? 109.374 132.695 125.013 1.00 93.98  ? 351 THR A C   1 
ATOM 2477 O O   . THR A 1 351 ? 110.059 131.878 124.382 1.00 93.98  ? 351 THR A O   1 
ATOM 2478 C CB  . THR A 1 351 ? 107.492 134.008 124.033 1.00 93.98  ? 351 THR A CB  1 
ATOM 2479 O OG1 . THR A 1 351 ? 106.068 134.142 123.995 1.00 93.98  ? 351 THR A OG1 1 
ATOM 2480 C CG2 . THR A 1 351 ? 108.027 133.907 122.622 1.00 93.98  ? 351 THR A CG2 1 
ATOM 2481 N N   . LEU A 1 352 ? 109.910 133.555 125.881 1.00 96.19  ? 352 LEU A N   1 
ATOM 2482 C CA  . LEU A 1 352 ? 111.355 133.631 126.056 1.00 96.19  ? 352 LEU A CA  1 
ATOM 2483 C C   . LEU A 1 352 ? 111.911 132.347 126.654 1.00 96.19  ? 352 LEU A C   1 
ATOM 2484 O O   . LEU A 1 352 ? 112.936 131.834 126.187 1.00 96.19  ? 352 LEU A O   1 
ATOM 2485 C CB  . LEU A 1 352 ? 111.708 134.833 126.928 1.00 96.19  ? 352 LEU A CB  1 
ATOM 2486 C CG  . LEU A 1 352 ? 111.876 136.146 126.165 1.00 96.19  ? 352 LEU A CG  1 
ATOM 2487 C CD1 . LEU A 1 352 ? 112.254 137.269 127.109 1.00 96.19  ? 352 LEU A CD1 1 
ATOM 2488 C CD2 . LEU A 1 352 ? 112.914 135.987 125.071 1.00 96.19  ? 352 LEU A CD2 1 
ATOM 2489 N N   . ILE A 1 353 ? 111.250 131.809 127.683 1.00 95.94  ? 353 ILE A N   1 
ATOM 2490 C CA  . ILE A 1 353 ? 111.740 130.582 128.299 1.00 95.94  ? 353 ILE A CA  1 
ATOM 2491 C C   . ILE A 1 353 ? 111.686 129.430 127.308 1.00 95.94  ? 353 ILE A C   1 
ATOM 2492 O O   . ILE A 1 353 ? 112.620 128.623 127.228 1.00 95.94  ? 353 ILE A O   1 
ATOM 2493 C CB  . ILE A 1 353 ? 110.950 130.264 129.580 1.00 95.94  ? 353 ILE A CB  1 
ATOM 2494 C CG1 . ILE A 1 353 ? 111.273 131.282 130.669 1.00 95.94  ? 353 ILE A CG1 1 
ATOM 2495 C CG2 . ILE A 1 353 ? 111.261 128.862 130.056 1.00 95.94  ? 353 ILE A CG2 1 
ATOM 2496 C CD1 . ILE A 1 353 ? 110.340 131.210 131.843 1.00 95.94  ? 353 ILE A CD1 1 
ATOM 2497 N N   . LEU A 1 354 ? 110.599 129.329 126.537 1.00 93.32  ? 354 LEU A N   1 
ATOM 2498 C CA  . LEU A 1 354 ? 110.507 128.266 125.543 1.00 93.32  ? 354 LEU A CA  1 
ATOM 2499 C C   . LEU A 1 354 ? 111.613 128.384 124.506 1.00 93.32  ? 354 LEU A C   1 
ATOM 2500 O O   . LEU A 1 354 ? 112.265 127.389 124.169 1.00 93.32  ? 354 LEU A O   1 
ATOM 2501 C CB  . LEU A 1 354 ? 109.136 128.293 124.869 1.00 93.32  ? 354 LEU A CB  1 
ATOM 2502 C CG  . LEU A 1 354 ? 108.063 127.382 125.462 1.00 93.32  ? 354 LEU A CG  1 
ATOM 2503 C CD1 . LEU A 1 354 ? 108.457 125.938 125.248 1.00 93.32  ? 354 LEU A CD1 1 
ATOM 2504 C CD2 . LEU A 1 354 ? 107.851 127.661 126.935 1.00 93.32  ? 354 LEU A CD2 1 
ATOM 2505 N N   . MET A 1 355 ? 111.852 129.595 124.002 1.00 93.75  ? 355 MET A N   1 
ATOM 2506 C CA  . MET A 1 355 ? 112.902 129.782 123.008 1.00 93.75  ? 355 MET A CA  1 
ATOM 2507 C C   . MET A 1 355 ? 114.262 129.387 123.568 1.00 93.75  ? 355 MET A C   1 
ATOM 2508 O O   . MET A 1 355 ? 115.040 128.677 122.914 1.00 93.75  ? 355 MET A O   1 
ATOM 2509 C CB  . MET A 1 355 ? 112.915 131.234 122.535 1.00 93.75  ? 355 MET A CB  1 
ATOM 2510 C CG  . MET A 1 355 ? 112.007 131.517 121.356 1.00 93.75  ? 355 MET A CG  1 
ATOM 2511 S SD  . MET A 1 355 ? 112.165 133.214 120.773 1.00 93.75  ? 355 MET A SD  1 
ATOM 2512 C CE  . MET A 1 355 ? 110.543 133.480 120.072 1.00 93.75  ? 355 MET A CE  1 
ATOM 2513 N N   . PHE A 1 356 ? 114.563 129.831 124.791 1.00 97.33  ? 356 PHE A N   1 
ATOM 2514 C CA  . PHE A 1 356 ? 115.867 129.532 125.368 1.00 97.33  ? 356 PHE A CA  1 
ATOM 2515 C C   . PHE A 1 356 ? 116.022 128.040 125.625 1.00 97.33  ? 356 PHE A C   1 
ATOM 2516 O O   . PHE A 1 356 ? 117.105 127.481 125.428 1.00 97.33  ? 356 PHE A O   1 
ATOM 2517 C CB  . PHE A 1 356 ? 116.078 130.325 126.655 1.00 97.33  ? 356 PHE A CB  1 
ATOM 2518 C CG  . PHE A 1 356 ? 117.422 130.103 127.279 1.00 97.33  ? 356 PHE A CG  1 
ATOM 2519 C CD1 . PHE A 1 356 ? 118.549 130.696 126.740 1.00 97.33  ? 356 PHE A CD1 1 
ATOM 2520 C CD2 . PHE A 1 356 ? 117.566 129.293 128.385 1.00 97.33  ? 356 PHE A CD2 1 
ATOM 2521 C CE1 . PHE A 1 356 ? 119.793 130.492 127.302 1.00 97.33  ? 356 PHE A CE1 1 
ATOM 2522 C CE2 . PHE A 1 356 ? 118.810 129.086 128.950 1.00 97.33  ? 356 PHE A CE2 1 
ATOM 2523 C CZ  . PHE A 1 356 ? 119.923 129.685 128.409 1.00 97.33  ? 356 PHE A CZ  1 
ATOM 2524 N N   . ALA A 1 357 ? 114.951 127.378 126.071 1.00 97.38  ? 357 ALA A N   1 
ATOM 2525 C CA  . ALA A 1 357 ? 115.009 125.938 126.290 1.00 97.38  ? 357 ALA A CA  1 
ATOM 2526 C C   . ALA A 1 357 ? 115.242 125.194 124.985 1.00 97.38  ? 357 ALA A C   1 
ATOM 2527 O O   . ALA A 1 357 ? 116.022 124.237 124.938 1.00 97.38  ? 357 ALA A O   1 
ATOM 2528 C CB  . ALA A 1 357 ? 113.725 125.455 126.960 1.00 97.38  ? 357 ALA A CB  1 
ATOM 2529 N N   . TRP A 1 358 ? 114.574 125.623 123.913 1.00 92.81  ? 358 TRP A N   1 
ATOM 2530 C CA  . TRP A 1 358 ? 114.805 125.030 122.600 1.00 92.81  ? 358 TRP A CA  1 
ATOM 2531 C C   . TRP A 1 358 ? 116.266 125.160 122.190 1.00 92.81  ? 358 TRP A C   1 
ATOM 2532 O O   . TRP A 1 358 ? 116.905 124.180 121.780 1.00 92.81  ? 358 TRP A O   1 
ATOM 2533 C CB  . TRP A 1 358 ? 113.904 125.707 121.569 1.00 92.81  ? 358 TRP A CB  1 
ATOM 2534 C CG  . TRP A 1 358 ? 112.509 125.176 121.493 1.00 92.81  ? 358 TRP A CG  1 
ATOM 2535 C CD1 . TRP A 1 358 ? 111.408 125.665 122.128 1.00 92.81  ? 358 TRP A CD1 1 
ATOM 2536 C CD2 . TRP A 1 358 ? 112.055 124.084 120.694 1.00 92.81  ? 358 TRP A CD2 1 
ATOM 2537 N NE1 . TRP A 1 358 ? 110.300 124.931 121.793 1.00 92.81  ? 358 TRP A NE1 1 
ATOM 2538 C CE2 . TRP A 1 358 ? 110.672 123.954 120.911 1.00 92.81  ? 358 TRP A CE2 1 
ATOM 2539 C CE3 . TRP A 1 358 ? 112.687 123.196 119.825 1.00 92.81  ? 358 TRP A CE3 1 
ATOM 2540 C CZ2 . TRP A 1 358 ? 109.915 122.973 120.291 1.00 92.81  ? 358 TRP A CZ2 1 
ATOM 2541 C CZ3 . TRP A 1 358 ? 111.932 122.230 119.209 1.00 92.81  ? 358 TRP A CZ3 1 
ATOM 2542 C CH2 . TRP A 1 358 ? 110.566 122.122 119.446 1.00 92.81  ? 358 TRP A CH2 1 
ATOM 2543 N N   . PHE A 1 359 ? 116.814 126.373 122.304 1.00 96.77  ? 359 PHE A N   1 
ATOM 2544 C CA  . PHE A 1 359 ? 118.196 126.608 121.894 1.00 96.77  ? 359 PHE A CA  1 
ATOM 2545 C C   . PHE A 1 359 ? 119.171 125.789 122.732 1.00 96.77  ? 359 PHE A C   1 
ATOM 2546 O O   . PHE A 1 359 ? 120.111 125.179 122.198 1.00 96.77  ? 359 PHE A O   1 
ATOM 2547 C CB  . PHE A 1 359 ? 118.512 128.100 122.000 1.00 96.77  ? 359 PHE A CB  1 
ATOM 2548 C CG  . PHE A 1 359 ? 119.955 128.433 121.778 1.00 96.77  ? 359 PHE A CG  1 
ATOM 2549 C CD1 . PHE A 1 359 ? 120.569 128.142 120.573 1.00 96.77  ? 359 PHE A CD1 1 
ATOM 2550 C CD2 . PHE A 1 359 ? 120.698 129.040 122.773 1.00 96.77  ? 359 PHE A CD2 1 
ATOM 2551 C CE1 . PHE A 1 359 ? 121.896 128.451 120.365 1.00 96.77  ? 359 PHE A CE1 1 
ATOM 2552 C CE2 . PHE A 1 359 ? 122.027 129.349 122.571 1.00 96.77  ? 359 PHE A CE2 1 
ATOM 2553 C CZ  . PHE A 1 359 ? 122.627 129.053 121.366 1.00 96.77  ? 359 PHE A CZ  1 
ATOM 2554 N N   . THR A 1 360 ? 118.961 125.766 124.050 1.00 96.55  ? 360 THR A N   1 
ATOM 2555 C CA  . THR A 1 360 ? 119.841 125.024 124.942 1.00 96.55  ? 360 THR A CA  1 
ATOM 2556 C C   . THR A 1 360 ? 119.788 123.532 124.651 1.00 96.55  ? 360 THR A C   1 
ATOM 2557 O O   . THR A 1 360 ? 120.826 122.860 124.622 1.00 96.55  ? 360 THR A O   1 
ATOM 2558 C CB  . THR A 1 360 ? 119.459 125.305 126.394 1.00 96.55  ? 360 THR A CB  1 
ATOM 2559 O OG1 . THR A 1 360 ? 119.904 126.617 126.759 1.00 96.55  ? 360 THR A OG1 1 
ATOM 2560 C CG2 . THR A 1 360 ? 120.089 124.285 127.325 1.00 96.55  ? 360 THR A CG2 1 
ATOM 2561 N N   . SER A 1 361 ? 118.588 122.995 124.426 1.00 94.66  ? 361 SER A N   1 
ATOM 2562 C CA  . SER A 1 361 ? 118.471 121.586 124.079 1.00 94.66  ? 361 SER A CA  1 
ATOM 2563 C C   . SER A 1 361 ? 119.210 121.283 122.786 1.00 94.66  ? 361 SER A C   1 
ATOM 2564 O O   . SER A 1 361 ? 119.921 120.276 122.692 1.00 94.66  ? 361 SER A O   1 
ATOM 2565 C CB  . SER A 1 361 ? 116.999 121.197 123.960 1.00 94.66  ? 361 SER A CB  1 
ATOM 2566 O OG  . SER A 1 361 ? 116.866 119.838 123.591 1.00 94.66  ? 361 SER A OG  1 
ATOM 2567 N N   . ALA A 1 362 ? 119.071 122.154 121.784 1.00 95.18  ? 362 ALA A N   1 
ATOM 2568 C CA  . ALA A 1 362 ? 119.761 121.933 120.517 1.00 95.18  ? 362 ALA A CA  1 
ATOM 2569 C C   . ALA A 1 362 ? 121.273 121.876 120.712 1.00 95.18  ? 362 ALA A C   1 
ATOM 2570 O O   . ALA A 1 362 ? 121.936 120.933 120.257 1.00 95.18  ? 362 ALA A O   1 
ATOM 2571 C CB  . ALA A 1 362 ? 119.388 123.030 119.522 1.00 95.18  ? 362 ALA A CB  1 
ATOM 2572 N N   . VAL A 1 363 ? 121.835 122.873 121.402 1.00 98.97  ? 363 VAL A N   1 
ATOM 2573 C CA  . VAL A 1 363 ? 123.291 122.932 121.525 1.00 98.97  ? 363 VAL A CA  1 
ATOM 2574 C C   . VAL A 1 363 ? 123.811 121.783 122.383 1.00 98.97  ? 363 VAL A C   1 
ATOM 2575 O O   . VAL A 1 363 ? 124.848 121.181 122.072 1.00 98.97  ? 363 VAL A O   1 
ATOM 2576 C CB  . VAL A 1 363 ? 123.747 124.303 122.062 1.00 98.97  ? 363 VAL A CB  1 
ATOM 2577 C CG1 . VAL A 1 363 ? 123.443 125.392 121.051 1.00 98.97  ? 363 VAL A CG1 1 
ATOM 2578 C CG2 . VAL A 1 363 ? 123.107 124.618 123.395 1.00 98.97  ? 363 VAL A CG2 1 
ATOM 2579 N N   . VAL A 1 364 ? 123.105 121.451 123.468 1.00 99.10  ? 364 VAL A N   1 
ATOM 2580 C CA  . VAL A 1 364 ? 123.549 120.365 124.336 1.00 99.10  ? 364 VAL A CA  1 
ATOM 2581 C C   . VAL A 1 364 ? 123.503 119.038 123.595 1.00 99.10  ? 364 VAL A C   1 
ATOM 2582 O O   . VAL A 1 364 ? 124.425 118.217 123.702 1.00 99.10  ? 364 VAL A O   1 
ATOM 2583 C CB  . VAL A 1 364 ? 122.701 120.330 125.620 1.00 99.10  ? 364 VAL A CB  1 
ATOM 2584 C CG1 . VAL A 1 364 ? 122.822 118.982 126.304 1.00 99.10  ? 364 VAL A CG1 1 
ATOM 2585 C CG2 . VAL A 1 364 ? 123.120 121.446 126.560 1.00 99.10  ? 364 VAL A CG2 1 
ATOM 2586 N N   . TYR A 1 365 ? 122.431 118.799 122.835 1.00 99.66  ? 365 TYR A N   1 
ATOM 2587 C CA  . TYR A 1 365 ? 122.344 117.569 122.061 1.00 99.66  ? 365 TYR A CA  1 
ATOM 2588 C C   . TYR A 1 365 ? 123.467 117.488 121.039 1.00 99.66  ? 365 TYR A C   1 
ATOM 2589 O O   . TYR A 1 365 ? 124.074 116.425 120.860 1.00 99.66  ? 365 TYR A O   1 
ATOM 2590 C CB  . TYR A 1 365 ? 120.979 117.473 121.380 1.00 99.66  ? 365 TYR A CB  1 
ATOM 2591 C CG  . TYR A 1 365 ? 120.790 116.231 120.539 1.00 99.66  ? 365 TYR A CG  1 
ATOM 2592 C CD1 . TYR A 1 365 ? 120.245 115.080 121.085 1.00 99.66  ? 365 TYR A CD1 1 
ATOM 2593 C CD2 . TYR A 1 365 ? 121.125 116.221 119.193 1.00 99.66  ? 365 TYR A CD2 1 
ATOM 2594 C CE1 . TYR A 1 365 ? 120.063 113.947 120.323 1.00 99.66  ? 365 TYR A CE1 1 
ATOM 2595 C CE2 . TYR A 1 365 ? 120.943 115.094 118.422 1.00 99.66  ? 365 TYR A CE2 1 
ATOM 2596 C CZ  . TYR A 1 365 ? 120.413 113.959 118.993 1.00 99.66  ? 365 TYR A CZ  1 
ATOM 2597 O OH  . TYR A 1 365 ? 120.229 112.831 118.229 1.00 99.66  ? 365 TYR A OH  1 
ATOM 2598 N N   . GLN A 1 366 ? 123.764 118.599 120.361 1.00 101.80 ? 366 GLN A N   1 
ATOM 2599 C CA  . GLN A 1 366 ? 124.856 118.584 119.393 1.00 101.80 ? 366 GLN A CA  1 
ATOM 2600 C C   . GLN A 1 366 ? 126.182 118.252 120.066 1.00 101.80 ? 366 GLN A C   1 
ATOM 2601 O O   . GLN A 1 366 ? 126.954 117.425 119.563 1.00 101.80 ? 366 GLN A O   1 
ATOM 2602 C CB  . GLN A 1 366 ? 124.940 119.928 118.672 1.00 101.80 ? 366 GLN A CB  1 
ATOM 2603 C CG  . GLN A 1 366 ? 123.876 120.122 117.608 1.00 101.80 ? 366 GLN A CG  1 
ATOM 2604 C CD  . GLN A 1 366 ? 123.784 118.950 116.651 1.00 101.80 ? 366 GLN A CD  1 
ATOM 2605 O OE1 . GLN A 1 366 ? 122.693 118.463 116.354 1.00 101.80 ? 366 GLN A OE1 1 
ATOM 2606 N NE2 . GLN A 1 366 ? 124.929 118.497 116.154 1.00 101.80 ? 366 GLN A NE2 1 
ATOM 2607 N N   . GLY A 1 367 ? 126.454 118.875 121.215 1.00 103.62 ? 367 GLY A N   1 
ATOM 2608 C CA  . GLY A 1 367 ? 127.701 118.602 121.911 1.00 103.62 ? 367 GLY A CA  1 
ATOM 2609 C C   . GLY A 1 367 ? 127.824 117.151 122.337 1.00 103.62 ? 367 GLY A C   1 
ATOM 2610 O O   . GLY A 1 367 ? 128.860 116.513 122.129 1.00 103.62 ? 367 GLY A O   1 
ATOM 2611 N N   . LEU A 1 368 ? 126.759 116.605 122.927 1.00 103.83 ? 368 LEU A N   1 
ATOM 2612 C CA  . LEU A 1 368 ? 126.806 115.217 123.379 1.00 103.83 ? 368 LEU A CA  1 
ATOM 2613 C C   . LEU A 1 368 ? 126.954 114.254 122.208 1.00 103.83 ? 368 LEU A C   1 
ATOM 2614 O O   . LEU A 1 368 ? 127.709 113.279 122.293 1.00 103.83 ? 368 LEU A O   1 
ATOM 2615 C CB  . LEU A 1 368 ? 125.565 114.886 124.203 1.00 103.83 ? 368 LEU A CB  1 
ATOM 2616 C CG  . LEU A 1 368 ? 125.450 115.671 125.508 1.00 103.83 ? 368 LEU A CG  1 
ATOM 2617 C CD1 . LEU A 1 368 ? 124.107 115.431 126.172 1.00 103.83 ? 368 LEU A CD1 1 
ATOM 2618 C CD2 . LEU A 1 368 ? 126.584 115.287 126.436 1.00 103.83 ? 368 LEU A CD2 1 
ATOM 2619 N N   . VAL A 1 369 ? 126.245 114.507 121.104 1.00 106.94 ? 369 VAL A N   1 
ATOM 2620 C CA  . VAL A 1 369 ? 126.361 113.633 119.940 1.00 106.94 ? 369 VAL A CA  1 
ATOM 2621 C C   . VAL A 1 369 ? 127.776 113.673 119.382 1.00 106.94 ? 369 VAL A C   1 
ATOM 2622 O O   . VAL A 1 369 ? 128.335 112.638 118.996 1.00 106.94 ? 369 VAL A O   1 
ATOM 2623 C CB  . VAL A 1 369 ? 125.316 114.013 118.876 1.00 106.94 ? 369 VAL A CB  1 
ATOM 2624 C CG1 . VAL A 1 369 ? 125.599 113.289 117.574 1.00 106.94 ? 369 VAL A CG1 1 
ATOM 2625 C CG2 . VAL A 1 369 ? 123.932 113.656 119.370 1.00 106.94 ? 369 VAL A CG2 1 
ATOM 2626 N N   . MET A 1 370 ? 128.383 114.861 119.332 1.00 110.86 ? 370 MET A N   1 
ATOM 2627 C CA  . MET A 1 370 ? 129.775 114.942 118.904 1.00 110.86 ? 370 MET A CA  1 
ATOM 2628 C C   . MET A 1 370 ? 130.684 114.165 119.848 1.00 110.86 ? 370 MET A C   1 
ATOM 2629 O O   . MET A 1 370 ? 131.645 113.521 119.411 1.00 110.86 ? 370 MET A O   1 
ATOM 2630 C CB  . MET A 1 370 ? 130.214 116.403 118.812 1.00 110.86 ? 370 MET A CB  1 
ATOM 2631 C CG  . MET A 1 370 ? 131.049 116.718 117.583 1.00 110.86 ? 370 MET A CG  1 
ATOM 2632 S SD  . MET A 1 370 ? 130.224 116.246 116.051 1.00 110.86 ? 370 MET A SD  1 
ATOM 2633 C CE  . MET A 1 370 ? 128.872 117.420 116.018 1.00 110.86 ? 370 MET A CE  1 
ATOM 2634 N N   . ARG A 1 371 ? 130.390 114.212 121.150 1.00 112.62 ? 371 ARG A N   1 
ATOM 2635 C CA  . ARG A 1 371 ? 131.198 113.481 122.122 1.00 112.62 ? 371 ARG A CA  1 
ATOM 2636 C C   . ARG A 1 371 ? 131.072 111.971 121.942 1.00 112.62 ? 371 ARG A C   1 
ATOM 2637 O O   . ARG A 1 371 ? 132.041 111.234 122.160 1.00 112.62 ? 371 ARG A O   1 
ATOM 2638 C CB  . ARG A 1 371 ? 130.796 113.885 123.540 1.00 112.62 ? 371 ARG A CB  1 
ATOM 2639 C CG  . ARG A 1 371 ? 131.584 113.191 124.635 1.00 112.62 ? 371 ARG A CG  1 
ATOM 2640 C CD  . ARG A 1 371 ? 133.072 113.455 124.503 1.00 112.62 ? 371 ARG A CD  1 
ATOM 2641 N NE  . ARG A 1 371 ? 133.389 114.870 124.646 1.00 112.62 ? 371 ARG A NE  1 
ATOM 2642 C CZ  . ARG A 1 371 ? 134.455 115.338 125.281 1.00 112.62 ? 371 ARG A CZ  1 
ATOM 2643 N NH1 . ARG A 1 371 ? 135.329 114.528 125.854 1.00 112.62 ? 371 ARG A NH1 1 
ATOM 2644 N NH2 . ARG A 1 371 ? 134.648 116.652 125.343 1.00 112.62 ? 371 ARG A NH2 1 
ATOM 2645 N N   . LEU A 1 372 ? 129.886 111.493 121.552 1.00 111.80 ? 372 LEU A N   1 
ATOM 2646 C CA  . LEU A 1 372 ? 129.644 110.051 121.495 1.00 111.80 ? 372 LEU A CA  1 
ATOM 2647 C C   . LEU A 1 372 ? 130.576 109.351 120.515 1.00 111.80 ? 372 LEU A C   1 
ATOM 2648 O O   . LEU A 1 372 ? 131.145 108.300 120.832 1.00 111.80 ? 372 LEU A O   1 
ATOM 2649 C CB  . LEU A 1 372 ? 128.190 109.774 121.116 1.00 111.80 ? 372 LEU A CB  1 
ATOM 2650 C CG  . LEU A 1 372 ? 127.104 110.187 122.104 1.00 111.80 ? 372 LEU A CG  1 
ATOM 2651 C CD1 . LEU A 1 372 ? 125.736 109.936 121.510 1.00 111.80 ? 372 LEU A CD1 1 
ATOM 2652 C CD2 . LEU A 1 372 ? 127.268 109.404 123.385 1.00 111.80 ? 372 LEU A CD2 1 
ATOM 2653 N N   . GLY A 1 373 ? 130.746 109.910 119.324 1.00 116.55 ? 373 GLY A N   1 
ATOM 2654 C CA  . GLY A 1 373 ? 131.527 109.216 118.312 1.00 116.55 ? 373 GLY A CA  1 
ATOM 2655 C C   . GLY A 1 373 ? 130.724 108.080 117.711 1.00 116.55 ? 373 GLY A C   1 
ATOM 2656 O O   . GLY A 1 373 ? 129.530 108.219 117.424 1.00 116.55 ? 373 GLY A O   1 
ATOM 2657 N N   . ILE A 1 374 ? 131.376 106.935 117.521 1.00 119.20 ? 374 ILE A N   1 
ATOM 2658 C CA  . ILE A 1 374 ? 130.764 105.762 116.908 1.00 119.20 ? 374 ILE A CA  1 
ATOM 2659 C C   . ILE A 1 374 ? 130.655 104.659 117.951 1.00 119.20 ? 374 ILE A C   1 
ATOM 2660 O O   . ILE A 1 374 ? 131.568 104.462 118.761 1.00 119.20 ? 374 ILE A O   1 
ATOM 2661 C CB  . ILE A 1 374 ? 131.559 105.282 115.678 1.00 119.20 ? 374 ILE A CB  1 
ATOM 2662 C CG1 . ILE A 1 374 ? 133.040 105.114 116.026 1.00 119.20 ? 374 ILE A CG1 1 
ATOM 2663 C CG2 . ILE A 1 374 ? 131.384 106.250 114.519 1.00 119.20 ? 374 ILE A CG2 1 
ATOM 2664 C CD1 . ILE A 1 374 ? 133.802 104.243 115.051 1.00 119.20 ? 374 ILE A CD1 1 
ATOM 2665 N N   . ILE A 1 375 ? 129.530 103.948 117.936 1.00 115.48 ? 375 ILE A N   1 
ATOM 2666 C CA  . ILE A 1 375 ? 129.262 102.855 118.862 1.00 115.48 ? 375 ILE A CA  1 
ATOM 2667 C C   . ILE A 1 375 ? 128.973 101.597 118.055 1.00 115.48 ? 375 ILE A C   1 
ATOM 2668 O O   . ILE A 1 375 ? 128.118 101.610 117.163 1.00 115.48 ? 375 ILE A O   1 
ATOM 2669 C CB  . ILE A 1 375 ? 128.085 103.182 119.799 1.00 115.48 ? 375 ILE A CB  1 
ATOM 2670 C CG1 . ILE A 1 375 ? 128.491 104.253 120.813 1.00 115.48 ? 375 ILE A CG1 1 
ATOM 2671 C CG2 . ILE A 1 375 ? 127.594 101.927 120.504 1.00 115.48 ? 375 ILE A CG2 1 
ATOM 2672 C CD1 . ILE A 1 375 ? 127.356 105.163 121.220 1.00 115.48 ? 375 ILE A CD1 1 
ATOM 2673 N N   . GLY A 1 376 ? 129.686 100.516 118.366 1.00 118.80 ? 376 GLY A N   1 
ATOM 2674 C CA  . GLY A 1 376 ? 129.457 99.237  117.734 1.00 118.80 ? 376 GLY A CA  1 
ATOM 2675 C C   . GLY A 1 376 ? 130.231 98.997  116.456 1.00 118.80 ? 376 GLY A C   1 
ATOM 2676 O O   . GLY A 1 376 ? 130.195 97.876  115.933 1.00 118.80 ? 376 GLY A O   1 
ATOM 2677 N N   . GLY A 1 377 ? 130.926 100.006 115.936 1.00 113.39 ? 377 GLY A N   1 
ATOM 2678 C CA  . GLY A 1 377 ? 131.732 99.843  114.745 1.00 113.39 ? 377 GLY A CA  1 
ATOM 2679 C C   . GLY A 1 377 ? 130.975 99.875  113.437 1.00 113.39 ? 377 GLY A C   1 
ATOM 2680 O O   . GLY A 1 377 ? 131.594 99.691  112.381 1.00 113.39 ? 377 GLY A O   1 
ATOM 2681 N N   . ASN A 1 378 ? 129.664 100.101 113.465 1.00 102.77 ? 378 ASN A N   1 
ATOM 2682 C CA  . ASN A 1 378 ? 128.843 100.135 112.263 1.00 102.77 ? 378 ASN A CA  1 
ATOM 2683 C C   . ASN A 1 378 ? 127.957 101.369 112.292 1.00 102.77 ? 378 ASN A C   1 
ATOM 2684 O O   . ASN A 1 378 ? 127.481 101.774 113.355 1.00 102.77 ? 378 ASN A O   1 
ATOM 2685 C CB  . ASN A 1 378 ? 127.983 98.872  112.145 1.00 102.77 ? 378 ASN A CB  1 
ATOM 2686 C CG  . ASN A 1 378 ? 127.383 98.703  110.766 1.00 102.77 ? 378 ASN A CG  1 
ATOM 2687 O OD1 . ASN A 1 378 ? 126.545 99.496  110.337 1.00 102.77 ? 378 ASN A OD1 1 
ATOM 2688 N ND2 . ASN A 1 378 ? 127.809 97.663  110.061 1.00 102.77 ? 378 ASN A ND2 1 
ATOM 2689 N N   . LEU A 1 379 ? 127.747 101.972 111.121 1.00 96.07  ? 379 LEU A N   1 
ATOM 2690 C CA  . LEU A 1 379 ? 126.881 103.144 111.040 1.00 96.07  ? 379 LEU A CA  1 
ATOM 2691 C C   . LEU A 1 379 ? 125.417 102.764 111.232 1.00 96.07  ? 379 LEU A C   1 
ATOM 2692 O O   . LEU A 1 379 ? 124.700 103.389 112.025 1.00 96.07  ? 379 LEU A O   1 
ATOM 2693 C CB  . LEU A 1 379 ? 127.084 103.848 109.699 1.00 96.07  ? 379 LEU A CB  1 
ATOM 2694 C CG  . LEU A 1 379 ? 125.994 104.834 109.280 1.00 96.07  ? 379 LEU A CG  1 
ATOM 2695 C CD1 . LEU A 1 379 ? 126.051 106.090 110.135 1.00 96.07  ? 379 LEU A CD1 1 
ATOM 2696 C CD2 . LEU A 1 379 ? 126.128 105.177 107.806 1.00 96.07  ? 379 LEU A CD2 1 
ATOM 2697 N N   . TYR A 1 380 ? 124.956 101.735 110.515 1.00 95.88  ? 380 TYR A N   1 
ATOM 2698 C CA  . TYR A 1 380 ? 123.559 101.326 110.618 1.00 95.88  ? 380 TYR A CA  1 
ATOM 2699 C C   . TYR A 1 380 ? 123.231 100.828 112.018 1.00 95.88  ? 380 TYR A C   1 
ATOM 2700 O O   . TYR A 1 380 ? 122.195 101.189 112.586 1.00 95.88  ? 380 TYR A O   1 
ATOM 2701 C CB  . TYR A 1 380 ? 123.250 100.246 109.582 1.00 95.88  ? 380 TYR A CB  1 
ATOM 2702 C CG  . TYR A 1 380 ? 123.722 100.582 108.189 1.00 95.88  ? 380 TYR A CG  1 
ATOM 2703 C CD1 . TYR A 1 380 ? 123.217 101.681 107.512 1.00 95.88  ? 380 TYR A CD1 1 
ATOM 2704 C CD2 . TYR A 1 380 ? 124.676 99.803  107.554 1.00 95.88  ? 380 TYR A CD2 1 
ATOM 2705 C CE1 . TYR A 1 380 ? 123.649 101.994 106.238 1.00 95.88  ? 380 TYR A CE1 1 
ATOM 2706 C CE2 . TYR A 1 380 ? 125.114 100.107 106.280 1.00 95.88  ? 380 TYR A CE2 1 
ATOM 2707 C CZ  . TYR A 1 380 ? 124.597 101.203 105.627 1.00 95.88  ? 380 TYR A CZ  1 
ATOM 2708 O OH  . TYR A 1 380 ? 125.032 101.508 104.358 1.00 95.88  ? 380 TYR A OH  1 
ATOM 2709 N N   . ILE A 1 381 ? 124.105 99.999  112.591 1.00 99.25  ? 381 ILE A N   1 
ATOM 2710 C CA  . ILE A 1 381 ? 123.859 99.467  113.926 1.00 99.25  ? 381 ILE A CA  1 
ATOM 2711 C C   . ILE A 1 381 ? 123.869 100.585 114.960 1.00 99.25  ? 381 ILE A C   1 
ATOM 2712 O O   . ILE A 1 381 ? 123.029 100.614 115.867 1.00 99.25  ? 381 ILE A O   1 
ATOM 2713 C CB  . ILE A 1 381 ? 124.886 98.373  114.263 1.00 99.25  ? 381 ILE A CB  1 
ATOM 2714 C CG1 . ILE A 1 381 ? 124.855 97.269  113.206 1.00 99.25  ? 381 ILE A CG1 1 
ATOM 2715 C CG2 . ILE A 1 381 ? 124.612 97.796  115.639 1.00 99.25  ? 381 ILE A CG2 1 
ATOM 2716 C CD1 . ILE A 1 381 ? 125.866 96.169  113.441 1.00 99.25  ? 381 ILE A CD1 1 
ATOM 2717 N N   . ASP A 1 382 ? 124.825 101.509 114.855 1.00 103.89 ? 382 ASP A N   1 
ATOM 2718 C CA  . ASP A 1 382 ? 124.877 102.625 115.794 1.00 103.89 ? 382 ASP A CA  1 
ATOM 2719 C C   . ASP A 1 382 ? 123.611 103.464 115.709 1.00 103.89 ? 382 ASP A C   1 
ATOM 2720 O O   . ASP A 1 382 ? 123.034 103.843 116.734 1.00 103.89 ? 382 ASP A O   1 
ATOM 2721 C CB  . ASP A 1 382 ? 126.108 103.490 115.524 1.00 103.89 ? 382 ASP A CB  1 
ATOM 2722 C CG  . ASP A 1 382 ? 126.422 104.442 116.668 1.00 103.89 ? 382 ASP A CG  1 
ATOM 2723 O OD1 . ASP A 1 382 ? 125.558 104.643 117.547 1.00 103.89 ? 382 ASP A OD1 1 
ATOM 2724 O OD2 . ASP A 1 382 ? 127.541 104.996 116.686 1.00 103.89 ? 382 ASP A OD2 1 
ATOM 2725 N N   . PHE A 1 383 ? 123.161 103.764 114.489 1.00 94.31  ? 383 PHE A N   1 
ATOM 2726 C CA  . PHE A 1 383 ? 121.950 104.562 114.340 1.00 94.31  ? 383 PHE A CA  1 
ATOM 2727 C C   . PHE A 1 383 ? 120.733 103.824 114.882 1.00 94.31  ? 383 PHE A C   1 
ATOM 2728 O O   . PHE A 1 383 ? 119.871 104.427 115.533 1.00 94.31  ? 383 PHE A O   1 
ATOM 2729 C CB  . PHE A 1 383 ? 121.745 104.938 112.876 1.00 94.31  ? 383 PHE A CB  1 
ATOM 2730 C CG  . PHE A 1 383 ? 120.963 106.198 112.690 1.00 94.31  ? 383 PHE A CG  1 
ATOM 2731 C CD1 . PHE A 1 383 ? 121.443 107.400 113.176 1.00 94.31  ? 383 PHE A CD1 1 
ATOM 2732 C CD2 . PHE A 1 383 ? 119.742 106.181 112.044 1.00 94.31  ? 383 PHE A CD2 1 
ATOM 2733 C CE1 . PHE A 1 383 ? 120.724 108.558 113.014 1.00 94.31  ? 383 PHE A CE1 1 
ATOM 2734 C CE2 . PHE A 1 383 ? 119.020 107.334 111.880 1.00 94.31  ? 383 PHE A CE2 1 
ATOM 2735 C CZ  . PHE A 1 383 ? 119.510 108.524 112.366 1.00 94.31  ? 383 PHE A CZ  1 
ATOM 2736 N N   . PHE A 1 384 ? 120.654 102.516 114.635 1.00 93.03  ? 384 PHE A N   1 
ATOM 2737 C CA  . PHE A 1 384 ? 119.536 101.725 115.135 1.00 93.03  ? 384 PHE A CA  1 
ATOM 2738 C C   . PHE A 1 384 ? 119.507 101.720 116.658 1.00 93.03  ? 384 PHE A C   1 
ATOM 2739 O O   . PHE A 1 384 ? 118.448 101.893 117.268 1.00 93.03  ? 384 PHE A O   1 
ATOM 2740 C CB  . PHE A 1 384 ? 119.630 100.302 114.586 1.00 93.03  ? 384 PHE A CB  1 
ATOM 2741 C CG  . PHE A 1 384 ? 118.501 99.411  115.007 1.00 93.03  ? 384 PHE A CG  1 
ATOM 2742 C CD1 . PHE A 1 384 ? 117.252 99.533  114.426 1.00 93.03  ? 384 PHE A CD1 1 
ATOM 2743 C CD2 . PHE A 1 384 ? 118.692 98.442  115.976 1.00 93.03  ? 384 PHE A CD2 1 
ATOM 2744 C CE1 . PHE A 1 384 ? 116.214 98.710  114.808 1.00 93.03  ? 384 PHE A CE1 1 
ATOM 2745 C CE2 . PHE A 1 384 ? 117.658 97.616  116.362 1.00 93.03  ? 384 PHE A CE2 1 
ATOM 2746 C CZ  . PHE A 1 384 ? 116.417 97.750  115.778 1.00 93.03  ? 384 PHE A CZ  1 
ATOM 2747 N N   . ILE A 1 385 ? 120.666 101.522 117.290 1.00 95.19  ? 385 ILE A N   1 
ATOM 2748 C CA  . ILE A 1 385 ? 120.727 101.518 118.751 1.00 95.19  ? 385 ILE A CA  1 
ATOM 2749 C C   . ILE A 1 385 ? 120.373 102.890 119.305 1.00 95.19  ? 385 ILE A C   1 
ATOM 2750 O O   . ILE A 1 385 ? 119.647 103.007 120.302 1.00 95.19  ? 385 ILE A O   1 
ATOM 2751 C CB  . ILE A 1 385 ? 122.117 101.061 119.229 1.00 95.19  ? 385 ILE A CB  1 
ATOM 2752 C CG1 . ILE A 1 385 ? 122.388 99.622  118.796 1.00 95.19  ? 385 ILE A CG1 1 
ATOM 2753 C CG2 . ILE A 1 385 ? 122.236 101.200 120.735 1.00 95.19  ? 385 ILE A CG2 1 
ATOM 2754 C CD1 . ILE A 1 385 ? 123.821 99.188  118.999 1.00 95.19  ? 385 ILE A CD1 1 
ATOM 2755 N N   . SER A 1 386 ? 120.885 103.950 118.675 1.00 93.34  ? 386 SER A N   1 
ATOM 2756 C CA  . SER A 1 386 ? 120.588 105.299 119.138 1.00 93.34  ? 386 SER A CA  1 
ATOM 2757 C C   . SER A 1 386 ? 119.099 105.592 119.047 1.00 93.34  ? 386 SER A C   1 
ATOM 2758 O O   . SER A 1 386 ? 118.528 106.232 119.937 1.00 93.34  ? 386 SER A O   1 
ATOM 2759 C CB  . SER A 1 386 ? 121.389 106.316 118.330 1.00 93.34  ? 386 SER A CB  1 
ATOM 2760 O OG  . SER A 1 386 ? 120.898 106.403 117.005 1.00 93.34  ? 386 SER A OG  1 
ATOM 2761 N N   . GLY A 1 387 ? 118.453 105.141 117.973 1.00 91.13  ? 387 GLY A N   1 
ATOM 2762 C CA  . GLY A 1 387 ? 117.014 105.302 117.875 1.00 91.13  ? 387 GLY A CA  1 
ATOM 2763 C C   . GLY A 1 387 ? 116.259 104.475 118.899 1.00 91.13  ? 387 GLY A C   1 
ATOM 2764 O O   . GLY A 1 387 ? 115.307 104.958 119.517 1.00 91.13  ? 387 GLY A O   1 
ATOM 2765 N N   . VAL A 1 388 ? 116.673 103.221 119.093 1.00 90.45  ? 388 VAL A N   1 
ATOM 2766 C CA  . VAL A 1 388 ? 115.944 102.319 119.981 1.00 90.45  ? 388 VAL A CA  1 
ATOM 2767 C C   . VAL A 1 388 ? 115.992 102.822 121.416 1.00 90.45  ? 388 VAL A C   1 
ATOM 2768 O O   . VAL A 1 388 ? 114.971 102.845 122.114 1.00 90.45  ? 388 VAL A O   1 
ATOM 2769 C CB  . VAL A 1 388 ? 116.499 100.888 119.863 1.00 90.45  ? 388 VAL A CB  1 
ATOM 2770 C CG1 . VAL A 1 388 ? 116.033 100.040 121.031 1.00 90.45  ? 388 VAL A CG1 1 
ATOM 2771 C CG2 . VAL A 1 388 ? 116.060 100.259 118.555 1.00 90.45  ? 388 VAL A CG2 1 
ATOM 2772 N N   . VAL A 1 389 ? 117.170 103.248 121.879 1.00 93.93  ? 389 VAL A N   1 
ATOM 2773 C CA  . VAL A 1 389 ? 117.295 103.719 123.255 1.00 93.93  ? 389 VAL A CA  1 
ATOM 2774 C C   . VAL A 1 389 ? 116.515 104.998 123.514 1.00 93.93  ? 389 VAL A C   1 
ATOM 2775 O O   . VAL A 1 389 ? 116.410 105.422 124.669 1.00 93.93  ? 389 VAL A O   1 
ATOM 2776 C CB  . VAL A 1 389 ? 118.773 103.931 123.636 1.00 93.93  ? 389 VAL A CB  1 
ATOM 2777 C CG1 . VAL A 1 389 ? 119.556 102.640 123.457 1.00 93.93  ? 389 VAL A CG1 1 
ATOM 2778 C CG2 . VAL A 1 389 ? 119.378 105.049 122.814 1.00 93.93  ? 389 VAL A CG2 1 
ATOM 2779 N N   . GLU A 1 390 ? 115.969 105.625 122.471 1.00 96.36  ? 390 GLU A N   1 
ATOM 2780 C CA  . GLU A 1 390 ? 115.133 106.804 122.667 1.00 96.36  ? 390 GLU A CA  1 
ATOM 2781 C C   . GLU A 1 390 ? 113.757 106.440 123.210 1.00 96.36  ? 390 GLU A C   1 
ATOM 2782 O O   . GLU A 1 390 ? 113.160 107.222 123.959 1.00 96.36  ? 390 GLU A O   1 
ATOM 2783 C CB  . GLU A 1 390 ? 114.985 107.563 121.351 1.00 96.36  ? 390 GLU A CB  1 
ATOM 2784 C CG  . GLU A 1 390 ? 116.265 108.174 120.828 1.00 96.36  ? 390 GLU A CG  1 
ATOM 2785 C CD  . GLU A 1 390 ? 116.769 109.276 121.721 1.00 96.36  ? 390 GLU A CD  1 
ATOM 2786 O OE1 . GLU A 1 390 ? 115.923 109.951 122.336 1.00 96.36  ? 390 GLU A OE1 1 
ATOM 2787 O OE2 . GLU A 1 390 ? 118.000 109.474 121.803 1.00 96.36  ? 390 GLU A OE2 1 
ATOM 2788 N N   . LEU A 1 391 ? 113.238 105.272 122.835 1.00 89.70  ? 391 LEU A N   1 
ATOM 2789 C CA  . LEU A 1 391 ? 111.880 104.895 123.219 1.00 89.70  ? 391 LEU A CA  1 
ATOM 2790 C C   . LEU A 1 391 ? 111.653 104.791 124.726 1.00 89.70  ? 391 LEU A C   1 
ATOM 2791 O O   . LEU A 1 391 ? 110.608 105.279 125.190 1.00 89.70  ? 391 LEU A O   1 
ATOM 2792 C CB  . LEU A 1 391 ? 111.505 103.580 122.523 1.00 89.70  ? 391 LEU A CB  1 
ATOM 2793 C CG  . LEU A 1 391 ? 111.052 103.716 121.069 1.00 89.70  ? 391 LEU A CG  1 
ATOM 2794 C CD1 . LEU A 1 391 ? 110.835 102.352 120.440 1.00 89.70  ? 391 LEU A CD1 1 
ATOM 2795 C CD2 . LEU A 1 391 ? 109.791 104.554 120.981 1.00 89.70  ? 391 LEU A CD2 1 
ATOM 2796 N N   . PRO A 1 392 ? 112.533 104.169 125.529 1.00 91.04  ? 392 PRO A N   1 
ATOM 2797 C CA  . PRO A 1 392 ? 112.227 104.044 126.966 1.00 91.04  ? 392 PRO A CA  1 
ATOM 2798 C C   . PRO A 1 392 ? 111.979 105.372 127.658 1.00 91.04  ? 392 PRO A C   1 
ATOM 2799 O O   . PRO A 1 392 ? 111.119 105.453 128.544 1.00 91.04  ? 392 PRO A O   1 
ATOM 2800 C CB  . PRO A 1 392 ? 113.470 103.339 127.524 1.00 91.04  ? 392 PRO A CB  1 
ATOM 2801 C CG  . PRO A 1 392 ? 114.018 102.589 126.376 1.00 91.04  ? 392 PRO A CG  1 
ATOM 2802 C CD  . PRO A 1 392 ? 113.773 103.452 125.181 1.00 91.04  ? 392 PRO A CD  1 
ATOM 2803 N N   . GLY A 1 393 ? 112.710 106.420 127.279 1.00 90.15  ? 393 GLY A N   1 
ATOM 2804 C CA  . GLY A 1 393 ? 112.424 107.734 127.827 1.00 90.15  ? 393 GLY A CA  1 
ATOM 2805 C C   . GLY A 1 393 ? 111.026 108.206 127.483 1.00 90.15  ? 393 GLY A C   1 
ATOM 2806 O O   . GLY A 1 393 ? 110.328 108.779 128.323 1.00 90.15  ? 393 GLY A O   1 
ATOM 2807 N N   . ALA A 1 394 ? 110.594 107.965 126.244 1.00 89.71  ? 394 ALA A N   1 
ATOM 2808 C CA  . ALA A 1 394 ? 109.240 108.336 125.847 1.00 89.71  ? 394 ALA A CA  1 
ATOM 2809 C C   . ALA A 1 394 ? 108.199 107.560 126.642 1.00 89.71  ? 394 ALA A C   1 
ATOM 2810 O O   . ALA A 1 394 ? 107.170 108.117 127.041 1.00 89.71  ? 394 ALA A O   1 
ATOM 2811 C CB  . ALA A 1 394 ? 109.053 108.109 124.348 1.00 89.71  ? 394 ALA A CB  1 
ATOM 2812 N N   . LEU A 1 395 ? 108.442 106.267 126.872 1.00 91.89  ? 395 LEU A N   1 
ATOM 2813 C CA  . LEU A 1 395 ? 107.521 105.475 127.682 1.00 91.89  ? 395 LEU A CA  1 
ATOM 2814 C C   . LEU A 1 395 ? 107.440 106.015 129.103 1.00 91.89  ? 395 LEU A C   1 
ATOM 2815 O O   . LEU A 1 395 ? 106.350 106.114 129.683 1.00 91.89  ? 395 LEU A O   1 
ATOM 2816 C CB  . LEU A 1 395 ? 107.959 104.011 127.691 1.00 91.89  ? 395 LEU A CB  1 
ATOM 2817 C CG  . LEU A 1 395 ? 107.894 103.259 126.362 1.00 91.89  ? 395 LEU A CG  1 
ATOM 2818 C CD1 . LEU A 1 395 ? 108.490 101.868 126.501 1.00 91.89  ? 395 LEU A CD1 1 
ATOM 2819 C CD2 . LEU A 1 395 ? 106.461 103.177 125.869 1.00 91.89  ? 395 LEU A CD2 1 
ATOM 2820 N N   . LEU A 1 396 ? 108.590 106.369 129.679 1.00 91.39  ? 396 LEU A N   1 
ATOM 2821 C CA  . LEU A 1 396 ? 108.606 106.940 131.020 1.00 91.39  ? 396 LEU A CA  1 
ATOM 2822 C C   . LEU A 1 396 ? 107.828 108.247 131.062 1.00 91.39  ? 396 LEU A C   1 
ATOM 2823 O O   . LEU A 1 396 ? 107.066 108.496 132.002 1.00 91.39  ? 396 LEU A O   1 
ATOM 2824 C CB  . LEU A 1 396 ? 110.052 107.146 131.472 1.00 91.39  ? 396 LEU A CB  1 
ATOM 2825 C CG  . LEU A 1 396 ? 110.377 107.286 132.959 1.00 91.39  ? 396 LEU A CG  1 
ATOM 2826 C CD1 . LEU A 1 396 ? 111.849 106.991 133.174 1.00 91.39  ? 396 LEU A CD1 1 
ATOM 2827 C CD2 . LEU A 1 396 ? 110.044 108.675 133.478 1.00 91.39  ? 396 LEU A CD2 1 
ATOM 2828 N N   . ILE A 1 397 ? 107.999 109.090 130.042 1.00 89.55  ? 397 ILE A N   1 
ATOM 2829 C CA  . ILE A 1 397 ? 107.235 110.333 129.970 1.00 89.55  ? 397 ILE A CA  1 
ATOM 2830 C C   . ILE A 1 397 ? 105.742 110.035 129.906 1.00 89.55  ? 397 ILE A C   1 
ATOM 2831 O O   . ILE A 1 397 ? 104.939 110.636 130.630 1.00 89.55  ? 397 ILE A O   1 
ATOM 2832 C CB  . ILE A 1 397 ? 107.693 111.170 128.761 1.00 89.55  ? 397 ILE A CB  1 
ATOM 2833 C CG1 . ILE A 1 397 ? 109.154 111.584 128.912 1.00 89.55  ? 397 ILE A CG1 1 
ATOM 2834 C CG2 . ILE A 1 397 ? 106.834 112.399 128.604 1.00 89.55  ? 397 ILE A CG2 1 
ATOM 2835 C CD1 . ILE A 1 397 ? 109.738 112.179 127.655 1.00 89.55  ? 397 ILE A CD1 1 
ATOM 2836 N N   . LEU A 1 398 ? 105.350 109.088 129.051 1.00 88.45  ? 398 LEU A N   1 
ATOM 2837 C CA  . LEU A 1 398 ? 103.934 108.776 128.884 1.00 88.45  ? 398 LEU A CA  1 
ATOM 2838 C C   . LEU A 1 398 ? 103.318 108.295 130.190 1.00 88.45  ? 398 LEU A C   1 
ATOM 2839 O O   . LEU A 1 398 ? 102.180 108.649 130.516 1.00 88.45  ? 398 LEU A O   1 
ATOM 2840 C CB  . LEU A 1 398 ? 103.757 107.731 127.784 1.00 88.45  ? 398 LEU A CB  1 
ATOM 2841 C CG  . LEU A 1 398 ? 102.344 107.502 127.247 1.00 88.45  ? 398 LEU A CG  1 
ATOM 2842 C CD1 . LEU A 1 398 ? 102.381 107.254 125.753 1.00 88.45  ? 398 LEU A CD1 1 
ATOM 2843 C CD2 . LEU A 1 398 ? 101.698 106.326 127.951 1.00 88.45  ? 398 LEU A CD2 1 
ATOM 2844 N N   . LEU A 1 399 ? 104.053 107.485 130.951 1.00 89.52  ? 399 LEU A N   1 
ATOM 2845 C CA  . LEU A 1 399 ? 103.517 107.004 132.219 1.00 89.52  ? 399 LEU A CA  1 
ATOM 2846 C C   . LEU A 1 399 ? 103.652 108.027 133.343 1.00 89.52  ? 399 LEU A C   1 
ATOM 2847 O O   . LEU A 1 399 ? 103.009 107.874 134.386 1.00 89.52  ? 399 LEU A O   1 
ATOM 2848 C CB  . LEU A 1 399 ? 104.199 105.696 132.619 1.00 89.52  ? 399 LEU A CB  1 
ATOM 2849 C CG  . LEU A 1 399 ? 104.231 104.602 131.551 1.00 89.52  ? 399 LEU A CG  1 
ATOM 2850 C CD1 . LEU A 1 399 ? 105.245 103.532 131.910 1.00 89.52  ? 399 LEU A CD1 1 
ATOM 2851 C CD2 . LEU A 1 399 ? 102.851 103.994 131.366 1.00 89.52  ? 399 LEU A CD2 1 
ATOM 2852 N N   . THR A 1 400 ? 104.466 109.070 133.162 1.00 94.21  ? 400 THR A N   1 
ATOM 2853 C CA  . THR A 1 400 ? 104.745 109.966 134.280 1.00 94.21  ? 400 THR A CA  1 
ATOM 2854 C C   . THR A 1 400 ? 103.969 111.279 134.212 1.00 94.21  ? 400 THR A C   1 
ATOM 2855 O O   . THR A 1 400 ? 103.624 111.832 135.262 1.00 94.21  ? 400 THR A O   1 
ATOM 2856 C CB  . THR A 1 400 ? 106.247 110.250 134.343 1.00 94.21  ? 400 THR A CB  1 
ATOM 2857 O OG1 . THR A 1 400 ? 106.958 109.013 134.470 1.00 94.21  ? 400 THR A OG1 1 
ATOM 2858 C CG2 . THR A 1 400 ? 106.584 111.129 135.537 1.00 94.21  ? 400 THR A CG2 1 
ATOM 2859 N N   . ILE A 1 401 ? 103.674 111.784 133.008 1.00 99.15  ? 401 ILE A N   1 
ATOM 2860 C CA  . ILE A 1 401 ? 103.104 113.129 132.876 1.00 99.15  ? 401 ILE A CA  1 
ATOM 2861 C C   . ILE A 1 401 ? 101.830 113.280 133.698 1.00 99.15  ? 401 ILE A C   1 
ATOM 2862 O O   . ILE A 1 401 ? 101.635 114.288 134.387 1.00 99.15  ? 401 ILE A O   1 
ATOM 2863 C CB  . ILE A 1 401 ? 102.853 113.479 131.398 1.00 99.15  ? 401 ILE A CB  1 
ATOM 2864 C CG1 . ILE A 1 401 ? 104.151 113.434 130.603 1.00 99.15  ? 401 ILE A CG1 1 
ATOM 2865 C CG2 . ILE A 1 401 ? 102.165 114.821 131.269 1.00 99.15  ? 401 ILE A CG2 1 
ATOM 2866 C CD1 . ILE A 1 401 ? 105.184 114.417 131.090 1.00 99.15  ? 401 ILE A CD1 1 
ATOM 2867 N N   . GLU A 1 402 ? 100.934 112.297 133.626 1.00 104.51 ? 402 GLU A N   1 
ATOM 2868 C CA  . GLU A 1 402 ? 99.652  112.441 134.307 1.00 104.51 ? 402 GLU A CA  1 
ATOM 2869 C C   . GLU A 1 402 ? 99.824  112.546 135.819 1.00 104.51 ? 402 GLU A C   1 
ATOM 2870 O O   . GLU A 1 402 ? 99.207  113.406 136.459 1.00 104.51 ? 402 GLU A O   1 
ATOM 2871 C CB  . GLU A 1 402 ? 98.734  111.274 133.949 1.00 104.51 ? 402 GLU A CB  1 
ATOM 2872 C CG  . GLU A 1 402 ? 97.815  111.555 132.773 1.00 104.51 ? 402 GLU A CG  1 
ATOM 2873 C CD  . GLU A 1 402 ? 96.782  112.621 133.082 1.00 104.51 ? 402 GLU A CD  1 
ATOM 2874 O OE1 . GLU A 1 402 ? 96.217  112.599 134.195 1.00 104.51 ? 402 GLU A OE1 1 
ATOM 2875 O OE2 . GLU A 1 402 ? 96.536  113.481 132.211 1.00 104.51 ? 402 GLU A OE2 1 
ATOM 2876 N N   . ARG A 1 403 ? 100.664 111.692 136.406 1.00 103.36 ? 403 ARG A N   1 
ATOM 2877 C CA  . ARG A 1 403 ? 100.774 111.649 137.861 1.00 103.36 ? 403 ARG A CA  1 
ATOM 2878 C C   . ARG A 1 403 ? 101.480 112.885 138.411 1.00 103.36 ? 403 ARG A C   1 
ATOM 2879 O O   . ARG A 1 403 ? 100.992 113.523 139.350 1.00 103.36 ? 403 ARG A O   1 
ATOM 2880 C CB  . ARG A 1 403 ? 101.504 110.377 138.293 1.00 103.36 ? 403 ARG A CB  1 
ATOM 2881 C CG  . ARG A 1 403 ? 101.365 110.060 139.776 1.00 103.36 ? 403 ARG A CG  1 
ATOM 2882 C CD  . ARG A 1 403 ? 101.984 108.715 140.128 1.00 103.36 ? 403 ARG A CD  1 
ATOM 2883 N NE  . ARG A 1 403 ? 103.260 108.863 140.819 1.00 103.36 ? 403 ARG A NE  1 
ATOM 2884 C CZ  . ARG A 1 403 ? 104.318 108.089 140.616 1.00 103.36 ? 403 ARG A CZ  1 
ATOM 2885 N NH1 . ARG A 1 403 ? 104.291 107.095 139.744 1.00 103.36 ? 403 ARG A NH1 1 
ATOM 2886 N NH2 . ARG A 1 403 ? 105.431 108.319 141.305 1.00 103.36 ? 403 ARG A NH2 1 
ATOM 2887 N N   . LEU A 1 404 ? 102.626 113.243 137.834 1.00 101.61 ? 404 LEU A N   1 
ATOM 2888 C CA  . LEU A 1 404 ? 103.500 114.261 138.405 1.00 101.61 ? 404 LEU A CA  1 
ATOM 2889 C C   . LEU A 1 404 ? 103.417 115.608 137.704 1.00 101.61 ? 404 LEU A C   1 
ATOM 2890 O O   . LEU A 1 404 ? 104.064 116.561 138.152 1.00 101.61 ? 404 LEU A O   1 
ATOM 2891 C CB  . LEU A 1 404 ? 104.953 113.774 138.386 1.00 101.61 ? 404 LEU A CB  1 
ATOM 2892 C CG  . LEU A 1 404 ? 105.289 112.598 139.299 1.00 101.61 ? 404 LEU A CG  1 
ATOM 2893 C CD1 . LEU A 1 404 ? 106.715 112.137 139.065 1.00 101.61 ? 404 LEU A CD1 1 
ATOM 2894 C CD2 . LEU A 1 404 ? 105.082 112.989 140.751 1.00 101.61 ? 404 LEU A CD2 1 
ATOM 2895 N N   . GLY A 1 405 ? 102.647 115.723 136.636 1.00 103.59 ? 405 GLY A N   1 
ATOM 2896 C CA  . GLY A 1 405 ? 102.641 116.945 135.865 1.00 103.59 ? 405 GLY A CA  1 
ATOM 2897 C C   . GLY A 1 405 ? 103.676 116.922 134.760 1.00 103.59 ? 405 GLY A C   1 
ATOM 2898 O O   . GLY A 1 405 ? 104.134 115.871 134.302 1.00 103.59 ? 405 GLY A O   1 
ATOM 2899 N N   . ARG A 1 406 ? 104.053 118.123 134.326 1.00 102.82 ? 406 ARG A N   1 
ATOM 2900 C CA  . ARG A 1 406 ? 104.977 118.283 133.211 1.00 102.82 ? 406 ARG A CA  1 
ATOM 2901 C C   . ARG A 1 406 ? 106.233 119.066 133.554 1.00 102.82 ? 406 ARG A C   1 
ATOM 2902 O O   . ARG A 1 406 ? 107.258 118.874 132.898 1.00 102.82 ? 406 ARG A O   1 
ATOM 2903 C CB  . ARG A 1 406 ? 104.265 118.967 132.038 1.00 102.82 ? 406 ARG A CB  1 
ATOM 2904 C CG  . ARG A 1 406 ? 103.115 118.145 131.500 1.00 102.82 ? 406 ARG A CG  1 
ATOM 2905 C CD  . ARG A 1 406 ? 102.320 118.860 130.431 1.00 102.82 ? 406 ARG A CD  1 
ATOM 2906 N NE  . ARG A 1 406 ? 101.210 118.035 129.969 1.00 102.82 ? 406 ARG A NE  1 
ATOM 2907 C CZ  . ARG A 1 406 ? 99.999  118.037 130.507 1.00 102.82 ? 406 ARG A CZ  1 
ATOM 2908 N NH1 . ARG A 1 406 ? 99.699  118.817 131.531 1.00 102.82 ? 406 ARG A NH1 1 
ATOM 2909 N NH2 . ARG A 1 406 ? 99.065  117.234 130.005 1.00 102.82 ? 406 ARG A NH2 1 
ATOM 2910 N N   . ARG A 1 407 ? 106.185 119.939 134.561 1.00 100.27 ? 407 ARG A N   1 
ATOM 2911 C CA  . ARG A 1 407 ? 107.366 120.720 134.914 1.00 100.27 ? 407 ARG A CA  1 
ATOM 2912 C C   . ARG A 1 407 ? 108.450 119.843 135.528 1.00 100.27 ? 407 ARG A C   1 
ATOM 2913 O O   . ARG A 1 407 ? 109.632 119.969 135.188 1.00 100.27 ? 407 ARG A O   1 
ATOM 2914 C CB  . ARG A 1 407 ? 106.979 121.850 135.867 1.00 100.27 ? 407 ARG A CB  1 
ATOM 2915 C CG  . ARG A 1 407 ? 106.334 123.031 135.175 1.00 100.27 ? 407 ARG A CG  1 
ATOM 2916 C CD  . ARG A 1 407 ? 105.669 123.965 136.166 1.00 100.27 ? 407 ARG A CD  1 
ATOM 2917 N NE  . ARG A 1 407 ? 106.613 124.528 137.121 1.00 100.27 ? 407 ARG A NE  1 
ATOM 2918 C CZ  . ARG A 1 407 ? 106.270 125.311 138.135 1.00 100.27 ? 407 ARG A CZ  1 
ATOM 2919 N NH1 . ARG A 1 407 ? 105.012 125.659 138.344 1.00 100.27 ? 407 ARG A NH1 1 
ATOM 2920 N NH2 . ARG A 1 407 ? 107.215 125.761 138.955 1.00 100.27 ? 407 ARG A NH2 1 
ATOM 2921 N N   . LEU A 1 408 ? 108.068 118.954 136.445 1.00 97.14  ? 408 LEU A N   1 
ATOM 2922 C CA  . LEU A 1 408 ? 109.064 118.152 137.154 1.00 97.14  ? 408 LEU A CA  1 
ATOM 2923 C C   . LEU A 1 408 ? 109.836 117.203 136.246 1.00 97.14  ? 408 LEU A C   1 
ATOM 2924 O O   . LEU A 1 408 ? 111.075 117.176 136.340 1.00 97.14  ? 408 LEU A O   1 
ATOM 2925 C CB  . LEU A 1 408 ? 108.393 117.401 138.308 1.00 97.14  ? 408 LEU A CB  1 
ATOM 2926 C CG  . LEU A 1 408 ? 107.922 118.251 139.488 1.00 97.14  ? 408 LEU A CG  1 
ATOM 2927 C CD1 . LEU A 1 408 ? 107.820 117.404 140.743 1.00 97.14  ? 408 LEU A CD1 1 
ATOM 2928 C CD2 . LEU A 1 408 ? 108.852 119.434 139.711 1.00 97.14  ? 408 LEU A CD2 1 
ATOM 2929 N N   . PRO A 1 409 ? 109.205 116.389 135.386 1.00 95.31  ? 409 PRO A N   1 
ATOM 2930 C CA  . PRO A 1 409 ? 110.013 115.530 134.502 1.00 95.31  ? 409 PRO A CA  1 
ATOM 2931 C C   . PRO A 1 409 ? 110.907 116.316 133.563 1.00 95.31  ? 409 PRO A C   1 
ATOM 2932 O O   . PRO A 1 409 ? 112.033 115.893 133.277 1.00 95.31  ? 409 PRO A O   1 
ATOM 2933 C CB  . PRO A 1 409 ? 108.957 114.719 133.738 1.00 95.31  ? 409 PRO A CB  1 
ATOM 2934 C CG  . PRO A 1 409 ? 107.740 114.785 134.580 1.00 95.31  ? 409 PRO A CG  1 
ATOM 2935 C CD  . PRO A 1 409 ? 107.765 116.140 135.203 1.00 95.31  ? 409 PRO A CD  1 
ATOM 2936 N N   . PHE A 1 410 ? 110.435 117.468 133.087 1.00 95.64  ? 410 PHE A N   1 
ATOM 2937 C CA  . PHE A 1 410 ? 111.224 118.285 132.170 1.00 95.64  ? 410 PHE A CA  1 
ATOM 2938 C C   . PHE A 1 410 ? 112.447 118.873 132.869 1.00 95.64  ? 410 PHE A C   1 
ATOM 2939 O O   . PHE A 1 410 ? 113.569 118.809 132.341 1.00 95.64  ? 410 PHE A O   1 
ATOM 2940 C CB  . PHE A 1 410 ? 110.314 119.365 131.582 1.00 95.64  ? 410 PHE A CB  1 
ATOM 2941 C CG  . PHE A 1 410 ? 110.954 120.212 130.529 1.00 95.64  ? 410 PHE A CG  1 
ATOM 2942 C CD1 . PHE A 1 410 ? 111.775 119.655 129.568 1.00 95.64  ? 410 PHE A CD1 1 
ATOM 2943 C CD2 . PHE A 1 410 ? 110.658 121.559 130.445 1.00 95.64  ? 410 PHE A CD2 1 
ATOM 2944 C CE1 . PHE A 1 410 ? 112.345 120.442 128.589 1.00 95.64  ? 410 PHE A CE1 1 
ATOM 2945 C CE2 . PHE A 1 410 ? 111.215 122.343 129.460 1.00 95.64  ? 410 PHE A CE2 1 
ATOM 2946 C CZ  . PHE A 1 410 ? 112.063 121.785 128.535 1.00 95.64  ? 410 PHE A CZ  1 
ATOM 2947 N N   . ALA A 1 411 ? 112.253 119.413 134.075 1.00 94.99  ? 411 ALA A N   1 
ATOM 2948 C CA  . ALA A 1 411 ? 113.380 119.901 134.863 1.00 94.99  ? 411 ALA A CA  1 
ATOM 2949 C C   . ALA A 1 411 ? 114.354 118.778 135.184 1.00 94.99  ? 411 ALA A C   1 
ATOM 2950 O O   . ALA A 1 411 ? 115.572 118.968 135.117 1.00 94.99  ? 411 ALA A O   1 
ATOM 2951 C CB  . ALA A 1 411 ? 112.881 120.553 136.151 1.00 94.99  ? 411 ALA A CB  1 
ATOM 2952 N N   . ALA A 1 412 ? 113.836 117.600 135.544 1.00 92.93  ? 412 ALA A N   1 
ATOM 2953 C CA  . ALA A 1 412 ? 114.709 116.478 135.864 1.00 92.93  ? 412 ALA A CA  1 
ATOM 2954 C C   . ALA A 1 412 ? 115.528 116.054 134.655 1.00 92.93  ? 412 ALA A C   1 
ATOM 2955 O O   . ALA A 1 412 ? 116.723 115.767 134.777 1.00 92.93  ? 412 ALA A O   1 
ATOM 2956 C CB  . ALA A 1 412 ? 113.885 115.306 136.391 1.00 92.93  ? 412 ALA A CB  1 
ATOM 2957 N N   . SER A 1 413 ? 114.904 116.012 133.477 1.00 93.09  ? 413 SER A N   1 
ATOM 2958 C CA  . SER A 1 413 ? 115.623 115.627 132.268 1.00 93.09  ? 413 SER A CA  1 
ATOM 2959 C C   . SER A 1 413 ? 116.734 116.621 131.951 1.00 93.09  ? 413 SER A C   1 
ATOM 2960 O O   . SER A 1 413 ? 117.872 116.230 131.650 1.00 93.09  ? 413 SER A O   1 
ATOM 2961 C CB  . SER A 1 413 ? 114.644 115.520 131.100 1.00 93.09  ? 413 SER A CB  1 
ATOM 2962 O OG  . SER A 1 413 ? 113.628 114.573 131.377 1.00 93.09  ? 413 SER A OG  1 
ATOM 2963 N N   . ASN A 1 414 ? 116.426 117.918 132.025 1.00 97.36  ? 414 ASN A N   1 
ATOM 2964 C CA  . ASN A 1 414 ? 117.450 118.918 131.735 1.00 97.36  ? 414 ASN A CA  1 
ATOM 2965 C C   . ASN A 1 414 ? 118.581 118.881 132.760 1.00 97.36  ? 414 ASN A C   1 
ATOM 2966 O O   . ASN A 1 414 ? 119.759 119.004 132.399 1.00 97.36  ? 414 ASN A O   1 
ATOM 2967 C CB  . ASN A 1 414 ? 116.825 120.306 131.672 1.00 97.36  ? 414 ASN A CB  1 
ATOM 2968 C CG  . ASN A 1 414 ? 116.250 120.627 130.311 1.00 97.36  ? 414 ASN A CG  1 
ATOM 2969 O OD1 . ASN A 1 414 ? 116.768 120.186 129.287 1.00 97.36  ? 414 ASN A OD1 1 
ATOM 2970 N ND2 . ASN A 1 414 ? 115.180 121.412 130.292 1.00 97.36  ? 414 ASN A ND2 1 
ATOM 2971 N N   . ILE A 1 415 ? 118.246 118.715 134.043 1.00 92.11  ? 415 ILE A N   1 
ATOM 2972 C CA  . ILE A 1 415 ? 119.269 118.647 135.082 1.00 92.11  ? 415 ILE A CA  1 
ATOM 2973 C C   . ILE A 1 415 ? 120.153 117.425 134.879 1.00 92.11  ? 415 ILE A C   1 
ATOM 2974 O O   . ILE A 1 415 ? 121.375 117.488 135.059 1.00 92.11  ? 415 ILE A O   1 
ATOM 2975 C CB  . ILE A 1 415 ? 118.615 118.648 136.476 1.00 92.11  ? 415 ILE A CB  1 
ATOM 2976 C CG1 . ILE A 1 415 ? 118.212 120.066 136.875 1.00 92.11  ? 415 ILE A CG1 1 
ATOM 2977 C CG2 . ILE A 1 415 ? 119.546 118.046 137.512 1.00 92.11  ? 415 ILE A CG2 1 
ATOM 2978 C CD1 . ILE A 1 415 ? 119.376 120.941 137.272 1.00 92.11  ? 415 ILE A CD1 1 
ATOM 2979 N N   . VAL A 1 416 ? 119.551 116.292 134.512 1.00 92.50  ? 416 VAL A N   1 
ATOM 2980 C CA  . VAL A 1 416 ? 120.330 115.090 134.237 1.00 92.50  ? 416 VAL A CA  1 
ATOM 2981 C C   . VAL A 1 416 ? 121.289 115.333 133.081 1.00 92.50  ? 416 VAL A C   1 
ATOM 2982 O O   . VAL A 1 416 ? 122.463 114.946 133.138 1.00 92.50  ? 416 VAL A O   1 
ATOM 2983 C CB  . VAL A 1 416 ? 119.391 113.903 133.957 1.00 92.50  ? 416 VAL A CB  1 
ATOM 2984 C CG1 . VAL A 1 416 ? 120.118 112.821 133.183 1.00 92.50  ? 416 VAL A CG1 1 
ATOM 2985 C CG2 . VAL A 1 416 ? 118.843 113.350 135.257 1.00 92.50  ? 416 VAL A CG2 1 
ATOM 2986 N N   . ALA A 1 417 ? 120.810 115.983 132.017 1.00 96.39  ? 417 ALA A N   1 
ATOM 2987 C CA  . ALA A 1 417 ? 121.688 116.278 130.888 1.00 96.39  ? 417 ALA A CA  1 
ATOM 2988 C C   . ALA A 1 417 ? 122.852 117.169 131.307 1.00 96.39  ? 417 ALA A C   1 
ATOM 2989 O O   . ALA A 1 417 ? 124.007 116.911 130.940 1.00 96.39  ? 417 ALA A O   1 
ATOM 2990 C CB  . ALA A 1 417 ? 120.891 116.931 129.760 1.00 96.39  ? 417 ALA A CB  1 
ATOM 2991 N N   . GLY A 1 418 ? 122.571 118.214 132.088 1.00 98.38  ? 418 GLY A N   1 
ATOM 2992 C CA  . GLY A 1 418 ? 123.635 119.110 132.518 1.00 98.38  ? 418 GLY A CA  1 
ATOM 2993 C C   . GLY A 1 418 ? 124.655 118.433 133.415 1.00 98.38  ? 418 GLY A C   1 
ATOM 2994 O O   . GLY A 1 418 ? 125.865 118.638 133.266 1.00 98.38  ? 418 GLY A O   1 
ATOM 2995 N N   . VAL A 1 419 ? 124.183 117.620 134.362 1.00 94.76  ? 419 VAL A N   1 
ATOM 2996 C CA  . VAL A 1 419 ? 125.093 116.915 135.258 1.00 94.76  ? 419 VAL A CA  1 
ATOM 2997 C C   . VAL A 1 419 ? 125.938 115.918 134.479 1.00 94.76  ? 419 VAL A C   1 
ATOM 2998 O O   . VAL A 1 419 ? 127.134 115.759 134.746 1.00 94.76  ? 419 VAL A O   1 
ATOM 2999 C CB  . VAL A 1 419 ? 124.308 116.234 136.392 1.00 94.76  ? 419 VAL A CB  1 
ATOM 3000 C CG1 . VAL A 1 419 ? 125.200 115.271 137.154 1.00 94.76  ? 419 VAL A CG1 1 
ATOM 3001 C CG2 . VAL A 1 419 ? 123.735 117.280 137.331 1.00 94.76  ? 419 VAL A CG2 1 
ATOM 3002 N N   . ALA A 1 420 ? 125.338 115.232 133.505 1.00 100.76 ? 420 ALA A N   1 
ATOM 3003 C CA  . ALA A 1 420 ? 126.113 114.319 132.674 1.00 100.76 ? 420 ALA A CA  1 
ATOM 3004 C C   . ALA A 1 420 ? 127.179 115.067 131.886 1.00 100.76 ? 420 ALA A C   1 
ATOM 3005 O O   . ALA A 1 420 ? 128.310 114.586 131.749 1.00 100.76 ? 420 ALA A O   1 
ATOM 3006 C CB  . ALA A 1 420 ? 125.190 113.547 131.734 1.00 100.76 ? 420 ALA A CB  1 
ATOM 3007 N N   . CYS A 1 421 ? 126.838 116.247 131.363 1.00 103.13 ? 421 CYS A N   1 
ATOM 3008 C CA  . CYS A 1 421 ? 127.826 117.059 130.658 1.00 103.13 ? 421 CYS A CA  1 
ATOM 3009 C C   . CYS A 1 421 ? 128.995 117.416 131.570 1.00 103.13 ? 421 CYS A C   1 
ATOM 3010 O O   . CYS A 1 421 ? 130.165 117.241 131.204 1.00 103.13 ? 421 CYS A O   1 
ATOM 3011 C CB  . CYS A 1 421 ? 127.168 118.327 130.115 1.00 103.13 ? 421 CYS A CB  1 
ATOM 3012 S SG  . CYS A 1 421 ? 126.258 118.111 128.573 1.00 103.13 ? 421 CYS A SG  1 
ATOM 3013 N N   . LEU A 1 422 ? 128.694 117.911 132.772 1.00 102.30 ? 422 LEU A N   1 
ATOM 3014 C CA  . LEU A 1 422 ? 129.758 118.311 133.689 1.00 102.30 ? 422 LEU A CA  1 
ATOM 3015 C C   . LEU A 1 422 ? 130.619 117.121 134.101 1.00 102.30 ? 422 LEU A C   1 
ATOM 3016 O O   . LEU A 1 422 ? 131.849 117.232 134.176 1.00 102.30 ? 422 LEU A O   1 
ATOM 3017 C CB  . LEU A 1 422 ? 129.165 118.995 134.918 1.00 102.30 ? 422 LEU A CB  1 
ATOM 3018 C CG  . LEU A 1 422 ? 128.745 120.446 134.703 1.00 102.30 ? 422 LEU A CG  1 
ATOM 3019 C CD1 . LEU A 1 422 ? 128.349 121.086 136.017 1.00 102.30 ? 422 LEU A CD1 1 
ATOM 3020 C CD2 . LEU A 1 422 ? 129.871 121.218 134.050 1.00 102.30 ? 422 LEU A CD2 1 
ATOM 3021 N N   . VAL A 1 423 ? 129.992 115.974 134.376 1.00 104.71 ? 423 VAL A N   1 
ATOM 3022 C CA  . VAL A 1 423 ? 130.746 114.788 134.766 1.00 104.71 ? 423 VAL A CA  1 
ATOM 3023 C C   . VAL A 1 423 ? 131.641 114.321 133.629 1.00 104.71 ? 423 VAL A C   1 
ATOM 3024 O O   . VAL A 1 423 ? 132.802 113.958 133.848 1.00 104.71 ? 423 VAL A O   1 
ATOM 3025 C CB  . VAL A 1 423 ? 129.794 113.674 135.235 1.00 104.71 ? 423 VAL A CB  1 
ATOM 3026 C CG1 . VAL A 1 423 ? 130.560 112.382 135.447 1.00 104.71 ? 423 VAL A CG1 1 
ATOM 3027 C CG2 . VAL A 1 423 ? 129.112 114.084 136.527 1.00 104.71 ? 423 VAL A CG2 1 
ATOM 3028 N N   . THR A 1 424 ? 131.126 114.321 132.398 1.00 108.24 ? 424 THR A N   1 
ATOM 3029 C CA  . THR A 1 424 ? 131.968 113.971 131.261 1.00 108.24 ? 424 THR A CA  1 
ATOM 3030 C C   . THR A 1 424 ? 133.132 114.943 131.125 1.00 108.24 ? 424 THR A C   1 
ATOM 3031 O O   . THR A 1 424 ? 134.237 114.539 130.747 1.00 108.24 ? 424 THR A O   1 
ATOM 3032 C CB  . THR A 1 424 ? 131.138 113.948 129.978 1.00 108.24 ? 424 THR A CB  1 
ATOM 3033 O OG1 . THR A 1 424 ? 130.090 112.981 130.106 1.00 108.24 ? 424 THR A OG1 1 
ATOM 3034 C CG2 . THR A 1 424 ? 132.002 113.554 128.795 1.00 108.24 ? 424 THR A CG2 1 
ATOM 3035 N N   . ALA A 1 425 ? 132.908 116.219 131.447 1.00 108.56 ? 425 ALA A N   1 
ATOM 3036 C CA  . ALA A 1 425 ? 133.987 117.200 131.382 1.00 108.56 ? 425 ALA A CA  1 
ATOM 3037 C C   . ALA A 1 425 ? 135.072 116.905 132.414 1.00 108.56 ? 425 ALA A C   1 
ATOM 3038 O O   . ALA A 1 425 ? 136.261 116.861 132.080 1.00 108.56 ? 425 ALA A O   1 
ATOM 3039 C CB  . ALA A 1 425 ? 133.428 118.608 131.579 1.00 108.56 ? 425 ALA A CB  1 
ATOM 3040 N N   . PHE A 1 426 ? 134.684 116.696 133.672 1.00 112.37 ? 426 PHE A N   1 
ATOM 3041 C CA  . PHE A 1 426 ? 135.633 116.489 134.765 1.00 112.37 ? 426 PHE A CA  1 
ATOM 3042 C C   . PHE A 1 426 ? 135.644 115.022 135.176 1.00 112.37 ? 426 PHE A C   1 
ATOM 3043 O O   . PHE A 1 426 ? 134.731 114.559 135.868 1.00 112.37 ? 426 PHE A O   1 
ATOM 3044 C CB  . PHE A 1 426 ? 135.292 117.366 135.968 1.00 112.37 ? 426 PHE A CB  1 
ATOM 3045 C CG  . PHE A 1 426 ? 135.381 118.835 135.700 1.00 112.37 ? 426 PHE A CG  1 
ATOM 3046 C CD1 . PHE A 1 426 ? 136.516 119.379 135.130 1.00 112.37 ? 426 PHE A CD1 1 
ATOM 3047 C CD2 . PHE A 1 426 ? 134.339 119.677 136.043 1.00 112.37 ? 426 PHE A CD2 1 
ATOM 3048 C CE1 . PHE A 1 426 ? 136.604 120.736 134.894 1.00 112.37 ? 426 PHE A CE1 1 
ATOM 3049 C CE2 . PHE A 1 426 ? 134.420 121.033 135.810 1.00 112.37 ? 426 PHE A CE2 1 
ATOM 3050 C CZ  . PHE A 1 426 ? 135.554 121.563 135.236 1.00 112.37 ? 426 PHE A CZ  1 
ATOM 3051 N N   . LEU A 1 427 ? 136.685 114.305 134.772 1.00 121.21 ? 427 LEU A N   1 
ATOM 3052 C CA  . LEU A 1 427 ? 136.974 112.969 135.277 1.00 121.21 ? 427 LEU A CA  1 
ATOM 3053 C C   . LEU A 1 427 ? 138.399 112.606 134.860 1.00 121.21 ? 427 LEU A C   1 
ATOM 3054 O O   . LEU A 1 427 ? 138.931 113.188 133.910 1.00 121.21 ? 427 LEU A O   1 
ATOM 3055 C CB  . LEU A 1 427 ? 135.957 111.933 134.762 1.00 121.21 ? 427 LEU A CB  1 
ATOM 3056 C CG  . LEU A 1 427 ? 135.661 111.748 133.280 1.00 121.21 ? 427 LEU A CG  1 
ATOM 3057 C CD1 . LEU A 1 427 ? 136.627 110.756 132.679 1.00 121.21 ? 427 LEU A CD1 1 
ATOM 3058 C CD2 . LEU A 1 427 ? 134.237 111.257 133.107 1.00 121.21 ? 427 LEU A CD2 1 
ATOM 3059 N N   . PRO A 1 428 ? 139.035 111.649 135.553 1.00 134.11 ? 428 PRO A N   1 
ATOM 3060 C CA  . PRO A 1 428 ? 140.487 111.427 135.341 1.00 134.11 ? 428 PRO A CA  1 
ATOM 3061 C C   . PRO A 1 428 ? 140.865 110.757 134.021 1.00 134.11 ? 428 PRO A C   1 
ATOM 3062 O O   . PRO A 1 428 ? 141.034 109.543 133.906 1.00 134.11 ? 428 PRO A O   1 
ATOM 3063 C CB  . PRO A 1 428 ? 140.869 110.557 136.542 1.00 134.11 ? 428 PRO A CB  1 
ATOM 3064 C CG  . PRO A 1 428 ? 139.620 109.848 136.910 1.00 134.11 ? 428 PRO A CG  1 
ATOM 3065 C CD  . PRO A 1 428 ? 138.509 110.816 136.650 1.00 134.11 ? 428 PRO A CD  1 
ATOM 3066 N N   . GLU A 1 429 ? 140.980 111.589 132.983 1.00 136.31 ? 429 GLU A N   1 
ATOM 3067 C CA  . GLU A 1 429 ? 141.596 111.234 131.703 1.00 136.31 ? 429 GLU A CA  1 
ATOM 3068 C C   . GLU A 1 429 ? 140.822 110.162 130.943 1.00 136.31 ? 429 GLU A C   1 
ATOM 3069 O O   . GLU A 1 429 ? 141.337 109.597 129.973 1.00 136.31 ? 429 GLU A O   1 
ATOM 3070 C CB  . GLU A 1 429 ? 143.053 110.791 131.890 1.00 136.31 ? 429 GLU A CB  1 
ATOM 3071 C CG  . GLU A 1 429 ? 143.977 111.875 132.427 1.00 136.31 ? 429 GLU A CG  1 
ATOM 3072 C CD  . GLU A 1 429 ? 143.924 111.996 133.938 1.00 136.31 ? 429 GLU A CD  1 
ATOM 3073 O OE1 . GLU A 1 429 ? 144.217 110.995 134.625 1.00 136.31 ? 429 GLU A OE1 1 
ATOM 3074 O OE2 . GLU A 1 429 ? 143.592 113.091 134.437 1.00 136.31 ? 429 GLU A OE2 1 
ATOM 3075 N N   . GLY A 1 430 ? 139.592 109.872 131.354 1.00 136.20 ? 430 GLY A N   1 
ATOM 3076 C CA  . GLY A 1 430 ? 138.791 108.887 130.645 1.00 136.20 ? 430 GLY A CA  1 
ATOM 3077 C C   . GLY A 1 430 ? 139.365 107.488 130.669 1.00 136.20 ? 430 GLY A C   1 
ATOM 3078 O O   . GLY A 1 430 ? 139.243 106.753 129.682 1.00 136.20 ? 430 GLY A O   1 
ATOM 3079 N N   . ILE A 1 431 ? 139.992 107.098 131.785 1.00 135.99 ? 431 ILE A N   1 
ATOM 3080 C CA  . ILE A 1 431 ? 140.517 105.744 131.925 1.00 135.99 ? 431 ILE A CA  1 
ATOM 3081 C C   . ILE A 1 431 ? 139.431 104.739 132.273 1.00 135.99 ? 431 ILE A C   1 
ATOM 3082 O O   . ILE A 1 431 ? 139.727 103.546 132.427 1.00 135.99 ? 431 ILE A O   1 
ATOM 3083 C CB  . ILE A 1 431 ? 141.632 105.686 132.990 1.00 135.99 ? 431 ILE A CB  1 
ATOM 3084 C CG1 . ILE A 1 431 ? 141.069 106.023 134.372 1.00 135.99 ? 431 ILE A CG1 1 
ATOM 3085 C CG2 . ILE A 1 431 ? 142.766 106.632 132.627 1.00 135.99 ? 431 ILE A CG2 1 
ATOM 3086 C CD1 . ILE A 1 431 ? 142.028 105.740 135.507 1.00 135.99 ? 431 ILE A CD1 1 
ATOM 3087 N N   . ALA A 1 432 ? 138.184 105.181 132.398 1.00 131.43 ? 432 ALA A N   1 
ATOM 3088 C CA  . ALA A 1 432 ? 137.061 104.318 132.726 1.00 131.43 ? 432 ALA A CA  1 
ATOM 3089 C C   . ALA A 1 432 ? 136.097 104.260 131.550 1.00 131.43 ? 432 ALA A C   1 
ATOM 3090 O O   . ALA A 1 432 ? 135.959 105.230 130.798 1.00 131.43 ? 432 ALA A O   1 
ATOM 3091 C CB  . ALA A 1 432 ? 136.334 104.814 133.978 1.00 131.43 ? 432 ALA A CB  1 
ATOM 3092 N N   . TRP A 1 433 ? 135.431 103.115 131.396 1.00 129.83 ? 433 TRP A N   1 
ATOM 3093 C CA  . TRP A 1 433 ? 134.480 102.921 130.309 1.00 129.83 ? 433 TRP A CA  1 
ATOM 3094 C C   . TRP A 1 433 ? 133.170 103.667 130.525 1.00 129.83 ? 433 TRP A C   1 
ATOM 3095 O O   . TRP A 1 433 ? 132.222 103.450 129.762 1.00 129.83 ? 433 TRP A O   1 
ATOM 3096 C CB  . TRP A 1 433 ? 134.200 101.429 130.127 1.00 129.83 ? 433 TRP A CB  1 
ATOM 3097 C CG  . TRP A 1 433 ? 135.381 100.662 129.619 1.00 129.83 ? 433 TRP A CG  1 
ATOM 3098 C CD1 . TRP A 1 433 ? 135.715 100.439 128.315 1.00 129.83 ? 433 TRP A CD1 1 
ATOM 3099 C CD2 . TRP A 1 433 ? 136.390 100.020 130.407 1.00 129.83 ? 433 TRP A CD2 1 
ATOM 3100 N NE1 . TRP A 1 433 ? 136.868 99.696  128.242 1.00 129.83 ? 433 TRP A NE1 1 
ATOM 3101 C CE2 . TRP A 1 433 ? 137.303 99.425  129.513 1.00 129.83 ? 433 TRP A CE2 1 
ATOM 3102 C CE3 . TRP A 1 433 ? 136.610 99.888  131.781 1.00 129.83 ? 433 TRP A CE3 1 
ATOM 3103 C CZ2 . TRP A 1 433 ? 138.416 98.710  129.949 1.00 129.83 ? 433 TRP A CZ2 1 
ATOM 3104 C CZ3 . TRP A 1 433 ? 137.716 99.178  132.212 1.00 129.83 ? 433 TRP A CZ3 1 
ATOM 3105 C CH2 . TRP A 1 433 ? 138.605 98.599  131.298 1.00 129.83 ? 433 TRP A CH2 1 
ATOM 3106 N N   . LEU A 1 434 ? 133.091 104.530 131.538 1.00 122.44 ? 434 LEU A N   1 
ATOM 3107 C CA  . LEU A 1 434 ? 131.855 105.230 131.860 1.00 122.44 ? 434 LEU A CA  1 
ATOM 3108 C C   . LEU A 1 434 ? 131.688 106.541 131.099 1.00 122.44 ? 434 LEU A C   1 
ATOM 3109 O O   . LEU A 1 434 ? 130.636 107.177 131.227 1.00 122.44 ? 434 LEU A O   1 
ATOM 3110 C CB  . LEU A 1 434 ? 131.778 105.490 133.367 1.00 122.44 ? 434 LEU A CB  1 
ATOM 3111 C CG  . LEU A 1 434 ? 131.157 104.380 134.225 1.00 122.44 ? 434 LEU A CG  1 
ATOM 3112 C CD1 . LEU A 1 434 ? 131.952 103.081 134.152 1.00 122.44 ? 434 LEU A CD1 1 
ATOM 3113 C CD2 . LEU A 1 434 ? 131.015 104.837 135.668 1.00 122.44 ? 434 LEU A CD2 1 
ATOM 3114 N N   . ARG A 1 435 ? 132.684 106.950 130.310 1.00 117.70 ? 435 ARG A N   1 
ATOM 3115 C CA  . ARG A 1 435 ? 132.526 108.124 129.455 1.00 117.70 ? 435 ARG A CA  1 
ATOM 3116 C C   . ARG A 1 435 ? 131.320 107.978 128.536 1.00 117.70 ? 435 ARG A C   1 
ATOM 3117 O O   . ARG A 1 435 ? 130.424 108.833 128.520 1.00 117.70 ? 435 ARG A O   1 
ATOM 3118 C CB  . ARG A 1 435 ? 133.792 108.330 128.623 1.00 117.70 ? 435 ARG A CB  1 
ATOM 3119 C CG  . ARG A 1 435 ? 134.801 109.323 129.165 1.00 117.70 ? 435 ARG A CG  1 
ATOM 3120 C CD  . ARG A 1 435 ? 134.256 110.737 129.077 1.00 117.70 ? 435 ARG A CD  1 
ATOM 3121 N NE  . ARG A 1 435 ? 134.954 111.663 129.958 1.00 117.70 ? 435 ARG A NE  1 
ATOM 3122 C CZ  . ARG A 1 435 ? 136.018 112.369 129.600 1.00 117.70 ? 435 ARG A CZ  1 
ATOM 3123 N NH1 . ARG A 1 435 ? 136.540 112.266 128.389 1.00 117.70 ? 435 ARG A NH1 1 
ATOM 3124 N NH2 . ARG A 1 435 ? 136.570 113.202 130.477 1.00 117.70 ? 435 ARG A NH2 1 
ATOM 3125 N N   . THR A 1 436 ? 131.274 106.882 127.775 1.00 112.28 ? 436 THR A N   1 
ATOM 3126 C CA  . THR A 1 436 ? 130.204 106.699 126.803 1.00 112.28 ? 436 THR A CA  1 
ATOM 3127 C C   . THR A 1 436 ? 128.858 106.485 127.480 1.00 112.28 ? 436 THR A C   1 
ATOM 3128 O O   . THR A 1 436 ? 127.840 106.985 126.993 1.00 112.28 ? 436 THR A O   1 
ATOM 3129 C CB  . THR A 1 436 ? 130.536 105.536 125.865 1.00 112.28 ? 436 THR A CB  1 
ATOM 3130 O OG1 . THR A 1 436 ? 129.441 105.315 124.968 1.00 112.28 ? 436 THR A OG1 1 
ATOM 3131 C CG2 . THR A 1 436 ? 130.825 104.264 126.648 1.00 112.28 ? 436 THR A CG2 1 
ATOM 3132 N N   . THR A 1 437 ? 128.827 105.762 128.602 1.00 110.64 ? 437 THR A N   1 
ATOM 3133 C CA  . THR A 1 437 ? 127.564 105.559 129.303 1.00 110.64 ? 437 THR A CA  1 
ATOM 3134 C C   . THR A 1 437 ? 127.016 106.873 129.841 1.00 110.64 ? 437 THR A C   1 
ATOM 3135 O O   . THR A 1 437 ? 125.816 107.147 129.717 1.00 110.64 ? 437 THR A O   1 
ATOM 3136 C CB  . THR A 1 437 ? 127.742 104.554 130.438 1.00 110.64 ? 437 THR A CB  1 
ATOM 3137 O OG1 . THR A 1 437 ? 128.592 105.116 131.444 1.00 110.64 ? 437 THR A OG1 1 
ATOM 3138 C CG2 . THR A 1 437 ? 128.367 103.273 129.914 1.00 110.64 ? 437 THR A CG2 1 
ATOM 3139 N N   . VAL A 1 438 ? 127.878 107.703 130.433 1.00 105.91 ? 438 VAL A N   1 
ATOM 3140 C CA  . VAL A 1 438 ? 127.423 108.986 130.959 1.00 105.91 ? 438 VAL A CA  1 
ATOM 3141 C C   . VAL A 1 438 ? 126.950 109.890 129.828 1.00 105.91 ? 438 VAL A C   1 
ATOM 3142 O O   . VAL A 1 438 ? 125.919 110.568 129.942 1.00 105.91 ? 438 VAL A O   1 
ATOM 3143 C CB  . VAL A 1 438 ? 128.536 109.646 131.792 1.00 105.91 ? 438 VAL A CB  1 
ATOM 3144 C CG1 . VAL A 1 438 ? 128.246 111.121 131.992 1.00 105.91 ? 438 VAL A CG1 1 
ATOM 3145 C CG2 . VAL A 1 438 ? 128.673 108.946 133.130 1.00 105.91 ? 438 VAL A CG2 1 
ATOM 3146 N N   . ALA A 1 439 ? 127.690 109.915 128.716 1.00 106.17 ? 439 ALA A N   1 
ATOM 3147 C CA  . ALA A 1 439 ? 127.277 110.737 127.584 1.00 106.17 ? 439 ALA A CA  1 
ATOM 3148 C C   . ALA A 1 439 ? 125.940 110.273 127.017 1.00 106.17 ? 439 ALA A C   1 
ATOM 3149 O O   . ALA A 1 439 ? 125.073 111.096 126.699 1.00 106.17 ? 439 ALA A O   1 
ATOM 3150 C CB  . ALA A 1 439 ? 128.358 110.720 126.505 1.00 106.17 ? 439 ALA A CB  1 
ATOM 3151 N N   . THR A 1 440 ? 125.750 108.958 126.890 1.00 103.72 ? 440 THR A N   1 
ATOM 3152 C CA  . THR A 1 440 ? 124.487 108.436 126.379 1.00 103.72 ? 440 THR A CA  1 
ATOM 3153 C C   . THR A 1 440 ? 123.337 108.751 127.327 1.00 103.72 ? 440 THR A C   1 
ATOM 3154 O O   . THR A 1 440 ? 122.233 109.088 126.886 1.00 103.72 ? 440 THR A O   1 
ATOM 3155 C CB  . THR A 1 440 ? 124.601 106.929 126.148 1.00 103.72 ? 440 THR A CB  1 
ATOM 3156 O OG1 . THR A 1 440 ? 125.576 106.676 125.131 1.00 103.72 ? 440 THR A OG1 1 
ATOM 3157 C CG2 . THR A 1 440 ? 123.267 106.351 125.708 1.00 103.72 ? 440 THR A CG2 1 
ATOM 3158 N N   . LEU A 1 441 ? 123.577 108.647 128.635 1.00 99.66  ? 441 LEU A N   1 
ATOM 3159 C CA  . LEU A 1 441 ? 122.540 108.983 129.604 1.00 99.66  ? 441 LEU A CA  1 
ATOM 3160 C C   . LEU A 1 441 ? 122.156 110.455 129.511 1.00 99.66  ? 441 LEU A C   1 
ATOM 3161 O O   . LEU A 1 441 ? 120.968 110.803 129.563 1.00 99.66  ? 441 LEU A O   1 
ATOM 3162 C CB  . LEU A 1 441 ? 123.018 108.623 131.010 1.00 99.66  ? 441 LEU A CB  1 
ATOM 3163 C CG  . LEU A 1 441 ? 122.107 108.918 132.197 1.00 99.66  ? 441 LEU A CG  1 
ATOM 3164 C CD1 . LEU A 1 441 ? 122.112 107.738 133.147 1.00 99.66  ? 441 LEU A CD1 1 
ATOM 3165 C CD2 . LEU A 1 441 ? 122.575 110.172 132.912 1.00 99.66  ? 441 LEU A CD2 1 
ATOM 3166 N N   . GLY A 1 442 ? 123.147 111.336 129.365 1.00 97.16  ? 442 GLY A N   1 
ATOM 3167 C CA  . GLY A 1 442 ? 122.842 112.746 129.178 1.00 97.16  ? 442 GLY A CA  1 
ATOM 3168 C C   . GLY A 1 442 ? 122.073 113.011 127.898 1.00 97.16  ? 442 GLY A C   1 
ATOM 3169 O O   . GLY A 1 442 ? 121.161 113.843 127.868 1.00 97.16  ? 442 GLY A O   1 
ATOM 3170 N N   . ARG A 1 443 ? 122.431 112.307 126.821 1.00 97.56  ? 443 ARG A N   1 
ATOM 3171 C CA  . ARG A 1 443 ? 121.698 112.453 125.569 1.00 97.56  ? 443 ARG A CA  1 
ATOM 3172 C C   . ARG A 1 443 ? 120.248 112.016 125.727 1.00 97.56  ? 443 ARG A C   1 
ATOM 3173 O O   . ARG A 1 443 ? 119.334 112.677 125.223 1.00 97.56  ? 443 ARG A O   1 
ATOM 3174 C CB  . ARG A 1 443 ? 122.377 111.651 124.460 1.00 97.56  ? 443 ARG A CB  1 
ATOM 3175 C CG  . ARG A 1 443 ? 121.731 111.834 123.101 1.00 97.56  ? 443 ARG A CG  1 
ATOM 3176 C CD  . ARG A 1 443 ? 122.288 110.868 122.073 1.00 97.56  ? 443 ARG A CD  1 
ATOM 3177 N NE  . ARG A 1 443 ? 121.775 109.516 122.249 1.00 97.56  ? 443 ARG A NE  1 
ATOM 3178 C CZ  . ARG A 1 443 ? 122.074 108.496 121.457 1.00 97.56  ? 443 ARG A CZ  1 
ATOM 3179 N NH1 . ARG A 1 443 ? 122.874 108.642 120.414 1.00 97.56  ? 443 ARG A NH1 1 
ATOM 3180 N NH2 . ARG A 1 443 ? 121.555 107.299 121.716 1.00 97.56  ? 443 ARG A NH2 1 
ATOM 3181 N N   . LEU A 1 444 ? 120.020 110.902 126.423 1.00 96.61  ? 444 LEU A N   1 
ATOM 3182 C CA  . LEU A 1 444 ? 118.654 110.446 126.653 1.00 96.61  ? 444 LEU A CA  1 
ATOM 3183 C C   . LEU A 1 444 ? 117.873 111.459 127.478 1.00 96.61  ? 444 LEU A C   1 
ATOM 3184 O O   . LEU A 1 444 ? 116.700 111.735 127.192 1.00 96.61  ? 444 LEU A O   1 
ATOM 3185 C CB  . LEU A 1 444 ? 118.663 109.083 127.341 1.00 96.61  ? 444 LEU A CB  1 
ATOM 3186 C CG  . LEU A 1 444 ? 119.278 107.951 126.519 1.00 96.61  ? 444 LEU A CG  1 
ATOM 3187 C CD1 . LEU A 1 444 ? 119.253 106.646 127.294 1.00 96.61  ? 444 LEU A CD1 1 
ATOM 3188 C CD2 . LEU A 1 444 ? 118.564 107.809 125.189 1.00 96.61  ? 444 LEU A CD2 1 
ATOM 3189 N N   . GLY A 1 445 ? 118.508 112.029 128.503 1.00 91.10  ? 445 GLY A N   1 
ATOM 3190 C CA  . GLY A 1 445 ? 117.840 113.053 129.287 1.00 91.10  ? 445 GLY A CA  1 
ATOM 3191 C C   . GLY A 1 445 ? 117.458 114.263 128.457 1.00 91.10  ? 445 GLY A C   1 
ATOM 3192 O O   . GLY A 1 445 ? 116.341 114.779 128.565 1.00 91.10  ? 445 GLY A O   1 
ATOM 3193 N N   . ILE A 1 446 ? 118.370 114.721 127.597 1.00 91.65  ? 446 ILE A N   1 
ATOM 3194 C CA  . ILE A 1 446 ? 118.064 115.905 126.800 1.00 91.65  ? 446 ILE A CA  1 
ATOM 3195 C C   . ILE A 1 446 ? 117.006 115.597 125.745 1.00 91.65  ? 446 ILE A C   1 
ATOM 3196 O O   . ILE A 1 446 ? 116.202 116.468 125.398 1.00 91.65  ? 446 ILE A O   1 
ATOM 3197 C CB  . ILE A 1 446 ? 119.344 116.500 126.182 1.00 91.65  ? 446 ILE A CB  1 
ATOM 3198 C CG1 . ILE A 1 446 ? 119.157 117.998 125.948 1.00 91.65  ? 446 ILE A CG1 1 
ATOM 3199 C CG2 . ILE A 1 446 ? 119.712 115.806 124.883 1.00 91.65  ? 446 ILE A CG2 1 
ATOM 3200 C CD1 . ILE A 1 446 ? 118.905 118.783 127.213 1.00 91.65  ? 446 ILE A CD1 1 
ATOM 3201 N N   . THR A 1 447 ? 116.961 114.365 125.232 1.00 91.45  ? 447 THR A N   1 
ATOM 3202 C CA  . THR A 1 447 ? 115.908 114.018 124.280 1.00 91.45  ? 447 THR A CA  1 
ATOM 3203 C C   . THR A 1 447 ? 114.548 113.944 124.962 1.00 91.45  ? 447 THR A C   1 
ATOM 3204 O O   . THR A 1 447 ? 113.533 114.347 124.381 1.00 91.45  ? 447 THR A O   1 
ATOM 3205 C CB  . THR A 1 447 ? 116.224 112.697 123.588 1.00 91.45  ? 447 THR A CB  1 
ATOM 3206 O OG1 . THR A 1 447 ? 116.440 111.680 124.572 1.00 91.45  ? 447 THR A OG1 1 
ATOM 3207 C CG2 . THR A 1 447 ? 117.455 112.829 122.708 1.00 91.45  ? 447 THR A CG2 1 
ATOM 3208 N N   . MET A 1 448 ? 114.532 113.464 126.208 1.00 92.33  ? 448 MET A N   1 
ATOM 3209 C CA  . MET A 1 448 ? 113.263 113.408 126.980 1.00 92.33  ? 448 MET A CA  1 
ATOM 3210 C C   . MET A 1 448 ? 112.761 114.847 127.148 1.00 92.33  ? 448 MET A C   1 
ATOM 3211 O O   . MET A 1 448 ? 111.547 115.075 126.996 1.00 92.33  ? 448 MET A O   1 
ATOM 3212 C CB  . MET A 1 448 ? 113.486 112.781 128.359 1.00 92.33  ? 448 MET A CB  1 
ATOM 3213 C CG  . MET A 1 448 ? 113.702 111.283 128.310 1.00 92.33  ? 448 MET A CG  1 
ATOM 3214 S SD  . MET A 1 448 ? 113.342 110.496 129.897 1.00 92.33  ? 448 MET A SD  1 
ATOM 3215 C CE  . MET A 1 448 ? 112.810 111.916 130.851 1.00 92.33  ? 448 MET A CE  1 
ATOM 3216 N N   . ALA A 1 449 ? 113.679 115.768 127.458 1.00 90.90  ? 449 ALA A N   1 
ATOM 3217 C CA  . ALA A 1 449 ? 113.366 117.208 127.618 1.00 90.90  ? 449 ALA A CA  1 
ATOM 3218 C C   . ALA A 1 449 ? 112.885 117.771 126.277 1.00 90.90  ? 449 ALA A C   1 
ATOM 3219 O O   . ALA A 1 449 ? 111.968 118.614 126.280 1.00 90.90  ? 449 ALA A O   1 
ATOM 3220 C CB  . ALA A 1 449 ? 114.579 117.948 128.124 1.00 90.90  ? 449 ALA A CB  1 
ATOM 3221 N N   . PHE A 1 450 ? 113.501 117.321 125.179 1.00 91.90  ? 450 PHE A N   1 
ATOM 3222 C CA  . PHE A 1 450 ? 113.144 117.773 123.808 1.00 91.90  ? 450 PHE A CA  1 
ATOM 3223 C C   . PHE A 1 450 ? 111.691 117.390 123.513 1.00 91.90  ? 450 PHE A C   1 
ATOM 3224 O O   . PHE A 1 450 ? 110.964 118.202 122.909 1.00 91.90  ? 450 PHE A O   1 
ATOM 3225 C CB  . PHE A 1 450 ? 114.051 117.091 122.780 1.00 91.90  ? 450 PHE A CB  1 
ATOM 3226 C CG  . PHE A 1 450 ? 114.914 118.017 121.961 1.00 91.90  ? 450 PHE A CG  1 
ATOM 3227 C CD1 . PHE A 1 450 ? 114.595 119.358 121.829 1.00 91.90  ? 450 PHE A CD1 1 
ATOM 3228 C CD2 . PHE A 1 450 ? 116.046 117.543 121.318 1.00 91.90  ? 450 PHE A CD2 1 
ATOM 3229 C CE1 . PHE A 1 450 ? 115.391 120.205 121.074 1.00 91.90  ? 450 PHE A CE1 1 
ATOM 3230 C CE2 . PHE A 1 450 ? 116.841 118.389 120.563 1.00 91.90  ? 450 PHE A CE2 1 
ATOM 3231 C CZ  . PHE A 1 450 ? 116.513 119.719 120.442 1.00 91.90  ? 450 PHE A CZ  1 
ATOM 3232 N N   . GLU A 1 451 ? 111.292 116.186 123.934 1.00 87.50  ? 451 GLU A N   1 
ATOM 3233 C CA  . GLU A 1 451 ? 109.915 115.675 123.705 1.00 87.50  ? 451 GLU A CA  1 
ATOM 3234 C C   . GLU A 1 451 ? 108.924 116.392 124.629 1.00 87.50  ? 451 GLU A C   1 
ATOM 3235 O O   . GLU A 1 451 ? 107.849 116.783 124.136 1.00 87.50  ? 451 GLU A O   1 
ATOM 3236 C CB  . GLU A 1 451 ? 109.872 114.159 123.903 1.00 87.50  ? 451 GLU A CB  1 
ATOM 3237 C CG  . GLU A 1 451 ? 110.798 113.410 122.964 1.00 87.50  ? 451 GLU A CG  1 
ATOM 3238 C CD  . GLU A 1 451 ? 110.819 111.905 123.168 1.00 87.50  ? 451 GLU A CD  1 
ATOM 3239 O OE1 . GLU A 1 451 ? 110.137 111.428 124.095 1.00 87.50  ? 451 GLU A OE1 1 
ATOM 3240 O OE2 . GLU A 1 451 ? 111.518 111.216 122.398 1.00 87.50  ? 451 GLU A OE2 1 
ATOM 3241 N N   . ILE A 1 452 ? 109.264 116.560 125.912 1.00 86.69  ? 452 ILE A N   1 
ATOM 3242 C CA  . ILE A 1 452 ? 108.335 117.224 126.822 1.00 86.69  ? 452 ILE A CA  1 
ATOM 3243 C C   . ILE A 1 452 ? 108.129 118.680 126.419 1.00 86.69  ? 452 ILE A C   1 
ATOM 3244 O O   . ILE A 1 452 ? 107.015 119.218 126.521 1.00 86.69  ? 452 ILE A O   1 
ATOM 3245 C CB  . ILE A 1 452 ? 108.824 117.099 128.275 1.00 86.69  ? 452 ILE A CB  1 
ATOM 3246 C CG1 . ILE A 1 452 ? 108.857 115.631 128.697 1.00 86.69  ? 452 ILE A CG1 1 
ATOM 3247 C CG2 . ILE A 1 452 ? 107.925 117.880 129.213 1.00 86.69  ? 452 ILE A CG2 1 
ATOM 3248 C CD1 . ILE A 1 452 ? 109.563 115.390 130.008 1.00 86.69  ? 452 ILE A CD1 1 
ATOM 3249 N N   . VAL A 1 453 ? 109.195 119.349 125.971 1.00 88.85  ? 453 VAL A N   1 
ATOM 3250 C CA  . VAL A 1 453 ? 109.077 120.760 125.629 1.00 88.85  ? 453 VAL A CA  1 
ATOM 3251 C C   . VAL A 1 453 ? 108.228 120.936 124.381 1.00 88.85  ? 453 VAL A C   1 
ATOM 3252 O O   . VAL A 1 453 ? 107.444 121.885 124.289 1.00 88.85  ? 453 VAL A O   1 
ATOM 3253 C CB  . VAL A 1 453 ? 110.463 121.421 125.483 1.00 88.85  ? 453 VAL A CB  1 
ATOM 3254 C CG1 . VAL A 1 453 ? 111.137 121.056 124.175 1.00 88.85  ? 453 VAL A CG1 1 
ATOM 3255 C CG2 . VAL A 1 453 ? 110.338 122.927 125.603 1.00 88.85  ? 453 VAL A CG2 1 
ATOM 3256 N N   . TYR A 1 454 ? 108.341 120.019 123.413 1.00 88.52  ? 454 TYR A N   1 
ATOM 3257 C CA  . TYR A 1 454 ? 107.536 120.170 122.205 1.00 88.52  ? 454 TYR A CA  1 
ATOM 3258 C C   . TYR A 1 454 ? 106.047 120.080 122.504 1.00 88.52  ? 454 TYR A C   1 
ATOM 3259 O O   . TYR A 1 454 ? 105.232 120.665 121.783 1.00 88.52  ? 454 TYR A O   1 
ATOM 3260 C CB  . TYR A 1 454 ? 107.921 119.131 121.157 1.00 88.52  ? 454 TYR A CB  1 
ATOM 3261 C CG  . TYR A 1 454 ? 107.352 119.468 119.802 1.00 88.52  ? 454 TYR A CG  1 
ATOM 3262 C CD1 . TYR A 1 454 ? 107.923 120.455 119.023 1.00 88.52  ? 454 TYR A CD1 1 
ATOM 3263 C CD2 . TYR A 1 454 ? 106.232 118.824 119.313 1.00 88.52  ? 454 TYR A CD2 1 
ATOM 3264 C CE1 . TYR A 1 454 ? 107.412 120.786 117.793 1.00 88.52  ? 454 TYR A CE1 1 
ATOM 3265 C CE2 . TYR A 1 454 ? 105.714 119.147 118.078 1.00 88.52  ? 454 TYR A CE2 1 
ATOM 3266 C CZ  . TYR A 1 454 ? 106.305 120.131 117.325 1.00 88.52  ? 454 TYR A CZ  1 
ATOM 3267 O OH  . TYR A 1 454 ? 105.791 120.456 116.093 1.00 88.52  ? 454 TYR A OH  1 
ATOM 3268 N N   . LEU A 1 455 ? 105.671 119.359 123.558 1.00 86.08  ? 455 LEU A N   1 
ATOM 3269 C CA  . LEU A 1 455 ? 104.267 119.280 123.939 1.00 86.08  ? 455 LEU A CA  1 
ATOM 3270 C C   . LEU A 1 455 ? 103.846 120.501 124.747 1.00 86.08  ? 455 LEU A C   1 
ATOM 3271 O O   . LEU A 1 455 ? 102.888 121.198 124.380 1.00 86.08  ? 455 LEU A O   1 
ATOM 3272 C CB  . LEU A 1 455 ? 104.015 117.998 124.732 1.00 86.08  ? 455 LEU A CB  1 
ATOM 3273 C CG  . LEU A 1 455 ? 102.616 117.810 125.314 1.00 86.08  ? 455 LEU A CG  1 
ATOM 3274 C CD1 . LEU A 1 455 ? 101.634 117.468 124.210 1.00 86.08  ? 455 LEU A CD1 1 
ATOM 3275 C CD2 . LEU A 1 455 ? 102.628 116.736 126.382 1.00 86.08  ? 455 LEU A CD2 1 
ATOM 3276 N N   . VAL A 1 456 ? 104.567 120.786 125.837 1.00 89.96  ? 456 VAL A N   1 
ATOM 3277 C CA  . VAL A 1 456 ? 104.175 121.895 126.705 1.00 89.96  ? 456 VAL A CA  1 
ATOM 3278 C C   . VAL A 1 456 ? 104.169 123.200 125.925 1.00 89.96  ? 456 VAL A C   1 
ATOM 3279 O O   . VAL A 1 456 ? 103.364 124.099 126.202 1.00 89.96  ? 456 VAL A O   1 
ATOM 3280 C CB  . VAL A 1 456 ? 105.090 121.968 127.943 1.00 89.96  ? 456 VAL A CB  1 
ATOM 3281 C CG1 . VAL A 1 456 ? 106.510 122.296 127.545 1.00 89.96  ? 456 VAL A CG1 1 
ATOM 3282 C CG2 . VAL A 1 456 ? 104.564 122.990 128.933 1.00 89.96  ? 456 VAL A CG2 1 
ATOM 3283 N N   . ASN A 1 457 ? 105.027 123.306 124.909 1.00 91.57  ? 457 ASN A N   1 
ATOM 3284 C CA  . ASN A 1 457 ? 104.998 124.448 124.011 1.00 91.57  ? 457 ASN A CA  1 
ATOM 3285 C C   . ASN A 1 457 ? 103.653 124.545 123.305 1.00 91.57  ? 457 ASN A C   1 
ATOM 3286 O O   . ASN A 1 457 ? 103.100 125.640 123.150 1.00 91.57  ? 457 ASN A O   1 
ATOM 3287 C CB  . ASN A 1 457 ? 106.142 124.307 123.007 1.00 91.57  ? 457 ASN A CB  1 
ATOM 3288 C CG  . ASN A 1 457 ? 106.098 125.341 121.922 1.00 91.57  ? 457 ASN A CG  1 
ATOM 3289 O OD1 . ASN A 1 457 ? 105.637 126.452 122.138 1.00 91.57  ? 457 ASN A OD1 1 
ATOM 3290 N ND2 . ASN A 1 457 ? 106.589 124.984 120.743 1.00 91.57  ? 457 ASN A ND2 1 
ATOM 3291 N N   . SER A 1 458 ? 103.106 123.403 122.883 1.00 91.41  ? 458 SER A N   1 
ATOM 3292 C CA  . SER A 1 458 ? 101.811 123.407 122.213 1.00 91.41  ? 458 SER A CA  1 
ATOM 3293 C C   . SER A 1 458 ? 100.691 123.813 123.162 1.00 91.41  ? 458 SER A C   1 
ATOM 3294 O O   . SER A 1 458 ? 99.833  124.625 122.799 1.00 91.41  ? 458 SER A O   1 
ATOM 3295 C CB  . SER A 1 458 ? 101.534 122.036 121.602 1.00 91.41  ? 458 SER A CB  1 
ATOM 3296 O OG  . SER A 1 458 ? 102.584 121.657 120.732 1.00 91.41  ? 458 SER A OG  1 
ATOM 3297 N N   . GLU A 1 459 ? 100.673 123.262 124.381 1.00 92.91  ? 459 GLU A N   1 
ATOM 3298 C CA  . GLU A 1 459 ? 99.604  123.667 125.301 1.00 92.91  ? 459 GLU A CA  1 
ATOM 3299 C C   . GLU A 1 459 ? 99.695  125.144 125.672 1.00 92.91  ? 459 GLU A C   1 
ATOM 3300 O O   . GLU A 1 459 ? 98.666  125.805 125.845 1.00 92.91  ? 459 GLU A O   1 
ATOM 3301 C CB  . GLU A 1 459 ? 99.533  122.837 126.591 1.00 92.91  ? 459 GLU A CB  1 
ATOM 3302 C CG  . GLU A 1 459 ? 99.031  121.402 126.481 1.00 92.91  ? 459 GLU A CG  1 
ATOM 3303 C CD  . GLU A 1 459 ? 100.091 120.385 126.195 1.00 92.91  ? 459 GLU A CD  1 
ATOM 3304 O OE1 . GLU A 1 459 ? 101.268 120.760 126.180 1.00 92.91  ? 459 GLU A OE1 1 
ATOM 3305 O OE2 . GLU A 1 459 ? 99.742  119.203 126.004 1.00 92.91  ? 459 GLU A OE2 1 
ATOM 3306 N N   . LEU A 1 460 ? 100.909 125.678 125.818 1.00 92.91  ? 460 LEU A N   1 
ATOM 3307 C CA  . LEU A 1 460 ? 101.046 127.013 126.398 1.00 92.91  ? 460 LEU A CA  1 
ATOM 3308 C C   . LEU A 1 460 ? 100.409 128.093 125.526 1.00 92.91  ? 460 LEU A C   1 
ATOM 3309 O O   . LEU A 1 460 ? 99.795  129.030 126.045 1.00 92.91  ? 460 LEU A O   1 
ATOM 3310 C CB  . LEU A 1 460 ? 102.518 127.329 126.653 1.00 92.91  ? 460 LEU A CB  1 
ATOM 3311 C CG  . LEU A 1 460 ? 103.066 126.777 127.968 1.00 92.91  ? 460 LEU A CG  1 
ATOM 3312 C CD1 . LEU A 1 460 ? 104.555 126.499 127.862 1.00 92.91  ? 460 LEU A CD1 1 
ATOM 3313 C CD2 . LEU A 1 460 ? 102.767 127.735 129.105 1.00 92.91  ? 460 LEU A CD2 1 
ATOM 3314 N N   . TYR A 1 461 ? 100.544 127.986 124.206 1.00 91.70  ? 461 TYR A N   1 
ATOM 3315 C CA  . TYR A 1 461 ? 100.160 129.092 123.339 1.00 91.70  ? 461 TYR A CA  1 
ATOM 3316 C C   . TYR A 1 461 ? 98.645  129.153 123.136 1.00 91.70  ? 461 TYR A C   1 
ATOM 3317 O O   . TYR A 1 461 ? 97.961  128.129 123.198 1.00 91.70  ? 461 TYR A O   1 
ATOM 3318 C CB  . TYR A 1 461 ? 100.850 128.965 121.988 1.00 91.70  ? 461 TYR A CB  1 
ATOM 3319 C CG  . TYR A 1 461 ? 102.304 129.364 122.018 1.00 91.70  ? 461 TYR A CG  1 
ATOM 3320 C CD1 . TYR A 1 461 ? 102.731 130.467 122.741 1.00 91.70  ? 461 TYR A CD1 1 
ATOM 3321 C CD2 . TYR A 1 461 ? 103.252 128.636 121.323 1.00 91.70  ? 461 TYR A CD2 1 
ATOM 3322 C CE1 . TYR A 1 461 ? 104.064 130.826 122.767 1.00 91.70  ? 461 TYR A CE1 1 
ATOM 3323 C CE2 . TYR A 1 461 ? 104.578 128.993 121.347 1.00 91.70  ? 461 TYR A CE2 1 
ATOM 3324 C CZ  . TYR A 1 461 ? 104.981 130.085 122.067 1.00 91.70  ? 461 TYR A CZ  1 
ATOM 3325 O OH  . TYR A 1 461 ? 106.313 130.427 122.078 1.00 91.70  ? 461 TYR A OH  1 
ATOM 3326 N N   . PRO A 1 462 ? 98.102  130.347 122.888 1.00 95.02  ? 462 PRO A N   1 
ATOM 3327 C CA  . PRO A 1 462 ? 96.668  130.471 122.602 1.00 95.02  ? 462 PRO A CA  1 
ATOM 3328 C C   . PRO A 1 462 ? 96.292  129.743 121.321 1.00 95.02  ? 462 PRO A C   1 
ATOM 3329 O O   . PRO A 1 462 ? 97.141  129.267 120.567 1.00 95.02  ? 462 PRO A O   1 
ATOM 3330 C CB  . PRO A 1 462 ? 96.462  131.981 122.459 1.00 95.02  ? 462 PRO A CB  1 
ATOM 3331 C CG  . PRO A 1 462 ? 97.565  132.586 123.240 1.00 95.02  ? 462 PRO A CG  1 
ATOM 3332 C CD  . PRO A 1 462 ? 98.739  131.661 123.073 1.00 95.02  ? 462 PRO A CD  1 
ATOM 3333 N N   . THR A 1 463 ? 94.982  129.664 121.076 1.00 94.61  ? 463 THR A N   1 
ATOM 3334 C CA  . THR A 1 463 ? 94.491  128.947 119.902 1.00 94.61  ? 463 THR A CA  1 
ATOM 3335 C C   . THR A 1 463 ? 94.878  129.651 118.607 1.00 94.61  ? 463 THR A C   1 
ATOM 3336 O O   . THR A 1 463 ? 95.238  128.996 117.621 1.00 94.61  ? 463 THR A O   1 
ATOM 3337 C CB  . THR A 1 463 ? 92.976  128.781 119.985 1.00 94.61  ? 463 THR A CB  1 
ATOM 3338 O OG1 . THR A 1 463 ? 92.363  130.068 120.124 1.00 94.61  ? 463 THR A OG1 1 
ATOM 3339 C CG2 . THR A 1 463 ? 92.603  127.913 121.172 1.00 94.61  ? 463 THR A CG2 1 
ATOM 3340 N N   . THR A 1 464 ? 94.803  130.981 118.583 1.00 92.88  ? 464 THR A N   1 
ATOM 3341 C CA  . THR A 1 464 ? 95.123  131.719 117.366 1.00 92.88  ? 464 THR A CA  1 
ATOM 3342 C C   . THR A 1 464 ? 96.611  131.629 117.048 1.00 92.88  ? 464 THR A C   1 
ATOM 3343 O O   . THR A 1 464 ? 97.005  131.212 115.953 1.00 92.88  ? 464 THR A O   1 
ATOM 3344 C CB  . THR A 1 464 ? 94.689  133.178 117.510 1.00 92.88  ? 464 THR A CB  1 
ATOM 3345 O OG1 . THR A 1 464 ? 95.459  133.808 118.539 1.00 92.88  ? 464 THR A OG1 1 
ATOM 3346 C CG2 . THR A 1 464 ? 93.218  133.258 117.875 1.00 92.88  ? 464 THR A CG2 1 
ATOM 3347 N N   . LEU A 1 465 ? 97.450  132.008 117.999 1.00 91.75  ? 465 LEU A N   1 
ATOM 3348 C CA  . LEU A 1 465 ? 98.904  132.030 117.888 1.00 91.75  ? 465 LEU A CA  1 
ATOM 3349 C C   . LEU A 1 465 ? 99.536  130.654 117.951 1.00 91.75  ? 465 LEU A C   1 
ATOM 3350 O O   . LEU A 1 465 ? 100.771 130.615 117.919 1.00 91.75  ? 465 LEU A O   1 
ATOM 3351 C CB  . LEU A 1 465 ? 99.483  132.903 119.002 1.00 91.75  ? 465 LEU A CB  1 
ATOM 3352 C CG  . LEU A 1 465 ? 99.081  134.376 119.016 1.00 91.75  ? 465 LEU A CG  1 
ATOM 3353 C CD1 . LEU A 1 465 ? 99.561  135.038 120.294 1.00 91.75  ? 465 LEU A CD1 1 
ATOM 3354 C CD2 . LEU A 1 465 ? 99.650  135.084 117.810 1.00 91.75  ? 465 LEU A CD2 1 
ATOM 3355 N N   . ARG A 1 466 ? 98.773  129.561 118.036 1.00 92.69  ? 466 ARG A N   1 
ATOM 3356 C CA  . ARG A 1 466 ? 99.360  128.272 118.391 1.00 92.69  ? 466 ARG A CA  1 
ATOM 3357 C C   . ARG A 1 466 ? 100.377 127.813 117.356 1.00 92.69  ? 466 ARG A C   1 
ATOM 3358 O O   . ARG A 1 466 ? 101.518 127.487 117.698 1.00 92.69  ? 466 ARG A O   1 
ATOM 3359 C CB  . ARG A 1 466 ? 98.266  127.222 118.573 1.00 92.69  ? 466 ARG A CB  1 
ATOM 3360 C CG  . ARG A 1 466 ? 98.778  125.792 118.609 1.00 92.69  ? 466 ARG A CG  1 
ATOM 3361 C CD  . ARG A 1 466 ? 97.870  124.905 119.447 1.00 92.69  ? 466 ARG A CD  1 
ATOM 3362 N NE  . ARG A 1 466 ? 97.462  125.571 120.679 1.00 92.69  ? 466 ARG A NE  1 
ATOM 3363 C CZ  . ARG A 1 466 ? 96.225  125.969 120.947 1.00 92.69  ? 466 ARG A CZ  1 
ATOM 3364 N NH1 . ARG A 1 466 ? 95.233  125.756 120.100 1.00 92.69  ? 466 ARG A NH1 1 
ATOM 3365 N NH2 . ARG A 1 466 ? 95.978  126.592 122.095 1.00 92.69  ? 466 ARG A NH2 1 
ATOM 3366 N N   . ASN A 1 467 ? 99.993  127.786 116.084 1.00 88.64  ? 467 ASN A N   1 
ATOM 3367 C CA  . ASN A 1 467 ? 100.936 127.330 115.075 1.00 88.64  ? 467 ASN A CA  1 
ATOM 3368 C C   . ASN A 1 467 ? 101.915 128.420 114.666 1.00 88.64  ? 467 ASN A C   1 
ATOM 3369 O O   . ASN A 1 467 ? 102.861 128.136 113.925 1.00 88.64  ? 467 ASN A O   1 
ATOM 3370 C CB  . ASN A 1 467 ? 100.195 126.797 113.850 1.00 88.64  ? 467 ASN A CB  1 
ATOM 3371 C CG  . ASN A 1 467 ? 101.036 125.828 113.043 1.00 88.64  ? 467 ASN A CG  1 
ATOM 3372 O OD1 . ASN A 1 467 ? 101.158 125.953 111.829 1.00 88.64  ? 467 ASN A OD1 1 
ATOM 3373 N ND2 . ASN A 1 467 ? 101.629 124.857 113.722 1.00 88.64  ? 467 ASN A ND2 1 
ATOM 3374 N N   . PHE A 1 468 ? 101.713 129.656 115.129 1.00 94.21  ? 468 PHE A N   1 
ATOM 3375 C CA  . PHE A 1 468 ? 102.695 130.707 114.885 1.00 94.21  ? 468 PHE A CA  1 
ATOM 3376 C C   . PHE A 1 468 ? 103.765 130.713 115.968 1.00 94.21  ? 468 PHE A C   1 
ATOM 3377 O O   . PHE A 1 468 ? 104.962 130.701 115.667 1.00 94.21  ? 468 PHE A O   1 
ATOM 3378 C CB  . PHE A 1 468 ? 102.008 132.071 114.809 1.00 94.21  ? 468 PHE A CB  1 
ATOM 3379 C CG  . PHE A 1 468 ? 102.945 133.212 114.552 1.00 94.21  ? 468 PHE A CG  1 
ATOM 3380 C CD1 . PHE A 1 468 ? 103.949 133.102 113.606 1.00 94.21  ? 468 PHE A CD1 1 
ATOM 3381 C CD2 . PHE A 1 468 ? 102.811 134.402 115.243 1.00 94.21  ? 468 PHE A CD2 1 
ATOM 3382 C CE1 . PHE A 1 468 ? 104.808 134.152 113.364 1.00 94.21  ? 468 PHE A CE1 1 
ATOM 3383 C CE2 . PHE A 1 468 ? 103.667 135.457 115.004 1.00 94.21  ? 468 PHE A CE2 1 
ATOM 3384 C CZ  . PHE A 1 468 ? 104.666 135.331 114.063 1.00 94.21  ? 468 PHE A CZ  1 
ATOM 3385 N N   . GLY A 1 469 ? 103.349 130.733 117.236 1.00 92.88  ? 469 GLY A N   1 
ATOM 3386 C CA  . GLY A 1 469 ? 104.317 130.663 118.317 1.00 92.88  ? 469 GLY A CA  1 
ATOM 3387 C C   . GLY A 1 469 ? 105.123 129.381 118.279 1.00 92.88  ? 469 GLY A C   1 
ATOM 3388 O O   . GLY A 1 469 ? 106.352 129.400 118.376 1.00 92.88  ? 469 GLY A O   1 
ATOM 3389 N N   . VAL A 1 470 ? 104.440 128.245 118.145 1.00 90.19  ? 470 VAL A N   1 
ATOM 3390 C CA  . VAL A 1 470 ? 105.141 127.009 117.839 1.00 90.19  ? 470 VAL A CA  1 
ATOM 3391 C C   . VAL A 1 470 ? 105.731 127.131 116.442 1.00 90.19  ? 470 VAL A C   1 
ATOM 3392 O O   . VAL A 1 470 ? 105.149 127.761 115.549 1.00 90.19  ? 470 VAL A O   1 
ATOM 3393 C CB  . VAL A 1 470 ? 104.202 125.795 117.957 1.00 90.19  ? 470 VAL A CB  1 
ATOM 3394 C CG1 . VAL A 1 470 ? 104.941 124.507 117.647 1.00 90.19  ? 470 VAL A CG1 1 
ATOM 3395 C CG2 . VAL A 1 470 ? 103.602 125.734 119.346 1.00 90.19  ? 470 VAL A CG2 1 
ATOM 3396 N N   . SER A 1 471 ? 106.915 126.555 116.262 1.00 89.26  ? 471 SER A N   1 
ATOM 3397 C CA  . SER A 1 471 ? 107.790 126.656 115.102 1.00 89.26  ? 471 SER A CA  1 
ATOM 3398 C C   . SER A 1 471 ? 108.480 128.015 115.038 1.00 89.26  ? 471 SER A C   1 
ATOM 3399 O O   . SER A 1 471 ? 109.436 128.161 114.282 1.00 89.26  ? 471 SER A O   1 
ATOM 3400 C CB  . SER A 1 471 ? 107.071 126.392 113.764 1.00 89.26  ? 471 SER A CB  1 
ATOM 3401 O OG  . SER A 1 471 ? 106.227 127.476 113.419 1.00 89.26  ? 471 SER A OG  1 
ATOM 3402 N N   . LEU A 1 472 ? 108.066 129.002 115.829 1.00 90.74  ? 472 LEU A N   1 
ATOM 3403 C CA  . LEU A 1 472 ? 108.918 130.170 116.006 1.00 90.74  ? 472 LEU A CA  1 
ATOM 3404 C C   . LEU A 1 472 ? 110.057 129.850 116.962 1.00 90.74  ? 472 LEU A C   1 
ATOM 3405 O O   . LEU A 1 472 ? 111.184 130.321 116.776 1.00 90.74  ? 472 LEU A O   1 
ATOM 3406 C CB  . LEU A 1 472 ? 108.100 131.358 116.510 1.00 90.74  ? 472 LEU A CB  1 
ATOM 3407 C CG  . LEU A 1 472 ? 108.855 132.681 116.632 1.00 90.74  ? 472 LEU A CG  1 
ATOM 3408 C CD1 . LEU A 1 472 ? 109.166 133.227 115.257 1.00 90.74  ? 472 LEU A CD1 1 
ATOM 3409 C CD2 . LEU A 1 472 ? 108.042 133.684 117.425 1.00 90.74  ? 472 LEU A CD2 1 
ATOM 3410 N N   . CYS A 1 473 ? 109.775 129.040 117.984 1.00 87.00  ? 473 CYS A N   1 
ATOM 3411 C CA  . CYS A 1 473 ? 110.828 128.549 118.863 1.00 87.00  ? 473 CYS A CA  1 
ATOM 3412 C C   . CYS A 1 473 ? 111.626 127.438 118.193 1.00 87.00  ? 473 CYS A C   1 
ATOM 3413 O O   . CYS A 1 473 ? 112.847 127.340 118.375 1.00 87.00  ? 473 CYS A O   1 
ATOM 3414 C CB  . CYS A 1 473 ? 110.212 128.067 120.172 1.00 87.00  ? 473 CYS A CB  1 
ATOM 3415 S SG  . CYS A 1 473 ? 108.901 129.141 120.797 1.00 87.00  ? 473 CYS A SG  1 
ATOM 3416 N N   . SER A 1 474 ? 110.954 126.590 117.411 1.00 90.12  ? 474 SER A N   1 
ATOM 3417 C CA  . SER A 1 474 ? 111.679 125.608 116.616 1.00 90.12  ? 474 SER A CA  1 
ATOM 3418 C C   . SER A 1 474 ? 112.607 126.290 115.623 1.00 90.12  ? 474 SER A C   1 
ATOM 3419 O O   . SER A 1 474 ? 113.652 125.738 115.263 1.00 90.12  ? 474 SER A O   1 
ATOM 3420 C CB  . SER A 1 474 ? 110.699 124.689 115.893 1.00 90.12  ? 474 SER A CB  1 
ATOM 3421 O OG  . SER A 1 474 ? 109.853 124.026 116.814 1.00 90.12  ? 474 SER A OG  1 
ATOM 3422 N N   . GLY A 1 475 ? 112.254 127.496 115.183 1.00 92.76  ? 475 GLY A N   1 
ATOM 3423 C CA  . GLY A 1 475 ? 113.213 128.298 114.449 1.00 92.76  ? 475 GLY A CA  1 
ATOM 3424 C C   . GLY A 1 475 ? 114.468 128.553 115.258 1.00 92.76  ? 475 GLY A C   1 
ATOM 3425 O O   . GLY A 1 475 ? 115.581 128.504 114.730 1.00 92.76  ? 475 GLY A O   1 
ATOM 3426 N N   . LEU A 1 476 ? 114.309 128.802 116.560 1.00 91.27  ? 476 LEU A N   1 
ATOM 3427 C CA  . LEU A 1 476 ? 115.479 129.043 117.394 1.00 91.27  ? 476 LEU A CA  1 
ATOM 3428 C C   . LEU A 1 476 ? 116.285 127.770 117.614 1.00 91.27  ? 476 LEU A C   1 
ATOM 3429 O O   . LEU A 1 476 ? 117.516 127.830 117.693 1.00 91.27  ? 476 LEU A O   1 
ATOM 3430 C CB  . LEU A 1 476 ? 115.070 129.656 118.731 1.00 91.27  ? 476 LEU A CB  1 
ATOM 3431 C CG  . LEU A 1 476 ? 116.277 130.199 119.492 1.00 91.27  ? 476 LEU A CG  1 
ATOM 3432 C CD1 . LEU A 1 476 ? 117.043 131.163 118.611 1.00 91.27  ? 476 LEU A CD1 1 
ATOM 3433 C CD2 . LEU A 1 476 ? 115.858 130.887 120.762 1.00 91.27  ? 476 LEU A CD2 1 
ATOM 3434 N N   . CYS A 1 477 ? 115.630 126.611 117.703 1.00 92.81  ? 477 CYS A N   1 
ATOM 3435 C CA  . CYS A 1 477 ? 116.417 125.385 117.806 1.00 92.81  ? 477 CYS A CA  1 
ATOM 3436 C C   . CYS A 1 477 ? 117.146 125.092 116.500 1.00 92.81  ? 477 CYS A C   1 
ATOM 3437 O O   . CYS A 1 477 ? 118.257 124.554 116.519 1.00 92.81  ? 477 CYS A O   1 
ATOM 3438 C CB  . CYS A 1 477 ? 115.548 124.192 118.204 1.00 92.81  ? 477 CYS A CB  1 
ATOM 3439 S SG  . CYS A 1 477 ? 114.602 123.426 116.877 1.00 92.81  ? 477 CYS A SG  1 
ATOM 3440 N N   . ASP A 1 478 ? 116.552 125.452 115.361 1.00 92.20  ? 478 ASP A N   1 
ATOM 3441 C CA  . ASP A 1 478 ? 117.256 125.318 114.089 1.00 92.20  ? 478 ASP A CA  1 
ATOM 3442 C C   . ASP A 1 478 ? 118.446 126.271 114.011 1.00 92.20  ? 478 ASP A C   1 
ATOM 3443 O O   . ASP A 1 478 ? 119.498 125.925 113.457 1.00 92.20  ? 478 ASP A O   1 
ATOM 3444 C CB  . ASP A 1 478 ? 116.285 125.565 112.938 1.00 92.20  ? 478 ASP A CB  1 
ATOM 3445 C CG  . ASP A 1 478 ? 115.252 124.466 112.808 1.00 92.20  ? 478 ASP A CG  1 
ATOM 3446 O OD1 . ASP A 1 478 ? 115.563 123.313 113.172 1.00 92.20  ? 478 ASP A OD1 1 
ATOM 3447 O OD2 . ASP A 1 478 ? 114.125 124.757 112.356 1.00 92.20  ? 478 ASP A OD2 1 
ATOM 3448 N N   . PHE A 1 479 ? 118.291 127.482 114.549 1.00 96.50  ? 479 PHE A N   1 
ATOM 3449 C CA  . PHE A 1 479 ? 119.419 128.405 114.630 1.00 96.50  ? 479 PHE A CA  1 
ATOM 3450 C C   . PHE A 1 479 ? 120.520 127.844 115.521 1.00 96.50  ? 479 PHE A C   1 
ATOM 3451 O O   . PHE A 1 479 ? 121.711 127.964 115.208 1.00 96.50  ? 479 PHE A O   1 
ATOM 3452 C CB  . PHE A 1 479 ? 118.945 129.763 115.143 1.00 96.50  ? 479 PHE A CB  1 
ATOM 3453 C CG  . PHE A 1 479 ? 120.049 130.632 115.663 1.00 96.50  ? 479 PHE A CG  1 
ATOM 3454 C CD1 . PHE A 1 479 ? 120.967 131.199 114.798 1.00 96.50  ? 479 PHE A CD1 1 
ATOM 3455 C CD2 . PHE A 1 479 ? 120.168 130.886 117.017 1.00 96.50  ? 479 PHE A CD2 1 
ATOM 3456 C CE1 . PHE A 1 479 ? 121.984 132.001 115.273 1.00 96.50  ? 479 PHE A CE1 1 
ATOM 3457 C CE2 . PHE A 1 479 ? 121.183 131.687 117.498 1.00 96.50  ? 479 PHE A CE2 1 
ATOM 3458 C CZ  . PHE A 1 479 ? 122.092 132.245 116.625 1.00 96.50  ? 479 PHE A CZ  1 
ATOM 3459 N N   . GLY A 1 480 ? 120.142 127.235 116.643 1.00 97.33  ? 480 GLY A N   1 
ATOM 3460 C CA  . GLY A 1 480 ? 121.126 126.539 117.454 1.00 97.33  ? 480 GLY A CA  1 
ATOM 3461 C C   . GLY A 1 480 ? 121.819 125.434 116.682 1.00 97.33  ? 480 GLY A C   1 
ATOM 3462 O O   . GLY A 1 480 ? 123.028 125.235 116.811 1.00 97.33  ? 480 GLY A O   1 
ATOM 3463 N N   . GLY A 1 481 ? 121.062 124.713 115.858 1.00 95.66  ? 481 GLY A N   1 
ATOM 3464 C CA  . GLY A 1 481 ? 121.656 123.665 115.046 1.00 95.66  ? 481 GLY A CA  1 
ATOM 3465 C C   . GLY A 1 481 ? 122.670 124.191 114.048 1.00 95.66  ? 481 GLY A C   1 
ATOM 3466 O O   . GLY A 1 481 ? 123.712 123.570 113.825 1.00 95.66  ? 481 GLY A O   1 
ATOM 3467 N N   . ILE A 1 482 ? 122.375 125.330 113.415 1.00 97.44  ? 482 ILE A N   1 
ATOM 3468 C CA  . ILE A 1 482 ? 123.333 125.876 112.453 1.00 97.44  ? 482 ILE A CA  1 
ATOM 3469 C C   . ILE A 1 482 ? 124.563 126.418 113.172 1.00 97.44  ? 482 ILE A C   1 
ATOM 3470 O O   . ILE A 1 482 ? 125.690 126.286 112.680 1.00 97.44  ? 482 ILE A O   1 
ATOM 3471 C CB  . ILE A 1 482 ? 122.700 126.950 111.542 1.00 97.44  ? 482 ILE A CB  1 
ATOM 3472 C CG1 . ILE A 1 482 ? 122.211 128.160 112.329 1.00 97.44  ? 482 ILE A CG1 1 
ATOM 3473 C CG2 . ILE A 1 482 ? 121.562 126.377 110.745 1.00 97.44  ? 482 ILE A CG2 1 
ATOM 3474 C CD1 . ILE A 1 482 ? 121.802 129.322 111.459 1.00 97.44  ? 482 ILE A CD1 1 
ATOM 3475 N N   . ILE A 1 483 ? 124.377 127.033 114.343 1.00 99.44  ? 483 ILE A N   1 
ATOM 3476 C CA  . ILE A 1 483 ? 125.495 127.693 115.012 1.00 99.44  ? 483 ILE A CA  1 
ATOM 3477 C C   . ILE A 1 483 ? 126.336 126.731 115.849 1.00 99.44  ? 483 ILE A C   1 
ATOM 3478 O O   . ILE A 1 483 ? 127.472 127.070 116.209 1.00 99.44  ? 483 ILE A O   1 
ATOM 3479 C CB  . ILE A 1 483 ? 124.981 128.851 115.888 1.00 99.44  ? 483 ILE A CB  1 
ATOM 3480 C CG1 . ILE A 1 483 ? 126.134 129.722 116.385 1.00 99.44  ? 483 ILE A CG1 1 
ATOM 3481 C CG2 . ILE A 1 483 ? 124.240 128.311 117.089 1.00 99.44  ? 483 ILE A CG2 1 
ATOM 3482 C CD1 . ILE A 1 483 ? 125.690 131.039 116.974 1.00 99.44  ? 483 ILE A CD1 1 
ATOM 3483 N N   . ALA A 1 484 ? 125.829 125.534 116.143 1.00 99.18  ? 484 ALA A N   1 
ATOM 3484 C CA  . ALA A 1 484 ? 126.543 124.625 117.038 1.00 99.18  ? 484 ALA A CA  1 
ATOM 3485 C C   . ALA A 1 484 ? 127.943 124.251 116.562 1.00 99.18  ? 484 ALA A C   1 
ATOM 3486 O O   . ALA A 1 484 ? 128.871 124.283 117.389 1.00 99.18  ? 484 ALA A O   1 
ATOM 3487 C CB  . ALA A 1 484 ? 125.691 123.376 117.281 1.00 99.18  ? 484 ALA A CB  1 
ATOM 3488 N N   . PRO A 1 485 ? 128.177 123.861 115.301 1.00 99.35  ? 485 PRO A N   1 
ATOM 3489 C CA  . PRO A 1 485 ? 129.549 123.469 114.923 1.00 99.35  ? 485 PRO A CA  1 
ATOM 3490 C C   . PRO A 1 485 ? 130.578 124.572 115.110 1.00 99.35  ? 485 PRO A C   1 
ATOM 3491 O O   . PRO A 1 485 ? 131.691 124.299 115.583 1.00 99.35  ? 485 PRO A O   1 
ATOM 3492 C CB  . PRO A 1 485 ? 129.403 123.073 113.447 1.00 99.35  ? 485 PRO A CB  1 
ATOM 3493 C CG  . PRO A 1 485 ? 127.977 122.714 113.292 1.00 99.35  ? 485 PRO A CG  1 
ATOM 3494 C CD  . PRO A 1 485 ? 127.235 123.652 114.187 1.00 99.35  ? 485 PRO A CD  1 
ATOM 3495 N N   . PHE A 1 486 ? 130.237 125.815 114.764 1.00 103.82 ? 486 PHE A N   1 
ATOM 3496 C CA  . PHE A 1 486 ? 131.190 126.910 114.910 1.00 103.82 ? 486 PHE A CA  1 
ATOM 3497 C C   . PHE A 1 486 ? 131.521 127.155 116.376 1.00 103.82 ? 486 PHE A C   1 
ATOM 3498 O O   . PHE A 1 486 ? 132.692 127.315 116.741 1.00 103.82 ? 486 PHE A O   1 
ATOM 3499 C CB  . PHE A 1 486 ? 130.634 128.181 114.266 1.00 103.82 ? 486 PHE A CB  1 
ATOM 3500 C CG  . PHE A 1 486 ? 131.142 129.452 114.890 1.00 103.82 ? 486 PHE A CG  1 
ATOM 3501 C CD1 . PHE A 1 486 ? 132.428 129.900 114.635 1.00 103.82 ? 486 PHE A CD1 1 
ATOM 3502 C CD2 . PHE A 1 486 ? 130.332 130.201 115.728 1.00 103.82 ? 486 PHE A CD2 1 
ATOM 3503 C CE1 . PHE A 1 486 ? 132.896 131.069 115.206 1.00 103.82 ? 486 PHE A CE1 1 
ATOM 3504 C CE2 . PHE A 1 486 ? 130.796 131.370 116.301 1.00 103.82 ? 486 PHE A CE2 1 
ATOM 3505 C CZ  . PHE A 1 486 ? 132.079 131.804 116.040 1.00 103.82 ? 486 PHE A CZ  1 
ATOM 3506 N N   . LEU A 1 487 ? 130.497 127.190 117.230 1.00 102.57 ? 487 LEU A N   1 
ATOM 3507 C CA  . LEU A 1 487 ? 130.727 127.381 118.656 1.00 102.57 ? 487 LEU A CA  1 
ATOM 3508 C C   . LEU A 1 487 ? 131.564 126.247 119.227 1.00 102.57 ? 487 LEU A C   1 
ATOM 3509 O O   . LEU A 1 487 ? 132.478 126.479 120.026 1.00 102.57 ? 487 LEU A O   1 
ATOM 3510 C CB  . LEU A 1 487 ? 129.392 127.483 119.390 1.00 102.57 ? 487 LEU A CB  1 
ATOM 3511 C CG  . LEU A 1 487 ? 129.353 128.374 120.629 1.00 102.57 ? 487 LEU A CG  1 
ATOM 3512 C CD1 . LEU A 1 487 ? 129.634 129.818 120.252 1.00 102.57 ? 487 LEU A CD1 1 
ATOM 3513 C CD2 . LEU A 1 487 ? 128.010 128.250 121.329 1.00 102.57 ? 487 LEU A CD2 1 
ATOM 3514 N N   . LEU A 1 488 ? 131.268 125.012 118.818 1.00 103.39 ? 488 LEU A N   1 
ATOM 3515 C CA  . LEU A 1 488 ? 132.010 123.861 119.315 1.00 103.39 ? 488 LEU A CA  1 
ATOM 3516 C C   . LEU A 1 488 ? 133.479 123.949 118.927 1.00 103.39 ? 488 LEU A C   1 
ATOM 3517 O O   . LEU A 1 488 ? 134.363 123.737 119.762 1.00 103.39 ? 488 LEU A O   1 
ATOM 3518 C CB  . LEU A 1 488 ? 131.383 122.571 118.784 1.00 103.39 ? 488 LEU A CB  1 
ATOM 3519 C CG  . LEU A 1 488 ? 131.855 121.248 119.388 1.00 103.39 ? 488 LEU A CG  1 
ATOM 3520 C CD1 . LEU A 1 488 ? 130.684 120.293 119.529 1.00 103.39 ? 488 LEU A CD1 1 
ATOM 3521 C CD2 . LEU A 1 488 ? 132.948 120.622 118.536 1.00 103.39 ? 488 LEU A CD2 1 
ATOM 3522 N N   . PHE A 1 489 ? 133.761 124.270 117.662 1.00 104.40 ? 489 PHE A N   1 
ATOM 3523 C CA  . PHE A 1 489 ? 135.152 124.367 117.227 1.00 104.40 ? 489 PHE A CA  1 
ATOM 3524 C C   . PHE A 1 489 ? 135.877 125.509 117.930 1.00 104.40 ? 489 PHE A C   1 
ATOM 3525 O O   . PHE A 1 489 ? 137.015 125.342 118.390 1.00 104.40 ? 489 PHE A O   1 
ATOM 3526 C CB  . PHE A 1 489 ? 135.217 124.542 115.712 1.00 104.40 ? 489 PHE A CB  1 
ATOM 3527 C CG  . PHE A 1 489 ? 136.608 124.475 115.155 1.00 104.40 ? 489 PHE A CG  1 
ATOM 3528 C CD1 . PHE A 1 489 ? 137.188 123.254 114.858 1.00 104.40 ? 489 PHE A CD1 1 
ATOM 3529 C CD2 . PHE A 1 489 ? 137.333 125.630 114.924 1.00 104.40 ? 489 PHE A CD2 1 
ATOM 3530 C CE1 . PHE A 1 489 ? 138.468 123.187 114.343 1.00 104.40 ? 489 PHE A CE1 1 
ATOM 3531 C CE2 . PHE A 1 489 ? 138.613 125.570 114.409 1.00 104.40 ? 489 PHE A CE2 1 
ATOM 3532 C CZ  . PHE A 1 489 ? 139.180 124.347 114.118 1.00 104.40 ? 489 PHE A CZ  1 
ATOM 3533 N N   . ARG A 1 490 ? 135.230 126.674 118.035 1.00 106.93 ? 490 ARG A N   1 
ATOM 3534 C CA  . ARG A 1 490 ? 135.862 127.817 118.684 1.00 106.93 ? 490 ARG A CA  1 
ATOM 3535 C C   . ARG A 1 490 ? 136.177 127.524 120.144 1.00 106.93 ? 490 ARG A C   1 
ATOM 3536 O O   . ARG A 1 490 ? 137.265 127.855 120.630 1.00 106.93 ? 490 ARG A O   1 
ATOM 3537 C CB  . ARG A 1 490 ? 134.963 129.047 118.568 1.00 106.93 ? 490 ARG A CB  1 
ATOM 3538 C CG  . ARG A 1 490 ? 135.377 130.210 119.453 1.00 106.93 ? 490 ARG A CG  1 
ATOM 3539 C CD  . ARG A 1 490 ? 136.716 130.789 119.034 1.00 106.93 ? 490 ARG A CD  1 
ATOM 3540 N NE  . ARG A 1 490 ? 137.137 131.861 119.927 1.00 106.93 ? 490 ARG A NE  1 
ATOM 3541 C CZ  . ARG A 1 490 ? 136.791 133.133 119.787 1.00 106.93 ? 490 ARG A CZ  1 
ATOM 3542 N NH1 . ARG A 1 490 ? 136.016 133.532 118.792 1.00 106.93 ? 490 ARG A NH1 1 
ATOM 3543 N NH2 . ARG A 1 490 ? 137.232 134.027 120.667 1.00 106.93 ? 490 ARG A NH2 1 
ATOM 3544 N N   . LEU A 1 491 ? 135.243 126.900 120.863 1.00 102.97 ? 491 LEU A N   1 
ATOM 3545 C CA  . LEU A 1 491 ? 135.482 126.619 122.274 1.00 102.97 ? 491 LEU A CA  1 
ATOM 3546 C C   . LEU A 1 491 ? 136.492 125.493 122.453 1.00 102.97 ? 491 LEU A C   1 
ATOM 3547 O O   . LEU A 1 491 ? 137.310 125.532 123.379 1.00 102.97 ? 491 LEU A O   1 
ATOM 3548 C CB  . LEU A 1 491 ? 134.164 126.289 122.972 1.00 102.97 ? 491 LEU A CB  1 
ATOM 3549 C CG  . LEU A 1 491 ? 133.175 127.447 123.131 1.00 102.97 ? 491 LEU A CG  1 
ATOM 3550 C CD1 . LEU A 1 491 ? 132.210 127.174 124.270 1.00 102.97 ? 491 LEU A CD1 1 
ATOM 3551 C CD2 . LEU A 1 491 ? 133.905 128.762 123.350 1.00 102.97 ? 491 LEU A CD2 1 
ATOM 3552 N N   . ALA A 1 492 ? 136.459 124.483 121.579 1.00 103.03 ? 492 ALA A N   1 
ATOM 3553 C CA  . ALA A 1 492 ? 137.414 123.387 121.670 1.00 103.03 ? 492 ALA A CA  1 
ATOM 3554 C C   . ALA A 1 492 ? 138.828 123.826 121.330 1.00 103.03 ? 492 ALA A C   1 
ATOM 3555 O O   . ALA A 1 492 ? 139.786 123.181 121.769 1.00 103.03 ? 492 ALA A O   1 
ATOM 3556 C CB  . ALA A 1 492 ? 136.993 122.239 120.753 1.00 103.03 ? 492 ALA A CB  1 
ATOM 3557 N N   . ALA A 1 493 ? 138.982 124.896 120.547 1.00 104.38 ? 493 ALA A N   1 
ATOM 3558 C CA  . ALA A 1 493 ? 140.316 125.434 120.312 1.00 104.38 ? 493 ALA A CA  1 
ATOM 3559 C C   . ALA A 1 493 ? 140.955 125.907 121.613 1.00 104.38 ? 493 ALA A C   1 
ATOM 3560 O O   . ALA A 1 493 ? 142.140 125.657 121.858 1.00 104.38 ? 493 ALA A O   1 
ATOM 3561 C CB  . ALA A 1 493 ? 140.253 126.574 119.297 1.00 104.38 ? 493 ALA A CB  1 
ATOM 3562 N N   . VAL A 1 494 ? 140.183 126.591 122.461 1.00 105.72 ? 494 VAL A N   1 
ATOM 3563 C CA  . VAL A 1 494 ? 140.724 127.098 123.719 1.00 105.72 ? 494 VAL A CA  1 
ATOM 3564 C C   . VAL A 1 494 ? 141.041 125.949 124.671 1.00 105.72 ? 494 VAL A C   1 
ATOM 3565 O O   . VAL A 1 494 ? 142.126 125.891 125.259 1.00 105.72 ? 494 VAL A O   1 
ATOM 3566 C CB  . VAL A 1 494 ? 139.746 128.103 124.354 1.00 105.72 ? 494 VAL A CB  1 
ATOM 3567 C CG1 . VAL A 1 494 ? 140.261 128.564 125.707 1.00 105.72 ? 494 VAL A CG1 1 
ATOM 3568 C CG2 . VAL A 1 494 ? 139.533 129.289 123.430 1.00 105.72 ? 494 VAL A CG2 1 
ATOM 3569 N N   . TRP A 1 495 ? 140.101 125.021 124.834 1.00 104.20 ? 495 TRP A N   1 
ATOM 3570 C CA  . TRP A 1 495 ? 140.291 123.878 125.716 1.00 104.20 ? 495 TRP A CA  1 
ATOM 3571 C C   . TRP A 1 495 ? 139.359 122.763 125.269 1.00 104.20 ? 495 TRP A C   1 
ATOM 3572 O O   . TRP A 1 495 ? 138.285 123.020 124.721 1.00 104.20 ? 495 TRP A O   1 
ATOM 3573 C CB  . TRP A 1 495 ? 140.031 124.246 127.181 1.00 104.20 ? 495 TRP A CB  1 
ATOM 3574 C CG  . TRP A 1 495 ? 140.367 123.150 128.147 1.00 104.20 ? 495 TRP A CG  1 
ATOM 3575 C CD1 . TRP A 1 495 ? 141.359 122.223 128.022 1.00 104.20 ? 495 TRP A CD1 1 
ATOM 3576 C CD2 . TRP A 1 495 ? 139.707 122.864 129.386 1.00 104.20 ? 495 TRP A CD2 1 
ATOM 3577 N NE1 . TRP A 1 495 ? 141.358 121.378 129.105 1.00 104.20 ? 495 TRP A NE1 1 
ATOM 3578 C CE2 . TRP A 1 495 ? 140.353 121.751 129.957 1.00 104.20 ? 495 TRP A CE2 1 
ATOM 3579 C CE3 . TRP A 1 495 ? 138.632 123.442 130.067 1.00 104.20 ? 495 TRP A CE3 1 
ATOM 3580 C CZ2 . TRP A 1 495 ? 139.960 121.206 131.175 1.00 104.20 ? 495 TRP A CZ2 1 
ATOM 3581 C CZ3 . TRP A 1 495 ? 138.244 122.899 131.276 1.00 104.20 ? 495 TRP A CZ3 1 
ATOM 3582 C CH2 . TRP A 1 495 ? 138.906 121.793 131.817 1.00 104.20 ? 495 TRP A CH2 1 
ATOM 3583 N N   . LEU A 1 496 ? 139.781 121.521 125.516 1.00 101.74 ? 496 LEU A N   1 
ATOM 3584 C CA  . LEU A 1 496 ? 139.033 120.370 125.020 1.00 101.74 ? 496 LEU A CA  1 
ATOM 3585 C C   . LEU A 1 496 ? 137.641 120.289 125.636 1.00 101.74 ? 496 LEU A C   1 
ATOM 3586 O O   . LEU A 1 496 ? 136.662 120.003 124.937 1.00 101.74 ? 496 LEU A O   1 
ATOM 3587 C CB  . LEU A 1 496 ? 139.810 119.082 125.293 1.00 101.74 ? 496 LEU A CB  1 
ATOM 3588 C CG  . LEU A 1 496 ? 140.839 118.627 124.255 1.00 101.74 ? 496 LEU A CG  1 
ATOM 3589 C CD1 . LEU A 1 496 ? 140.161 118.321 122.928 1.00 101.74 ? 496 LEU A CD1 1 
ATOM 3590 C CD2 . LEU A 1 496 ? 141.954 119.648 124.072 1.00 101.74 ? 496 LEU A CD2 1 
ATOM 3591 N N   . GLU A 1 497 ? 137.528 120.532 126.940 1.00 104.70 ? 497 GLU A N   1 
ATOM 3592 C CA  . GLU A 1 497 ? 136.288 120.293 127.666 1.00 104.70 ? 497 GLU A CA  1 
ATOM 3593 C C   . GLU A 1 497 ? 135.494 121.564 127.945 1.00 104.70 ? 497 GLU A C   1 
ATOM 3594 O O   . GLU A 1 497 ? 134.487 121.503 128.656 1.00 104.70 ? 497 GLU A O   1 
ATOM 3595 C CB  . GLU A 1 497 ? 136.584 119.565 128.978 1.00 104.70 ? 497 GLU A CB  1 
ATOM 3596 C CG  . GLU A 1 497 ? 137.023 118.121 128.797 1.00 104.70 ? 497 GLU A CG  1 
ATOM 3597 C CD  . GLU A 1 497 ? 138.530 117.969 128.757 1.00 104.70 ? 497 GLU A CD  1 
ATOM 3598 O OE1 . GLU A 1 497 ? 139.235 118.908 129.179 1.00 104.70 ? 497 GLU A OE1 1 
ATOM 3599 O OE2 . GLU A 1 497 ? 139.009 116.908 128.303 1.00 104.70 ? 497 GLU A OE2 1 
ATOM 3600 N N   . LEU A 1 498 ? 135.920 122.707 127.412 1.00 101.16 ? 498 LEU A N   1 
ATOM 3601 C CA  . LEU A 1 498 ? 135.153 123.939 127.595 1.00 101.16 ? 498 LEU A CA  1 
ATOM 3602 C C   . LEU A 1 498 ? 133.744 123.867 127.013 1.00 101.16 ? 498 LEU A C   1 
ATOM 3603 O O   . LEU A 1 498 ? 132.798 124.311 127.694 1.00 101.16 ? 498 LEU A O   1 
ATOM 3604 C CB  . LEU A 1 498 ? 135.935 125.119 127.010 1.00 101.16 ? 498 LEU A CB  1 
ATOM 3605 C CG  . LEU A 1 498 ? 135.378 126.509 127.317 1.00 101.16 ? 498 LEU A CG  1 
ATOM 3606 C CD1 . LEU A 1 498 ? 134.978 126.622 128.777 1.00 101.16 ? 498 LEU A CD1 1 
ATOM 3607 C CD2 . LEU A 1 498 ? 136.389 127.581 126.954 1.00 101.16 ? 498 LEU A CD2 1 
ATOM 3608 N N   . PRO A 1 499 ? 133.521 123.363 125.788 1.00 101.60 ? 499 PRO A N   1 
ATOM 3609 C CA  . PRO A 1 499 ? 132.139 123.307 125.283 1.00 101.60 ? 499 PRO A CA  1 
ATOM 3610 C C   . PRO A 1 499 ? 131.214 122.513 126.181 1.00 101.60 ? 499 PRO A C   1 
ATOM 3611 O O   . PRO A 1 499 ? 130.059 122.906 126.384 1.00 101.60 ? 499 PRO A O   1 
ATOM 3612 C CB  . PRO A 1 499 ? 132.291 122.640 123.907 1.00 101.60 ? 499 PRO A CB  1 
ATOM 3613 C CG  . PRO A 1 499 ? 133.701 122.819 123.537 1.00 101.60 ? 499 PRO A CG  1 
ATOM 3614 C CD  . PRO A 1 499 ? 134.471 122.799 124.811 1.00 101.60 ? 499 PRO A CD  1 
ATOM 3615 N N   . LEU A 1 500 ? 131.703 121.405 126.737 1.00 100.42 ? 500 LEU A N   1 
ATOM 3616 C CA  . LEU A 1 500 ? 130.872 120.588 127.610 1.00 100.42 ? 500 LEU A CA  1 
ATOM 3617 C C   . LEU A 1 500 ? 130.514 121.334 128.886 1.00 100.42 ? 500 LEU A C   1 
ATOM 3618 O O   . LEU A 1 500 ? 129.383 121.234 129.368 1.00 100.42 ? 500 LEU A O   1 
ATOM 3619 C CB  . LEU A 1 500 ? 131.579 119.273 127.923 1.00 100.42 ? 500 LEU A CB  1 
ATOM 3620 C CG  . LEU A 1 500 ? 131.228 118.124 126.977 1.00 100.42 ? 500 LEU A CG  1 
ATOM 3621 C CD1 . LEU A 1 500 ? 131.746 118.383 125.573 1.00 100.42 ? 500 LEU A CD1 1 
ATOM 3622 C CD2 . LEU A 1 500 ? 131.783 116.825 127.506 1.00 100.42 ? 500 LEU A CD2 1 
ATOM 3623 N N   . ILE A 1 501 ? 131.457 122.097 129.440 1.00 98.15  ? 501 ILE A N   1 
ATOM 3624 C CA  . ILE A 1 501 ? 131.167 122.886 130.635 1.00 98.15  ? 501 ILE A CA  1 
ATOM 3625 C C   . ILE A 1 501 ? 130.101 123.932 130.335 1.00 98.15  ? 501 ILE A C   1 
ATOM 3626 O O   . ILE A 1 501 ? 129.149 124.119 131.107 1.00 98.15  ? 501 ILE A O   1 
ATOM 3627 C CB  . ILE A 1 501 ? 132.453 123.536 131.174 1.00 98.15  ? 501 ILE A CB  1 
ATOM 3628 C CG1 . ILE A 1 501 ? 133.485 122.465 131.517 1.00 98.15  ? 501 ILE A CG1 1 
ATOM 3629 C CG2 . ILE A 1 501 ? 132.145 124.389 132.390 1.00 98.15  ? 501 ILE A CG2 1 
ATOM 3630 C CD1 . ILE A 1 501 ? 134.725 123.012 132.177 1.00 98.15  ? 501 ILE A CD1 1 
ATOM 3631 N N   . ILE A 1 502 ? 130.244 124.633 129.207 1.00 102.14 ? 502 ILE A N   1 
ATOM 3632 C CA  . ILE A 1 502 ? 129.269 125.666 128.862 1.00 102.14 ? 502 ILE A CA  1 
ATOM 3633 C C   . ILE A 1 502 ? 127.891 125.051 128.648 1.00 102.14 ? 502 ILE A C   1 
ATOM 3634 O O   . ILE A 1 502 ? 126.874 125.583 129.115 1.00 102.14 ? 502 ILE A O   1 
ATOM 3635 C CB  . ILE A 1 502 ? 129.738 126.455 127.627 1.00 102.14 ? 502 ILE A CB  1 
ATOM 3636 C CG1 . ILE A 1 502 ? 131.098 127.099 127.895 1.00 102.14 ? 502 ILE A CG1 1 
ATOM 3637 C CG2 . ILE A 1 502 ? 128.717 127.516 127.260 1.00 102.14 ? 502 ILE A CG2 1 
ATOM 3638 C CD1 . ILE A 1 502 ? 131.084 128.101 129.026 1.00 102.14 ? 502 ILE A CD1 1 
ATOM 3639 N N   . PHE A 1 503 ? 127.835 123.918 127.944 1.00 104.17 ? 503 PHE A N   1 
ATOM 3640 C CA  . PHE A 1 503 ? 126.559 123.255 127.702 1.00 104.17 ? 503 PHE A CA  1 
ATOM 3641 C C   . PHE A 1 503 ? 125.938 122.767 129.004 1.00 104.17 ? 503 PHE A C   1 
ATOM 3642 O O   . PHE A 1 503 ? 124.717 122.843 129.185 1.00 104.17 ? 503 PHE A O   1 
ATOM 3643 C CB  . PHE A 1 503 ? 126.747 122.092 126.726 1.00 104.17 ? 503 PHE A CB  1 
ATOM 3644 C CG  . PHE A 1 503 ? 127.279 122.502 125.378 1.00 104.17 ? 503 PHE A CG  1 
ATOM 3645 C CD1 . PHE A 1 503 ? 127.277 123.830 124.982 1.00 104.17 ? 503 PHE A CD1 1 
ATOM 3646 C CD2 . PHE A 1 503 ? 127.766 121.550 124.499 1.00 104.17 ? 503 PHE A CD2 1 
ATOM 3647 C CE1 . PHE A 1 503 ? 127.764 124.200 123.744 1.00 104.17 ? 503 PHE A CE1 1 
ATOM 3648 C CE2 . PHE A 1 503 ? 128.254 121.915 123.259 1.00 104.17 ? 503 PHE A CE2 1 
ATOM 3649 C CZ  . PHE A 1 503 ? 128.252 123.241 122.881 1.00 104.17 ? 503 PHE A CZ  1 
ATOM 3650 N N   . GLY A 1 504 ? 126.762 122.252 129.918 1.00 99.66  ? 504 GLY A N   1 
ATOM 3651 C CA  . GLY A 1 504 ? 126.248 121.826 131.206 1.00 99.66  ? 504 GLY A CA  1 
ATOM 3652 C C   . GLY A 1 504 ? 125.655 122.971 131.999 1.00 99.66  ? 504 GLY A C   1 
ATOM 3653 O O   . GLY A 1 504 ? 124.603 122.825 132.622 1.00 99.66  ? 504 GLY A O   1 
ATOM 3654 N N   . ILE A 1 505 ? 126.313 124.132 131.977 1.00 100.78 ? 505 ILE A N   1 
ATOM 3655 C CA  . ILE A 1 505 ? 125.756 125.301 132.658 1.00 100.78 ? 505 ILE A CA  1 
ATOM 3656 C C   . ILE A 1 505 ? 124.435 125.715 132.018 1.00 100.78 ? 505 ILE A C   1 
ATOM 3657 O O   . ILE A 1 505 ? 123.450 126.014 132.715 1.00 100.78 ? 505 ILE A O   1 
ATOM 3658 C CB  . ILE A 1 505 ? 126.772 126.457 132.659 1.00 100.78 ? 505 ILE A CB  1 
ATOM 3659 C CG1 . ILE A 1 505 ? 128.063 126.032 133.360 1.00 100.78 ? 505 ILE A CG1 1 
ATOM 3660 C CG2 . ILE A 1 505 ? 126.178 127.685 133.326 1.00 100.78 ? 505 ILE A CG2 1 
ATOM 3661 C CD1 . ILE A 1 505 ? 127.839 125.346 134.688 1.00 100.78 ? 505 ILE A CD1 1 
ATOM 3662 N N   . LEU A 1 506 ? 124.392 125.741 130.683 1.00 102.82 ? 506 LEU A N   1 
ATOM 3663 C CA  . LEU A 1 506 ? 123.163 126.117 129.991 1.00 102.82 ? 506 LEU A CA  1 
ATOM 3664 C C   . LEU A 1 506 ? 122.019 125.182 130.357 1.00 102.82 ? 506 LEU A C   1 
ATOM 3665 O O   . LEU A 1 506 ? 120.902 125.633 130.636 1.00 102.82 ? 506 LEU A O   1 
ATOM 3666 C CB  . LEU A 1 506 ? 123.389 126.118 128.480 1.00 102.82 ? 506 LEU A CB  1 
ATOM 3667 C CG  . LEU A 1 506 ? 124.326 127.184 127.915 1.00 102.82 ? 506 LEU A CG  1 
ATOM 3668 C CD1 . LEU A 1 506 ? 124.220 127.237 126.400 1.00 102.82 ? 506 LEU A CD1 1 
ATOM 3669 C CD2 . LEU A 1 506 ? 124.020 128.541 128.526 1.00 102.82 ? 506 LEU A CD2 1 
ATOM 3670 N N   . ALA A 1 507 ? 122.281 123.875 130.371 1.00 100.24 ? 507 ALA A N   1 
ATOM 3671 C CA  . ALA A 1 507 ? 121.251 122.921 130.763 1.00 100.24 ? 507 ALA A CA  1 
ATOM 3672 C C   . ALA A 1 507 ? 120.852 123.107 132.221 1.00 100.24 ? 507 ALA A C   1 
ATOM 3673 O O   . ALA A 1 507 ? 119.672 122.987 132.565 1.00 100.24 ? 507 ALA A O   1 
ATOM 3674 C CB  . ALA A 1 507 ? 121.734 121.494 130.514 1.00 100.24 ? 507 ALA A CB  1 
ATOM 3675 N N   . SER A 1 508 ? 121.819 123.400 133.092 1.00 102.01 ? 508 SER A N   1 
ATOM 3676 C CA  . SER A 1 508 ? 121.529 123.543 134.512 1.00 102.01 ? 508 SER A CA  1 
ATOM 3677 C C   . SER A 1 508 ? 120.680 124.769 134.821 1.00 102.01 ? 508 SER A C   1 
ATOM 3678 O O   . SER A 1 508 ? 120.013 124.791 135.860 1.00 102.01 ? 508 SER A O   1 
ATOM 3679 C CB  . SER A 1 508 ? 122.834 123.597 135.305 1.00 102.01 ? 508 SER A CB  1 
ATOM 3680 O OG  . SER A 1 508 ? 123.570 122.397 135.143 1.00 102.01 ? 508 SER A OG  1 
ATOM 3681 N N   . ILE A 1 509 ? 120.695 125.789 133.959 1.00 105.20 ? 509 ILE A N   1 
ATOM 3682 C CA  . ILE A 1 509 ? 119.795 126.931 134.144 1.00 105.20 ? 509 ILE A CA  1 
ATOM 3683 C C   . ILE A 1 509 ? 118.318 126.519 134.151 1.00 105.20 ? 509 ILE A C   1 
ATOM 3684 O O   . ILE A 1 509 ? 117.448 127.280 134.618 1.00 105.20 ? 509 ILE A O   1 
ATOM 3685 C CB  . ILE A 1 509 ? 120.059 127.999 133.058 1.00 105.20 ? 509 ILE A CB  1 
ATOM 3686 C CG1 . ILE A 1 509 ? 121.545 128.335 132.986 1.00 105.20 ? 509 ILE A CG1 1 
ATOM 3687 C CG2 . ILE A 1 509 ? 119.316 129.285 133.364 1.00 105.20 ? 509 ILE A CG2 1 
ATOM 3688 C CD1 . ILE A 1 509 ? 122.157 128.691 134.323 1.00 105.20 ? 509 ILE A CD1 1 
ATOM 3689 N N   . CYS A 1 510 ? 118.011 125.313 133.669 1.00 102.11 ? 510 CYS A N   1 
ATOM 3690 C CA  . CYS A 1 510 ? 116.631 124.847 133.604 1.00 102.11 ? 510 CYS A CA  1 
ATOM 3691 C C   . CYS A 1 510 ? 115.926 124.904 134.948 1.00 102.11 ? 510 CYS A C   1 
ATOM 3692 O O   . CYS A 1 510 ? 114.706 125.091 134.979 1.00 102.11 ? 510 CYS A O   1 
ATOM 3693 C CB  . CYS A 1 510 ? 116.587 123.413 133.105 1.00 102.11 ? 510 CYS A CB  1 
ATOM 3694 S SG  . CYS A 1 510 ? 117.096 122.257 134.387 1.00 102.11 ? 510 CYS A SG  1 
ATOM 3695 N N   . GLY A 1 511 ? 116.666 124.758 136.048 1.00 104.81 ? 511 GLY A N   1 
ATOM 3696 C CA  . GLY A 1 511 ? 116.037 124.726 137.358 1.00 104.81 ? 511 GLY A CA  1 
ATOM 3697 C C   . GLY A 1 511 ? 115.166 125.937 137.621 1.00 104.81 ? 511 GLY A C   1 
ATOM 3698 O O   . GLY A 1 511 ? 114.123 125.833 138.269 1.00 104.81 ? 511 GLY A O   1 
ATOM 3699 N N   . GLY A 1 512 ? 115.576 127.098 137.125 1.00 107.13 ? 512 GLY A N   1 
ATOM 3700 C CA  . GLY A 1 512 ? 114.722 128.266 137.181 1.00 107.13 ? 512 GLY A CA  1 
ATOM 3701 C C   . GLY A 1 512 ? 113.884 128.397 135.927 1.00 107.13 ? 512 GLY A C   1 
ATOM 3702 O O   . GLY A 1 512 ? 112.689 128.735 135.993 1.00 107.13 ? 512 GLY A O   1 
ATOM 3703 N N   . LEU A 1 513 ? 114.505 128.091 134.778 1.00 104.98 ? 513 LEU A N   1 
ATOM 3704 C CA  . LEU A 1 513 ? 113.835 128.294 133.495 1.00 104.98 ? 513 LEU A CA  1 
ATOM 3705 C C   . LEU A 1 513 ? 112.454 127.656 133.475 1.00 104.98 ? 513 LEU A C   1 
ATOM 3706 O O   . LEU A 1 513 ? 111.455 128.312 133.160 1.00 104.98 ? 513 LEU A O   1 
ATOM 3707 C CB  . LEU A 1 513 ? 114.682 127.718 132.362 1.00 104.98 ? 513 LEU A CB  1 
ATOM 3708 C CG  . LEU A 1 513 ? 116.083 128.263 132.121 1.00 104.98 ? 513 LEU A CG  1 
ATOM 3709 C CD1 . LEU A 1 513 ? 116.779 127.402 131.088 1.00 104.98 ? 513 LEU A CD1 1 
ATOM 3710 C CD2 . LEU A 1 513 ? 116.036 129.715 131.684 1.00 104.98 ? 513 LEU A CD2 1 
ATOM 3711 N N   . VAL A 1 514 ? 112.372 126.380 133.843 1.00 100.44 ? 514 VAL A N   1 
ATOM 3712 C CA  . VAL A 1 514 ? 111.117 125.660 133.678 1.00 100.44 ? 514 VAL A CA  1 
ATOM 3713 C C   . VAL A 1 514 ? 110.277 125.755 134.943 1.00 100.44 ? 514 VAL A C   1 
ATOM 3714 O O   . VAL A 1 514 ? 109.055 125.574 134.906 1.00 100.44 ? 514 VAL A O   1 
ATOM 3715 C CB  . VAL A 1 514 ? 111.394 124.203 133.280 1.00 100.44 ? 514 VAL A CB  1 
ATOM 3716 C CG1 . VAL A 1 514 ? 112.265 124.179 132.047 1.00 100.44 ? 514 VAL A CG1 1 
ATOM 3717 C CG2 . VAL A 1 514 ? 112.044 123.460 134.417 1.00 100.44 ? 514 VAL A CG2 1 
ATOM 3718 N N   . MET A 1 515 ? 110.913 126.033 136.084 1.00 105.54 ? 515 MET A N   1 
ATOM 3719 C CA  . MET A 1 515 ? 110.140 126.301 137.291 1.00 105.54 ? 515 MET A CA  1 
ATOM 3720 C C   . MET A 1 515 ? 109.263 127.532 137.118 1.00 105.54 ? 515 MET A C   1 
ATOM 3721 O O   . MET A 1 515 ? 108.203 127.629 137.748 1.00 105.54 ? 515 MET A O   1 
ATOM 3722 C CB  . MET A 1 515 ? 111.061 126.476 138.500 1.00 105.54 ? 515 MET A CB  1 
ATOM 3723 C CG  . MET A 1 515 ? 110.315 126.607 139.825 1.00 105.54 ? 515 MET A CG  1 
ATOM 3724 S SD  . MET A 1 515 ? 111.233 127.422 141.149 1.00 105.54 ? 515 MET A SD  1 
ATOM 3725 C CE  . MET A 1 515 ? 112.820 126.606 141.040 1.00 105.54 ? 515 MET A CE  1 
ATOM 3726 N N   . LEU A 1 516 ? 109.671 128.475 136.268 1.00 101.41 ? 516 LEU A N   1 
ATOM 3727 C CA  . LEU A 1 516 ? 108.826 129.644 136.045 1.00 101.41 ? 516 LEU A CA  1 
ATOM 3728 C C   . LEU A 1 516 ? 107.629 129.378 135.132 1.00 101.41 ? 516 LEU A C   1 
ATOM 3729 O O   . LEU A 1 516 ? 106.973 130.339 134.717 1.00 101.41 ? 516 LEU A O   1 
ATOM 3730 C CB  . LEU A 1 516 ? 109.656 130.798 135.480 1.00 101.41 ? 516 LEU A CB  1 
ATOM 3731 C CG  . LEU A 1 516 ? 110.251 131.776 136.498 1.00 101.41 ? 516 LEU A CG  1 
ATOM 3732 C CD1 . LEU A 1 516 ? 109.138 132.494 137.243 1.00 101.41 ? 516 LEU A CD1 1 
ATOM 3733 C CD2 . LEU A 1 516 ? 111.179 131.084 137.476 1.00 101.41 ? 516 LEU A CD2 1 
ATOM 3734 N N   . LEU A 1 517 ? 107.319 128.119 134.816 1.00 101.77 ? 517 LEU A N   1 
ATOM 3735 C CA  . LEU A 1 517 ? 106.202 127.796 133.935 1.00 101.77 ? 517 LEU A CA  1 
ATOM 3736 C C   . LEU A 1 517 ? 104.937 127.471 134.736 1.00 101.77 ? 517 LEU A C   1 
ATOM 3737 O O   . LEU A 1 517 ? 105.010 127.143 135.922 1.00 101.77 ? 517 LEU A O   1 
ATOM 3738 C CB  . LEU A 1 517 ? 106.577 126.624 133.031 1.00 101.77 ? 517 LEU A CB  1 
ATOM 3739 C CG  . LEU A 1 517 ? 107.535 126.949 131.883 1.00 101.77 ? 517 LEU A CG  1 
ATOM 3740 C CD1 . LEU A 1 517 ? 107.525 125.847 130.840 1.00 101.77 ? 517 LEU A CD1 1 
ATOM 3741 C CD2 . LEU A 1 517 ? 107.185 128.283 131.254 1.00 101.77 ? 517 LEU A CD2 1 
ATOM 3742 N N   . PRO A 1 518 ? 103.762 127.565 134.111 1.00 99.93  ? 518 PRO A N   1 
ATOM 3743 C CA  . PRO A 1 518 ? 102.497 127.357 134.834 1.00 99.93  ? 518 PRO A CA  1 
ATOM 3744 C C   . PRO A 1 518 ? 101.957 125.930 134.846 1.00 99.93  ? 518 PRO A C   1 
ATOM 3745 O O   . PRO A 1 518 ? 100.810 125.738 135.259 1.00 99.93  ? 518 PRO A O   1 
ATOM 3746 C CB  . PRO A 1 518 ? 101.540 128.275 134.066 1.00 99.93  ? 518 PRO A CB  1 
ATOM 3747 C CG  . PRO A 1 518 ? 102.023 128.181 132.674 1.00 99.93  ? 518 PRO A CG  1 
ATOM 3748 C CD  . PRO A 1 518 ? 103.526 128.117 132.765 1.00 99.93  ? 518 PRO A CD  1 
ATOM 3749 N N   . GLU A 1 519 ? 102.725 124.942 134.391 1.00 106.30 ? 519 GLU A N   1 
ATOM 3750 C CA  . GLU A 1 519 ? 102.514 123.501 134.510 1.00 106.30 ? 519 GLU A CA  1 
ATOM 3751 C C   . GLU A 1 519 ? 101.435 122.958 133.559 1.00 106.30 ? 519 GLU A C   1 
ATOM 3752 O O   . GLU A 1 519 ? 101.442 121.757 133.285 1.00 106.30 ? 519 GLU A O   1 
ATOM 3753 C CB  . GLU A 1 519 ? 102.173 123.079 135.958 1.00 106.30 ? 519 GLU A CB  1 
ATOM 3754 C CG  . GLU A 1 519 ? 101.688 121.652 136.171 1.00 106.30 ? 519 GLU A CG  1 
ATOM 3755 C CD  . GLU A 1 519 ? 102.798 120.632 136.043 1.00 106.30 ? 519 GLU A CD  1 
ATOM 3756 O OE1 . GLU A 1 519 ? 103.580 120.475 137.004 1.00 106.30 ? 519 GLU A OE1 1 
ATOM 3757 O OE2 . GLU A 1 519 ? 102.892 119.990 134.978 1.00 106.30 ? 519 GLU A OE2 1 
ATOM 3758 N N   . THR A 1 520 ? 100.604 123.805 132.953 1.00 106.52 ? 520 THR A N   1 
ATOM 3759 C CA  . THR A 1 520 ? 99.641  123.411 131.914 1.00 106.52 ? 520 THR A CA  1 
ATOM 3760 C C   . THR A 1 520 ? 99.005  122.047 132.187 1.00 106.52 ? 520 THR A C   1 
ATOM 3761 O O   . THR A 1 520 ? 99.092  121.121 131.377 1.00 106.52 ? 520 THR A O   1 
ATOM 3762 C CB  . THR A 1 520 ? 100.299 123.414 130.537 1.00 106.52 ? 520 THR A CB  1 
ATOM 3763 O OG1 . THR A 1 520 ? 101.371 122.463 130.517 1.00 106.52 ? 520 THR A OG1 1 
ATOM 3764 C CG2 . THR A 1 520 ? 100.845 124.792 130.214 1.00 106.52 ? 520 THR A CG2 1 
ATOM 3765 N N   . LYS A 1 521 ? 98.362  121.917 133.343 1.00 112.36 ? 521 LYS A N   1 
ATOM 3766 C CA  . LYS A 1 521 ? 97.781  120.647 133.768 1.00 112.36 ? 521 LYS A CA  1 
ATOM 3767 C C   . LYS A 1 521 ? 96.262  120.750 133.795 1.00 112.36 ? 521 LYS A C   1 
ATOM 3768 O O   . LYS A 1 521 ? 95.702  121.532 134.572 1.00 112.36 ? 521 LYS A O   1 
ATOM 3769 C CB  . LYS A 1 521 ? 98.310  120.233 135.142 1.00 112.36 ? 521 LYS A CB  1 
ATOM 3770 C CG  . LYS A 1 521 ? 97.659  118.976 135.705 1.00 112.36 ? 521 LYS A CG  1 
ATOM 3771 C CD  . LYS A 1 521 ? 97.741  117.807 134.734 1.00 112.36 ? 521 LYS A CD  1 
ATOM 3772 C CE  . LYS A 1 521 ? 99.180  117.394 134.481 1.00 112.36 ? 521 LYS A CE  1 
ATOM 3773 N NZ  . LYS A 1 521 ? 99.271  116.269 133.511 1.00 112.36 ? 521 LYS A NZ  1 
ATOM 3774 N N   . GLY A 1 522 ? 95.602  119.954 132.955 1.00 111.17 ? 522 GLY A N   1 
ATOM 3775 C CA  . GLY A 1 522 ? 94.158  119.833 132.980 1.00 111.17 ? 522 GLY A CA  1 
ATOM 3776 C C   . GLY A 1 522 ? 93.384  121.093 132.675 1.00 111.17 ? 522 GLY A C   1 
ATOM 3777 O O   . GLY A 1 522 ? 92.203  121.172 133.025 1.00 111.17 ? 522 GLY A O   1 
ATOM 3778 N N   . ILE A 1 523 ? 94.001  122.081 132.036 1.00 109.58 ? 523 ILE A N   1 
ATOM 3779 C CA  . ILE A 1 523 ? 93.330  123.332 131.717 1.00 109.58 ? 523 ILE A CA  1 
ATOM 3780 C C   . ILE A 1 523 ? 92.902  123.362 130.244 1.00 109.58 ? 523 ILE A C   1 
ATOM 3781 O O   . ILE A 1 523 ? 92.574  124.420 129.708 1.00 109.58 ? 523 ILE A O   1 
ATOM 3782 C CB  . ILE A 1 523 ? 94.211  124.537 132.094 1.00 109.58 ? 523 ILE A CB  1 
ATOM 3783 C CG1 . ILE A 1 523 ? 94.633  124.419 133.556 1.00 109.58 ? 523 ILE A CG1 1 
ATOM 3784 C CG2 . ILE A 1 523 ? 93.446  125.852 132.021 1.00 109.58 ? 523 ILE A CG2 1 
ATOM 3785 C CD1 . ILE A 1 523 ? 95.700  125.407 133.970 1.00 109.58 ? 523 ILE A CD1 1 
ATOM 3786 N N   . ALA A 1 524 ? 92.878  122.202 129.590 1.00 106.21 ? 524 ALA A N   1 
ATOM 3787 C CA  . ALA A 1 524 ? 92.504  122.068 128.174 1.00 106.21 ? 524 ALA A CA  1 
ATOM 3788 C C   . ALA A 1 524 ? 93.478  122.926 127.369 1.00 106.21 ? 524 ALA A C   1 
ATOM 3789 O O   . ALA A 1 524 ? 94.696  122.809 127.574 1.00 106.21 ? 524 ALA A O   1 
ATOM 3790 C CB  . ALA A 1 524 ? 91.027  122.397 127.995 1.00 106.21 ? 524 ALA A CB  1 
ATOM 3791 N N   . LEU A 1 525 ? 93.009  123.773 126.457 1.00 100.52 ? 525 LEU A N   1 
ATOM 3792 C CA  . LEU A 1 525 ? 93.873  124.667 125.711 1.00 100.52 ? 525 LEU A CA  1 
ATOM 3793 C C   . LEU A 1 525 ? 93.340  126.088 125.822 1.00 100.52 ? 525 LEU A C   1 
ATOM 3794 O O   . LEU A 1 525 ? 92.145  126.316 125.587 1.00 100.52 ? 525 LEU A O   1 
ATOM 3795 C CB  . LEU A 1 525 ? 93.963  124.252 124.234 1.00 100.52 ? 525 LEU A CB  1 
ATOM 3796 C CG  . LEU A 1 525 ? 94.849  123.043 123.923 1.00 100.52 ? 525 LEU A CG  1 
ATOM 3797 C CD1 . LEU A 1 525 ? 94.108  121.748 124.178 1.00 100.52 ? 525 LEU A CD1 1 
ATOM 3798 C CD2 . LEU A 1 525 ? 95.348  123.086 122.494 1.00 100.52 ? 525 LEU A CD2 1 
ATOM 3799 N N   . PRO A 1 526 ? 94.177  127.061 126.183 1.00 102.55 ? 526 PRO A N   1 
ATOM 3800 C CA  . PRO A 1 526 ? 93.675  128.421 126.420 1.00 102.55 ? 526 PRO A CA  1 
ATOM 3801 C C   . PRO A 1 526 ? 93.120  129.039 125.145 1.00 102.55 ? 526 PRO A C   1 
ATOM 3802 O O   . PRO A 1 526 ? 93.616  128.785 124.047 1.00 102.55 ? 526 PRO A O   1 
ATOM 3803 C CB  . PRO A 1 526 ? 94.913  129.173 126.916 1.00 102.55 ? 526 PRO A CB  1 
ATOM 3804 C CG  . PRO A 1 526 ? 96.057  128.426 126.329 1.00 102.55 ? 526 PRO A CG  1 
ATOM 3805 C CD  . PRO A 1 526 ? 95.642  126.983 126.301 1.00 102.55 ? 526 PRO A CD  1 
ATOM 3806 N N   . GLU A 1 527 ? 92.087  129.857 125.304 1.00 106.86 ? 527 GLU A N   1 
ATOM 3807 C CA  . GLU A 1 527 ? 91.430  130.526 124.192 1.00 106.86 ? 527 GLU A CA  1 
ATOM 3808 C C   . GLU A 1 527 ? 91.798  132.004 124.193 1.00 106.86 ? 527 GLU A C   1 
ATOM 3809 O O   . GLU A 1 527 ? 91.884  132.624 125.256 1.00 106.86 ? 527 GLU A O   1 
ATOM 3810 C CB  . GLU A 1 527 ? 89.911  130.365 124.287 1.00 106.86 ? 527 GLU A CB  1 
ATOM 3811 C CG  . GLU A 1 527 ? 89.133  130.992 123.142 1.00 106.86 ? 527 GLU A CG  1 
ATOM 3812 C CD  . GLU A 1 527 ? 89.411  130.323 121.812 1.00 106.86 ? 527 GLU A CD  1 
ATOM 3813 O OE1 . GLU A 1 527 ? 89.782  129.132 121.811 1.00 106.86 ? 527 GLU A OE1 1 
ATOM 3814 O OE2 . GLU A 1 527 ? 89.258  130.988 120.766 1.00 106.86 ? 527 GLU A OE2 1 
ATOM 3815 N N   . THR A 1 528 ? 92.009  132.556 122.998 1.00 106.49 ? 528 THR A N   1 
ATOM 3816 C CA  . THR A 1 528 ? 92.310  133.982 122.737 1.00 106.49 ? 528 THR A CA  1 
ATOM 3817 C C   . THR A 1 528 ? 93.288  134.485 123.800 1.00 106.49 ? 528 THR A C   1 
ATOM 3818 O O   . THR A 1 528 ? 94.346  133.865 123.990 1.00 106.49 ? 528 THR A O   1 
ATOM 3819 C CB  . THR A 1 528 ? 91.014  134.797 122.585 1.00 106.49 ? 528 THR A CB  1 
ATOM 3820 O OG1 . THR A 1 528 ? 91.341  136.181 122.412 1.00 106.49 ? 528 THR A OG1 1 
ATOM 3821 C CG2 . THR A 1 528 ? 90.070  134.655 123.781 1.00 106.49 ? 528 THR A CG2 1 
ATOM 3822 N N   . VAL A 1 529 ? 92.995  135.581 124.501 1.00 109.01 ? 529 VAL A N   1 
ATOM 3823 C CA  . VAL A 1 529 ? 93.947  136.207 125.413 1.00 109.01 ? 529 VAL A CA  1 
ATOM 3824 C C   . VAL A 1 529 ? 93.783  135.600 126.803 1.00 109.01 ? 529 VAL A C   1 
ATOM 3825 O O   . VAL A 1 529 ? 94.468  135.993 127.753 1.00 109.01 ? 529 VAL A O   1 
ATOM 3826 C CB  . VAL A 1 529 ? 93.752  137.737 125.432 1.00 109.01 ? 529 VAL A CB  1 
ATOM 3827 C CG1 . VAL A 1 529 ? 92.390  138.101 126.012 1.00 109.01 ? 529 VAL A CG1 1 
ATOM 3828 C CG2 . VAL A 1 529 ? 94.900  138.456 126.148 1.00 109.01 ? 529 VAL A CG2 1 
ATOM 3829 N N   . ASP A 1 530 ? 92.889  134.618 126.933 1.00 111.67 ? 530 ASP A N   1 
ATOM 3830 C CA  . ASP A 1 530 ? 92.741  133.932 128.212 1.00 111.67 ? 530 ASP A CA  1 
ATOM 3831 C C   . ASP A 1 530 ? 93.920  133.023 128.530 1.00 111.67 ? 530 ASP A C   1 
ATOM 3832 O O   . ASP A 1 530 ? 93.864  132.294 129.526 1.00 111.67 ? 530 ASP A O   1 
ATOM 3833 C CB  . ASP A 1 530 ? 91.444  133.123 128.242 1.00 111.67 ? 530 ASP A CB  1 
ATOM 3834 C CG  . ASP A 1 530 ? 90.210  134.001 128.224 1.00 111.67 ? 530 ASP A CG  1 
ATOM 3835 O OD1 . ASP A 1 530 ? 90.028  134.792 129.173 1.00 111.67 ? 530 ASP A OD1 1 
ATOM 3836 O OD2 . ASP A 1 530 ? 89.423  133.902 127.260 1.00 111.67 ? 530 ASP A OD2 1 
ATOM 3837 N N   . ASP A 1 531 ? 94.971  133.039 127.707 1.00 106.32 ? 531 ASP A N   1 
ATOM 3838 C CA  . ASP A 1 531 ? 96.202  132.340 128.059 1.00 106.32 ? 531 ASP A CA  1 
ATOM 3839 C C   . ASP A 1 531 ? 96.765  132.865 129.371 1.00 106.32 ? 531 ASP A C   1 
ATOM 3840 O O   . ASP A 1 531 ? 97.183  132.084 130.234 1.00 106.32 ? 531 ASP A O   1 
ATOM 3841 C CB  . ASP A 1 531 ? 97.229  132.498 126.938 1.00 106.32 ? 531 ASP A CB  1 
ATOM 3842 C CG  . ASP A 1 531 ? 98.450  131.617 127.129 1.00 106.32 ? 531 ASP A CG  1 
ATOM 3843 O OD1 . ASP A 1 531 ? 98.492  130.840 128.103 1.00 106.32 ? 531 ASP A OD1 1 
ATOM 3844 O OD2 . ASP A 1 531 ? 99.380  131.712 126.303 1.00 106.32 ? 531 ASP A OD2 1 
ATOM 3845 N N   . VAL A 1 532 ? 96.779  134.183 129.543 1.00 112.53 ? 532 VAL A N   1 
ATOM 3846 C CA  . VAL A 1 532 ? 97.290  134.769 130.773 1.00 112.53 ? 532 VAL A CA  1 
ATOM 3847 C C   . VAL A 1 532 ? 96.151  134.898 131.774 1.00 112.53 ? 532 VAL A C   1 
ATOM 3848 O O   . VAL A 1 532 ? 95.571  135.976 131.945 1.00 112.53 ? 532 VAL A O   1 
ATOM 3849 C CB  . VAL A 1 532 ? 97.952  136.130 130.494 1.00 112.53 ? 532 VAL A CB  1 
ATOM 3850 C CG1 . VAL A 1 532 ? 98.541  136.720 131.769 1.00 112.53 ? 532 VAL A CG1 1 
ATOM 3851 C CG2 . VAL A 1 532 ? 99.014  135.974 129.421 1.00 112.53 ? 532 VAL A CG2 1 
ATOM 3852 N N   . GLU A 1 533 ? 95.806  133.788 132.423 1.00 114.45 ? 533 GLU A N   1 
ATOM 3853 C CA  . GLU A 1 533 ? 94.987  133.823 133.625 1.00 114.45 ? 533 GLU A CA  1 
ATOM 3854 C C   . GLU A 1 533 ? 95.744  133.148 134.757 1.00 114.45 ? 533 GLU A C   1 
ATOM 3855 O O   . GLU A 1 533 ? 95.979  133.751 135.809 1.00 114.45 ? 533 GLU A O   1 
ATOM 3856 C CB  . GLU A 1 533 ? 93.639  133.143 133.385 1.00 114.45 ? 533 GLU A CB  1 
ATOM 3857 C CG  . GLU A 1 533 ? 92.741  133.891 132.419 1.00 114.45 ? 533 GLU A CG  1 
ATOM 3858 C CD  . GLU A 1 533 ? 92.230  135.195 132.997 1.00 114.45 ? 533 GLU A CD  1 
ATOM 3859 O OE1 . GLU A 1 533 ? 91.253  135.160 133.774 1.00 114.45 ? 533 GLU A OE1 1 
ATOM 3860 O OE2 . GLU A 1 533 ? 92.807  136.255 132.678 1.00 114.45 ? 533 GLU A OE2 1 
ATOM 3861 N N   . LYS A 1 534 ? 96.151  131.903 134.515 1.00 113.84 ? 534 LYS A N   1 
ATOM 3862 C CA  . LYS A 1 534 ? 96.962  131.096 135.426 1.00 113.84 ? 534 LYS A CA  1 
ATOM 3863 C C   . LYS A 1 534 ? 96.583  131.245 136.898 1.00 113.84 ? 534 LYS A C   1 
ATOM 3864 O O   . LYS A 1 534 ? 95.647  130.604 137.375 1.00 113.84 ? 534 LYS A O   1 
ATOM 3865 C CB  . LYS A 1 534 ? 98.441  131.435 135.231 1.00 113.84 ? 534 LYS A CB  1 
ATOM 3866 C CG  . LYS A 1 534 ? 98.996  130.983 133.884 1.00 113.84 ? 534 LYS A CG  1 
ATOM 3867 C CD  . LYS A 1 534 ? 98.288  129.733 133.375 1.00 113.84 ? 534 LYS A CD  1 
ATOM 3868 C CE  . LYS A 1 534 ? 98.482  129.552 131.880 1.00 113.84 ? 534 LYS A CE  1 
ATOM 3869 N NZ  . LYS A 1 534 ? 97.757  128.358 131.365 1.00 113.84 ? 534 LYS A NZ  1 
# 
